Saurabh Chatterjee

Picture of Saurabh Chatterjee
Professor, Environmental and Occupational Health
Public Health
Professor, Medicine
School of Medicine
Ph.D., University of Mumbai, 2006, Pharmacology
Phone: (919)5992278
University of California, Irvine
5270 California Avenue, Suite 200
Irvine, CA 92697
Research Interests
1. Role of Microbiome (Liver-Gut-Brain Axis) in environment-linked NAFLD: Role of Climate Change Stressors-Harmful Algal Blooms (NIH funding received in 2018) 2. Microbiome alterations, gut-brain axis and Gulf War Illness and chronic multi-symptom illness
Intramural Research Fellow, NIEHS/NIH 2007-2011
Division of Gastroenterology, Duke University School of Medicine, 2011-2012
Awards and Honors
2022: Society of Toxicology SIG “Outstanding Early Career Toxicologist” Award, 2022
2022: Invited panelist and speaker at the American Association for the Advancement of Science (AAAS) on climate change and Health Effects, co-hosted by NIH/NIEHS, February 17th, Philadelphia, 2022
2021: Invited speaker at the Gulf War Illness Research Advisory Council meeting on progress of Biomarkers and Therapeutics, March 10th 2021; Host Professor Lawrence Steinman, Stanford University, Member, National Academy of Sciences, USA
2019: Part of the ASPH delegation and speaker at the Symposium on Environmental and Public Health at the Nanjing Medical University, Nanjing, China, 2019
2019: Panelist and plenary speaker at the Gordon Research Conference (Water, Urbanization and Food Security, Hong University and Technology, Honkong, 2019
2019: VA merit Award, 2019,
2018: Investigator Initiated Research Focus Award, Department of Defense, 2018
2017: Invited Panelist for Ford Foundation Fellowships and Biological and Biomedical Sciences, National Academy of Sciences, United States of America, 2017-2019
2017: Invited Strategic panelist, Veterans' Administration Strategic Group on Gulf War veterans' Illnesses,
2017: Nominated for the Arnold School of Public Health Outstanding Research Award, 2017.
2016: Awarded "2016 Breakthrough Star" from the office of Vice President of Research, USC, the highest research award for Junior faculty at the University.
2016: Nominated for the Arnold School of Public Health Outstanding Research Award 2016.
2015: Elected to the Program committee of the Immunotoxicology Specialty Section, Society of Toxicology
2015: Elected as a council member and Board of Directors, Association of Scientists of Indian Origin, Society of Toxicology, 2015.
2015: Outstanding Young Investigator Award 2015, Society of Toxicology, Immunotoxicology SS, recognizing the contributions to the field of immunotoxicology in the last 10 years.
2015: Board of Publications Honorable Mention Award, Category: National Award, Society of Toxicology (3 out of 300 publications (2013-2014)
2014: ASPIRE-I (Advanced Support Program for Innovative Research Excellence) award from the office of Vice President of Research, USC, 2014
2013: ASPIRE-I award from the office of Vice President of Research, USC, 2013
2012: Fellows Award for Research Excellence (FARE), National Institutes of Health, 2012
2011: Best Postdoctoral Abstract Award, Association of Scientists of Indian Origin (ASIO), 50TH Annual Meeting of Society of Toxicology, 2011
2010: Young Investigator Award, Society for Free Radical Biology and Medicine, 2010
2010: Fellows Award for Research Excellence (FARE), National Institutes of Health, 2010
2007: Intramural Research Training Award, National Institutes of Health, 2007
2006: Research Fellowship Award, University of Brighton, UK-India Education and Research Initiative, British Council (not accepted), 2006
1997: National Scholarship, Department of Science & Technology, Government of India, 1997
1996: National Talent Scholarship, Department of Education, Government of India, 1996
Short Biography
Dr. Chatterjee is a human physiologist with specialized training in immunology. After completing his Ph.D in inflammation biology (Life Sciences) at Bhabha Atomic Research Center affiliated to the University of Mumbai He pursued his postdoctoral work at the Laboratory of Pharmacology and Toxicology, National Institute of Environmental Health Sciences, NIH. Later he continued his specialized research in chronic liver disease at Duke Gastroenterology under the K99 portion of his NIH pathway to Independence Award. He has made significant contributions to the field of host microbiome interactions with redox biology, neuroimmune pathology and gut-brain interactions in pro-inflammatory disease processes like Gulf War illness, chronic multi-symptom illnesses and brain manifestations of liver diseases, drug discovery and gut-brain directed therapeutics. He has been continually funded by NIH, DOD and the VA. Total: $7,564,895 million Extramural: $7,300,895; NIH (P20, P01), DOD (IIRFA), VA (Merit) grants.
