Mark Mapstone
Professor, Neurology
School of Medicine
School of Medicine
Vice Chair for Research, Neurology
School of Medicine
School of Medicine
Chief, Neuropsychology Division, Neurology
School of Medicine
School of Medicine
Faculty, Institute for Memory Impairments and Neurological Disorders (UCI MIND)
Fellow, Center for the Neurobiology of Learning and Memory
Co-Director, Center for Aging Research in Down Syndrome
School of Medicine
School of Medicine
Director, Precision Neurology Program, Neurology
School of Medicine
School of Medicine
Ph.D., Northwestern University, 2000, Clinical Psychology
M.A., Boston University, 1990, Psychology
B.S., Hobart College, 1989, Psychology
M.A., Boston University, 1990, Psychology
B.S., Hobart College, 1989, Psychology
ORCiD: 0000-0003-0280-8057
University of California, Irvine
318 Sprague Hall
839 Health Sciences Road
Mail Code: 3910
Irvine, CA 92697
318 Sprague Hall
839 Health Sciences Road
Mail Code: 3910
Irvine, CA 92697
Research Interests
Cognitive Phenotyping, Biomarkers of Neurological Disease, Cognitive Neuroscience
Appointments
2000-2002, Post-doctoral Fellow, Clinical Neuropsychology, University of Rochester School of Medicine
2002-2008, Assistant Professor, Neurology, University of Rochester School of Medicine
2008-2015, Associate Professor, Neurology, University of Rochester School of Medicine
2002-2008, Assistant Professor, Neurology, University of Rochester School of Medicine
2008-2015, Associate Professor, Neurology, University of Rochester School of Medicine
Research Abstract
I am a translational neuroscientist. My goal is to translate discoveries about the aging brain into practical and implementable approaches for successful cognitive aging at the individual level. My current work is focused on early detection of age-related neurological disease especially Alzheimer’s disease and Parkinson’s disease using careful cognitive phenotyping and biomarkers obtained from blood. We are using this information to develop screening tools that can be used to enrich clinical trials with appropriate subjects for disease modifying interventions. We hope to develop reliable biomarkers for clinical use.
Awards and Honors
1996, University Scholar, The Graduate School, Northwestern University
1998, Fellow, Buehler Center on Aging, Northwestern University Medical School
2000, George Yacorzinski Scholar, Northwestern University Medical School
2001, NIH Post-doctoral Fellowship, University of Rochester
2003, NIH Career Development Award (K23)
2004, John Henry Hobart Fellow in Ethics and Social Justice, Hobart College
2020, Sigma Xi, International Scientific Research Honor Society
1998, Fellow, Buehler Center on Aging, Northwestern University Medical School
2000, George Yacorzinski Scholar, Northwestern University Medical School
2001, NIH Post-doctoral Fellowship, University of Rochester
2003, NIH Career Development Award (K23)
2004, John Henry Hobart Fellow in Ethics and Social Justice, Hobart College
2020, Sigma Xi, International Scientific Research Honor Society
Publications
Past year (2025)
1: Mirza SS, Duff-Canning S, Mapstone M, Fox S, Black SE, Binns MA, Breen DP, Fishman KN, Grimes DA, Lang AE, Levine B, McLaughlin PM, Troyer AK, Masellis M, Marras C. Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease. Alzheimers Dement. 2025 Dec;21(12):e70912. doi: 10.1002/alz.70912. PMID: 41388800; PMCID: PMC12701370.
2: Clina JG, Helsel BC, Hartley SL, Fleming-Batayneh VL, Handen B, Christian B, Head E, Mapstone M, Hom CL, Burns J, Ances B, Ptomey LT; Alzheimer Biomarker Consortium–Down Syndrome (ABC-DS) Investigators. The joint association of obesity and physical activity on cognitive function in Down syndrome. J Alzheimers Dis. 2025 Dec;108(3):1328-1338. doi: 10.1177/13872877251386474. Epub 2025 Oct 16. PMID: 41100837.
