George Osapay
Researcher, Pathology
School of Medicine
School of Medicine
Ph.D., Eötvös Lorand University, Budapest, Hungary, 1980, Chemistry
University of California, Irvine
B146 Medical Science
Mail Code: 4800
Irvine, CA 92697
B146 Medical Science
Mail Code: 4800
Irvine, CA 92697
Research Interests
Protein chemistry, peptide synthesis, antimicrobial peptides - defensins, opioids, peptidomimetics (phosphono- and lanthionine peptides), drug design/development, alternative medication
Academic Distinctions
Young Investigator Award in Medicinal Chemistry (1984 and 1986, Budapest)
Collegium Fellowship Award (1994, Munich)
D.Sc. degree - Hungarian Academy of Sciences (1996)
“Design Principles in the Construction of Biologically Active Peptides.”
Collegium Fellowship Award (1994, Munich)
D.Sc. degree - Hungarian Academy of Sciences (1996)
“Design Principles in the Construction of Biologically Active Peptides.”
Research Abstract
Our studies are focused on alpha-, beta-, and theta-defensins, these peptides provide the host with the ability to fend off potentially invasive pathogens. We have isolated, synthesized and characterized several theta-defensins, 18-residue cyclic molecules, with strong antimicrobial activity. Their gene expression process is under our investigation.
Publications
PAPERS:
(1) - G. Ösapay, K. Ösapay: Hydrolysis of peptide substrates containing amino-phosphonic acids by proteolytic enzymes.
Acta Biochimica et Biophysica ASH (1982) 17, 99.
(2) - G. Ösapay, I. Szilagyi, P. Körmöczy: Synthesis and biological activity of some new N-phosphono-acetyl-dipeptides.
Acta Biochimica et Biophysica ASH (1984) 19, 68.
(3) - G. Ösapay, I. Szilagyi, J. Seres: Aminoalkylphosphonic acids and phosphonopeptides. General method for synthesis of aminophosphonic acids from aminocarboxylic acids.
Tetrahedron (1987) 43, 2977.
(4) - T. Cserhati, B. Bordas, G. Ösapay: Lipophilicity determination of some fully protected peptides and amino acids.
Chromatographia (1987) 23, 184.
(5) - T. Cserhati, G. Ösapay, M. Szögyi: Dependence of the silanophyl effect on the chemical structure of peptides and on the type of organic mobile phase in RP-TLC.
J. Chromat. (1989) 27, 540.
(6) - G. Ösapay, P. Körmöczy, I. Szilagyi, J. Kajtar, B. Kiss: Synthesis of N-(phosphonoacetyl)-dipeptide derivatives and evaluation of their antihypertensive activity.
Die Pharmazie (1990) 45, 666.
(7) - J.W. Taylor, G. Ösapay: Determining the functional conformations of biologically active peptides.
Acc. Chem. Res. (1990) 23, 338.
(8) - G. Ösapay, J.W. Taylor: Multicyclic polypeptide model compounds 1. Synthesis of a tricyclic amphiphilic a-helical peptide using an oxime resin, segment-condensation approach.
J. Am. Chem. Soc. (1990) 112, 6046.
(9) - G. Ösapay, A. Profit, J.W. Taylor: Synthesis of Tyrocidine A; Use of oxime resin for peptide chain assembly and cyclization.
Tetrahedron Lett. (1990) 31, 6121.
(10) - M. Bouvier, J. W. Taylor, G. Ösapay: Design, synthesis and study of conformationally constrained analogs of neuropeptide Y.
"Peptides 1990", Proc. 21st Eur. Peptide Symp. (E. Giralt and D. Andreu, eds.) ESCOM, Leiden, 1991, p.652.
(11) - K. S. Petrakis, E. T. Kaiser, G. Ösapay: Polymer-supported acidolysis of protecting groups used in the synthesis of large peptides.
J. Chem. Soc., Chem. Commun. (1991) 53.
(12) - G. Ösapay, J. Gulyas, A. Profit, E. S. Gulyas, J. W. Taylor: Multicyclic peptides synthesized using the Kaiser-oxime resin: Helix stabilizing effects of lactame bridges.
