Professor in Residence, Radiological Sciences
School of Medicine

Professor, Radiological Sciences
School of Medicine

Radiopharmaceutical Design & Development; PET Imaging and Quantitation; Neuroscience

Preclinical Imaging

2015 Distinguished Investigator, Academy Radiology Research (http://www.acadrad.org/2015-distinguished-investigators-award/)

The mission of preclinical imaging is to promote the development and use of non-invasive molecular imaging technology by supporting service, research and teaching. These imaging modalities include positron emission tomography (PET), single photon emission computed tomography (SPECT), computer assisted tomography (CT), focused ultrasound (FUS), optical imaging methods and other emerging technologies. Radiopharmaceuticals for PET play a key role in the advancement of this technology. Using state of the art methods and appropriate quality control procedures, preclinical imaging designs and produces novel radiopharmaceuticals, which are suitable for animal and human use research. Advancements in imaging are carried out at preclinical imaging with an emphasis in five areas of research: 1. Biomarker Research and Development; 2. Radiopharmaceutical Production; 3. In Vitro Testing, Pharmacology and Neuroscience; 4. In Vivo Imaging in normal and disease models; and 5. Image Analysis and Quantitation.

2025 University of California-Irvine, Chancellors Award for Distinguished Fostering of Undergraduate Research in School of Medicine.

Karim, F., Ngo, A., Danh, T.B., Delaney, B.D., Liang, C., Serrano, G.E., Beach, T.G., Mukherjee, J. Human hippocampal [18F]nifene binding to nicotinic acetylcholinergic a4ß2* receptors in hippocampus-subiculum of postmortem Alzheimer’s disease brains. BRAIN RESEARCH, 1857, 149600, 2025. https://doi.org/10.1016/j.brainres.2025.149600

Liang, C., Okamoto, A.A., Karim, F., Kawauchi, S., Mukherjee, J. Disruption of normal brain distribution of [18F]nifene to ?4?2* nicotinic acetylcholinergic receptors in B6129SF2/J mice and transgenic 3xTg mouse model of Alzheimer’s disease: In vivo [18F]Nifene PET/CT imaging studies. NEUROIMAGE, 310, 121092, 2025. https://doi.org/10.1016/j.neuroimage.2025.121092

Paclibar, C.G., Schafer, D.M., Biju, A.P., Karim, F., Sison, S.A., Liang, C., Ahmed, S.T., Mukherjee, J. Towards imaging Tau hyperphosphorylation: Is DYRK1A a potential target for imaging hyperphosphorylation of Tau? Molecular modeling assessment and synthesis of [125I]radioiodinated DYRK1A inhibitor. MOLECULES, 30(5), 990, 2025. https://doi.org/10.3390/molecules30050990

Sandhu, Y.K., Bath, H.S., Shergill, J., Liang, C., Syed, A.U., Ngo, A., Karim, F., Serrano, G.E., Beach, T.G., Mukherjee, J. [18F]Flotaza for A? plaque diagnostic imaging: Evaluation in postmortem human Alzheimer’s disease brain hippocampus and PET/CT imaging in 5xFAD transgenic mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(14), 7890, 2024. doi.org/10.3390/ijms25147890

Mondal, R., Sandhu, Y.K., Kamalia, V.M., Delaney, B.A., Syed, A.U., Nguyen, G.A.H., Moran, T.R., Limpengco, R.R., Liang, C., Mukherjee, J. Measurement of A? amyloid plaques and Tau protein in postmortem human Alzheimer’s disease brain by autoradiography using [18F]flotaza, [125I]IBETA and [124/125I]IPPI and immunohistochemistry analysis using QuPath. BIOMEDICINES, 11, 1033, 2023. doi.org/10.3390/biomedicines11041033.

Syed, A.U., Liang, C., Patel, K.K., Mondal, R., Kamalia, V.M., Moran, T.R., Ahmed, S.T., Mukherjee, J. Comparison of Monoamine oxidase-A, A? plaques, Tau and Translocator protein in postmortem human Alzheimer’s disease brain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(13): 10808, 2023. doi.org/10.3390//ijms241310808

https://www.ncbi.nlm.nih.gov/myncbi/14UOideAnwlks/bibliography/public/
For full list of publications, please click on the link above.

National Institute of Health, R01: “Novel Tau-targeted radiopharmaceuticals for Alzheimer's disease". Principal Investigator: J. Mukherjee

National Institute of Health, R21: "Evaluation of monoamine oxidase A as a new biomarker for Alzheimer's disease". Principal Investigator: J. Mukherjee.

Society of Nuclear Medicine

Society of Neuroscience

Indo-American Society of Nuclear Medicine

Link to this profile
https://faculty.uci.edu/profile/?facultyId=5942

Last updated
07/08/2025