3: Zammit MD, Bruzzone H, Cody KA, Morse J, Wilson R, Bettcher BT, McLachlan MJ, McVea AK, DiFilippo AH, Carey FJ, Janelidze S, Hansson O, Price JC, Laymon CM, Minhas DS, Luo W, Rosas HD, Lai F, Lee JH, Lao PJ, Ances BM, Krinsky-McHale SJ, Hom CL, Hartley SL, Zaman SH, Johnson SC, Cohen AD, Head E, Mapstone ME, Handen BL, Christian BT, Tudorascu DL, Langhough RE, Betthauser TJ; Alzheimer Biomarker Consortium–Down Syndrome. The tau biomarker cascade is condensed in Down syndrome compared to sporadic Alzheimer's disease. Brain. 2025 Nov 15:awaf428.
doi: 10.1093/brain/awaf428. Epub ahead of print. PMID: 41240365.
4: Wisch JK, Jiao Z, Kennedy JT, Cohen AD, Schlachetzki Z, Petersen M, Handen BL, Christian BT, Mapstone M, Rosas HD, Lai F, Lee JH, Krinsky-McHale SJ, Schmitt FA, Harp JP, Hom C, Lott IT, Hartley S, Zaman S, Ptomey L, Burns JM, Tudorascu D, Ibanez L, Rafii MS, Head E, Ances BM. Imaging and plasma biomarkers for pathological accumulation in Down syndrome. Brain. 2025 Nov 5:awaf418. doi: 10.1093/brain/awaf418. Epub ahead of print. PMID: 41205623.
5: Stringer CA, Miyasato HKS, Camey KA, Ghadia KA, Andrews EJ, Ngo PT, Pascual JR, Wright ST, Silva JA, Gawronski BM, Gonzalez L, Wood KA, Phelan MJ, Lai F, Schmitt FA, Harp JP, Brickman AM, Lao PJ, Mapstone ME, Kofler JK, Ikonomovic MD,Head E; Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS). Regional differences in astrocytic Aquaporin-4 protein levels and distribution in aging and Alzheimer's disease in down syndrome. Neurobiol Dis. 2025 Nov;216:107114.doi: 10.1016/j.nbd.2025.107114. Epub 2025 Sep 21. PMID: 40987419.
6: Dass D, Dang LT, Xicota L, Krinsky-McHale S, Kannappan B, Brickman AM,
Christian BT, Head E, O'Bryant SE, Mapstone M, Handen B, Marder K, Lee JH; Alzheimer Biomarker Consortium – Down syndrome (ABC-DS). Examination of metabolic syndrome in Down syndrome and association with dementia. Alzheimers Dement. 2025 Oct;21(10):e70799. doi: 0.1002/alz.70799. PMID: 41104603; PMCID: PMC12531894.
7: Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA; Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock DM, Head E, Brickman AM. Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome. Alzheimers Dement. 2025 Oct;21(10):e70726. doi: 10.1002/alz.70726. PMID: 41014048; PMCID: PMC12475832.
8: Lao P, Edwards N, Flores-Aguilar L, Alshikho MJ, Smith A, LeMay R, Hahm J, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian B, Mapstone M, Handen B; Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock D, Head E, Brickman AM. Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome. Alzheimers Dement. 2025 Sep;21(9):e70679. doi: 10.1002/alz.70679. PMID: 40951960; PMCID: PMC12434704.
9: LeMerise LG, Guerrero-Gonzalez J, McVea A, Zammit M, Kecskemeti S, Hartley S, Head E, Mapstone M, Handen B, Alexander A, Christian B; ABC-DS Investigators. Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome. Alzheimers Dement. 2025 Aug;21(8):e70572. doi: 10.1002/alz.70572. PMID: 40779433; PMCID: PMC12333877.