Peptides, Proc. 12th Amer. Peptide Symp. (J. A. Smith and J. E. Rivier, eds.) ESCOM, Leiden, 1992, p. 239.
(14) - G. Ösapay, M. Bouvier, J.W. Taylor: Peptide cyclization on oxime resin (PCOR).
Techniques in Protein Chemistry II. (J. Villafranca, ed.) Academic Press, San Diego, 1991 p. 221.
(15) - G. Ösapay, I. Szilagyi: Novel synthetic route to phosphorous peptidomimetics. Synthesis of phosphonic (and phosphinic) analogs of aspartic and glutamic acid peptides.
Peptides, Proc. 12th Amer. Peptide Symp. (J. A. Smith and J. E. Rivier, eds.) ESCOM, Leiden, 1992, p. 609.
(16) - G. Ösapay, J.W. Taylor: Multicyclic polypeptide model compounds 2. Synthesis and conformational properties of a highly a-helical uncosapeptide constrained by three side-chain to side-chain lactam bridges.
J. Am. Chem. Soc. (1992) 114, 6966.
(17) - M. Goodman, S. Ro, G. Ösapay, T. Yamazaki, A. Polinsky: The molecular basis of opioid potency and selectivity: Morphiceptins, Dermorphins, Deltorphins and Enkephalins. in "Medication development: drug discovery, databases and computer aided drug design" in NIDA Research Monograph, Vol. 134, (R. Rapaka and R.L. Hawks, eds.) 1993, 195.
(18) - G. Ösapay, A. Csiba: Inhibitory effect of synthetic aminophosphonic acid derivatives on human carbonic anhydrase. Eur. J. Med. Chem. (1993) 28, 355.
(19) - G. Ösapay, K. Ösapay, A. Csiba: Investigation of the role of His200 in hydratase and esterase activities of human carbonic anhydrase-I. Protein Engineering (1993) 6 Suppl., 47.
(20) - M. Goodman, S. Ro, T. Yamazaki, G. Ösapay, A. Polinsky, A. Palmer-Toy: An integrated approach for bioactive conformations of peptide and peptidomimetic opioids. in "Peptide Chemistry 1992", Proceedings of 2nd Japan Symposium on Peptide Chemistry (N. Yanaihara, ed.) ESCOM, Leiden, 1993, p. 239.
(21) - G. Ösapay, S. Wang, H. Shao, M. Goodman: Synthesis and characteristics of lanthionine peptides. in "Peptide Chemistry 1992", Proceedings of 2nd Japan Symposium on Peptide Chemistry (N. Yanaihara, ed.) ESCOM, Leiden, 1993, p. 152.
(22) - G. Ösapay, M. Goodman: A New Application of PCOR Methodology: Preparation of Lanthionine Peptides.
J. Chem. Soc., Chem. Commun. (1994) 1599.
(23) - G. Ösapay, H. Shao, M. Goodman, J.W. Taylor: Peptide cyclization on an oxime resin. Reaction conditions and applications.
Peptides, Proc. 13th Amer. Peptide Symp., (R.S. Hodges, J.A. Smith, eds.) ESCOM, Leiden, 1994, p. 101.
(24) - G. Ösapay, S. Wang, D. Comer, A. Palmer-Toy, Q. Zhu, M. Goodman: Superactive lanthionine enkephalins.
Peptides, Proc. 13th Amer. Peptide Symp., (R.S. Hodges, J.A. Smith, eds.) ESCOM, Leiden, 1994, p. 435.
(25) - G. Ösapay, G. Melacini, Q. Zhu, L. Tehrani, M. Goodman: Synthesis and physicochemical characterization of the lanthionione analog of somatostatin[1-14].
Letters in Peptide Science (1994) 1 , 81.
(26) - C.-W. Lee, Q. Zhu, H. Shao, S. Wang, G. Ösapay, M. Goodman: Design and synthesis of substituted lanthionine enkephalin opioids.
