Ariel B. Neikrug

Picture of Ariel B. Neikrug
Associate Clinical Professor, Psychiatry & Human Behavior
School of Medicine
Ph.D., SDSU/UCSD Joint Doctoral Program in Clinical Psychology, 2014, Clinical Psychology
M.S., San Diego State University, 2012, Psychology
B.A., University of San Diego, 2006, Psychology
Phone: (714) 790-8406
University of California, Irvine
5141 California Ave
Irvine, CA 92617
Research Interests
Sleep, Circadian Rhythms, Physical Activity, Chronic Disease, Mood, Functioning, Quality of Life,
Research Abstract
Dr. Neikrug’s core research interests are in the development, implementation, and evaluation of treatments for sleep disorders in chronic disease populations. His research has focused on better understanding sleep and activity rhythms disturbances in chronic disease and how treating sleep and rhythm dysfunction in chronic disease may impact biopsychosocial factors (e.g., sleep, fatigue, circadian rhythms, mood, cognition, and quality of life). Dr. Neikrug’s research involved several chronic disease patient populations and sleep disorders including treating sleep apnea, Parkinson’s disease, treatment of rhythm disturbances in women undergoing chemotherapy for breast cancer, and evaluation of activity and sleep patterns in patients with fibromyalgia. Dr. Neikrug also specialized in the use of actigraphy as a continuous outcome measure. In recent years Dr. Neikrug has been using actigraphy for assessment of circadian and activity rhythms using different modeling approaches including cosine, extended cosine, and double logistic regression.
Neikrug, A. B., Mander, B. A., Radom-Aizik, al. (2021) Aerobic Fitness and the Sleeping Brain of Adolescents–A Pilot Study. Sleep Advances. In Press
Neikrug, A. B., Chen, I. Y., Palmer, J. R., McCurry, S. M., Von Korff, M., Perlis, M., & Vitiello, M. V. (2020). Characterizing Behavioral Activity Rhythms in Older Adults Using Actigraphy. Sensors, 20, 549.

Okifuji, A. & Neikrug, A. B., (2019) Update and future perspective of behavioral medicine in the treatment for chronic pain. Pain Management, 9, 161-173.
Patel, N., LeWitt, P., Neikrug, A. B., Kesslak, P., Coate, B., and Ancoli-Israel, S. (2018) Nighttime sleep and daytime sleepiness improved with pimavaserin during treatment of Parkinson’s disease psychosis. Clinical Neuropharmacology. In press.

Neikrug, A. B., (2018) Obstructive sleep apnea in Parkinson’s disease – A mini-review. Current Sleep Medicine Reports. In press.

Neikrug, A. B., Donaldson, G. W., Iacob, E., Williams, S., Hamilton, C. A., & Okifuji, A. (2017) Activity rhythms and clinical correlates in fibromylagia. Pain. 158, 1417-1429

Harmell, A. L., Neikrug, A. B., Palmer, B. W., Avanzino J. A., Liu, L., Maglione, J. E., et al. (2016) Obstractive sleep apnea and cognition in Parkinson’s disease. Sleep Medicine, 20, 28-34.

Neikrug, A. B., Crawford , A. R. & Ong, J. C. (2016) Behavioral sleep medicine for hypersomnia disorders – a survey study. Behavioral Sleep Medicine, 20, 1-14.

Neikrug, A. B., Avanzino, J., Liu, L., Maglione, J.E., Natajaran, L., Corey-Bloom, J., et al. (2014) Parkinson disease and REM sleep behavior disorder result in increased non-motor symptoms. Sleep Medicine. 15, 959-966.

Ancoli-Israel, S., Liu, L., Natajaran, L., Neikrug, A. B., Rissling, M., Maglione, J.E., (2014) Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: A 1-year longitudinal study. Supportive Care in Caner, 22, 2535-2545.

Neikrug, A. B., Liu, L., Avanzino, J., Maglione, J.E., Natajaran, L., Bradley, L. et al. (2014) Continuous positive airway pressure improves sleep in Parkinson’s disease patients with obstructive sleep apnea. Sleep, 37, 177-185.

Neikrug, A. B., Avanzino, J., Liu, L., Maglione, J.E., Natajaran, L., Loredo J., et al. (2013) Effect of sleep disorders on the non-motor symptoms of Parkinson’s disease. Journal of Clinical Sleep Medicine, 9, 1109-17.