1. Saha P, Bose D, Stebliankin V, Cickovski T, Seth RK, Porter DE, Brooks BW, Mathee K, Narasimhan G, Colwell R, Scott GI, Chatterjee S. Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models. Sci Rep. 2022 Jul 7;12(1):11516. doi: 10.1038/s41598-022-15708-3. PMID: 35799048
2. Bose D, Chatterjee SD, Older E, Seth RK, Janulewicz PA, Saha P, Mondal A, Decho A, Sullivan K, Klimas N, Lasley S, Li J, Chatterjee S. Gut resistome presents a unique biome signature in chronic multi-symptom illness patients and links persistent pro-inflammatory phenotype in a mouse model reversible by fecal microbiota transfer. Communications Biology (Nature Portfolio Journal) April, 2022, Accepted, IF:6.2
3. Obesity II: Establishing Causal Links Between Chemical Exposures and Obesity. Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis C, Kay MK, Ji Kim M, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B. Biochem Pharmacol. 2022 Mar 24:115015. doi: 10.1016/j.bcp.2022.115015. Online ahead of print. PMID: 35395240, IF:5.85
4. Obesity I: Overview and molecular and biochemical mechanisms. Lustig RH, Collier D, Kassotis C, Roepke TA, Ji Kim M, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. Biochem Pharmacol. 2022 Mar 30:115012. doi: 10.1016/j.bcp.2022.115012. Online ahead of print. PMID: 35393120, IF: 5.85
5. Muthanna Sultan, Kiesha Wilson, Osama A. Abdulla, Philip Brandon Busbee, Alina Hall, Taylor Carter, Narendra Singh, Chatterjee S, Prakash Nagarkatti and Mitzi Nagarkatti. Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis. Cells 2021, 10(12), 3305; IF:6.6
6. Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks B, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood brain barrier dysfunction and neurodegeneration are NLRP3 and S100B dependent. Toxicology July, 2021. IF:4.332 . Last/Senior/Corresponding author
7. Saha P, Skidmore PT, Holland LA, Mondal A, Bose D, Seth RK, Sullivan K, Janulewicz PA, Horner R, Klimas N, Nagarkatti M, Nagarkatti P, Lim ES, Chatterjee S. Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk. Brain Sci. 2021 Jul 9;11(7):905. doi: 10.3390/brainsci11070905, IF:3.332 . Last/Senior/Corresponding author
8. Lovin LM, Kim S, Taylor RB, Scarlett KR, Langan LM, Chambliss CK, Chatterjee S, Scott JT, Brooks BW Differential influences of (±) anatoxin-a on photolocomotor behavior and gene transcription in larval zebrafish and fathead minnows. Environ Sci Eur. 2021;33(1):40. doi: 10.1186/s12302-021-00479-x. Epub 2021 Mar 30. PMID: 34367861
9. Chatterjee.S, Bose, D., Seth R., Host Gut Microbiome and current state of therapeutics in Gulf War Veterans' Illnesses: A short review. Life Sciences (Elsevier), 2021, IF- 5.02 First/Senior/Corresponding author
10. Abdulla OA, Neamah W, Sultan M, Chatterjee S, Singh N, Nagarkatti M, Nagarkatti P. AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response. Front Immunol. 2021 Feb 19;12:635903. doi: 10.3389/fimmu.2021.635903. eCollection 2021. PMID: 33679792; IF: 6.429;
11. Bose D, Saha P, Mondal A, Fanelli B, Seth RK, Janulewicz P, Sullivan K, Lasley S, Horner R, Colwell RR, Shetty AK, Klimas N, Chatterjee S. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. 2020 Sep 10;12(9):2764. doi: 10.3390/nu12092764. PMID: 32927823; PMCID: PMC7551189. IF: 4.546. Last/Senior/Corresponding author
12. Sarkar S, Saha P, Seth RK, Mondal A, Bose D, Kimono D, Albadrani M, Mukherjee A, Porter DE, Scott GI, Xiao S, Brooks B, Ferry J, Nagarkatti M, Nagarkatti P, Chatterjee S. Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec;238:108854. doi: 10.1016/j.cbpc.2020.108854. Epub 2020 Aug 8. IF: 2.892. Last/Senior/Corresponding author
13. Bose D, Punnag Saha, Kimono D, Ratanesh K. Seth, Ayan Mondal, Patricia Janulewicz, Kimberly Sulivan, Stephen Lasley, Ronnie Horner, Nancy Klimas, Chatterjee S. TLR Antagonism by Sparstolonin B alters microbial signature and modulates gastrointestinal and neuronal inflammation in Gulf War Illness preclinical model. Brain Sci. 2020 Aug 8;10(8). doi: 10.3390/brainsci10080532. IF:3.332 . Last/Senior/Corresponding author
14. Jiang B, Kauffman AE, Li L, McFee W, Cai B, Weinstein J, Lead JR, Chatterjee S, Scott GI, Xiao S. Health impacts of environmental contamination of micro- and nanoplastics: a review. Environ Health Prev Med. 2020 Jul 14;25(1):29. doi: 10.1186/s12199-020-00870-9. IF: 2.71 .
