Thomas K Lee

Picture of Thomas K Lee
Associate Clinical Professor, Pathology and Laboratory Medicine, and Urology (secondary)
School of Medicine
M.D., George Washington University, 2006
Ph.D., University of Rochester, 2002, Toxicology
Phone: (714) 456-6141
University of California, Irvine
UCIMC, Bldg. 1, Rm. 3625
Mail Code: 4805
Irvine, CA 92697
Research Interests
Urologic pathology prognostic markers; clinicopathologic correlation
Lyou Y, Barber E, Mehta R, Lee T, Goreal W, Parajuli R. (2018) Radiation Associated Angiosarcoma (RAS) of the Breast: A Case Report and Literature Review. Case Reports in Oncology (accepted).
Lama DJ, Safiullah S, Patel RM, Lee TK, Balani JP, Zhang L, Okhunov Z, Margulis V, Savage SJ, Uchio E, Landman J. (2018) Multi-Institutional Evaluation of Upper Urinary Tract Biopsy Using Backloaded Cup Biopsy Forceps, a Nitinol Basket, and Standard Cup Biopsy Forceps. Urology (accepted)
Lee TK and Ro JY. (2018). Spectrum of cribriform proliferations of the prostate: from benign to malignant. Arch Pathol Lab Med (in press).
Lall C, Bura V, Lee TK, Bhosale P, Faria SC, Choi JI, Wang ZJ. (2017) Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy. Abdom Radiol (NY). 2017 Nov 6. s00261-017-1366-2. [Epub ahead of print]
Nguyentat M, Ushinsky A, Miranda-Aguirre A, Uchio E, Lall C, Shirkhoda L, Lee T, Green C, Houshyar R. (2017) Validation of Prostate Imaging-Reporting and Data System Version 2: A Retrospective Analysis. Curr Probl Diagn Radiol. 2017 Oct 12. pii: S0363-0188(17)30188-3. [Epub ahead of print]
Okhunov Z, Yoon R, Spradling K, Suarez M, Lusch A, Hwang C, Osann K, Lee TK, and Landman J. (2017) Evaluation and Comparison of Contemporary Energy-based Surgical Vessel Sealing Devices. J Endourol (in press)
Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Mucci LA, Giovannucci EL, Stampfer MJ, Yoon GS, Lee TK, Hicks JL, DeMarzo AM, Meeker AK, Platz EA. (2017) Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells. The Prostate (in press)
Sung CT, Shetty A, Menias CO, Houshyar R, Chatterjee S, Lee TK, Tung P, Helmy M, Lall C. (2017)Collision and Composite Tumors; Radiologic and Pathologic Correlation. Abdominal Radiology (accepted, in press)
Ou SI, Lee TK, Young L, Fernandez-Rocha MY, Pavlick D, Schrock AB, Zhu VW, Milliken J, Ali SM, Gitlitz B. (2017) Dual occurrence of ALK G1202R solvent front mutation and small cell lung cancer transformation as resistance mechanisms to second generation ALK inhibitors without prior exposure to crizotinib. Pitfall of solely relying on liquid re-biopsy? Lung Cancer 106:110-114.
Darvishazadeh, A, McEachern, W, Lee, TK, Bhosale, P, Shirkhoda, A, Menias, C, and Lall, C. (2016) Deep Pelvic Endometriosis: A Radiologist’s Guide to Key Imaging Features with Clinical and Histopathologic Review. Abdominal Radiology, 41(12):2380-2400.
Weinberg BA, Gowen K, Lee TK, Ou SI, Bristow R, Krill L, Almira-Suarez MI, Ali SM, Miller VA, Liu AV, Klempner AJ. (2016) Comprehensive genomic profiling aids in distinguishing metastatic recurrence from second primary cancers. Oncologist, 22(2):152-157.

Vernez SL, Okhunov Z, Khoyilar C, Wikenheiser J, Khoyilar C, Dutta R, Osann K, Kaler K, Lee TK, Clayman RV, and Landman J. (2016) Precise characterization and three-dimensional reconstruction of the autonomic nerve distribution of the human ureter. J Urol., 197(3 pt.1): 723-729.
Wood ML, Lee TK, Armstrong WB, Wang BY (2016) Cervical Spine Synovial Chondromatosis: A Case Report and Literature Review. Med Rep Case Stud 1: 114.
Klempner SJ, Gershenhorn B, Tran P, Lee TK, Erlander MG, Gowen K, Schrock AB, Morosini D, Ross JS, Miller VA, Stephens PJ, Ou SH, Ali SM. (2016) BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy. Cancer Discov. 6(6):594-600.
Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Van Blarigan E, Mucci LA, Giovannucci E, Stampfer MJ, GhilSuk Yun, Lee TK, Hicks JL, De Marzo AM, Meeker AK, Platz EA. (2015) Pre-diagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cells. Cancer Prev Res (Phila). 8(8):737-42.