Liu, L., Rissling, M., Neikrug, A. B., Fiorentino, L., Natajaran, L., Faiermen M. et al. (2013) Fatigue and circadian activity rhythms in breast cancer patients before and after chemotherapy: a controlled study. Fatigue: Biomedicine, Health & Behavior, 1, 12-26.

Maglione, J.E., Liu, L., Neikrug, A. B., Poon, T., Natajaran, L., Calderon, J. et al. (2012) Actigraphy for the assessment of sleep measures in Parkinson’s disease. Sleep, 36, 1209-2017.

Covassin, N., Neikrug, A. B., Liu, L., Maglione, J.E., Natajaran, L., Corey-Bloom, J. et al. (2012) Relationship between clinical characteristics and nocturnal cardiac autonomic activity in Parkinson’s disease. Autonomic Neuroscience: Basic and Clinical, 171, 85-88.

Neikrug, A. B., Rissling, M., Trofimenko, V., Liu, L., Natajaran, L., Lawton, S. et al. (2012). Bright light therapy protects women from circadian rhythm desynchronization during chemotherapy for breast cancer. Behavioral Sleep Medicine, 10, 202-216.

Covassin, N., Neikrug, A. B., Liu, L., Corey-Bloom, J., Loredo, J. S., Palmer, B. W. et al. (2012). Clinical correlates of periodic limb movements in sleep in Parkinson's disease. Journal of the Neurological Sciences, 316 , 131-136.

Ancoli-Israel, S., Rissling, M., Neikrug, A. B., Trofimenko, V., Natajaran, L., Parker, B. A. et al. (2011). Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer. Support.Care Cancer, 20, 1211-1219.

Neikrug, A. B. & Ancoli-Israel, S. (2011). Diagnostic tools for REM sleep behavior disorder. Sleep Medicine Reviews, 16, 415-29.

Neikrug, A. B. & Ancoli-Israel, S. (2010). Sleep disorders in the older adult - A mini-review. The Gerontologist, 56, 181-189.

Neikrug, A. B. & Ancoli-Israel, S. (2010). Sleep disturbances in nursing homes. J Nutr.Health Aging., 14, 207-211.

Savard, J., Liu, L., Natajaran, L., Rissling, M., Neikrug, A. B., He, F. et al. (2009). Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy. Sleep, 32, 1155-1160.

Other Publications

Neikrug, A. B. & Ancoli-Israel, S. Sleep-wake disturbances and sleep disorders in patients with dementia. UpToDate. Topic #97863

Book Chapters

Neikrug, A. B., & Ong, J. C. (2016). Behavioral and non-pharmacological management of narcolepsy. In Narcolepsy – A clinical guide. Pg 369-383.

Neikrug, A. B. & Ancoli-Israel, S. (2013). Sleep in older adults. In Encyclopedia of Sleep, Assessment, Methodology, Training, and Policies of Sleep. Pg 654-658.

Neikrug, A. B. & Ancoli-Israel, S. (2013). Sleep disturbances in nursing homes. In Encyclopedia of Sleep, Assessment, Methodology, Training, and Policies of Sleep. Pg 664-668.
Neikrug, A. B., Stehli, A., Xiong G. L., Suo S., & McCarron R. M. (2021). Train New Trainers Primary Care Psychiatry Fellowship – A Brief Report and Overview. Journal of Continuing Education in the Health Professions. Accepted with Revisions
Next Step Pilot Award, University of Utah (PI: Neikrug) $25,932 07/01/16 – 07/30/17 Social and Behavioral Rhythms in Chronic Pain
NIH/NHLBI R01 HL153807 (MPI: Benca/Neikrug) $706,498 04/15/21 – 03/31/25 Interacting Mechanisms of sleep and aerobic fitness: Implications for health in the growing child.
Pilot from UCI ADRC P30AG066519 (MPI: Benca/Neikrug) $200,000 06/15/20 – 02/28/22 Effect of treating insomnia and circadian activity rhythms on AD risk
Professional Societies
Sleep Research Society
Society of Behavioral Sleep Medicine
Other Experience
Rush University Medical Center 2013—2014
Clinical Postdoctoral Fellowship Primary Care Integration
Salt Lake City Veterans Administration (VA) 2014—2015
Postdoctoral Fellowship in Chronic Pain
University of Utah, Department of Anesthesiology 2015—2017
Graduate Programs
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