15. Al-Badrani M, Saha P, Mondal A, Seth RK, Sarkar S, Kimono D, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Chatterjee S. Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance. Environ Toxicol Pharmacol. 2020 Jul 17;80:103457. doi: 10.1016/j.etap.2020.103457. IF: 3.292 . Last/Senior/Corresponding author
16. Mohammed A, Alghetaa H, Zhou J, Chatterjee S, Nagarkatti P, Nagarkatti M . Protective Effects of ?9-Tetrahydrocannabinol Against Enterotoxin-induced Acute Respiratory Distress Syndrome is Mediated by Modulation of Microbiota. Br J Pharmacol. 2020 Aug 4. doi: 10.1111/bph.15226. IF: 7.730 .
17. Kimono D, Dipro Bose, Ratanesh K. Seth, Ayan Mondal, Punnag Saha, Patricia Janulewicz, Kimberly Sulivan, Stephen Lasley, Ronnie Horner, Nancy Klimas, Chatterjee S. Host Akkermensia muciniphila abundance correlates with Gulf War Illness symptom persistence via NLRP3 mediated neuroinflammation and decreased brain derived neurotrophic factor. Neurosci Insights. 2020 Jul 27;15:2633105520942480. doi: 10.1177/2633105520942480. eCollection 2020.PMID: 32832901 IF: 3.10 . Last/Senior/Corresponding author
18. Mondal A, Bose D, Saha P, Sarkar S, Seth R, Kimono D, Albadrani M, Nagarkatti M, Nagarkatti P, Chatterjee S. Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. J Neuroinflammation. 2020 Jul 4;17(1):201. doi: 10.1186/s12974-020-01876-4. PMID: 32622362. IF: 7.861 . Last/Senior/Corresponding author
19. Scarlett KR, Kim S, Lovin LM, Chatterjee S, Scott JT, Brooks BW Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards. Sci Total Environ. 2020 Jun 2;738:139807. doi: 10.1016/j.scitotenv.2020.139807. PMID: 32585507 IF: 6.551.
20. Wang Y, Xu J, Stanley JE, Xu M, Brooks BW, Scott GI, Chatterjee S, Zhang Q, Zelinski MB, Xiao S. A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies endocrine disrupting activity of microcystins. Reprod Toxicol. 2020 Feb 1;93:118-130. IF: 3.121
21. Philip B. Busbee, Lorenzo P Menzel, Haider R. Alrafas, Nicholas Dopkins, William Becker, Kathryn Miranda, Chuanbing Tang, Chatterjee S, Udai P Singh, Mitzi Nagarkatti, Prakash Nagarkatti. Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an interleukin 22-dependent manner. JCI Insight. 2020 Jan 16;5(1):e127551. doi: 10.1172/jci.insight.127551.PMID: 31941837. IF:6.205
22. Smith J, Neupane R, McAmis W, Singh U, Chatterjee S, Raychoudhury S. Toxicity of polycyclic aromatic hydrocarbons involves NOX2 activation. Toxicol Rep. 2019 Nov 6;6:1176-1181. doi: 10.1016/j.toxrep.2019.11.006. eCollection 2019. PubMed PMID: 31763181; PMCID: PMC6861563. IF:4.143
23. Sarkar S, Alhasson F, Kimono D, Muayad Albadrani, Ratanesh K. Seth, Shuo Xiao, Dwayne E. Porter, Geoff I. Scott, Bryan Brooks, Mitzi Nagarkatti, Prakash Nagarkatti, Chatterjee S, Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via nox-2-mir21 axis, Environmental Toxicology and Pharmacology,2019,103281,ISSN1382-6689, Last/Senior/Corresponding author
24. Kimono D, Sarkar S, Albadrani M, Seth R, Bose D, Mondal A, Li Y, Kar AN, Nagarkatti M, Nagarkatti P, Sullivan K, Janulewicz P, Lasley S, Horner R, Klimas N, Chatterjee S. (2019). Dysbiosis-Associated Enteric Glial Cell Immune-Activation and Redox Imbalance Modulate Tight Junction Protein Expression in Gulf War Illness Pathology. Frontiers in Physiology. 10. 1229. 10.3389/fphys.2019.01229. IF: 4.134 . Last/Senior/Corresponding author
25. Seth RK, Maqsood R, Mondal A, Bose D, Kimono D, Holland LA, Janulewicz Lloyd P, Klimas N, Horner RD, Sullivan K, Lim ES, Chatterjee S. Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness. Viruses. 2019 Oct 21;11(10). pii: E968. doi: 10.3390/v11100968. PMID: 31640184 IF: 3.841 . Last/Senior/Corresponding author
26. Janulewicz PA, Seth RK, Carlson JM, Ajama J, Quinn E, Heeren T, Klimas N, Lasley SM, Horner RD, Sullivan K, Chatterjee S. The Gut-Microbiome in Gulf War Veterans: A Preliminary Report. Int J Environ Res Public Health. 2019 Oct 4;16(19). pii: E3751. doi: 10.3390/ijerph16193751. PMID:31590322. IF:2.849 . Last/Senior/Co-Corresponding author
27. Neamah WH, Singh NP, Alghetaa H, Abdulla OA, Chatterjee S, Busbee PB, Nagarkatti M, Nagarkatti P. AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes. J Immunol. 2019 Oct 1;203(7):1830-1844. doi: 10.4049/jimmunol.1900291. Epub 2019 Sep 6. IF:4.886 .