10: Bamford AR, Adams JN, Kim S, Taylor LM, Tuteja N, McMillan LC, Sattari N, Chen IY, Chappel-Farley MG, Escalante Y, Lawrence AL, Meza NJ, Berisha DE, Dave A, Malhas R, Mapstone M, Mander BA, Yassa MA, Thomas EA. Salivary levels of amyloid beta reflect brain amyloid beta burden in cognitively-normal older adults. J Prev Alzheimers Dis. 2025 Aug;12(7):100216. doi:
10.1016/j.tjpad.2025.100216. Epub 2025 Jun 9. PMID: 40494737; PMCID:
PMC12252581.
11: Fan KH, Shi R, Cheema AN, Dang LT, Xicota L, Krinsky-McHale S, Aslam MM, Zafari N, Acharya V, Feingold E, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS); Cruchaga C, Lee JH, Kamboh MI. Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul;21(7):e70398. doi: 10.1002/alz.70398. PMID: 40667715; PMCID: PMC12264832.
12: Aslam MM, Dang LT, Shi R, Fan KH, Cheema AN, Xicota L, Minhas D, Luo W, Zafari N, Acharya V, Feingold E, Krinsky-McHale S, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS); Lee JH, Cruchaga C, Kamboh MI. Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul;21(7):e70358. doi: 10.1002/alz.70358. PMID: 40667702; PMCID: PMC12265027.
13: Fu JF, Garimella A, Lapointe A, Aye WWT, Chen CD, Lee JH, Krinsky-McHale SJ, Zaman S, Lott IT, Hom C, Ances B, Head E, Mapstone M, Lai F, Handen BL, Laymon CM, Hartley SL, Christian BT, Rentz DM, Johnson KA, Rosas HD, Price JC; Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS). Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments. Alzheimers Dement. 2025 Jul;21(7):e70424. doi: 10.1002/alz.70424. PMID: 40588723; PMCID: PMC12208798.
14: Fleming VL, Peven J, Helsel BC, Ptomey LT, Clina J, Barry A, Ances BM,
Handen BL, Christian BT, Laymon C, Zammit M, Head E, Mapstone M, Okonkwo O, Hartley SL; Alzheimer Biomarkers Consortium – Down Syndrome. Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease. Alzheimers Dement (N Y). 2025 Jun 27;11(3):e70127. doi: 10.1002/trc2.70127. PMID: 40584896; PMCID: PMC12204845.
15: Janelidze S, Collij LE, Mattsson-Carlgren N, Antill A, Laymon CM, Lott I,
Rosas HD, Minhas DS, Luo W, Zaman S; Alzheimer's Biomarker Consortium–Down Syndrome investigators; Mapstone M, Head E, Lai F, Hartley SL, Ances BM, Krinsky-McHale SJ, Lee JH, Ossenkoppele R, Christian BT, Handen BL, Hansson O. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. Lancet Neurol. 2025 Jul;24(7):591-600. doi: 10.1016/S1474-4422(25)00158-9. PMID:40541209; PMCID: PMC12174012.
16: Schworer EK, Handen BL, Krinsky-McHale S, Hom CL, Clare ICH, Harp JP, Pulsifer MB, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer Biomarker Consortium-Down Syndrome. Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome. J Intellect Disabil Res. 2025 Jul;69(7):569-581. doi: 0.1111/jir.13237. Epub 2025 Apr 20. PMID: 40254895; PMCID: PMC12199718.
17: McVea A, DiFilippo A, McLachlan M, Betcher B, Zammit M, Betthauser TJ,
Converse A, Murali D, Stone C, Hartley S, Johnson S, Tudorascu DL, Laymon CM, Cohen AD, Minhas D, Luo W, Mathis C, Lao PJ, Ances B, Zaman S, Mapstone M, Head E, Handen BL, Christian BT; ABC-DS investigators. PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations. Alzheimers Dement. 2025 Jun;21(6):e70357. doi: 10.1002/alz.70357. PMID: 40556306; PMCID: PMC12187968.
18: Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL; Alzheimer's Biomarkers Consortium–Down Syndrome. Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 Jun;21(6):e70387. doi: 10.1002/alz.70387. PMID: 40545561; PMCID:
PMC12183108.
