Javier Diaz Alonso
Assistant Professor, Anatomy & Neurobiology
School of Medicine
School of Medicine
Ph.D., Complutense University of Madrid, 2014, Biochemistry and Molecular Biology
University of California, Irvine
835 Health Sciences Road.
Irvine Hall room 140
UC Irvine
Irvine, CA 92697
835 Health Sciences Road.
Irvine Hall room 140
UC Irvine
Irvine, CA 92697
Research Interests
Synaptic transmission; Synapse organization; Synaptic plasticity; AMPA receptors; endocannabinoid system
Websites
Publications
Díaz-Alonso J#, Nicoll RA#. “AMPA receptor trafficking and LTP: Carboxy-termini, Amino-termini and TARPs” Neuropharmacology. 2021, Jul 12. Accepted for publication. #Co-corresponding authors. Review.
Paraíso-Luna J, Aguareles J, Martín R, Ayo-Martín AC, Simón-Sánchez S, García-Rincón D, Costas-Insua C, García-Taboada E, Salas-Quiroga A, Díaz-Alonso J, Isabel Liste I, Sánchez-Prieto J, Cappello S, Guzmán M, Galve-Roperh I “Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB 1 receptors” Development. 2020 Nov 9;dev.192161. doi: 10.1242/dev.192161. Online ahead of print.
Díaz-Alonso J#, Morishita W, Incontro S, Simms J, Holtzman J, Gill M, Mucke L, Malenka RC, Nicoll RA#. “Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit”. Elife. 2020 Aug 24;9:e58042. doi: 10.7554/eLife.58042. #Co-corresponding authors.
Zeng M*, Díaz-Alonso J*, Ye F, Chen X, Xu J, Ji Z, Nicoll RA, Zhang M. “Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission”. Neuron. 2019 Nov 6;104(3):529-543. *First authors.
García-Rincón D, Diaz-Alonso J, Ortega Z, de Salas-Quiroga A, Paraíso-Luna J, Aguareles J, Jou C, De Prada I, Martinez Cerdeño V, Aronica E, Guzmán M, Pérez-Jimenez MA and Galve-Roperh I. “Contribution of altered endocannabinoid system to overactive mTORC1 signaling in focal cortical dysplasia” Front Pharmacol. 2019 Jan 9;9:1508.
Tao W, Díaz-Alonso J, Sheng N, Nicoll RA. “Postsynaptic d1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin”. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23) :E5373-E5381.
Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA. “The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms”. Nat Commun. 2018 May 25;9(1):2069.
Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA. “LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes”. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3948-3953.
Ancona Esselmann SG, Díaz-Alonso J, Levy JM, Bemben MA, Nicoll RA. “Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2”. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13266-13271.
Díaz-Alonso J*#, Sun YJ*, Granger AJ*, Levy JM, Blankenship SM, Nicoll RA# “Subunit specific role for the amino-terminal domain of AMPA receptors in synaptic targeting”. Proc Natl Acad Sci U S A. Jul 3;114(27):7136-7141. *First authors. #Corresponding authors.
Bravo-Ferrer I, Cuartero M, Zarruk J, Pradillo J, Hurtado O, Romera V, Díaz-Alonso J, García-Segura JM, Guzmán M, Lizasoain I, Galve-Roperh I, Moro MA “The cannabinoid type-2 receptor drives neurogenesis and improves functional outcome after stroke”. Stroke. 2017, Jan; 48(1): 204-212.
Sanchez AM, Quattrone F, Pannese M, Ulisse A, Candiani M, Diaz-Alonso J, Velasco G, Panina-Bordignon P. “The cannabinoid receptor CB1 contributes to the development of ectopic lesions in a mouse model of endometriosis”. Hum Reprod. 2017 Jan;32(1):175-184.
Díaz-Alonso J*#, de Salas-Quiroga A*, Garcez PP, Parsons M, Andradas C, Paraíso-Luna J, García-Rincón D, Sánchez C, Guillemot F, Guzmán M, Galve-Roperh I# “Loss of cannabinoid CB1 receptors induces cortical migration malformations and increases seizure susceptibility”. Cereb Cortex. 2017 Nov 1;27(11):5303-5317.*First authors. #Corresponding authors.