28. Wang Y, Liu M, Johnson SB, Yuan G, Arriba AK, Zubizarreta ME, Chatterjee S, Nagarkatti M, Nagarkatti P, Xiao S. Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation. Toxicol Appl Pharmacol. 2019 Oct 15;381:114714. doi: 10.1016/j.taap.2019.114714. Epub 2019 Aug 19. PMID: 31437492. IF:3.347
29. Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S. Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G408-G428. doi: 10.1152/ajpgi.00061.2019. Epub 2019 Aug 8. PMID: 31393787. IF:3.725. Last/Senior/Corresponding author
30. Sarkar S, Kimono D, Albadrani M, Seth RK, Busbee P, Alghetaa H, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease. Sci Rep. 2019 Jun 19;9(1):8742. doi: 10.1038/s41598-019-450091. IF:3.998 . Last/Senior/Corresponding author
31. Kadhim S, Singh NP, Zumbrun EE, Cui T, Chatterjee S, Hofseth L, Abood A, Nagarkatti P, Nagarkatti M. Resveratrol-Mediated Attenuation of Staphylococcus aureus Enterotoxin B-Induced Acute Liver Injury Is Associated With Regulation of microRNA and Induction of Myeloid-Derived Suppressor Cells. Front Microbiol. 2018 Dec 17;9:2910. doi: 10.3389/fmicb.2018.02910. eCollection 2018. IF: 4.076
32. Alharris E, Alghetaa H, Seth R, Chatterjee S, Singh NP, Nagarkatti M, Nagarkatti P. Resveratrol Attenuates Allergic Asthma and Associated Inflammation in the Lungs Through Regulation of miRNA-34a That Targets FoxP3 in Mice. Front Immunol. 2018 Dec 20;9:2992. IF: 6.429
33. Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V,Hasson FA, Singh UP, Seth RK, Scappinie E, Tucker JC, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Sparstolonin B (SSnB) attenuates liverfibrosisvia a parallel conjugate pathway involving P53-P21 axis, TGF-betasignaling and focal adhesion that is TLR4 dependent. Eur J Pharmacol. 2018 Sep 5.pii: S0014-2999(18)30503-X. doi: 10.1016/j.ejphar.2018.08.040. [Epub ahead ofprint] PubMed PMID: 30194936. IF: 3.170. Last/Senior/Corresponding author
34. Seth RK, Kimono D, Alhasson F, Sarkar S, Albadrani M, Lasley SK, Horner R, Janulewicz P, Nagarkatti M, Nagarkatti P, Sullivan K, Chatterjee S. Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness. Toxicol Appl Pharmacol. 2018 Jul 1;350:64-77. doi:10.1016/j.taap.2018.05.006. Epub 2018 May 9. PubMed PMID: 29751049PubMedCentral PMCID: PMC6121708. IF:3.705 . Last/Senior/Corresponding author
35. Alhasson F, Seth RK, Sarkar S, Kimono DA, Albadrani MS, Dattaroy D, Chandrashekaran V, Scott GI, Raychoudhury S, Nagarkatti M, Nagarkatti P, DiehlAM, Chatterjee S. High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axisactivate mesangial cells and promotes renal inflammatory pathology innonalcoholic fatty liver disease. Redox Biol. 2018 Jul;17:1-15. doi:10.1016/j.redox.2018.04.002. Epub 2018 Apr 7. PubMed PMID: 29660503;PubMedCentral PMCID: PMC6006523. IF:9.986 . Last/Senior/Corresponding author
36. Alghetaa H, Mohammed A, Sultan M, Busbee P, Murphy A, Chatterjee S, Nagarkatti M, Nagarkatti P. Resveratrol protects mice against SEB-induced acute lung injury and mortality by miR-193a modulation that targets TGF-ß signalling.J Cell Mol Med. 2018 Mar 7. doi: 10.1111/jcmm.13542. IF: 4.688