Heaphy CM, Yun GS, Peskoe SB, Joshu CE, Lee TK, Giovannucci E, Mucci LA, Kenfield SA, Stamfer MJ, Hicks JL, Demarzo AM, Platz EA, Meeker AK. (2013) Prostate Cancer Cell Telomere Length Variation and Stromal Cell Telomere Length as Prognostic Markers for Metastasis and Death. Cancer Discoveries. Cancer Discov. 3(10):1130-41.

Chaux A, Karram S, Miller JS, Fajardo DA, Lee TK, Miyamoto H, Netto GJ. (2012) High-grade papillary urothelial carcinoma of the urinary tract: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Human Pathol. 43(1):115-20.

Fajardo DA, Miyamoto H, Miller JS, Lee TK, Epstein JI. (2011) Identification of Gleason pattern 5 on prostatic needle core biopsy: frequency of underdiagnosis and relation to morphology. Am J Surg Pathol. 35(11):1706-11.

Lee TK, Chaux, A, Karram S, Miyamoto H, Miller JS, Fajardo DA, Epstein JI, and Netto GJ. (2011) Papillary Urothelial Neoplasm of Low Malignant Potential of the Urinary Bladder: Clinicopathologic and Outcome Analysis from a Single Academic Center. Human Pathol. 42(11):1799-803.

Ling SZ , Chang XF , Lee TK, Marchionni L, Netto GJ, Sidransky D, Schultz L, Chaux A, and Berman, DM. (2011) An EGFR-ERK1/2-Sox9 Signaling Cascade Links Urothelial Development, Regeneration, and Cancer. Cancer Res. 71(11):3812-21.

Miyamoto H, Brimo F, Schultz L, Ye H, Miller JS, Fajardo DA, Lee TK, Epstein JI, Netto GJ. (2010) Low-grade papillary urothelial carcinoma of the urinary bladder: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Arch Pathol Lab Med.134(8):1160-3.

Lee TK, Miller JS, Epstein JI. (2010) Rare histological patterns of prostatic ductal adenocarcinoma. Pathology. 42(4):319-24.

Lee TK, Miyamoto H, Osunkoya, AO, Guo CC, Weiss SW, and Epstein JI. (2010) Smooth muscle neoplasms of the urinary bladder: A clinicopathological study of 51 cases. Am. J. Surg. Pathol. 34(4):502-9.

Lee TK, Chuang ST, and Netto, GJ. (2010) Conventional prostatic adenocarcinoma arising in a multilocular prostatic cystadenoma. Pathol. Int. 60(5):413-6.

Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, and Epstein JI. (2010) Non-invasive papillary urothelial neoplasms: The 2004 WHO/ISUP classification system. Pathol. International. 60(1):1-8.

Duffield AS, Lee TK, Miyamoto H, Carter HM, and Epstein JI. (2009) Radical prostatectomy findings in patients who fail active surveillance. J. Urol. 182:2272-2276.

Tavora F, Fajardo DA, Lee TK, Lotan T, Miller JS, Miyamoto H and Epstein JI. (2009) Small endoscopic biopsies of the ureter and renal pelvis: Pathologic pitfalls. Am. J. Surg. Pathol. 33(10):1540-1546.

Miller JS, Lee TK, Epstein JI, and Ulbright TM. (2009) The utility of microscopic findings and immunohistochemistry in the classification of necrotic testicular tumors: A study of 11 cases. Am. J. Surg. Pathol. 33(9):1293-8.

Lee TK, Koh AS, Cui Z, Pierce RH, and Ballatori N. (2003) N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Am. J. Physiol. Gastrointest. Liver Physiol. 285(2):G371-81.

Lee TK, Hammond CL, and Ballatori N. (2001) Intracellular glutathione regulates taurocholate transport in HepG2 cells. Toxicol. Appl. Pharmacol. 174(3):207-15.

Hammond CL, Lee TK, and Ballatori N. (2001) Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J. Hepatol. 34(6):946-54.

Li L, Lee TK, Meier PJ, and Ballatori N. (1998) Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J. Biol. Chem. 273(26):16184-91.

Li L, Lee TK, and Ballatori N. (1997) Functional re-evaluation of the putative glutathione transporters, RcGshT and RsGshT. Yale J. Biol. Med. 70(4):301-10.

Lee TK, Li L, and Ballatori N. (1997) Hepatic glutathione and glutathione S-conjugate transport mechanisms. Yale J. Biol. Med. 70(4):287-300.
Professional Societies
United States and Canadian Academy of Pathology
College of American Pathologists
International Society of Urologic Pathology
Korean American Pathology Association of North America
Other Experience
Resident/Fellow - Anatomic Pathology/Urologic Pathology
Johns Hopkins Hospital 2006—2009
Fellow - Surgical Pathology
Stanford University Medical Center 2009—2010
Swedish Medical Center and CellNetix Pathology, Seattle, WA 2010—2014
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