"Peptides 1994", Proc. 23rd Eur. Peptide Symp. (H. Maya, ed.) ESCOM, Leiden, 1995, p. 627.
(27) - M. Goodman, G. Ösapay, G. Melacini, Q. Zhu: Design and synthesis of lanthionine sandostatin.
"Peptides 1994", Proc. 23srd Eur. Peptide Symp. (H. Maya, ed.) ESCOM, Leiden, 1995, 561.
(28) - G.Ösapay, Q. Zhu, H. Shao, R.K. Chadha, M. Goodman: Synthesis, crystal structure and conformations in solution of four stereoisomeric cyclo-lanthionine derivatives.
Int. J. Peptide and Protein Research (1995) 46, 290.
(29) - H. Shao, S.H.-H. Wang, C.-W. Lee, G. Ösapay, M. Goodman: A facile synthesis of orthogonally protected stereoisomeric lanthionines by regioselective ring opening of serine b-lactone derivatives.
J. Org. Chem. (1995) 60, 2956.
(30) - R.K. Chadha, G. Ösapay: Crystal structure of (S)-[1-(benzyloxycarbonylamino)-ethyl]-phosphonic acid.
Acta Crystallographica, Section C (1995) 51, 2340-2342.
(31) - G. Ösapay, K. Ösapay, A. Csiba: Complex formation assisted site-directed alkylation in proteins.
Peptides: Chemistry, Structure & Biology, Proc. 14th Amer. Peptide Symp., (T.P. Kaumaya, R.S. Hodges, eds.) ESCOM, Leiden, 1996, p. 269-270.
(32) - J. Lutz, S. Rudolph-Bohner, L. Moroder, W. Kolbeck, G. Ösapay, M. Goodman: A novel and facile route to benzodiazepines.
Peptides: Chemistry, Structure & Biology, Proc. 14th Amer. Peptide Symp., (T.P. Kaumaya, R.S. Hodges, eds.) ESCOM, Leiden, 1996, p. 61-62.
(33) - L. Moroder, J. Lutz, F. Grams, S. Rudolf-Bšhner, G. Ösapay, M. Goodman, W. Kolbeck: Na-(2-aminobenzoyl)-peptides as precursors of 1,4-benzo-diazepine-2,5-dione derivatives.
Biopolymers 38, 295-300 (1996)
(34) - G. Ösapay, L. Prokai, F.C. Walls, K. Medzichradszky, D.H. Coy, T. Reisine, G. Melacini, Q. Zhu, S.H.-H. Wang, M. Goodman: Lanthionine-somatostatin analogs: Synthesis, characterization, biological activity and metabolic stability.
J. Med. Chem. 40, 2241-2251 (1997).
(35) - G. Melacini, Q. Zhu, G. Ösapay, M. Goodman: Refinement of the model for somatostatin pharmacophores: Conformational analysis of lanthionine-sandostatin analogs.
J. Med. Chem. 40, 2252-2258 (1997).
(36) - G. Ösapay, M. Bodaszky: Coupling in the absence of tertiary amines VI. Studies on the racemization of
Cysteine residues
Peptides 1998, Proc. 25th Eur. Peptide Symp., (S. Bajusz, F. Hudecz, eds.) Akademia, Budapest 1998, p. 158-159.
(37) - G. Ösapay, K. Ösapay: Therapeutic applications of somatostatin analogues
Exp. Opin. Ther. Pat. 8, 855-870 (1998).
(38) -Y-Q. Tang, J. Yuan, G. Ösapay, K. Ösapay, D. Tran, C.J. Miller, A.J. Ouellette, M.E. Selsted: A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.
Science, 286, 498-502 (1999).
(39) - L. Bibbs, N.P. Ambulos , Jr. S.A. Kates, A. Khatri, K.F. Medzihradszky, G. Ösapay and S.T. Weintraub:
Strategies for the synthesis of labeled peptides.