37. Kenne GJ, Gummadidala PM, Omebeyinje MH, Mondal AM, Bett DK, McFadden S, Bromfield S, Banaszek N, Velez-Martinez M, Mitra C, Mikell I, Chatterjee S, Wee J, Chanda A. Activation of Aflatoxin Biosynthesis Alleviates Total ROS in Aspergillus parasiticus. Toxins (Basel). 2018 Jan 29;10(2). pii: E57. doi: 10.3390/toxins10020057. IF: 3.531
38. Gängler S, Charisiadis P, Seth R, Chatterjee S, Makris KC. Time of the day dictates the variability of biomarkers of exposure to disinfection byproducts. Environ Int. 2017 Dec 13;112:33-40. doi: 10.1016/j.envint.2017.12.013. [Epub ahead of print] . IF: 7.577
39. Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S. HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol. 2017 Oct;13:8-19. doi: 10.1016/j.redox.2017.05.005. Epub 2017 May 10. IF: 9.986. Last/Senior/Corresponding author
40. Chitrala KN, Guan H, Singh NP, Busbee B, Gandy A, Mehrpouya-Bahrami P, Ganewatta MS, Tang C, Chatterjee S, Nagarkatti P, Nagarkatti M. CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792. Epub 2017 Jun 6. IF: 5.179
41. Alhasson F, Das S, Seth R, Dattaroy D, Chandrashekaran V, Ryan CN, Chan LS, Testerman T, Burch J, Hofseth LJ, Horner R, Nagarkatti M, Nagarkatti P, Lasley SM, Chatterjee S. Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation. PLoS One. 2017 Mar 22;12(3):e0172914. doi: 10.1371/journal.pone.0172914. eCollection 2017. IF: 2.74 Last/Senior/Corresponding author
42. Seth RK, Das S, Dattaroy D, Chandrashekaran V, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM5, Bell PD, Liedtke W , Chatterjee S. TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. Free radical Biology and Medicine, 2016 IF: 6.17. Last/Senior/Corresponding author
43. Shamran H1, Singh NP1, Zumbrun EE1, Murphy A1, Taub DD2, Mishra MK3, Price RL4, Chatterjee S, Nagarkatti M1, Nagarkatti PS1, Singh UP6. Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation. Brain Behav Immun. 2016 Jun 17. pii: S0889-1591(16)30188-X. doi: 10.1016/j.bbi.2016.06.008. IF: 6.306.
44. Makris KC, Andrianou, XD, Pantelis Charisiadis P, Burch JB, Seth RK, Androniki Ioannou A, Michael Picolos M, Costas Christophi C, and Chatterjee S. Association between exposures to brominated trihalomethanes, hepatic injury and type II diabetes mellitus.Environ Int. 2016 May 9;92-93:486-493. doi: 10.1016/j.envint.2016.04.012. IF: 7.577. Last/Senior/Co-Corresponding author
45. Kaur K, Fayad R, Saxena A, Frizzell N, Chanda A, Das S, Chatterjee S, Hegde S, Baliga MS, Ponemone V, Rorro M, Greene J, Elraheb Y, Redd AJ, Bian J, Restaino J, Norris LB, Qureshi ZP, Love BL, Brookstaver B, Georgantopoulos P, Sartor O, Raisch DW, Rao G, Lu K, Ray P, Hrusheshky W, Schulz R, Ablin R, Noxon V, Bennett CL; Southern Network on Adverse Reactions (SONAR) project. Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network.J Community Support Oncol. 2016 Feb;14(2):54-65. doi: 10.12788/jcso.0167.PMID:26955658 IF: 0.34.
46. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Chatterjee S………(many authors) et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. No abstract available. IF: 9.77.
