Ramy M. Hanna

Picture of Ramy M. Hanna
Associate Clinical Professor, Step I, Medicine
School of Medicine
Program Director, Nephrology Fellowship Training Program
School of Medicine
B.S., UCLA, 2003, MIMG-Microbiology Immunology and Molecular Genetics
M.D., UCSD, 2007, Medicine
Phone: (714) 456-5142
Fax: (714) 456-6034
Email: ramyh1@uci.edu
University of California, Irvine
333 City Boulevard West
Suite 400
Mail Code: 4088
Orange, CA 92868
Research Interests
VEGF blockade, nephrotoxicity of intravitreal VEGF blockade, systemic toxicity. V2 blockers, hyponatremia, SIADH, TMA, aHUS, TTP, Glomerular disease, CKD, AKI, advanced mechanical cardiac support and dailysis.
Academic Distinctions
Phi Beta Kappa 2003
Top Physicians 2018
Marquis Who's Who 2019
FASN 2017
FACP 2019
Research Abstract
I am an Associate Clinical Professor of Medicine and Nephrology at the University of California Irvine UCI-Health. Currently I am best described as a clinician-educator working on reporting of anti vegf agent toxicity (systemic, and intravitreal). I am also interested in AHUS and TMA treatment and clinical outcomes, as well as cases of C3 GN and novel outcomes with C5 and C3 complement blockade. I have done prior work on dysnatremias and sodium correction modeling, as well as optimization of vaptan clinical response. Glomerular disease is also a key area of interest, with case reports written up when evidence of novel pathology or interest is found. I am also generally familiar with onco-nephrology. As far as Clinical interests GNs, care of underserved populations are my niche areas. I am looking to grow in EMR optimization and automation, and have specific interests within the expansive field of Artificial Intelligence/Machine Learning related to diagnostic algorithms to assist with TMA diagnoses.
Patient education article 6: Hanna RM Keeping your kidneys young. UCLA Core Kidney website. 06/2018.

Patient education article 5: Hanna RM Complement disorders and the kidney a patient education tool

Patient education article: 4 Hanna RM Diabetic Nephropathy Patient Education Seminar: “Diabetes and your kidneys” (slides)

Patient education article 3: Hanna RM. Glomerulonephritis a patient education tool. To be published on UCLA Core Kidney website-Published on UCLA Core Kidney website 11/2017.

Patient education article 2: Hanna RM. VEGF inhibitors & kidney disease. Published on UCLA Core Kidney website 10/2017.

Patient education article 1: Hanna RM, Hasnain H, The kidney rocks-stones of the urinary track, published on UCLA Core Kidney Site 10/2017.

1. Hanna RM, Marsh SE, Swistun D, Al-Gazali L, Zaki MS, Abdel-Salam GM, Al-Tawari A, Bastaki L, Kayserili H, Rajab A, Boglárka B, Dietrich RB, Dobyns WB, Truwit CL, Sattar S, Chuang NA, Sherr EH, Gleeson JG. Distinguishing 3 classes of corpus callosal abnormalities in consanguineous families. Neurology. 2011;76(4):373-82.

2. Hanna RM, Yang WT, Jene Kim S, Lopez EA, Riad JN, Wilson J. Three Presentations of Takayasu's Arteritis in Hispanic Patients. Case Rep Med. 2012;2012:839795

3. Viehman JA, Khalil D, Barhoma C, Hanna RM. Mycobacterium avium-intracellulare otomastoiditis in a young AIDS patient: case report and review of the literature. HIV AIDS (Auckl). 2013;5:61-6. Erratum in: HIV AIDS (Auckl). 2013; 5:275.

4. Shahedi K, Hanna RM, Melamed O, Wilson J. Wegener's granulomatosis mimicking inflammatory bowel disease and presenting with chronic enteritis. Int Med Case Rep J. 2013; 6:65-9.

5. Hanna RM, Nabil JR, Lopez EA, Corry DB, Wilson J. Multiple sites of calciphylaxis in a patient with chronic renal failure. Saudi J Kidney Dis Transpl. 2015;26(2):344-8.