19: Paterson T, Rohrs J, Hohman TJ, Mapstone M, Meikle PJ, Kaddurah-Daouk R, Levey AI, Hood L; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer Disease Metabolomics Consortium; Funk CC. Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown. bioRxiv [Preprint]. 2025 May 12:2024.07.23.604835. doi: 10.1101/2024.07.23.604835. PMID: 40462904; PMCID: PMC12132299.
20: Handen BL, Mapstone M, Hartley S, Andrews H, Christian B, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O'Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 May;21(5):e70294. doi: 10.1002/alz.70294. PMID:40371686; PMCID: PMC12079517.
21: Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL; Alzheimer Biomarker Consortium - Down syndrome. Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11;17(1):19. doi:10.1186/s11689-025-09604-w. PMID: 40217501; PMCID: PMC11987311.
22: Barry A, Peven JC, Handen BL, Bolt D, Krinsky-McHale SJ, Hom CL, Clare ICH, Glueck A, Harp J, Schmitt F, Zammit M, Minhas D, Luo W, Laymon C, Price J, Lee JH, Lott I, Cohen A, Ances BM, Pulsifer M, Rosa HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL; Alzheimer Biomarker Consortium - Down syndrome. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement. 2025 Apr;21(4):e70211. doi: 10.1002/alz.70211. PMID: 40289844; PMCID: PMC12035545.
23: McLachlan M, Bettcher B, McVea A, DiFilippo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Rosas HD, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT, Investigators AD. The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers. Alzheimers Dement. 2025 Apr;21(4):e70141. doi: 10.1002/alz.70141. PMID: 40189783; PMCID: PMC11972983.
24: Petersen ME, Zhang F, Hall J, Brock C, Rissman RA, Como T, Julovich D,
Mapstone M, Ances BM, Meeker K, Palmer R, Barber R, Mason D, Johnson L, Yaffe K, Toga AW, Cohen A, O'Bryant SE; HABS-HD Study Team. Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community-based cohort: an HABS-HD study. Alzheimers Dement (N Y). 2025 Feb 19;11(1):e70045. doi: 10.1002/trc2.70045. PMID: 39975470; PMCID: PMC11837735.
25: Liou JJ, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom CL, Doran EW,
Totoiu MO, Lott I, Mapstone M, Keator DB, Brickman AM, Wright ST, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E; Alzheimer Biomarker Consortium - Down Syndrome. A
neuropathology case report of a woman with Down syndrome who remained
cognitively stable: Implications for resilience to neuropathology. Alzheimers
Dement. 2025 Feb;21(2):e14479. doi: 10.1002/alz.14479. Epub 2025 Jan 27. PMID: 39868632; PMCID: PMC11851131.
26: Kennedy JT, Wisch JK, Dincer A, Roman J, Gordon BA, Handen B, Benzinger TLS, Head E, Mapstone M, Christian BT, Tudorascu DL, Laymon CL, Hartley SL, Lao P, Brickman AM, Zaman SH, Ances BM; ABC-DS and DIAN Consortia. Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome. Alzheimers Dement. 2025 Feb;21(2):e14519. doi: 10.1002/alz.14519. Epub 2025 Jan 14. PMID: 39807622; PMCID: PMC11848172.
27: Saeed A, McKennan C, Duan J, Yang YN, Kip KE, Finegold D, Vu M, Swanson J, Lopez OL, Cohen A, Mapstone M, Yu B, Ballantyne CM, Reis SE. Mid-life anti-inflammatory metabolites are inversely associated with long-term cardiovascular disease events. EBioMedicine. 2025 Feb;112:105551. doi:
10.1016/j.ebiom.2024.105551. Epub 2025 Jan 9. PMID: 39793479; PMCID:
PMC11764641.
28: Saeed A, Chang Y, Swanson J, Vu M, Mapstone M, Villemagne VL, Snitz BE, Royse SK, Wang H, Lopresti B, Aizenstein HJ, Wu M, Kip K, Reis SE, Lopez O, Cohen A. Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study. J Alzheimers Dis Rep. 2025 Jan 5;9:25424823241299297. doi:10.1177/25424823241299297. PMID: 40034508; PMCID: PMC11864267.