47. Dattaroy D, Seth RK; Chandrashekaran V; Das S; Alhasson F; Michelotti GA; Fan D, Nagarkatti M; Nagarkatti P; Diehl AM; Chatterjee S. Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4-trafficking in lipid rafts via NADPH oxidase activation. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G510-25. doi: 10.1152/ajpgi.00259.2015. Epub 2015 Dec 30.PMID: 26718771 IF: 3.725. Last/Senior/Corresponding author
48. Singh NP, Singh UP, Rouse M, Zhang J, Chatterjee S, Nagarkatti PS, Nagarkatti M. Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA. J Immunol. 2015 Dec 28. pii: 1501727. IF: 4.886
49. Chandrashekaran V, Das S, Seth RK, Dattaroy D, Alhasson F, Michelotti G, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S. Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. Biochim Biophys Acta. 2016 Jan;1862(1):32-45. doi: 10.1016/j.bbadis.2015.10.009. Epub 2015 Oct 22.PMID:26474534 IF: 3.422. Last/Senior/Corresponding author
50. Alhasson F, Dattaroy D, Das S., Seth R.K., Chandrasekharan V., Schnellmann R.G., Chatterjee S. NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity. Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F85-F101. doi: 10.1152/ajprenal.00243.2015. Epub 2015 Oct 7.PMID: 26447219. IF: 3.191. Last/Senior/Corresponding author
51. Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Gantner BN, Bonini MG. NOS1-derived nitric oxide promotes NF?B transcriptional activity through inhibition of Suppressor of Cytokine Signaling (SOCS-1). J Exp Med. 2015 Sep 21;212(10):1725-38. doi: 10.1084/jem.20140654. Epub 2015 Aug 31. PMID: 26324446. IF: 11.743
52. Chatterjee S., and Das S. P2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis. Oxid Med Cell Longev. 2015;2015:172493. doi: 10.1155/2015/172493. Epub 2015 Mar 1.PMID: 25815106; IF: 5.076. First/Senior/Corresponding author
53. Burch JM, Everson T, Seth RK, Wirth M and Chatterjee S. Exposure to Trihalomethanes and Biomonitoring for the Chronic Liver Disease Indicator, Alanine Aminotransferase, in the United States Population (NHANES 1999-2006). Sci Total Environ. 2015 Jul 15;521-522:226-34. doi: 10.1016/j.scitotenv.2015.03.050. Epub 2015 Apr 2. PMID: 25847167. IF: 6.551. Last/Senior/Co-Corresponding author
54. Narsale A, Enos R, Puppa M, Chatterjee S, Murphy AE, Fayad R, Pena M, Durstine LJ and Carson J.
Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression. PLoS One. 2015 Mar 19;10(3):e0119888. doi: 10.1371/journal.pone.0119888. eCollection 2015.PMID: 25789991. IF:2.740
55. Das S, Seth RK, Dattaroy D, Alhasson F, Pourhoseini S, Nagarkatti M, Nagarkatti P, Michelotti GA, Diehl AM, Chatterjee S. NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. Am J Pathol. 2015 Jul;185(7):1944-57. doi: 10.1016/j.ajpath.2015.03.024. Epub 2015 May 16.PMID: 25989356. IF: 4.069. Last/Senior/Corresponding author
56. Dattaroy D, Pourhosseini S, Das S, Alhasson F, Seth RK, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Micro RNA 21 inhibition of SMAD 7 enhances fibrogenesis via leptin mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G298-312. doi: 10.1152/ajpgi.00346.2014. Epub 2014 Dec 11.PMID: 25501551 IF: 3.725. Last/Senior/Corresponding author
57. Pourhoseini S, Seth RK, Das S, Dattaroy D, Kadiiska MB, Xie G, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S. Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. PLoS One. 2015 Feb 6;10(2):e0116780. doi: 10.1371/journal.pone.0116780. eCollection 2015.PMID: 25658689. IF: 2.740. Last/Senior/Corresponding author
58. Seth RK, Das S, Pourhoseini S, Dattaroy D, Igwe S, Basuray J, Fan D, Michelotti GA, Diehl AM, Chatterjee S. M1 Polarization bias and subsequent NASH progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1 induced oxidative stress in obese mice. J Pharmacol Exp Ther. 2015 Jan;352(1):77-89. doi: 10.1124/jpet.114.218131. Epub 2014 Oct 27.PMID: 25347994, IF: 3.867. Last/Senior/Corresponding author
59. Jia X, Iwanowycz S, Wang J, Saaoud F, Yu F, Wang Y, Hu J, Chatterjee S, Wang Q, Fan D., Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. Exp Biol Med (Maywood). 2014 Aug;239(8):1025-1035. doi: 10.1177/1535370214530247. Epub 2014 Apr 16.PMID: 24740873. IF: 3.139
60. Seth RK, Das S, Kumar A, Chanda A, Kadiiska MB, Michelotti G, Manautou J, Diehl AM and Chatterjee S. CYP2E1-Dependent and Leptin-Mediated Hepatic CD57 Expression on CD8+ve T Cells aid Progression of Environment-Linked Nonalcoholic Steatohepatitis" has been received for consideration in Toxicology and Applied Pharmacology. Toxicol Appl Pharmacol. 2014 Jan 1;274(1):42-54. doi: 10.1016/j.taap.2013.10.029. Epub 2013 Nov 7.PMID: 24211274. IF: 3.705. Last/Senior/Corresponding author
61. Das S, Seth RK, Kumar A, Kadiiska MB, Michelotti G, Diehl AM and Chatterjee S. Purinergic Receptor X7 is a Key Modulator of Metabolic Oxidative Stress- Mediated Autophagy and Inflammation in Experimental Nonalcoholic Steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G950-63. doi: 10.1152/ajpgi.00235.2013. Epub 2013 Oct 24.PMID: 24157968. IF: 3.725. Last/Senior/Corresponding author
62. Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A. The janus of oxidative stress signaling in different pathophysiological conditions. Oxid Med Cell Longev. 2013 doi: 10.1155/2013/708796. Epub 2013 Jun 19. IF:5.076
63. Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Muñoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: Advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta. 2013 May 2. doi:pii: S0304-4165(13)00194-3. IF:3.422
64. Seth RK, Kumar A, Das S, Michelotti G, Kadiiska MB, Diehl AM and Chatterjee S. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci. (2013) 134(2):291-303 . IF: 3.703. Last/Senior/Corresponding author
65. Kumar A, Ganini D, Deterding LJ, Ehrenshaft M, Chatterjee S, Mason RP. Immuno-spin trapping of heme-induced protein radicals: Implications for heme oxygenase-1 induction and heme degradation. Free Radic Biol Med. 2013 Apr 25;61C:265-272. IF: 6.170.