Díaz-Alonso J*, Paraíso-Luna J*, Navarrete C*, del Río C, Cantarero I, Palomares B, Aguareles J, Fernández-Ruiz J, Bellido ML, Pollastro F, Appendino G, Calzado MA, Galve-Roperh I, Muñoz E “VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease”. Sci Rep. 2016 Jul;6:29789. *First authors.
de Salas-Quiroga A*, Díaz-Alonso J*, García-Rincón D, Remmers F, Vega D, Gómez-Cañas M, Lutz B, Guzmán M, Galve-Roperh I “Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons”. Proc Natl Acad Sci U S A. 2015 Nov; 112(44):13693-8. *First authors.
Díaz-Alonso J, Aguado T, de Salas-Quiroga A, Ortega Z, Guzmán M, Galve-Roperh I “CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex”. Cereb Cortex. 2015 Sep; 25(9):2395-408.
Garcez, PP, Díaz-Alonso, J, Crespo, I, Castro, D, Bell, D, Guillemot, F “Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1”. Nat Commun. 2015 Mar 10;6:6474.
Galve-Roperh I, Chiurchiù V, Díaz-Alonso J, Bari M, Guzmán M, Maccarrone M “Cannabinoid receptor signaling in progenitor/stem cell proliferation and Differentiation”. Prog Lipid Res. 2013 Oct; 52:633-50. 2013.
Campos, AC, Palazuelos, J, Ortega, Z, Aguiar, DC, Díaz-Alonso, J, Moreira, FA, Guzmán, M, Guimarães, FS, Galve-Roperh, I "The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system”. Int J Neuropsychopharmacol. 2013 Jul; 9:1-13.
Díaz-Alonso J, Guzmán M, Galve-Roperh I "Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development". Philos Trans R Soc Lond B Biol Sci. 2012 Dec; 367:3229-41.
Díaz-Alonso, J, Aguado, T, Wu, C-S, Palazuelos, J, Hofmann, C, Garcez, P, Guillemot, F, Lu, H.C, Lutz, B, Guzmán, M, Galve-Roperh, I "The CB1 cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis". J Neurosci. 2012 Nov; 32:16651-65.
Palazuelos, J, Ortega, Z, Díaz-Alonso, J, Guzmán, M, Galve-Roperh, I "CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling". J Biol Chem. 2012 Jan; 287:1198-209.
Paraíso-Luna J, Aguareles J, Martín R, Ayo-Martín AC, Simón-Sánchez S, García-Rincón D, Costas-Insua C, García-Taboada E, Salas-Quiroga A, Díaz-Alonso J, Isabel Liste I, Sánchez-Prieto J, Cappello S, Guzmán M, Galve-Roperh I “Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB 1 receptors” Development. 2020 Nov 9;dev.192161. doi: 10.1242/dev.192161. Online ahead of print.
Díaz-Alonso J#, Morishita W, Incontro S, Simms J, Holtzman J, Gill M, Mucke L, Malenka RC, Nicoll RA#. “Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit”. Elife. 2020 Aug 24;9:e58042. doi: 10.7554/eLife.58042. #Co-corresponding authors.
Zeng M*, Díaz-Alonso J*, Ye F, Chen X, Xu J, Ji Z, Nicoll RA, Zhang M. “Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission”. Neuron. 2019 Nov 6;104(3):529-543. *First authors.
García-Rincón D, Diaz-Alonso J, Ortega Z, de Salas-Quiroga A, Paraíso-Luna J, Aguareles J, Jou C, De Prada I, Martinez Cerdeño V, Aronica E, Guzmán M, Pérez-Jimenez MA and Galve-Roperh I. “Contribution of altered endocannabinoid system to overactive mTORC1 signaling in focal cortical dysplasia” Front Pharmacol. 2019 Jan 9;9:1508.
Tao W, Díaz-Alonso J, Sheng N, Nicoll RA. “Postsynaptic d1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin”. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23) :E5373-E5381.
Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA. “The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms”. Nat Commun. 2018 May 25;9(1):2069.
Sheng N, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA. “LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes”. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3948-3953.
Ancona Esselmann SG, Díaz-Alonso J, Levy JM, Bemben MA, Nicoll RA. “Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2”. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13266-13271.
