Rémi Buisson

Picture of Rémi Buisson
Assistant Professor, Biological Chemistry
School of Medicine
Ph.D., University Laval, 2012
Phone: (949) 824-4835
Email: rbuisson@uci.edu
University of California, Irvine
Sprague Hall, Room 316
University of California, Irvine
Irvine, CA 92697-000
Research Interests
Genomic instability, DNA repair and Cancer
Academic Distinctions
2009-2010 Ph.D. Fellowship: CRHDQ fellowships (“Centre de recherche de L'Hôtel-Dieu de Québec”)
2010-2012 Ph.D. Fellowship: FQRNT fellowships (“Fonds de recherche du Québec”)
2012 Honor Roll - Laval University
2013-2014 Postdoctoral Fellowship: Philippe Foundation
2014-2015 Postdoctoral Fellowship: Tosteson Postdoctoral Fellowship Award
2015-2016 Postdoctoral Fellowship: Rivkin Center Scientific Scholar Award
2016 Postdoctoral Fellowship: Susan G. Komen Fellowship Award
2017-2021 NIH Career Development Award (K99/R00)
2018 Biological Sciences Scholar, University of Michigan (declined)
2013-2018: Research Fellow at MGH Cancer Center, Harvard Medical School
Research Abstract
Genomic instability is a hallmark of cancer. On one hand, genomic instability of cancer cells promotes loss of tumor suppressors and activation of oncogenes. On the other hand, genomic instability renders cancer cells susceptible to radiation and chemotherapy. The laboratory focus on dissecting mechanisms that result in compromised genomic integrity and study DNA repair pathways to understand how cells fix their genome. The long-term goal of our research is developing new strategies to eliminate cancer cells with high genomic instability to provide needed insight into potential novel targeted therapies.
#Langenbucher, A., #Bowen, D., #Sakhtemani, R., Bournique, E., *Zou, L., *Bhagwat, A., *Buisson, R., and *Lawrence, M. An extended APOBEC3A mutation signature in cancer. Nature Communications. (in press)
#co-first author *corresponding author

Jalili, P., Bowen, D., Langenbucher, A., Park, P., Aguirre, K., Corcoran, R., Fleischman A., Lawrence, M., Zou, L., and Buisson, R. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. (2020) Nature Communications. Jun 12;11(1):2971.

Buisson, R., Langenbucher, A., Bowen, D., Kwan, EE., Benes, CH., Zou, L., and Lawrence, MS. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019) Science. Jun 28;364(6447).

Dubois, E., Guitton-Sert, L., Béliveau, M., Parmar, K., Chagraoui, J., Vignard, J., Pauty, J., Caron, M., Coulombe, Y., Buisson, R., Jacquet, K., Gamblin, C., Gao, Y., Laprise, P., Lebel, M., Sauvageau, G., D’Andrea, A., and Masson, J-Y. A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2. (2019) Nucleic Acids Research. Aug 22;47(14):7532-7547.

Moquin, DM., Genois, MM., Zhang, JM., Ouyang, J., Yadav, T., Buisson, R., Yazinski, SA., Tan, J., Boukhali, M., Gagne, JP., Poirier, GG., Lan, L., Haas, W., and Zou, L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. (2019) Genes & Development. Jan 1;33(1-2):75-89.

Cheng, X., Jobin-Robitaille, O., Billon, P., Buisson, R., Niu, H., Lacoste, N., Abshiru, N., Côté, V., Thibault, P., Kron, SJ., Sung, P., Brandl, CJ., Masson, JY., and Côté, J. Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. (2018) Proceedings of the National Academy of Sciences. Oct 2;115(40):10028-10033

Bélanger, F., Fortier, E., Dubé, M., Lemay, JF., Buisson, R., Masson, JM., Elsherbiny, A., Costantino, S., Carmona, E., Mes-Masson, AM., Wurtele, H., and Drobetsky, E. Replication Protein A Availability During DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells. (2018) Cancer Research. Oct 1;78(19):5561-5573.

Kabeche, L., Nguyen, H.D., Buisson, R., and Zou, L. A Mitosis-specific and R-loop driven ATR pathway promotes faithful chromosome segregation. (2018) Science. Jan 5;359(6371):108-114. (Commented in Science 2018 Jan 5;359(6371):30-31 and Cancer Discovery 2018 Jan;8(1):11).

Boulay, B., Sandoval, GJ., Riggi, N., Iyer, S., Buisson, R., Naigles, B., Awad, ME., Rengarajan, S., Volorio, A., McBride, MJ., Broye, LB., Zou, L., Stamenkovic, I., Kadoch, C and Rivera, MN. Cancer-specific retargeting of BAF complexes by a prion-like domain. (2017) Cell. Sep 21;171(1):163-178.