29: Petersen ME, Flores-Aguilar L, Head E, Montoliu-Gaya L, Strydom A, Pape SE, Fortea J, Ashton NJ, Udeh-Momoh C, O'Bryant SE, German D, Despa F, Mapstone M, Zetterberg H. Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring. Alzheimers Dement. 2025 Jan;21(1):e14364. doi:10.1002/alz.14364. Epub 2024 Nov 13. PMID: 39535517; PMCID: PMC11782192.
30: Boerwinkle AH, Wisch JK, Handen BL, Head E, Mapstone M, Rafii MS, O'Bryant SE, Krinsky-McHale SJ, Lai F, Rosas HD, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Ances BM; Alzheimer's Biomarker Consortium-Down Syndrome. The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome. Alzheimers Dement. 2025 Jan;21(1):e14359. doi:10.1002/alz.14359. Epub 2024 Nov 13. PMID: 39535359; PMCID: PMC11782213.
1: Mirza SS, Duff-Canning S, Mapstone M, Fox S, Black SE, Binns MA, Breen DP, Fishman KN, Grimes DA, Lang AE, Levine B, McLaughlin PM, Troyer AK, Masellis M, Marras C. Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease. Alzheimers Dement. 2025 Dec;21(12):e70912. doi: 10.1002/alz.70912. PMID: 41388800; PMCID: PMC12701370.
2: Clina JG, Helsel BC, Hartley SL, Fleming-Batayneh VL, Handen B, Christian B, Head E, Mapstone M, Hom CL, Burns J, Ances B, Ptomey LT; Alzheimer Biomarker Consortium–Down Syndrome (ABC-DS) Investigators. The joint association of obesity and physical activity on cognitive function in Down syndrome. J Alzheimers Dis. 2025 Dec;108(3):1328-1338. doi: 10.1177/13872877251386474. Epub 2025 Oct 16. PMID: 41100837.
3: Zammit MD, Bruzzone H, Cody KA, Morse J, Wilson R, Bettcher BT, McLachlan MJ, McVea AK, DiFilippo AH, Carey FJ, Janelidze S, Hansson O, Price JC, Laymon CM, Minhas DS, Luo W, Rosas HD, Lai F, Lee JH, Lao PJ, Ances BM, Krinsky-McHale SJ, Hom CL, Hartley SL, Zaman SH, Johnson SC, Cohen AD, Head E, Mapstone ME, Handen BL, Christian BT, Tudorascu DL, Langhough RE, Betthauser TJ; Alzheimer Biomarker Consortium–Down Syndrome. The tau biomarker cascade is condensed in Down syndrome compared to sporadic Alzheimer's disease. Brain. 2025 Nov 15:awaf428.
doi: 10.1093/brain/awaf428. Epub ahead of print. PMID: 41240365.
4: Wisch JK, Jiao Z, Kennedy JT, Cohen AD, Schlachetzki Z, Petersen M, Handen BL, Christian BT, Mapstone M, Rosas HD, Lai F, Lee JH, Krinsky-McHale SJ, Schmitt FA, Harp JP, Hom C, Lott IT, Hartley S, Zaman S, Ptomey L, Burns JM, Tudorascu D, Ibanez L, Rafii MS, Head E, Ances BM. Imaging and plasma biomarkers for pathological accumulation in Down syndrome. Brain. 2025 Nov 5:awaf418. doi: 10.1093/brain/awaf418. Epub ahead of print. PMID: 41205623.
5: Stringer CA, Miyasato HKS, Camey KA, Ghadia KA, Andrews EJ, Ngo PT, Pascual JR, Wright ST, Silva JA, Gawronski BM, Gonzalez L, Wood KA, Phelan MJ, Lai F, Schmitt FA, Harp JP, Brickman AM, Lao PJ, Mapstone ME, Kofler JK, Ikonomovic MD,Head E; Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS). Regional differences in astrocytic Aquaporin-4 protein levels and distribution in aging and Alzheimer's disease in down syndrome. Neurobiol Dis. 2025 Nov;216:107114.doi: 10.1016/j.nbd.2025.107114. Epub 2025 Sep 21. PMID: 40987419.