6. Hanna RM, Lopez E, Wilson J, Barathan S, Cohen AH. Minimal change disease onset observed after bevacizumab administration. Clin Kidney J. 2016;9(2):239-44.

7. Hanna RM, Yang WT, Lopez EA, Riad JN, Wilson J. The utility and accuracy of four equations in predicting sodium levels in dysnatremic patients. Clin Kidney J.

8. Treger R, Hanna RM, Lee BM, Lopez EA, Wilson J, Corry D. Delayed clearance of hepatitis B surface antigen and development of hepatitis B surface antibody in a chronic hemodialysis patient. Saudi J Kidney Dis Transpl. 2016;27(5):1047-1051.

9. Lopez E, Hanna RM, Wilson J. Decreased sensitivity of anti-dsDNA antibody assay observed in a cohort of Hispanic patients with biopsy-proven lupus nephritis. Saudi J Kidney Dis Transpl. 2016 Nov-Dec;27(6):1270-1273.

10. Hanna RM, Hanna M, Larson B, Lopez EA, Wilson J, Hendifar A. Thrombotic microangiopathy due to catastrophic antiphospholipid antibody syndrome confirmed on skin biopsy and successfully treated with eculizumab. J Onco-Nephrology 2017:1(2): e1-e7

11. Hanna, RM, Lopez E, Wilson J. Granulomatosis with polyangitis with myocarditis and ventricular tachycardia. Hindawi Case Rep Med. 2017; 2017:6501738.

12. Hanna RM, Hasnain H, Kamgar M, Hanna M, Minasian R, Wilson J. Patient with a total artificial heart patient maintained on outpatient dialysis while listed for combined organ transplant, a single center experience Hemodialysis international (HI), 2017;

13. Kamgar M, Hanna RM, Hasnain H, Khalil D, Wilson J. Review/Editorial: Risk of serum sodium overcorrection with V2 antagonists in SIADH and other high-risk patients Running Head: Emerging evidence for efficacy and theoretically improved safety of lower dose in high risk patients. J Onco-Nephrol 2017: 1(3): 143-146.

14. Hanna RM, Kamgar M., Hasnain H, Cruz D, Nsair A, Wilson J. First combined heart and orthotopic liver transplant in patient with solitary kidney- (case report) Accepted to Transplantation Proceedings 1-4, 2017

15. Hanna RM, Cruz D, Selamet U, Hasnain H, Kwon M, Baas A, Wilson, J. Left Ventricular Assist Device (LVAD) patient maintained on home hemo-dialysis. Hemodialysis International. (Accepted on Dec/3/2017 DOI:10.1111/hdi.12631) e-published 01/2018.

16. Hanna RM, Lopez E, Hasnain H, Selamet U, Wilson J, Ekladious Y, Bunnapradist S, Gorin. Three patients with injection of intravitreal Vascular Endothelial Growth Factor (VEGF) inhibitors and subsequent exacerbation of chronic proteinuria and hypertension: Intra-vitreal VEGF inhibitors: More than meets the eye? CKJ. Epub 07/27/2018.

17. Hanna RM, Selamet U, Bui P, Sun SF, Wassef O, Nobakht N, Arman F, Rastogi A, Case report: Acute kidney injury after pembrolizumab induced adrenalitis and adrenal insufficiency. Sent Case Reports in Nephrology and Dialysis (Karger). Epub 08/2018.

18. Hanna RM, So N, Kaldas M, Hou J, Arman B, Yanny B, Selamet U, Sangalang, Saab S, Nobahkt N, Rastogi A Case report: patient with hepatitis C, presenting with necrotizing crescentic ANCA glomerulonephritis. Sent Case Reports in Nephrology and Dialysis (Karger) 03/2018. Epub 08/2018.

https://www.researchgate.net/publication/326962516_Case_Report_Patient_with_Hepatitis_C_p ANCA_and_Cryoglobulin_Antibodies_Presenting_with_Necrotizing_Crescentic_p-ANCA_Glomerulonephritis/fulltext/5b6eb3b4a6fdcc87df718772/326962516_Case_Report_Patient_with_Hepatitis_C_p-ANCA_and_Cryoglobulin_Antibodies_Presenting_with_Necrotizing_Crescentic_p-ANCA_Glomerulonephritis.pdf?origin=publication_detail
19. Hanna RM, Wang M, Kaldas M, Sinkowitz D, Arman F, Hammer T, Rastogi A. Hypercalcemia-induced acute kidney injury in a Caucasian female due to radiographically silent systemic sarcoidosis. Submitted to Clinical Nephrology (Dustri) Published 9/2018.

