Maria M Corrada-Bravo

Picture of Maria M Corrada-Bravo
Professor, Neurology
School of Medicine
Professor, Epidemiology and Biostatistics
Public Health
Professor, Institute for Memory Impairments and Neurological Disorders (UCI MIND)
ScD, Johns Hopkins School of Public Health, 2003, Epidemiology
ScM, Johns Hopkins School of Public Health, 1992, Biostatistics
Phone: (949) 824-9109
University of California, Irvine
Hewitt Hall Room 1513
Mail Code: 1400
Irvine, CA 92697
Research Interests
aging, dementia, oldest-old, risk and protective factors for dementia, longitudinal epidemiological studies

Kawas CH, Corrada MM, Whitmer RA. Diversity and disparities in dementia diagnosis and care: A challenge for all of us. JAMA Neurol doi: 10.1001/jamaneurol.2021.0285

Kawas CH, Legdeur N, Corrada MM. What have we learned from cognition in the oldest-old. Curr Opin Neurol [Epub Feb, 2021]. PMID: 33560671. doi: 10.1097/WCO.0000000000000910

Walker JM, Richardson E, Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, …, Crary JF. Early Selective Vulnerability of the CA2 hippocampal subfield in primary age-related tauopathy. J Neuropathol Exp Neurol 80(2):102-111, 2021. doi:10.1093/jnen/nlaa153.

Woodworth DC, Nguyen HL, Khan Z, Kawas CH, Corrada MM, Sajjadi SA. Utility of MRI in the diagnosis of hippocampal sclerosis of aging. Alzheimers Dement [Epub Dec 7, 2020] PMID: 33615673 doi: 10.1002/alz.12241

Fisher M, Phoenix D, Powell S, Mousa M, Rosenberg S, Greenia D, Corrada MM, Kawas CH, Paganini-Hill A. Cognition and Political Ideology in Aging. JAGS [Epub Oct 31, 2020]. PMID: 33128770. doi:/10.1111/jgs.16935

Wadi LC, Grigoryan MM, Kim RC, Kim J, Corrada MM, Paganini-Hill A, Fisher MJ. Mechanisms of cerebral microbleeds. J Neuropath Exp Neur 42(2):1093-1099, 2020. PMID: 32930790. PMCID: PMC7580489. doi:10.1093/jnen/nlaa082

Editors of Alzheimer’s & Dementia. New Thinking About Thinking, Part 3. Advice on preparing a successful manuscript for Alzheimer’s & Dementia. Alzheimers Dement 16:949-952, 2020. PMID: 32578941.

Kawas CH, Corrada MM. Successful cognitive aging: What the oldest-old can teach us about resistance and resilience [editorial] Neurology 95(8):329-330, 2020. PMID: 32699142. doi:10.1212/WNL.0000000000010251

Lau WL, Fisher M, Greenia D, Floriolli D, Fletcher E, Singh B, Sajjadi AS, Corrada MM, Whittle C, Kawas CH, Paganini-Hill A. Cystatin C, cognition and brain MRI findings in 90+ year-olds. Neurobiol Aging. 93:78-84, 2020. PMID: 32699142. PMCID: PMC7307913

Editors of Alzheimer’s & Dementia. Alzheimer's Disease Research Enterprise in the Era of COVID-19/SARS-CoV-2. Alzheimers Dement 16:587-8, 2020. PMID: 32202041. PMCID: PMC7161893.

Paganini-Hill A, Corrada MM, Kawas CH. Prior endogenous and exogenous estrogen and incident dementia in the 10th decade of life: The 90+ Study. Climacteric 23(3):311-315. [Epub Feb 28, 2020]. PMID: 32107945. PMCID: PMC7210048

Peters R, Yasar S, Anderson C, Andrews S, Antikainen R, Arima H, Beckett N, Beer JC, Bertens AS, Booth A, van Boxtel M, Brayne C, Brodaty H, Carlson MC, Chalmers J, Corrada MM, … Anstey KJ. Investigation of antihypertensive class, dementia and cognitive decline: A meta-analysis. Neurology 94(3):e267-e281, 2020. [Epub Dec 11, 2019]. PMID: 31827004. PMCID: PMC7108807.

Legdeur N, Visser PJ, Woodworth DC, Muller M, Fletcher E, Maillard P, Scheltens P, DeCarli C, Kawas CH, Corrada MM. White matter hyperintensities and hippocampal atrophy in relation to cognition: The 90+ Study. J Am Geriatr Soc 67(9):1827-1834, 2019. [Epub Jun 6, 2019]. PMID:31169919. PMCID: PMC6732042

Melikyan ZA, Corrada MM, Dick MB, Paganini-Hill A, Kawas CH. Neuropsychological test norms in cognitively intact oldest-old. J Int Neuropsychol Soc 25(5):530-545, 2019. [Epub May 24, 2019]. PMID: 31122309. PMCID: PMC6538395.

Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas CH, Hatami A, Albay R III, Glabe C, Gylys KH. Apolipoprotein E/Amyloid beta complex accumulates in AD cortical synapses via apoE receptors and is enhanced by APOE4. Am J Pathol 189(8):1621-1636. [Epub May 17, 2019]. PMID: 31108099. PMCID: PMC6680253.

Paganini-Hill A, Bryant N, Corrada MM, Greenia DE, Fletcher E, Singh B, Floriolli DR, Kawas CH, Fisher MJ. Blood pressure circadian variation, cognition, and brain imaging in 90+ year-olds. Front Aging Neurosci 11:54 [Epub Apr 17, 2019]. PMID: 31057391. PMCID: PMC6478755.

Gilsanz P, Lee C, Corrada MM, Kawas CH, Quesenberry CP Jr, Whitmer RA. Reproductive period and risk of dementia in a diverse cohort of healthcare members. Neurology 92(17):e2005-e2014. [Epub Mar 28, 2019]. PMID: 30923235. PMCID: PMC6511081.

Montine TJ, Cholerton BA, Corrada MM, Edland SD, Flanagan ME, Hemmy LS, Kawas CH, White LR. Concepts for brain aging: resistance, resilience, reserve, and compensation. Alzheimers Res Ther 11(1):22, 2019. PMID: 30857563. PMCID: PMC6410486.

Gilsanz P, Corrada MM, Kawas CH, Mayeda ER, Glymour MM, Quesenberry CP Jr, Lee C, Whitmer RA. Incidence of dementia after age 90 in a multiracial cohort. Alzheimers Dement 15(4):497-505, 2019. [Epub Feb 8, 2019]. PMID: 30797730.

Paganini-Hill A, Kawas CH, Corrada MM. Positive mental attitude associated with lower 35-year mortality: the Leisure World Cohort Study. J Aging Res [Epub Nov 25, 2018]. PMID: 30595919. PMCID: PMC6286774.

Trieu T, Sajjadi , Kawas CH, Nelson PT, Corrada MM. Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study. Neurology 91(19):e1788-e1798, 2018. [Epub Oct 12, 2018]. PMID: 30315072. PMCID: PMC7219089.

Sabeti S, Al-Darsani Z, Mander BA, Corrada MM, Kawas CH. