Jogeshwar Mukherjee
Professor in Residence, Radiological Sciences
School of Medicine
School of Medicine
PhD: University of Jodhpur (INDIA; renamed as Jai Narain Vyas University), Organic Chemistry (1980)
BS: University of Jodhpur (INDIA), Chemistry (1976)
MS: University of Jodhpur (INDIA), Organic Chemistry (1978)
BS: University of Jodhpur (INDIA), Chemistry (1976)
MS: University of Jodhpur (INDIA), Organic Chemistry (1978)
University of California, Irvine
Med Sci I, B140
Preclinical Imaging
Radiological Sciences
Mail Code: 5000
Irvine, CA 92697
Med Sci I, B140
Preclinical Imaging
Radiological Sciences
Mail Code: 5000
Irvine, CA 92697
Research Interests
Radiopharmaceutical Design & Development; PET Imaging and Quantitation; Neuroscience
Websites
Academic Distinctions
2015 Distinguished Investigator, Academy Radiology Research (http://www.acadrad.org/2015-distinguished-investigators-award/)
Research Abstract
The mission of preclinical imaging is to promote the development and use of non-invasive molecular imaging technology by supporting service, research and teaching. These imaging modalities include positron emission tomography (PET), single photon emission computed tomography (SPECT), computer assisted tomography (CT), focused ultrasound (FUS), optical imaging methods and other emerging technologies. Radiopharmaceuticals for PET play a key role in the advancement of this technology. Using state of the art methods and appropriate quality control procedures, preclinical imaging designs and produces novel radiopharmaceuticals, which are suitable for animal and human use research. Advancements in imaging are carried out at preclinical imaging with an emphasis in five areas of research: 1. Biomarker Research and Development; 2. Radiopharmaceutical Production; 3. In Vitro Testing, Pharmacology and Neuroscience; 4. In Vivo Imaging in normal and disease models; and 5. Image Analysis and Quantitation.
Awards and Honors
2025 University of California-Irvine, Chancellors Award for Distinguished Fostering of Undergraduate Research in School of Medicine.
Publications
Karim, F., Ngo, A., Danh, T.B., Delaney, B.D., Liang, C., Serrano, G.E., Beach, T.G., Mukherjee, J. Human hippocampal [18F]nifene binding to nicotinic acetylcholinergic a4ß2* receptors in hippocampus-subiculum of postmortem Alzheimer’s disease brains. BRAIN RESEARCH, 1857, 149600, 2025. https://doi.org/10.1016/j.brainres.2025.149600
Liang, C., Okamoto, A.A., Karim, F., Kawauchi, S., Mukherjee, J. Disruption of normal brain distribution of [18F]nifene to ?4?2* nicotinic acetylcholinergic receptors in B6129SF2/J mice and transgenic 3xTg mouse model of Alzheimer’s disease: In vivo [18F]Nifene PET/CT imaging studies. NEUROIMAGE, 310, 121092, 2025. https://doi.org/10.1016/j.neuroimage.2025.121092
Paclibar, C.G., Schafer, D.M., Biju, A.P., Karim, F., Sison, S.A., Liang, C., Ahmed, S.T., Mukherjee, J. Towards imaging Tau hyperphosphorylation: Is DYRK1A a potential target for imaging hyperphosphorylation of Tau? Molecular modeling assessment and synthesis of [125I]radioiodinated DYRK1A inhibitor. MOLECULES, 30(5), 990, 2025. https://doi.org/10.3390/molecules30050990
Sandhu, Y.K., Bath, H.S., Shergill, J., Liang, C., Syed, A.U., Ngo, A., Karim, F., Serrano, G.E., Beach, T.G., Mukherjee, J. [18F]Flotaza for A? plaque diagnostic imaging: Evaluation in postmortem human Alzheimer’s disease brain hippocampus and PET/CT imaging in 5xFAD transgenic mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(14), 7890, 2024. doi.org/10.3390/ijms25147890
Mondal, R., Sandhu, Y.K., Kamalia, V.M., Delaney, B.A., Syed, A.U., Nguyen, G.A.H., Moran, T.R., Limpengco, R.R., Liang, C., Mukherjee, J. Measurement of A? amyloid plaques and Tau protein in postmortem human Alzheimer’s disease brain by autoradiography using [18F]flotaza, [125I]IBETA and [124/125I]IPPI and immunohistochemistry analysis using QuPath. BIOMEDICINES, 11, 1033, 2023. doi.org/10.3390/biomedicines11041033.
Syed, A.U., Liang, C., Patel, K.K., Mondal, R., Kamalia, V.M., Moran, T.R., Ahmed, S.T., Mukherjee, J. Comparison of Monoamine oxidase-A, A? plaques, Tau and Translocator protein in postmortem human Alzheimer’s disease brain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(13): 10808, 2023. doi.org/10.3390//ijms241310808
https://www.ncbi.nlm.nih.gov/myncbi/14UOideAnwlks/bibliography/public/
For full list of publications, please click on the link above.
For full list of publications, please click on the link above.
Grants
National Institute of Health, R01: “Novel Tau-targeted radiopharmaceuticals for Alzheimer's disease". Principal Investigator: J. Mukherjee
National Institute of Health, R21: "Evaluation of monoamine oxidase A as a new biomarker for Alzheimer's disease". Principal Investigator: J. Mukherjee.
Professional Societies
Society of Nuclear Medicine
Society of Neuroscience
Indo-American Society of Nuclear Medicine
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5942
https://faculty.uci.edu/profile/?facultyId=5942
Last updated
06/29/2025
06/29/2025