Sanghyuk Shin

Picture of Sanghyuk Shin
Associate Professor
Sue & Bill Gross School of Nursing
Director, UCI Infectious Disease Science Initiative
Phone: (949) 576-8675
University of California, Irvine
106F Berk Hall
Mail Code: 3959
Irvine, CA 92697
Research Interests
Infectious disease epidemiology, COVID-19, tuberculosis, TB/HIV co-infection, genomic epidemiology, molecular diagnostics, community-based intervention trials, social determinants, global health
Baker CR*, Barilar I, Araujo LS de, Rimoin AW, Parker DM, Boyd R, Tobias JL, Moonan PK, Click ES, Finlay A, Oeltmann JE, Minin VN, Modongo C, Zetola NM, Niemann S, Shin SS. High-resolution characterization of recent tuberculosis transmission in Botswana using geospatial and genomic data - the Kopanyo Study [Internet]. medRxiv; 2022 [cited 2022 Apr 18].Available from:
Chalfin JS*, Baker CR*, Kizito B, Otukile D, Ogopotse MT, Shin SS, Modongo C. Association between HIV co-infection and delayed diagnosis with tuberculosis bacterial load in setting with widespread antiretroviral therapy use. medRxiv 2022 [Preprint]. p. 2022.03.28.22273071 [cited 2022 Apr 1]. Available from:
Goldstein I*, Bayer D, Barilar I, Kizito B, Matsiri O, Modongo C, Zetola NM, Niemann S*, Minin VN*, Shin SS. Investigating methods for using genetic data to estimate the association between host factors and being an infection source with application to probing the association between HIV infection and tuberculosis transmission [Internet]. 2021 Dec; doi:10.1101/2021.12.12.21267687. Available from:
Pham V, Nyamathi AM, Ekstrand ML, Sinha S, Yadav K, Shin SS. Association Between Maternal HIV Stigma Among South Indian Mothers Living with HIV and the CD4 Count of Children Living with HIV. AIDS Behav [Internet]. 2021 Dec 11 [cited 2021 Dec 11]; Available from:
Medina-Marino A, de Vos L, Bresenham D, Schumacher SG, Shin SS, Stevens W, Theron G, van der Walt M, Daniels J. “I got tested at home, the help came to me”: acceptability and feasibility of home-based TB testing of household contacts using portable molecular diagnostics in South Africa. Tropical Medicine & International. 2021 Mar;26(3):343-354. doi: 10.1111/tmi.13533. Epub 2021 Jan 4. PubMed PMID: 33289194; PubMed Central PMCID: PMC8060432.
Wang Q, Dima M, Ho-Foster A, Molebatsi K, Modongo C, Zetola NM, Shin SS. The association of household food insecurity and HIV infection with common mental disorders among newly diagnosed tuberculosis patients in Botswana. Public Health Nutrition; 2020: 1–22. 10.1017/S1368980020004139. NIHMSID 1638137.
Baik Y*, Modongo C, Moonan PK, Click ES, Tobias JL, Boyd R, Finlay A, Oeltmann JE, Shin SS(Co-Senior Author), Zetola NM. Possible Transmission Mechanisms of Mixed Mycobacterium tuberculosis Infection in High HIV Prevalence Country, Botswana. Emerging Infectious Diseases. 2020 May;26(5):953–60.
Mupfumi L*, Mpande C, Reid T Moyo S, Shin SS, Zetola NM, Mogashoa T, Musonda RM, Kasvosve I, Scriba TJ, Gaseitsiwe S. Immune phenotype and functionality of Mtb-specific T-cells in HIV/TB co-infected patients with controlled HIV-infection. Pathogens 2020;19.
Shin SS, Carpenter C, Ekstrand M, Wang Q*, Yadav K, Sinha S, Nyamathi AM. The effect of integrated nutritional interventions on children of women living with HIV in rural India: A 2 x 2 factorial intervention trial. Clin Infect Dis 2019 Oct 14;. doi: 10.1093/cid/ciz1009.
Mupfumi L*, Wang Q*, Moyo S, Shin SS, Zetola NM, Nnawa N, Kgwaadira BT, Chebani T, Iketleng T, Mogashoa T, Musonda R, Kasvosve I, Gaseitsiwe S. High Incidence of tuberculosis in the first six months in HIV-infected adults registered in the Botswana National Antiretroviral therapy programme between 2011 and 2016. AIDS 2019;33(15):2415-2422.
