Danh V. Nguyen

Picture of Danh V. Nguyen
Professor, Medicine
School of Medicine
Ph.D., University of California, Davis, Statistics
University of California, Irvine
5141 California Ave
Irvine, CA 92617
Research Interests
Biostatistics; Clinical trials; Research methodology and rigor; Research ethics, ethics in clinical trials; Fragile X spectrum of disorders; Nephrology; Epidemiology; Clinical and translational science
Selected Publications (from > 180)

Nguyen DV, Rocke DM (2002) Tumor classification by partial least squares using microarray gene expression data. Bioinformatics, 18, 39-50.

Nguyen DV, Rocke DM (2002) Multi-class cancer classification via partial least squares using gene expression profiles. Bioinformatics, 18, 1216-1226.

Nguyen DV, Rocke DM (2002) Partial least squares proportional hazard regression for application to DNA microarray survival data. Bioinformatics, 18, 1625-1632.

Nguyen DV, Arpat AB, Wang N, Carroll RJ (2002) DNA microarray experiments: Biological and technological aspects. Biometrics, 58, 701-717.

Nguyen DV, Wang N, Carroll RJ (2004) Evaluation of missing value estimation for microarray data. Journal of Data Science, 2, 347-370.

Nguyen DV, Senturk D, Carroll RJ (2008) Covariate-adjusted linear mixed effects models with an application to longitudinal data. Journal of Nonparametric Statistics, 20, 459-481.

Chee KG, Nguyen DV, Brown M, Gandara DR, Wun T, Lara PN (2008) Positron emission tomography and improved survival in lung cancer: The Will Rogers phenomenon revisited. Archives of Internal Medicine, 168, 1541-1549.

Senturk D, Nguyen DV, Tassone F, Hagerman RJ, Carroll RJ, Hagerman PJ (2009) Covariate adjusted correlation analysis with application to FMR1 premutation female carrier data. Biometrics, 65, 781-792.

Senturk D, Nguyen DV (2011) Varying coefficient models for sparse noise-contaminated longitudinal data. Statistica Sinica, 21, 1831-1856.

Dalrymple, LS, Mohammed SM, Mu Y, Johansen KL, Chertow GM, Grimes B, Kaysen GA, Nguyen DV (2011) Risk of cardiovascular-related events following infection-related hospitalizations in older patients on dialysis. Clinical Journal of the American Society of Nephrology, 6, 1708-1713.

Mohammed SM, Senturk D, Dalrymple DS, Nguyen DV (2012) Measurement error case series models with application to infection-cardiovascular risk in older patients on dialysis. Journal of the American Statistical Association, 107, 1310-1323.

Mohammed SM, Dalrymple DS, Senturk D, Nguyen DV (2013) Naïve hypothesis testing for case series models with time-varying exposure onset measurement error: Inference for infection-cardiovascular risk in patients on dialysis. Biometrics, 69, 520-529.

Senturk D, Dalrymple DS. Mohammed SM, Kaysen GA, Nguyen DV (2013) Modeling time varying effects with generalized and unsynchronized longitudinal data. Statistics in Medicine, 32, 2971-2987.

Estes JP, Nguyen DV, Dalrymple DS, Mu Y, Senturk D (2014) Cardiovascular event risk dynamics over time in older patients on dialysis: A generalized multiple-index varying coefficient model approach. Biometrics, 70, 754–764.

Dalrymple LS, Johansen KL, Romano PS, Chertow GM, Mu Y, Grimes B, Kaysen GA, Nguyen DV (2014) Comparison of hospitalization between for-profit and nonprofit dialysis facilities. Clinical Journal of the American Society of Nephrology, 9, 73-81.

Rhee CM, Chen Y, You SA, Brunelli SM, Kovesdy CP, Brent GA, Kalantar-Zadeh K, Nguyen DV (2017) Thyroid functional disease, quality of life, and mental health in hemodialysis patients. Clinical Journal of the American Society of Nephrology, 12(8):1274-1283.

Campos LF, Senturk D, Chen Y, Nguyen DV (2017) Bias and estimation under misspecification of the risk period in self-controlled case series studies. Stat, 6(1), 373-389.

Guner YS, Harting MT, Fairbairn K, Delaplain PT, Zhang L, Chen Y, Kabeer MH, Yu P, Cleary JP, Stein JE, Stolar C, Nguyen DV (2018) Outcomes of neonates with congenital diaphragmatic hernia treated with venovenous versus venoarterial extracorporeal membrane oxygenation: A propensity score approach. Journal of Pediatric Surgery, 53(11):2092-2099.