J. Biomol. Techn., 11, 155-165 (2000).
(40) - L. Bibbs, N.P. Ambulos , Jr. S.A. Kates, A. Khatri, K.F. Medzihradszky, G. Ösapay and S.T. Weintraub:
Strategies for the synthesis of labeled peptides 2000. In G.B. Fields, J.P. Tam & G. Barany (Eds.), ”Peptides for the New Millennium”, Kluwer Academic Publisher, Dordrecht, 2000, p. 113-114.
(41) - A. Kathri, N.P. Ambulos, S.A. Kates, K.F. Medzihradszky, G. Ösapay, H. Remmer, A. Somogyi: Strategies for the synthesis of cyclic peptides.
Peptides: The Wave of the Future. 17th Amer. Peptide Symp., (M. Lebl, R.A. Houghten, eds.) APS, San Diego 2001, p.140-141.
(42) - K. Medzihradszky, N.P. Ambulos, Jr., A. Khatri, G. Ösapay, H.A. Remmer, A. Somogyi and S.A. Kates: Mass spectrometry analysis for the determination of side reactions for cyclic peptides prepared from an Fmoc/tBu/Dmab protecting group strategy. Let. Peptide Sci. 8, 1-12 (2001).
(43) - D.C. Pecota, G. Ösapay, M. E. Selsted, and T. K. Wood: Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide, J. Biotechnol. 100, 1-12 (2003).
(44) - S. Vasudevan, J. Yuan, G. Ösapay, P. Tran, K. Tai, W. Liang, V. Kumar, M.E. Selsted , M.J. Cocco: Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque.
J. Biol. Chem., 283, 35869-77 (2008).
(45) - A.E. Garcia, G. Ösapay, P.A. Tran, J. Yuan, M.E. Selsted: Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes.
Infect. Immun., 76, 5883-91 (2008).
(46) - D. Tran, P. Tran, K. Roberts, G. Ösapay, J. Schaal, A. Ouellette, M.E. Selsted: Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins.
Antimicrob. Agents Chemother., 52, 944-53 (2008).
PATENT LITERATURE
(1) Inventors: M. Goodman and G. Ösapay, Assignee: W. Kolbeck: Lanthionine bridged peptides. United States Patent 6,028,168. February 22, 2000.
(2) Inventors: M. Goodman and G. Ösapay, Assignee: W. Kolbeck: Lanthionine bridged peptides. United States Patent 6,268,339. July 31, 2001.
(1) - G. Ösapay, K. Ösapay: Hydrolysis of peptide substrates containing amino-phosphonic acids by proteolytic enzymes.
Acta Biochimica et Biophysica ASH (1982) 17, 99.
(2) - G. Ösapay, I. Szilagyi, P. Körmöczy: Synthesis and biological activity of some new N-phosphono-acetyl-dipeptides.
Acta Biochimica et Biophysica ASH (1984) 19, 68.
(3) - G. Ösapay, I. Szilagyi, J. Seres: Aminoalkylphosphonic acids and phosphonopeptides. General method for synthesis of aminophosphonic acids from aminocarboxylic acids.
Tetrahedron (1987) 43, 2977.
(4) - T. Cserhati, B. Bordas, G. Ösapay: Lipophilicity determination of some fully protected peptides and amino acids.
Chromatographia (1987) 23, 184.
(5) - T. Cserhati, G. Ösapay, M. Szögyi: Dependence of the silanophyl effect on the chemical structure of peptides and on the type of organic mobile phase in RP-TLC.
J. Chromat. (1989) 27, 540.
(6) - G. Ösapay, P. Körmöczy, I. Szilagyi, J. Kajtar, B. Kiss: Synthesis of N-(phosphonoacetyl)-dipeptide derivatives and evaluation of their antihypertensive activity.
Die Pharmazie (1990) 45, 666.
(7) - J.W. Taylor, G. Ösapay: Determining the functional conformations of biologically active peptides.
Acc. Chem. Res. (1990) 23, 338.
(8) - G. Ösapay, J.W. Taylor: Multicyclic polypeptide model compounds 1. Synthesis of a tricyclic amphiphilic a-helical peptide using an oxime resin, segment-condensation approach.