Díaz-Alonso J*#, Sun YJ*, Granger AJ*, Levy JM, Blankenship SM, Nicoll RA# “Subunit specific role for the amino-terminal domain of AMPA receptors in synaptic targeting”. Proc Natl Acad Sci U S A. Jul 3;114(27):7136-7141. *First authors. #Corresponding authors.
Bravo-Ferrer I, Cuartero M, Zarruk J, Pradillo J, Hurtado O, Romera V, Díaz-Alonso J, García-Segura JM, Guzmán M, Lizasoain I, Galve-Roperh I, Moro MA “The cannabinoid type-2 receptor drives neurogenesis and improves functional outcome after stroke”. Stroke. 2017, Jan; 48(1): 204-212.
Sanchez AM, Quattrone F, Pannese M, Ulisse A, Candiani M, Diaz-Alonso J, Velasco G, Panina-Bordignon P. “The cannabinoid receptor CB1 contributes to the development of ectopic lesions in a mouse model of endometriosis”. Hum Reprod. 2017 Jan;32(1):175-184.
Díaz-Alonso J*#, de Salas-Quiroga A*, Garcez PP, Parsons M, Andradas C, Paraíso-Luna J, García-Rincón D, Sánchez C, Guillemot F, Guzmán M, Galve-Roperh I# “Loss of cannabinoid CB1 receptors induces cortical migration malformations and increases seizure susceptibility”. Cereb Cortex. 2017 Nov 1;27(11):5303-5317.*First authors. #Corresponding authors.
Díaz-Alonso J*, Paraíso-Luna J*, Navarrete C*, del Río C, Cantarero I, Palomares B, Aguareles J, Fernández-Ruiz J, Bellido ML, Pollastro F, Appendino G, Calzado MA, Galve-Roperh I, Muñoz E “VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease”. Sci Rep. 2016 Jul;6:29789. *First authors.
de Salas-Quiroga A*, Díaz-Alonso J*, García-Rincón D, Remmers F, Vega D, Gómez-Cañas M, Lutz B, Guzmán M, Galve-Roperh I “Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons”. Proc Natl Acad Sci U S A. 2015 Nov; 112(44):13693-8. *First authors.
Díaz-Alonso J, Aguado T, de Salas-Quiroga A, Ortega Z, Guzmán M, Galve-Roperh I “CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex”. Cereb Cortex. 2015 Sep; 25(9):2395-408.
Garcez, PP, Díaz-Alonso, J, Crespo, I, Castro, D, Bell, D, Guillemot, F “Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1”. Nat Commun. 2015 Mar 10;6:6474.
Galve-Roperh I, Chiurchiù V, Díaz-Alonso J, Bari M, Guzmán M, Maccarrone M “Cannabinoid receptor signaling in progenitor/stem cell proliferation and Differentiation”. Prog Lipid Res. 2013 Oct; 52:633-50. 2013.
Campos, AC, Palazuelos, J, Ortega, Z, Aguiar, DC, Díaz-Alonso, J, Moreira, FA, Guzmán, M, Guimarães, FS, Galve-Roperh, I "The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system”. Int J Neuropsychopharmacol. 2013 Jul; 9:1-13.
Díaz-Alonso J, Guzmán M, Galve-Roperh I "Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development". Philos Trans R Soc Lond B Biol Sci. 2012 Dec; 367:3229-41.
Díaz-Alonso, J, Aguado, T, Wu, C-S, Palazuelos, J, Hofmann, C, Garcez, P, Guillemot, F, Lu, H.C, Lutz, B, Guzmán, M, Galve-Roperh, I "The CB1 cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis". J Neurosci. 2012 Nov; 32:16651-65.
Palazuelos, J, Ortega, Z, Díaz-Alonso, J, Guzmán, M, Galve-Roperh, I "CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling". J Biol Chem. 2012 Jan; 287:1198-209.
Grants
MH118425 K99/R00 NIH/NIMH Pathway to Independence Award.
NARSAD BBRF Young Investigator Award.
Professional Societies
Society for Neuroscience
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6899
https://faculty.uci.edu/profile/?facultyId=6899
Last updated
10/04/2021
10/04/2021