20. Yanny B M.D, Durazo F M.D., Mitry A B.S. M.S., Mikhael M B.S., Latt N M.D., Hanna RM, Sahota A. M.D., Saab S. MD Eight Week Hepatitis C Treatment with New Direct Acting Agents Have A Better Safety Profile While Effective in the Geriatric Population with Hepatitis C Virus-RNA <6 Million IU/mL. Major revision Journal of clinical gastroenterology Published 09/2018.

21. Hanna RM, Barsoum B, Mikhail M, Arman F, Rastogi A “ANCA associated vasculitis, update on molecular pathogenesis, diagnosis, and treatment”. Journal: International journal of nephrology and reno-vascular hypertension (Invited review). Published 11/18.

22. Hanna RM, Selamet U, Hasnain H, El-Masry M, Saab S, Kaldas F, Wilson Development of renal dysfunction due to concomitant focal segmental glomerulosclerosis (FSGS) and thrombotic microangiopathy (TMA) in a liver transplant patient on sorafenib for hepatocellular carcinoma (HCC) submitted to Transplantation Proceedings Published 12/18.

23. Song L, Hanna RM, Nguyen M, Kurtz I, Wilson J A Novel Case of Pseudohyponatremia Caused by Hypercholesterolemia submitted to Kidney International Reports. Published 12/18.

24. Hanna RM, Sun S.F., Gaynor P. Altered mental status and vocal tremor in liver transplant patient on dialysis after receiving ertapenem. MDPI Antibiotics. Published 12/2018.

25. Hanna RM, Barsoum M, Vandross A et.al. Atypical Hemolytic Uremic Syndrome (aHUS) and Complement Blockade Established and Emerging Uses of Complement Inhibition. Minor revision requested 1/19 by Current Opinion in Nephrology and Hypertension. Epub 2/19.

26. Govindappagari S, Nguyen M, Gupta M, Hanna RM, Burwick R Severe Vitamin B12 deficiency in pregnancy mimicking HELLP syndrome. Case Reports in Nephrology. Minor revision requested 1/2019. Accepted 3/2019. Epub 3/2019.

27. Khorsan R, Hanna RM, Selamet U, Wilson J. Hyunh A, Farid A, Nobakht N, Rastogi A Primary membranous nephropathy with concomitant IgA nephropathy. Target journal: sent SJKDT. Epub 03/2019.

28. Hanna RM, Barsoum M, Arman F, et.al. Nephrotoxicity Induced by Intravitreal Vascular Endothelial growth Factor (VEGF) Inhibitors: Emerging evidence. Kidney International . Epub 2/19.

29. Hanna RM, Barsoum M, Vandross A. Light Heavy Chain Deposition Revealed by Repeat Renal Biopsy After Inconclusive Initial Biopsy A Hidden Monoclonal Gammopathy of Renal Significance. SAGE Nephrology@Point of Care. Epub 5/2019.

30. Hanna RM, Hasnain H, Burwick R. Atypical Hemolytic Uremic Syndrome in a patient with Protein Losing Enteropathy. Journal of International Medical Research (JIMR). EPub 8/19.