6: Dass D, Dang LT, Xicota L, Krinsky-McHale S, Kannappan B, Brickman AM,
Christian BT, Head E, O'Bryant SE, Mapstone M, Handen B, Marder K, Lee JH; Alzheimer Biomarker Consortium – Down syndrome (ABC-DS). Examination of metabolic syndrome in Down syndrome and association with dementia. Alzheimers Dement. 2025 Oct;21(10):e70799. doi: 0.1002/alz.70799. PMID: 41104603; PMCID: PMC12531894.
7: Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA; Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock DM, Head E, Brickman AM. Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome. Alzheimers Dement. 2025 Oct;21(10):e70726. doi: 10.1002/alz.70726. PMID: 41014048; PMCID: PMC12475832.
8: Lao P, Edwards N, Flores-Aguilar L, Alshikho MJ, Smith A, LeMay R, Hahm J, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian B, Mapstone M, Handen B; Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock D, Head E, Brickman AM. Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome. Alzheimers Dement. 2025 Sep;21(9):e70679. doi: 10.1002/alz.70679. PMID: 40951960; PMCID: PMC12434704.
9: LeMerise LG, Guerrero-Gonzalez J, McVea A, Zammit M, Kecskemeti S, Hartley S, Head E, Mapstone M, Handen B, Alexander A, Christian B; ABC-DS Investigators. Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome. Alzheimers Dement. 2025 Aug;21(8):e70572. doi: 10.1002/alz.70572. PMID: 40779433; PMCID: PMC12333877.
10: Bamford AR, Adams JN, Kim S, Taylor LM, Tuteja N, McMillan LC, Sattari N, Chen IY, Chappel-Farley MG, Escalante Y, Lawrence AL, Meza NJ, Berisha DE, Dave A, Malhas R, Mapstone M, Mander BA, Yassa MA, Thomas EA. Salivary levels of amyloid beta reflect brain amyloid beta burden in cognitively-normal older adults. J Prev Alzheimers Dis. 2025 Aug;12(7):100216. doi:
10.1016/j.tjpad.2025.100216. Epub 2025 Jun 9. PMID: 40494737; PMCID:
PMC12252581.
11: Fan KH, Shi R, Cheema AN, Dang LT, Xicota L, Krinsky-McHale S, Aslam MM, Zafari N, Acharya V, Feingold E, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS); Cruchaga C, Lee JH, Kamboh MI. Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul;21(7):e70398. doi: 10.1002/alz.70398. PMID: 40667715; PMCID: PMC12264832.
12: Aslam MM, Dang LT, Shi R, Fan KH, Cheema AN, Xicota L, Minhas D, Luo W, Zafari N, Acharya V, Feingold E, Krinsky-McHale S, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS); Lee JH, Cruchaga C, Kamboh MI. Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul;21(7):e70358. doi: 10.1002/alz.70358. PMID: 40667702; PMCID: PMC12265027.
13: Fu JF, Garimella A, Lapointe A, Aye WWT, Chen CD, Lee JH, Krinsky-McHale SJ, Zaman S, Lott IT, Hom C, Ances B, Head E, Mapstone M, Lai F, Handen BL, Laymon CM, Hartley SL, Christian BT, Rentz DM, Johnson KA, Rosas HD, Price JC; Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS). Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments. Alzheimers Dement. 2025 Jul;21(7):e70424. doi: 10.1002/alz.70424. PMID: 40588723; PMCID: PMC12208798.
14: Fleming VL, Peven J, Helsel BC, Ptomey LT, Clina J, Barry A, Ances BM,
Handen BL, Christian BT, Laymon C, Zammit M, Head E, Mapstone M, Okonkwo O, Hartley SL; Alzheimer Biomarkers Consortium – Down Syndrome. Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease. Alzheimers Dement (N Y). 2025 Jun 27;11(3):e70127. doi: 10.1002/trc2.70127. PMID: 40584896; PMCID: PMC12204845.