66. Das S., Kumar A., Seth R., Tokar EJ., Waalkes MP., Kadiiska MB., Mason RP., Chatterjee S. Proinflammatory Adipokine Leptin Mediates Disinfection Byproduct Bromodichloromethane-induced Early Steatohepatitic Injury in Obesity. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):297-306 IF: 3.705. Last/Senior/Corresponding author
67. Sinha BK, Bhattacharjee S, Chatterjee S, Jiang J, Motten AG, Kumar A, Espey MG, Mason RP. Role of nitric oxide in the chemistry and anticancer activity of etoposide (VP-16,213). Chem Res Toxicol. 2013 Mar 18;26(3):379-87. IF:3.278
68. Chatterjee S*, Ganini D, Tokar EJ, Kumar A, Das S, Corbett J, Kadiiska M, Waalkes M, Diehl AM, Mason RP. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental nonalcoholic steatohepatitis. J Hepatol. 2013 Apr;58(4):778-84 IF: 25.083 First/Corresponding author
69. Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol. 2013 Jan 15;266(2):224-32 IF: 3.705
70. Ansenberger-Fricano K, Ganini D, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG. The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med. 2013 Jan;54:116-24. IF:6.17
71. Bhattacharjee S, Chatterjee S, Jiang J, Sinha BK and Mason RP. Detection and imaging of the free radical DNA in cells--site-specific radical formation induced by Fenton chemistry and its repair in cellular DNA as seen by electron spin resonance, immuno-spin trapping and confocal microscopy. Nucleic Acids Res. 2012 Jul;40(12):5477-86. IF:11.502
72. Chatterjee S*, Rana R, Corbett J, Kadiiska MB, Goldstein J, Mason RP. P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. Free Radic Biol Med. 2012 May 1;52(9):1666-79. IF: 6.17, First/Corresponding author
73. Bhattacharjee S, Deterding LJ, Chatterjee S, Jiang J, Ehrenshaft M, Lardinois O, Ramirez DC, Tomer KB, and Mason RP. Site-specific radical formation in DNA induced by Cu9II)-H2O2 oxidizing system, using ESR, Immunospintrapping, LC/MS and MS/MS. Free Radic Biol Med. 2011 Jun 1;50(11):1536-45. IF: 6.17
74. Chatterjee S, Lardinois O, Bhattacharjee S, Tucker CJ, Corbett J, Deterding L, Ehrenshaft M, Bonini M.G. and Mason RP. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med. 2011 Apr 15;50(8):988-99. IF: 6.17, First/Corresponding author
75. Lardinois OM, Chatterjee S, Mason RP, Tomer KB, Deterding LJ. Biotinylated Analogue of the Spin-Trap 5,5-Dimethyl-1-pyrroline-N-oxide for the Detection of Low-Abundance Protein Radicals by Mass Spectrometry. Anal Chem. 2010 Nov 15;82(22):9155-8. IF: 6.785
76. Ranguelova K, Chatterjee S, Ehrenshaft M, Ramirez DC, Kadiiska M and Ronald P. Mason. Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite. J Biol Chem. 2010 Jul 30;285(31):24195-20. IF: 4.238
77. Chatterjee S*, Lardinois O, Bonini MG, Bhattacharjee S, Stadler K, Corbett J, Deterding L, Kadiiska M, Tomer KB and Mason RP. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol. 2009 Sep 15;183(6):4055-66 IF: 4.886, First/Corresponding author
78. Shukla J, Chatterjee S, Thakur VS, Premachandran S, Checker R, Poduval TB. L-Arginine reverses radiation-induced immune dysfunction: the need for optimum treatment window. Radiat Res. 2009 Feb;171(2):180-7. IF: 2.539
79. Chatterjee S*, Ehrenshaft M, Bhattacharjee S, Deterding LJ, Bonini MG, Corbett J, Kadiiska MB, Tomer KB, Mason RP. Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med. 2009 Feb 15;46(4):454-61. IF: 6.17, First/Corresponding author
80. Chatterjee S, Premachandran S, Shukla J, Poduval TB. Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide-induced septic shock. J Surg Res. 2007 Jun 1;140(1):99-108. IF: 2.187