J. Am. Chem. Soc. (1990) 112, 6046.
(9) - G. Ösapay, A. Profit, J.W. Taylor: Synthesis of Tyrocidine A; Use of oxime resin for peptide chain assembly and cyclization.
Tetrahedron Lett. (1990) 31, 6121.
(10) - M. Bouvier, J. W. Taylor, G. Ösapay: Design, synthesis and study of conformationally constrained analogs of neuropeptide Y.
"Peptides 1990", Proc. 21st Eur. Peptide Symp. (E. Giralt and D. Andreu, eds.) ESCOM, Leiden, 1991, p.652.
(11) - K. S. Petrakis, E. T. Kaiser, G. Ösapay: Polymer-supported acidolysis of protecting groups used in the synthesis of large peptides.
J. Chem. Soc., Chem. Commun. (1991) 53.
(12) - G. Ösapay, J. Gulyas, A. Profit, E. S. Gulyas, J. W. Taylor: Multicyclic peptides synthesized using the Kaiser-oxime resin: Helix stabilizing effects of lactame bridges.
Peptides, Proc. 12th Amer. Peptide Symp. (J. A. Smith and J. E. Rivier, eds.) ESCOM, Leiden, 1992, p. 239.
(14) - G. Ösapay, M. Bouvier, J.W. Taylor: Peptide cyclization on oxime resin (PCOR).
Techniques in Protein Chemistry II. (J. Villafranca, ed.) Academic Press, San Diego, 1991 p. 221.
(15) - G. Ösapay, I. Szilagyi: Novel synthetic route to phosphorous peptidomimetics. Synthesis of phosphonic (and phosphinic) analogs of aspartic and glutamic acid peptides.
Peptides, Proc. 12th Amer. Peptide Symp. (J. A. Smith and J. E. Rivier, eds.) ESCOM, Leiden, 1992, p. 609.
(16) - G. Ösapay, J.W. Taylor: Multicyclic polypeptide model compounds 2. Synthesis and conformational properties of a highly a-helical uncosapeptide constrained by three side-chain to side-chain lactam bridges.
J. Am. Chem. Soc. (1992) 114, 6966.
(17) - M. Goodman, S. Ro, G. Ösapay, T. Yamazaki, A. Polinsky: The molecular basis of opioid potency and selectivity: Morphiceptins, Dermorphins, Deltorphins and Enkephalins. in "Medication development: drug discovery, databases and computer aided drug design" in NIDA Research Monograph, Vol. 134, (R. Rapaka and R.L. Hawks, eds.) 1993, 195.
(18) - G. Ösapay, A. Csiba: Inhibitory effect of synthetic aminophosphonic acid derivatives on human carbonic anhydrase. Eur. J. Med. Chem. (1993) 28, 355.
(19) - G. Ösapay, K. Ösapay, A. Csiba: Investigation of the role of His200 in hydratase and esterase activities of human carbonic anhydrase-I. Protein Engineering (1993) 6 Suppl., 47.
(20) - M. Goodman, S. Ro, T. Yamazaki, G. Ösapay, A. Polinsky, A. Palmer-Toy: An integrated approach for bioactive conformations of peptide and peptidomimetic opioids. in "Peptide Chemistry 1992", Proceedings of 2nd Japan Symposium on Peptide Chemistry (N. Yanaihara, ed.) ESCOM, Leiden, 1993, p. 239.
(21) - G. Ösapay, S. Wang, H. Shao, M. Goodman: Synthesis and characteristics of lanthionine peptides. in "Peptide Chemistry 1992", Proceedings of 2nd Japan Symposium on Peptide Chemistry (N. Yanaihara, ed.) ESCOM, Leiden, 1993, p. 152.
(22) - G. Ösapay, M. Goodman: A New Application of PCOR Methodology: Preparation of Lanthionine Peptides.
J. Chem. Soc., Chem. Commun. (1994) 1599.
(23) - G. Ösapay, H. Shao, M. Goodman, J.W. Taylor: Peptide cyclization on an oxime resin. Reaction conditions and applications.