31. Shye M, Sisk A, Schultz C…Hanna RM, A case of renal and splenic LECT 2 amyloidosis, a recently recognized cause of renal and systemic amyloidosis. SJKDT. Proofs reviewed 6/2019. In press.
32. Hanna RM, Yanny B Everolimus induced exacerbation of proteinuria in a patient with
diabetic nephropathy. To SJKDT submitted 07/2018. Proofs reviewed 7/2019. In press.
33. Hanna RM, Hasnain H, Sangalang M… Arman, F, Rastogi A, Harari A et.al. Three patients with lithium associated hyperparathyroidism: literature review regarding medical and surgical management. Karger Case Reports in Nephrology and Dialysis. Accepted 7/2019. In press.
34. Hanna RM, Farman F, Wallace D Case Report: Secondary membranous nephropathy in a patient with myasthenia gravis without thymic disease, and partial remission induced by adrenocorticotropic hormone. SAGE Open Access Medical Case Reports. proofs reviewed 8/2019. In press.
35. Nobakht N, Nguyen H.A, Kamgar M, Abdelnour L, Rastogi A, Hanna RM Development of Focal and Segmental Glomerulosclerosis in a Patient Receiving Intravitreal Vascular Endothelial Growth Factor Blockade Kidney International Reports. Accepted 8/19. In press.
36. Hanna RM, Merin N, Burwick R Successful Use of Eculizumab to Treat Atypical Hemolytic Uremic Syndrome in Patients with Inflammatory Bowel Disease. BMC Thrombosis minor revision accepted 7/2019, proofs reviewed 8/2019. In press.
37. Umut Selamet, MD, Anthony Sisk, MD, and Ramy M. Hanna, MD. Proceedings of UCLA Healthcare. ANCA Antibodies without ANCA Vasculitis Found on Renal Biopsy The Importance of Obtaining Diagnostic Confirmation with Pathology Samples.

38. Hanna RM, Cader R Reverse Pseudohyperkalemia Complicating Management in a Patient with Chronic Kidney Disease. Proceedings of UCLA Healthcare.

39. Sun SF, Hanna RM Proceedings of UCLA Heatlhcare. Milk-Alkali Syndrome a Previously Common but Now Unusual Cause of Hypercalcemia.

40. Hanna RM, Khorsan R Non Anion Gap Metabolic Acidosis Induced During L-arginine Therapy in a Patient with Mitochondrial Encephalopathy Lactic Acidosis and Stroke (MELAS). Proceedings of UCLA Healthcare.

41. Hanna RM, Hasnain H Onset of Right-Sided Pleural Effusion after Peritoneal Dialysis Initiation – A Rare Complication of Dialysate Leakage from Diaphragmatic Hernia: The Sweet Hydrothorax Phenomenon. Proceedings of UCLA Heatlhcare.

42. Hanna RM, Borad A A Case of Congenital Benign Renal Glycosuria Likely Caused by Genetic SGLT2 Mutation . Proceedings of UCLA Healthcare.

43. Sun SF, Hanna RM A Hidden Danger: A 20-Year-Old Female with Recurrent Urinary Tract Infections Due to Underlying Vesicoureteral Reflux Resulting in Chronic Pyelonephritis and Chronic Pain. Proceedings of UCLA Healthcare.

44. Hanna RM, Nonbakht N, Sangalang M. A Review of Renal Tubular Acidosis and
Two Example Cases with Type I and IV Defects. Proceedings of UCLA Healthcare.

45. Hanna RM, Hasnain H. ANCA Antibodies with Moderate Proteinuria Associated with Transitional Cell Carcinoma, an ANCA Flare due to Malignancy The ANCA-malignancy link. Proceedings of UCLA Healthcare.

46. Hanna RM, Kochar M. Dextrocardia in a Patient with Chest Pain. Proceedings of UCLA Heatlhcare.

47. Hanna RM, Vandross A, Cader R.
Anti-Phospholipase A2 Receptor Antibody Positive Primary Membranous Glomerulonephritis with Partial Remission of Proteinuria and Complete Disappearance of Antibody Marker with Rituximab Therapy. Proceedings of UCLA Healthcare.

48. Hanna RM, Shultz C. Spectrum of IgA Glomerular Disease in Light of the MEST-C Classification: Why Clinical Presentation Matters as Much as Pathological Findings. Proceedings of UCLA Healthcare.

49. Hanna RM, Manthripragda G. Critical Hypomagnesemia Exacerbated by Alcohol and Thiazides Presenting with
Weakness with a Probable Underlying Genetic Basis. Proceedings of UCLA Healthcare.