Estes JP, Nguyen DV, Chen Y, Dalrymple LS, Rhee CM, Kalantar-Zedeh K, Senturk D (2018) Time-dynamic profiling with application to hospital readmission among patients on dialysis (with discussion). Biometrics, 74(4):1383-1394.

Chen Y, Rhee CM, Senturk D, Kurum E, Campos LF, Li Y, Kalantar-Zadeh K, Nguyen DV (2019) Association of U.S. dialysis facility staffing with profiling of hospital-wide 30-day unplanned readmission. Kidney Diseases, 5(3):153-162.

Estes JP, Chen Y, Senturk D, Rhee CM, Kurum E, You AS, Streja E, Kalantar-Zadeh K, Nguyen DV (2020) Profiling dialysis facilities for adverse recurrent events. Statistics in Medicine, 39:9, 1374-1389.

Li Y, Nguyen DV, Kurum E, Rhee CM, Chen Y, Kalantar-Zadeh K, Senturk D (2020) A multilevel mixed effects varying coefficient model with multilevel predictors and random effects for modeling hospitalization risk in patients on dialysis. Biometrics, 76(3), 924-938.

Chen Y, Senturk D, Estes JP, Campos LF, Rhee CM, Dalrymple LS, Kalantar-Zadeh K, Nguyen DV (2021) Performance characteristics of profiling methods and the impact of inadequate case-mix adjustment. Communications in Statistics – Simulation and Computation, 50, 1854-1871.

Li Y, Nguyen DV, Banerjee S, Rhee CM, Kalantar-Zadeh K, Kurum E, Senturk D (2021) Multilevel modeling of spatially nested functional data: Spatiotemporal patterns of hospitalization rates in the US dialysis population. Statistics in Medicine, 40(17):3937-3952.

Kurum E, Nguyen DV, Banerjee S, Li Y, Rhee CM, Senturk D (2022) A Bayesian multilevel time-varying framework for joint modeling of hospitalization and survival in patients on dialysis. Statistics in Medicine, 41(29): 5597-5611.

Guner YS, Harting M, Jancelewicz T, Yu PT, Di Nardo M, Nguyen DV (2022) Variation across centers in standardized mortality ratios for congenital diaphragmatic hernia receiving extracorporeal life support. Journal of Pediatric Surgery, 57(11): 606-613.

Rhee CM, You AS, Narasaki Y, Brent GA, Sim JJ, Little R, Dunning S, Dehart W, Kha C, Veeravalli N, Kovesdy CP, Kalantar-Zadeh K, Nguyen DV (2023) Development and validation of a risk prediction model for incident hypothyroidism in a national chronic kidney disease cohort. The Journal of Clinical Endocrinology and Metabolism, in-press.

Qian Q, Nguyen DV, Telesca D, Kurum E, Rhee CM, Banerjee S, Li Y, Senturk D (2023) Multivariate spatiotemporal functional principal component analysis for modeling hospitalization and mortality rates in dialysis patients. Biostatistics, in-press.

Nguyen DV, Qian Q, You AS, Kurum E, Rhee CM, Senturk D (2023) High-dimensional fixed effects profiling models and applications in end-stage kidney disease patients: Current state and future directions.
1) NIH NIDDK R01 DK092232 (2021-2026) Multilevel Time-Dynamic Modeling of Hospitalization and Survival in Patients on Dialysis (role: mPI; with Senturk D UCLA, Kurum E UC Riverside)
2) NIH NIDDK R01 DK092232 (2015-2021) Modeling Time Dynamic Multilevel Outcomes in Patients on Dialysis (role: PI, UCI; with Senturk D UCLA)
3) NIH NIDDK R01 DK092232 (2011-2015) Effective Semiparametric Models for Ultra-Sparse, Unsynchronized, Imprecise Data (role: PI, UCI; with D Senturk UCLA)
4) NIH NIDDK R01 DK122767 (2019-2024) A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients (role: Co-Investigator, PI: Rhee CM)
5) NIH NIDDK K23 DK102903 (2014-2019) Hypothyroidism, Cardiovascular Health, and Survival in Kidney Disease (role: mentor; PI Rhee CM)
6) NIH NIDDK K23 DK093584 (2012-2015) Infection in Dialysis Patients: Risk Factors and Outcomes (role: mentor; PI Dalrymple LS)
Other Experience
Professor of Biostatistics
UC Davis, Department of Public Health Sciences 2003—2013
Department of Statistics, Texas A&M 2001—2003
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