Buisson, R., Lawrence, MS., Benes, CH., and Zou, L. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. (2017) Cancer Research Sep 1;77(17):4567-4578.

Yazinski, SA., Comaills, V., Buisson, R., Ho, CH., Todorova, T., Nguyen, HD., Orsulic, S., Ellisen, LW., Benes, CH., Maheswaran, S., Haber, DA., and Zou, L. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. (2017) Genes & Development. Feb 1;31(3):318-332.

Buisson, R., Joshi, N., Ho, CK., Rodrigue, A., Foo, TK., Hardy, E., Haas, W., Xia, B., Masson, J-Y., and Zou, L. Coupling of Homologous Recombination and the Checkpoint by ATR. (2017) Molecular Cell. 19;65(2):336-346.

Comaills, V,. Kabeche, L,. Morris, R,. Buisson, R,. Yu, M,. Madden, MW,. LiCausi, JA,. Boukhali, M,. Tajima, K,. Pan, S,. Aceto, N,. Sil, S,. Zheng, Y,. Sundaresan, T,. Yae, T,. Jordan, NV,. Miyamoto, DT,. Ting, DT,. Ramaswamy, S,. Haas, W,. Zou, L,. Haber, DA,. Maheswaran, S. Genomic Instability Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. (2016) Cell Reports. Dec 6;17(10):2632-2647

Gaullier, G., Miron, S., Pisano, S., Buisson, R., Le Bihan, YV., Tellier-Lebegue, C., Messaoud, W., Roblin, P., Guimaraes, B., Thai, R., Giraud-Panis, M-J., Gilson, E., and Le Du, M-H. A higher-order entity formed by the flexible assembly of TRF2 and RAP1. (2016) Nucleic Acids Research. Feb 29;44(4):1962-76

Buisson, R., Boisvert, JL., Benes, CH., and Zou, L. Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. (2015) Molecular Cell. Sep 17;59(6):1011-24.

Pauty, P., Rodrigue, A., Couturier, A., Buisson, R., and Masson, JY., Exploring the roles of PALB2 at the crossroads of DNA repair and cancer. (2014) Biochemical Journal. Aug 1;461(3):539.

Buisson, R,. Niraj, J,. Pauty, J,. Maity R, Zhao,. W, Coulombe,. Y, Sung,. P,. and Masson, JY. Breast cancer proteins PALB2 and BRCA2 stimulate polymerase ? in recombination-associated DNA synthesis at blocked replication forks. (2014) Cell Reports. Feb 13;6(3):553-64.

Buisson, R., and Masson, J-Y. Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair. (2013) Medecine/Science. 2013 Mar;29(3):301-7.

Maity, R., Pauty, J., Krietsch, J., Buisson, R., Genois, MM., and Masson, JY. GST-His purification: A Two-step Affinity Purification Protocol Yielding Full-length Purified Proteins. (2013) Journal of Visualized Experiments. Oct 29;(80).

Buisson, R., and Masson J-Y. PALB2 self-interaction controls homologous recombination. (2012) Nucleic Acids Research. 40(20):10312-23.

Genois, G., Mukherjee, A., Ubeda, JM., Buisson, R., Paquet, E., Roy, G., Plourde, G., Coulombe, Y., Ouellette, M., and Masson, JY. Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. (2012) Nucleic Acids Research. 40(14):6570-84

Bleuyard, JY., Buisson, R., Masson, JY., and Esashi, F. ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair. (2012) EMBO reports. 13(2):135-41

Buisson, R., Dion-Côté, AM., Launay, H., Coulombe, Y., Cai, H., Stasiak, AZ., Stasiak, A., Xia, B., and Masson, JY. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. (2010) Nature Structural & Molecular Biology. 17(10):1247-54.

*Poulet, A., *Buisson, R., Faivre-Moskalenko,C., Koelblen, M., Amiard, S., Montel, F., Cuesta-Lopez, S., Bornet, O., Guerlesquin, F., Godet, T., Moukhtar, J., Argoul, F., Déclais, AC., Lilley, DM., Ip, SC, West, SC., Gilson, E. and Giraud-Panis, MJ. TRF2 promotes and remodels telomeric Holliday Junctions. (2009) EMBO Journal. 18;28(6):641-51. (*co-first authors)
NIH Pathway to Independence Award (K99/R00)
California Breast Cancer Research Program
Concern Foundation
Other Experience
Research Fellow
Massachusetts General Hospital, Harvard Medical School 2013—2018
Research Centers
Chao Family Comprehensive Cancer Center
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