15: Janelidze S, Collij LE, Mattsson-Carlgren N, Antill A, Laymon CM, Lott I,
Rosas HD, Minhas DS, Luo W, Zaman S; Alzheimer's Biomarker Consortium–Down Syndrome investigators; Mapstone M, Head E, Lai F, Hartley SL, Ances BM, Krinsky-McHale SJ, Lee JH, Ossenkoppele R, Christian BT, Handen BL, Hansson O. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. Lancet Neurol. 2025 Jul;24(7):591-600. doi: 10.1016/S1474-4422(25)00158-9. PMID:40541209; PMCID: PMC12174012.
16: Schworer EK, Handen BL, Krinsky-McHale S, Hom CL, Clare ICH, Harp JP, Pulsifer MB, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer Biomarker Consortium-Down Syndrome. Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome. J Intellect Disabil Res. 2025 Jul;69(7):569-581. doi: 0.1111/jir.13237. Epub 2025 Apr 20. PMID: 40254895; PMCID: PMC12199718.
17: McVea A, DiFilippo A, McLachlan M, Betcher B, Zammit M, Betthauser TJ,
Converse A, Murali D, Stone C, Hartley S, Johnson S, Tudorascu DL, Laymon CM, Cohen AD, Minhas D, Luo W, Mathis C, Lao PJ, Ances B, Zaman S, Mapstone M, Head E, Handen BL, Christian BT; ABC-DS investigators. PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations. Alzheimers Dement. 2025 Jun;21(6):e70357. doi: 10.1002/alz.70357. PMID: 40556306; PMCID: PMC12187968.
18: Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL; Alzheimer's Biomarkers Consortium–Down Syndrome. Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 Jun;21(6):e70387. doi: 10.1002/alz.70387. PMID: 40545561; PMCID:
PMC12183108.
19: Paterson T, Rohrs J, Hohman TJ, Mapstone M, Meikle PJ, Kaddurah-Daouk R, Levey AI, Hood L; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer Disease Metabolomics Consortium; Funk CC. Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown. bioRxiv [Preprint]. 2025 May 12:2024.07.23.604835. doi: 10.1101/2024.07.23.604835. PMID: 40462904; PMCID: PMC12132299.
20: Handen BL, Mapstone M, Hartley S, Andrews H, Christian B, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O'Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 May;21(5):e70294. doi: 10.1002/alz.70294. PMID:40371686; PMCID: PMC12079517.
21: Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL; Alzheimer Biomarker Consortium - Down syndrome. Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11;17(1):19. doi:10.1186/s11689-025-09604-w. PMID: 40217501; PMCID: PMC11987311.
22: Barry A, Peven JC, Handen BL, Bolt D, Krinsky-McHale SJ, Hom CL, Clare ICH, Glueck A, Harp J, Schmitt F, Zammit M, Minhas D, Luo W, Laymon C, Price J, Lee JH, Lott I, Cohen A, Ances BM, Pulsifer M, Rosa HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL; Alzheimer Biomarker Consortium - Down syndrome. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement. 2025 Apr;21(4):e70211. doi: 10.1002/alz.70211. PMID: 40289844; PMCID: PMC12035545.
23: McLachlan M, Bettcher B, McVea A, DiFilippo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Rosas HD, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT, Investigators AD. The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers. Alzheimers Dement. 2025 Apr;21(4):e70141. doi: 10.1002/alz.70141. PMID: 40189783; PMCID: PMC11972983.
24: Petersen ME, Zhang F, Hall J, Brock C, Rissman RA, Como T, Julovich D,
Mapstone M, Ances BM, Meeker K, Palmer R, Barber R, Mason D, Johnson L, Yaffe K, Toga AW, Cohen A, O'Bryant SE; HABS-HD Study Team. Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community-based cohort: an HABS-HD study. Alzheimers Dement (N Y). 2025 Feb 19;11(1):e70045. doi: 10.1002/trc2.70045. PMID: 39975470; PMCID: PMC11837735.
