Olivia L. Lee

Picture of Olivia L. Lee
Associate Clinical Professor, Ophthalmology
School of Medicine
Director, Anterior Segment Imaging Laboratory
School of Medicine
M.D., Baylor College of Medicine, 2005
Phone: Patient Appointments: (949) 824-2020; Academic Office: (949) 824-3476
Email: rlorn@hs.uci.edu
University of California, Irvine
Gavin Herbert Eye Institute
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
Research Interests
ocular imaging, confocal microscopy, dry eye/ocular surface disease, graft versus host disease, keratoplasty
Awards and Honors
2009 Louise J. Girard Award for Ophthalmic Research

April 23, 2012 Film Festival Winner: Category New Producer, ASCRS Symposium

2013, 2014, 2015 Los Angeles Magazine Super Doctors Southern California Rising Stars

2012 – 2016 Pasadena Magazine Top Doctors

April 29, 2014 Best Paper of Session 4-F: Cornea Pathology, Biomechanics; ASCRS Symposium

April 19, 2015 Best Paper of Session 2-J: Cornea Imaging and Topography; ASCRS Symposium

April 17-21, 2015 Best Electronic Poster: Cornea; ASCRS Symposium

May 10, 2016 Best Paper of Session: 4-A CORNEA Infectious Keratitis, ASCRS Symposium

May 6, 2017 Paper selected by ASCRS Young Eye Surgeons (YES) Clinical Committee for presentation at Residents and Fellows Best Papers and Poster Session

2018 Achievement Award, AAO
Short Biography
Dr. Olivia Lee is dual fellowship trained in both corneal diseases and uveitis. As a high school student, an internship at the Laboratory of Immunology at the National Eye Institute sparked her interest in uveitis and ophthalmology. She received her medical degree from Baylor College of Medicine and trained at both New York Eye & Ear Infirmary as well as Jules Stein Eye Institute. Prior to her arrival at UCI, Dr. Lee served as the cornea fellowship program director at Doheny Eye Center UCLA.

Her clinical interests include inflammatory ocular surface disease and complex anterior segment surgery. She performs many types of corneal surgeries such as DSAEK, DMEK, DALK, Boston keratoprosthesis, ocular surface reconstruction, and limbal stem cell transplantation. Furthermore, she also offers cataract surgery, particularly in complex situations in the setting of uveitis.

Dr. Lee's research focuses on the use of anterior segment ophthalmic imaging to develop new clinical endpoints to objectively characterize disease severity and guide clinical decision-making. She has particular expertise in confocal microscopy for diagnosis and prognostication of ocular surface disease and infectious keratitis.
Ro T, Shelton D, Lee OL, and Chang E. Extrageniculate mediation of unconscious vision in TMS induced blind sight. PNAS. 2004; 101(26):9933-5.

Koplin RS, Ritterband DC, Lee OL, Seedor JA. Flap lift and repair of postoperative laser in situ keratomileusis complications at the slit lamp. J Cataract Refract Surg. 2010 Jul;36(7):1069-72.

Wiaux C, Baghdasaryan E, Lee OL, Deng SX, Aldave AJ. Outcomes following Descemet stripping endothelial keratoplasty in glaucoma patients with previous trabeculectomy and tube shunt implantation. Cornea. 2011 Dec;30(12):1304-11.

Deng SX, Sejpal K, Tang Q, Aldave AJ, Lee OL, Yu F. Evaluation of cellular and structural changes in the cornea in limbal stem cell deficiency using in-vivo confocal microscopy. Arch Ophthalmol. 2012 Apr; 130(4):440-5.

Fox T, Gotlinger KH, Dunn MW, Lee OL, Milman T, Zaidman G, Schwartzman ML, Bellner L. Dysregulated Heme Oxygenase-Ferritin System in Pterygium Pathogenesis. Cornea. 2013 Sep;32(9):1276-82..

Abdelfattah NS, Dastiridou A, Sadda S, Lee OL. Noninvasive Imaging of Tear Film Dynamics in Eyes with Ocular Surface Disease. Cornea. 2015 Oct; 34 Suppl 10:S48-52.

Nguyen AH, Dastiridou AI, Chiu GB, Francis BA, Lee OL, Chopra V. Glaucoma surgical considerations for PROSE lens use in patients with ocular surface disease. Cont Lens Anterior Eye. 2016 Aug; 39(4):257-61..

Huang J, Maram J, Tepelus TC, Modak C, Marion K, Sadda SR, Chopra V, Lee OL. Comparison of manual & automated analysis methods for corneal endothelial cell density measurements by specular microscopy. J Optom. 2017 Jul-Sep; 11(3): 182-191.