50. Shye M, Sun SF, Hanna RM IgA Dominant Post Infectious Glomerulonephritis Resulting in an Aggressive Course and End Stage Renal Disease Despite Treatment. Proceedings of UCLA Healthcare.

51. Hanna RM, Poa H. Induction of Near Complete Remission of Steroid Dependent Tip Variant-Focal and Segmental Glomerulosclerosis with Addition of a Calcineurin Inhibitor Glucocorticoids May Not Be Enough Even for the Most Steroid Sensitive Variant. Proceedings of UCLA Healthcare.

52. Hanna RM, Shye M, Metformin Induced Lactic Acidosis – A Series of Two Patients
A Life-Threatening Complication of Metformin Use in Chronic Kidney Disease. Proceedings of UCLA Healthcare.

53. Sun SF, Borad A, Hanna RM Patient with Impaired Glucose Tolerance and Hypertension Shown to Have Moderately Advanced Diabetic Nephropathy on Renal Biopsy Why the Hemoglobin A1c May Not Reveal the Whole Story. Proceedings of UCLA Healthcare.

54. Hanna RM, Kaldas M, Wallace W. Remission Achieved with Tacrolimus in a Patient with ISN-RPS Class V Lupus Membranous Glomerulonephritis Unable to Tolerate Mycophenolate Mofetil. Proceedings of UCLA Healthcare.

55. Hanna RM, Aly O, Abdelnour L. Treating an Emergent Salicylate Overdose. Proceedings of UCLA Healthcare.

56. Doughty R, Solis-Cohen A, Hanna RM. Two Unusual Inpatient Presentations of Acute Allergic Interstitial Nephritis (AIN). Proceedings of UCLA Healthcare. AIN: Using Non-Invasive Diagnosis When Biopsy Risk is High. Proceedings of UCLA Healthcare.

57. Hanna RM, Kaldas M, Systemic Lupus Erythematosus Causing ISN-RPS Class III Focal Proliferative Glomerulonephritis and Cerebritis with Resulting Cerebrovascular Accident. Proceedings of UCLA Healthcare.

58. Hanna RM, Minhtri N, Wilson J, Kurtz I Original Research: The Clinical Utility and Accuracy of Four Equations Predicting Delta Serum Na+ Over Shorter Timeframes (2-4 hours) Proceedings of UCLA Health Submitted 7/2019. In press.
59. Abdelnour L, Hanna RM Case series.The Nephrologist as Rainmaker-The Art of Watchful Waiting for Renal Recovery in Patients with Acute Kidney Injury. Proceedings of UCLA Health. Submitted 7/2019. In press.
60. Belachew M, Hanna RM, Yanny B Clinical commentary: Albumin in patients with cirrhosis, when does it help? Proceedings of UCLA Healthcare Submitted 7/2019. In press.
61. Hanna RM, Wilson J,Kurtz I Case series, original research: Transcatheter Repair of Tricuspid Regurgitation with the MitraClip Device and the Observed Rate of Post Procedure Acute Kidney Injury: A Single Center Experience. Proceedings of UCLA Healthcare. In press.
62. Book Chapter: Kidney Protection, chapter 26: Chemotherapeutic agents and the Kidney

63. Book Chapter: Current Essentials of Nephrology: Bacteruria, funguria, and UTI chapters

Professional Societies
ASN- Fellow of ASN 2017
ACP-Fellow of ACP 2017
NKF-member of NKF 2019
Other Experience
Attending Nephrologist
Cedars Sinai 2012—2015
Clinical Instructor
UCLA Health 2017—2019
Hospitalist and Nephrologist
LBMMC 2015—2017
Intern and Resident
Olive View UCLA Medical Center 2007—2010
Renal Fellow
Olive View UCLA Medical Center 2010—2012
Assistant Professor I
UCLA Health 2019—2019
Assistant Professor IV
UCI 2019
Graduate Programs
Internal Medicine
Nephrology (IM)
Research Centers
Cedars Sinai
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