25: Liou JJ, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom CL, Doran EW,
Totoiu MO, Lott I, Mapstone M, Keator DB, Brickman AM, Wright ST, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E; Alzheimer Biomarker Consortium - Down Syndrome. A
neuropathology case report of a woman with Down syndrome who remained
cognitively stable: Implications for resilience to neuropathology. Alzheimers
Dement. 2025 Feb;21(2):e14479. doi: 10.1002/alz.14479. Epub 2025 Jan 27. PMID: 39868632; PMCID: PMC11851131.
26: Kennedy JT, Wisch JK, Dincer A, Roman J, Gordon BA, Handen B, Benzinger TLS, Head E, Mapstone M, Christian BT, Tudorascu DL, Laymon CL, Hartley SL, Lao P, Brickman AM, Zaman SH, Ances BM; ABC-DS and DIAN Consortia. Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome. Alzheimers Dement. 2025 Feb;21(2):e14519. doi: 10.1002/alz.14519. Epub 2025 Jan 14. PMID: 39807622; PMCID: PMC11848172.
27: Saeed A, McKennan C, Duan J, Yang YN, Kip KE, Finegold D, Vu M, Swanson J, Lopez OL, Cohen A, Mapstone M, Yu B, Ballantyne CM, Reis SE. Mid-life anti-inflammatory metabolites are inversely associated with long-term cardiovascular disease events. EBioMedicine. 2025 Feb;112:105551. doi:
10.1016/j.ebiom.2024.105551. Epub 2025 Jan 9. PMID: 39793479; PMCID:
PMC11764641.
28: Saeed A, Chang Y, Swanson J, Vu M, Mapstone M, Villemagne VL, Snitz BE, Royse SK, Wang H, Lopresti B, Aizenstein HJ, Wu M, Kip K, Reis SE, Lopez O, Cohen A. Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study. J Alzheimers Dis Rep. 2025 Jan 5;9:25424823241299297. doi:10.1177/25424823241299297. PMID: 40034508; PMCID: PMC11864267.
29: Petersen ME, Flores-Aguilar L, Head E, Montoliu-Gaya L, Strydom A, Pape SE, Fortea J, Ashton NJ, Udeh-Momoh C, O'Bryant SE, German D, Despa F, Mapstone M, Zetterberg H. Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring. Alzheimers Dement. 2025 Jan;21(1):e14364. doi:10.1002/alz.14364. Epub 2024 Nov 13. PMID: 39535517; PMCID: PMC11782192.
30: Boerwinkle AH, Wisch JK, Handen BL, Head E, Mapstone M, Rafii MS, O'Bryant SE, Krinsky-McHale SJ, Lai F, Rosas HD, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Ances BM; Alzheimer's Biomarker Consortium-Down Syndrome. The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome. Alzheimers Dement. 2025 Jan;21(1):e14359. doi:10.1002/alz.14359. Epub 2024 Nov 13. PMID: 39535359; PMCID: PMC11782213.
Grants
R01 AG058644 (Principal Investigator)
Multi-omic Investigation of Exercise Effects in MCI
U19 AG068054 (Principal Investigator)
The Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS)
U54 AG05439 (Co-Investigator)
UC Irvine MODEL-AD
R01 AG056726 (Co-Investigator)
Visceral fat, neuroinflammation and brain health: Towards early detection and prevention of preclinical dementia
R01 AG065314 (Co-Investigator)
Brain ERPs to assess emotional function in normal aging and MCI/AD
U19 AG078109 (Co-Investigator) Health and Aging Brain Study-Health Disparities (HABS-HD)
Professional Societies
Society for Neuroscience
International Neuropsychology Society
American Academy of Neurology
Alzheimer’s Association, International Society to Advance Alzheimer's Research and Treatment (ISTAART)
International Trisomy 21 Research Society
Graduate Programs
Interdepartmental Neuroscience Program
Research Centers
Center for Aging Research in Down Syndrome (CFAR-DS)
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6360
https://faculty.uci.edu/profile/?facultyId=6360
Last updated
12/19/2025
12/19/2025