Peptides, Proc. 13th Amer. Peptide Symp., (R.S. Hodges, J.A. Smith, eds.) ESCOM, Leiden, 1994, p. 101.
(24) - G. Ösapay, S. Wang, D. Comer, A. Palmer-Toy, Q. Zhu, M. Goodman: Superactive lanthionine enkephalins.
Peptides, Proc. 13th Amer. Peptide Symp., (R.S. Hodges, J.A. Smith, eds.) ESCOM, Leiden, 1994, p. 435.
(25) - G. Ösapay, G. Melacini, Q. Zhu, L. Tehrani, M. Goodman: Synthesis and physicochemical characterization of the lanthionione analog of somatostatin[1-14].
Letters in Peptide Science (1994) 1 , 81.
(26) - C.-W. Lee, Q. Zhu, H. Shao, S. Wang, G. Ösapay, M. Goodman: Design and synthesis of substituted lanthionine enkephalin opioids.
"Peptides 1994", Proc. 23rd Eur. Peptide Symp. (H. Maya, ed.) ESCOM, Leiden, 1995, p. 627.
(27) - M. Goodman, G. Ösapay, G. Melacini, Q. Zhu: Design and synthesis of lanthionine sandostatin.
"Peptides 1994", Proc. 23srd Eur. Peptide Symp. (H. Maya, ed.) ESCOM, Leiden, 1995, 561.
(28) - G.Ösapay, Q. Zhu, H. Shao, R.K. Chadha, M. Goodman: Synthesis, crystal structure and conformations in solution of four stereoisomeric cyclo-lanthionine derivatives.
Int. J. Peptide and Protein Research (1995) 46, 290.
(29) - H. Shao, S.H.-H. Wang, C.-W. Lee, G. Ösapay, M. Goodman: A facile synthesis of orthogonally protected stereoisomeric lanthionines by regioselective ring opening of serine b-lactone derivatives.
J. Org. Chem. (1995) 60, 2956.
(30) - R.K. Chadha, G. Ösapay: Crystal structure of (S)-[1-(benzyloxycarbonylamino)-ethyl]-phosphonic acid.
Acta Crystallographica, Section C (1995) 51, 2340-2342.
(31) - G. Ösapay, K. Ösapay, A. Csiba: Complex formation assisted site-directed alkylation in proteins.
Peptides: Chemistry, Structure & Biology, Proc. 14th Amer. Peptide Symp., (T.P. Kaumaya, R.S. Hodges, eds.) ESCOM, Leiden, 1996, p. 269-270.
(32) - J. Lutz, S. Rudolph-Bohner, L. Moroder, W. Kolbeck, G. Ösapay, M. Goodman: A novel and facile route to benzodiazepines.
Peptides: Chemistry, Structure & Biology, Proc. 14th Amer. Peptide Symp., (T.P. Kaumaya, R.S. Hodges, eds.) ESCOM, Leiden, 1996, p. 61-62.
(33) - L. Moroder, J. Lutz, F. Grams, S. Rudolf-Bšhner, G. Ösapay, M. Goodman, W. Kolbeck: Na-(2-aminobenzoyl)-peptides as precursors of 1,4-benzo-diazepine-2,5-dione derivatives.
Biopolymers 38, 295-300 (1996)
(34) - G. Ösapay, L. Prokai, F.C. Walls, K. Medzichradszky, D.H. Coy, T. Reisine, G. Melacini, Q. Zhu, S.H.-H. Wang, M. Goodman: Lanthionine-somatostatin analogs: Synthesis, characterization, biological activity and metabolic stability.
J. Med. Chem. 40, 2241-2251 (1997).
(35) - G. Melacini, Q. Zhu, G. Ösapay, M. Goodman: Refinement of the model for somatostatin pharmacophores: Conformational analysis of lanthionine-sandostatin analogs.