Huang P, Tepelus T, Vickers LA, Baghdasaryan E, Huang J, Irvine JA, Hsu HY, Sadda S, Lee OL. Quantitative Analysis of Depth, Distribution, and Density of Cysts in Acanthamoeba Keratitis Using Confocal Microscopy. Cornea. 2017 Aug;36(8):927-932.

Tepelus, TC, Huang J, Sadda RS, Lee OL. Characterization of Corneal Involvement in Eyes with Mucous Membrane Pemphigoid by in vivo Confocal Microscopy. Cornea. 2017 Aug;36(8):933-941.

Tepelus TC, Chiu GB, Huang J, Huang P, Sadda SR, Irvine J, Lee OL. Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes: a preliminary study. Graefes Arch Clin Exp Ophthalmol. 2017 Sep;255(9):1771-1778.

Huang J, Tepelus TC, Huang P, Fox A, Maxwell D, Sadda S, Lee OL. Specular microscopy image quality scale for endothelial cell density determination in donor cornea tissue. International Journal of Eye Banking. 2017(5):1.

Tepelus TC, Chiu G, Maram J, Chopra V, Sadda SR, Lee OL. Corneal features in ocular graft-versus-host disease by in vivo confocal microscopy. Graefes Arch Clin Exp Ophthalmol. 2017 Dec;255(12):2389-2397.

Huang J, Liu X, Tepelus TC, Nazikyan T, Chopra V, Sadda SR, Lee OL. Comparison of the Center and Flex-Center Methods of Corneal Endothelial Cell Analysis in the Presence of Guttae. Cornea. 2017 Dec;36(12):1514-1520

Huang J, Maram J, Modak C, Sadda SR, Chopra V, Lee OL. Comparison of non-contact specular and confocal microscopy for the evaluation of the corneal endothelium. Eye & Contact Lens. 2018 Sep; 44.

Baghdasaryan E, Tepelus TC, Marion KM, Huang J, Huang P, Sadda SR, Lee OL. Analysis of ocular inflammation in anterior chamber-involving uveitis using swept-source anterior segment OCT. Int Ophthalmol. 2018 Sep 20.

Huang P, Huang J, Tepelus T, Maram J, Sadda S, Lee OL. Validity of a new comprehensive pterygia grading scale for use in clinical research and clinical trial. Int Ophthalmol. 2018 Dec; 38(6): 2302-2311.

Lee OL, Tepelus TC, Huang J, Irvine AG, Irvine C, Chiu GB, Sadda SR. Evaluation of the corneal epithelium in non-Sjögren's and Sjögren's dry eyes: an in vivo confocal microscopy study using HRT III RCM. BMC Ophthalmol. 2018 Dec 4;18(1):309.

Baghdasaryan E, Tepelus TC, Vickers LA, Huang P, Chopra V, Sadda SR, Lee OL. Assessment of Corneal Changes Associated with Topical Antiglaucoma Therapy Using in vivo Confocal Microscopy. Ophthalmic Res. 2019; 61(1):51-59.

Wang YE, Tepelus TC, Gui W, Irvine JA, Lee OL, Hsu HY. Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis. Cornea. 2019 Jan 9.

Huang J, Tepelus T, Baghdasaryan E, Huang P, Shi Y, Hsu HY, Sadda SR, and Lee OL. Correlation between Guttata Severity and Thickness of Descemet’s Membrane and the Central Cornea. Current Eye Research. 2019 Mar 26:1-7

Shi Y, Huang J, Baghdasaryan E, Huang P, Huang X, Sadda SR, and Lee OL. Representation of central endothelial cell density by analysis of single best specular microscopy image regardless of cell size variance. Translational Vision Science & Technology. 2019 May 29; 8(3):23.

Wang EY, Tepelus TC, Vickers LA, Baghdasaryan E, Gui W, Huang P, Irvine JA, Hsu HY, Lee OL. Role of In Vivo Confocal Microscopy in the Diagnosis of Infectious Keratitis. Int Ophth. 2019 Dec; 39(12):2865-2874.

Shi Y, Huang J, Conrick P, Hoover C, and Lee OL. Discrepancies in Endothelial Cell Density Values of Human Donor Corneas Resulting from Comparison between Specular Microscopes and Endothelial Analysis Methods. Cornea. 2020 Apr;39(4):495-500.

Lee OL, Shi Y,Brown T, Maram J. Quantifying the Size of the Pterygium Head by Evaluating the Fibrous Area or the Vascularized Area. Cornea. 2020 June 15.
Professional Societies
American Academy of Ophthalmology
Cornea Society
Association for Research in Vision and Ophthalmology
Paton Society
American Society of Cataract and Refractive Surgery
Eye Bank Association of America
Chinese American Ophthalmologic Society
Max Fine Cornea Society
NEI Laboratory of Immunology Alumni Association
Research Centers
Gavin Herbert Eye Institute
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