Wang Q, Modongo C, Baik Y, Allender C, Engelthaler DM, Warren RM, Zetola NM, Shin SS. Utility of targeted, amplicon-based deep sequencing to detect resistance to first-line tuberculosis drugs in Botswana. Antimicrobial Agents and Chemotherapy AAC.00982-19 (2019). doi:10.1128/AAC.00982-19.
Shin SS, Modongo C, Zetola NM. Twice-Daily vs. Once-Daily Dolutegravir in Patients With Human Immunodeficiency Virus–Tuberculosis Coinfection Receiving Rifampicin-Based Tuberculosis Therapy. Clin Infect Dis 2020. doi:10.1093/cid/ciz917.
Molebatsi K, Wang Q, Dima M, Ho-Foster A, Modongo C, Zetola NM, Shin SS. Depression and delayed tuberculosis treatment initiation among newly diagnosed patients in Botswana. Global Public Health. 2020 Sep 29;0(0):1–11.
Modongo C, Wang Q, Dima M, Ogopotse M, Kgwaadira B, Rankgoane - Pono G, Shin SS , Zetola NM. Clinical and virological outcomes of TB/HIV co - infected patients treated with dolutegravir - based HIV antiretroviral regimens: Early programmatic experience from Botswana .J Acquir Immune Dec Syndr. 2019;82(2):5.
Baik Y*, Fane O, Wang Q, Modongo C, Caiphus C, Zetola NM, Shin SS . Undetected tuberculosis at enrollment and after hospitalization in medical and oncology wards in Botswana. PLOS ONE . 2019;14(7):e0219678. doi:10.1371/journal.pone.0219678
Shin SS, Carpenter C, Ekstrand M, Wang Q, Grover S, Zetola NM, Yadav K, Sinha S, Nyamathi AM. Cervical cancer screening and awareness survey among women living with HIV/AIDS in Rural Andhra Pradesh, India. Int J STD AIDS 2019 Feb 27:956462419825950. doi: 10.1177/0956462419825950. NIHMS1005234.
Shin SS , Modongo C, Baik Y, Allende r C, Engelthaler DM, Warren RM , Zetola NM. Mixed infections are associated with poor treatment outcomes among newly diagnosed tuberculosis patients independent of pre - treatment heteroresistance . Journal of Infectious Diseases 2 018; 218(12 ):1974 - 1982. doi: 10.1093/infdis/jiy480. PMCID: PMC6217728
Shin SS, Carpenter CL, Ekstrand ML, et al. Household Food Insecurity as Mediator of the Association Between Internalized Stigma and Opportunistic Infections. AIDS Behav. June 2018:1-8. doi:10.1007/s10461-018-2193-3. NIHMSID 973811.
Shin SS, Modongo C, Zetola NM, Wang Q, Phologolo T, Kestler M, Ho-Foster A. High rates of exposure to tuberculosis patients among HIV-infected healthcare workers in Botswana. Int J Tuberc Lung Dis 2018;22(4):366-370. PMCID: PMC5868425.

Shin SS, Modongo C, Boyd R, Caiphus C, Kuate L, Kgwaadira B, Zetola NM. High Treatment Success Rates among HIV-infected Multidrug-resistant Tuberculosis Patients after Expansion of Antiretroviral Therapy in Botswana, 2006–2013. J Acquir Immune Defic Syndr. 2017;74(1):65-71. PMCID: PMC5140728.
65328 CRDF Global Indo-US Joint Program on HIV/AIDS and STI Prevention Research Collaboration Award (PI: Shin, Shrinivasa) The effect of HIV infection on molecular diagnostics for drug-resistant tuberculosis in India 10/08/2019 – 10/7/2021 Role: Co-PI
R01AI147336 National Institute of Allergy and Infectious Diseases - NIH (PI: Shin) Improved understanding of TB transmission by accounting for within-host heterogeneity of M. tuberculosis: A population-based molecular epidemiology study in a high HIV prevalent setting 2/01/2020 – 1/31/2025 Role: Principal Investigator
R01 AI170204-01A1 National Institute of Allergy and Infectious Diseases - NIH (PI: Shin) The effect of HIV on SARS-CoV-2 transmission and emergence of variants of concern 07/05/2022 – 6/30/2026 Role: Principal Investigator
Research Centers
UCI Infectious Disease Science Initiative
Last updated