J. Med. Chem. 40, 2252-2258 (1997).
(36) - G. Ösapay, M. Bodaszky: Coupling in the absence of tertiary amines VI. Studies on the racemization of
Cysteine residues
Peptides 1998, Proc. 25th Eur. Peptide Symp., (S. Bajusz, F. Hudecz, eds.) Akademia, Budapest 1998, p. 158-159.
(37) - G. Ösapay, K. Ösapay: Therapeutic applications of somatostatin analogues
Exp. Opin. Ther. Pat. 8, 855-870 (1998).
(38) -Y-Q. Tang, J. Yuan, G. Ösapay, K. Ösapay, D. Tran, C.J. Miller, A.J. Ouellette, M.E. Selsted: A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.
Science, 286, 498-502 (1999).
(39) - L. Bibbs, N.P. Ambulos , Jr. S.A. Kates, A. Khatri, K.F. Medzihradszky, G. Ösapay and S.T. Weintraub:
Strategies for the synthesis of labeled peptides.
J. Biomol. Techn., 11, 155-165 (2000).
(40) - L. Bibbs, N.P. Ambulos , Jr. S.A. Kates, A. Khatri, K.F. Medzihradszky, G. Ösapay and S.T. Weintraub:
Strategies for the synthesis of labeled peptides 2000. In G.B. Fields, J.P. Tam & G. Barany (Eds.), ”Peptides for the New Millennium”, Kluwer Academic Publisher, Dordrecht, 2000, p. 113-114.
(41) - A. Kathri, N.P. Ambulos, S.A. Kates, K.F. Medzihradszky, G. Ösapay, H. Remmer, A. Somogyi: Strategies for the synthesis of cyclic peptides.
Peptides: The Wave of the Future. 17th Amer. Peptide Symp., (M. Lebl, R.A. Houghten, eds.) APS, San Diego 2001, p.140-141.
(42) - K. Medzihradszky, N.P. Ambulos, Jr., A. Khatri, G. Ösapay, H.A. Remmer, A. Somogyi and S.A. Kates: Mass spectrometry analysis for the determination of side reactions for cyclic peptides prepared from an Fmoc/tBu/Dmab protecting group strategy. Let. Peptide Sci. 8, 1-12 (2001).
(43) - D.C. Pecota, G. Ösapay, M. E. Selsted, and T. K. Wood: Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide, J. Biotechnol. 100, 1-12 (2003).
(44) - S. Vasudevan, J. Yuan, G. Ösapay, P. Tran, K. Tai, W. Liang, V. Kumar, M.E. Selsted , M.J. Cocco: Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque.
J. Biol. Chem., 283, 35869-77 (2008).
(45) - A.E. Garcia, G. Ösapay, P.A. Tran, J. Yuan, M.E. Selsted: Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes.
Infect. Immun., 76, 5883-91 (2008).
(46) - D. Tran, P. Tran, K. Roberts, G. Ösapay, J. Schaal, A. Ouellette, M.E. Selsted: Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins.
Antimicrob. Agents Chemother., 52, 944-53 (2008).
PATENT LITERATURE
(1) Inventors: M. Goodman and G. Ösapay, Assignee: W. Kolbeck: Lanthionine bridged peptides. United States Patent 6,028,168. February 22, 2000.
(2) Inventors: M. Goodman and G. Ösapay, Assignee: W. Kolbeck: Lanthionine bridged peptides. United States Patent 6,268,339. July 31, 2001.
Professional Societies
American Chemical Society
Division of Medicinal Chemistry, ACS
American Peptide Society
The Protein Society
New York Academy of Sciences
Other Experience
Senior scientist
CHINOIN Pharmaceut. Works, Budapest 1980—1988
CHINOIN Pharmaceut. Works, Budapest 1980—1988
Research Associate
The Rockefeller University 1988—1990
The Rockefeller University 1988—1990
Research Fellow
University of California San Diego 1990—1995
University of California San Diego 1990—1995
Graduate Programs
Medicinal Chemistry and Pharmacology
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5593
https://faculty.uci.edu/profile/?facultyId=5593
Last updated
03/18/2009
03/18/2009