81. Chatterjee S, Premachandran, S., Bagewadikar, RS.,Bhattacharya, S. , Chattopadhyay, S. and Poduval TB: Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: Role of Th1/Th2 cytokine Balance. Nitric Oxide. 2006 Dec;15(4):408-16. IF: 3.311
82. Chatterjee S, Premachandran S, Sharma D, Bagewadikar RS, Poduval TB. Therapeutic treatment with L-arginine rescues mice from heat stroke-induced death: physiological and molecular mechanisms. Shock. 2005 Oct;24(4):341-7. IF: 3.048
83. Chatterjee S, Premachandran S, Bagewadikar RS, Poduval TB. The use of ELISA to monitor amplified hemolysis by the combined action of osmotic stress and radiation: potential applications. Radiat Res. 2005 Mar;163(3):351-5. IF:2.539
84. Chatterjee S, Poduval TB, Tilak JC, Devasagayam TP. A modified, economic, sensitive method for measuring total antioxidant capacities of human plasma and natural compounds using Indian saffron (Crocus sativus). Clin Chim Acta. 2005 Feb;352(1-2):155-63. IF:2.535
85. Thakur VS, Shankar B, Chatterjee S, Premachandran S, Sainis KB. Role of tumor-derived transforming growth factor-beta1 (TGF-beta1) in site-dependent tumorigenicity of murine ascitic lymphosarcoma. Cancer Immunol Immunother. 2005 Sep;54(9):837-47 IF: 5.442
86. Poduval TB, Chatterjee S, Sainis KB. Effect of nitric oxide on mortality of mice after whole body hyperthermia. Int J Hyperthermia. 2003 Jan-Feb;19(1):35-44. IF: 3.98
Manuscripts under review/in preparation
1 .Seth RK, Saha P, Bose D, Mondal A, Sullivan K, Janulewicz PA, Shetty A, O'Callaghan J, Klimas N, Chatterjee S. Ampakine CX546 ameliorate Gut-derived extracellular HMGB1 induced neurological ailment in experimental Gulf War Illness. (Manuscript under preparation)
2 .Seth RK, Saha P, Bose D, Sullivan K, Janulewicz PA, Klimas N, Chatterjee S. Nexinhib 20 ameliorates hepatic extracellular HMGB1 mediated M1 polarization and liver inflammation in a mouse model of Gulf War Illness. (preparation)
Free Radical mechanisms of environmental potentiation of hepatotoxicity (completed) PI NIH/NIEHS (R00) $749,000 2012 2017 CAM Center for Epigenetic Regulation of Inflammation (Project 4). "Sparstolonin B as a TLR antagonist in suppression of liver inflammation through Epigenetic mechanisms" *Project PI NIH/NCC/AM P01AT003961 $8 million; Chatterjee Share $865,000 Under No- Cost extension 2014 2020 Department of Defense, Gulf War Research Consortium Pilot Funding: PI DOD/CDMRP W81XWH-13-2-0072 $26,895 2017 2018 IIFRA Department of Defense PI DOD/CDMRP W81XWH1810374-02 $ 1,002,520 2018 2022 NIH/NIEHS, P01 OHHI Center Grant *Project PI NIH: 5P01ES028942-02-5262 $ 1,425,000 2018 2023 NIH/NIGMS, P20, Inflammation and Epigenetics *Project PI NIH: 5P20GM10364107-5993 $ 1,125,000 2018 2023 VA Merit Award (CSRD) RFA: BX-18-007/CX-18-013 PI Department of Veterans Affairs 1 I01 CX001923-01 $ 2,422,000 2019 2023 VA Merit Award (CSRD) RFA: CX-21-013 PI Department of Veterans Affairs $ 2,529,000 2022 2027 NIH K01 (PI: Dr. Shuo Xiao) USC Mentor NIEHS $ 487,000 (No cost to Mentor) 2018 2021 USC VPR ASPIRE I PI U of SC internal $ 15,000 2013 2014 USC VPR ASPIRE I PI U of SC internal $ 15,000 2014 2015 USC Smart State Center PI: Mitzi Nagarkatti Co-I U of SC internal $ 10,000/year 2018 Present USC Center for Teaching Excellence Pedagogy Grant PI USC CTE $ 800 2018 2019 A: Grants and Contracts Received: Completed/Active *NIH Project PIs are independent PIs with induvial R01 like projects and are peer-reviewed in the same criteria as R01 projects. Blue: Funding obtained 2012-2016; Brown: Funding obtained 2016-2019; Peach: Funding obtained via internal mechanisms. P01 grants and the VA merit had 5-7% budget cuts in year 2 due to federal policies and the PI is not involved in the funding amount decisions.
Graduate Programs
Environmental Toxicology
Last updated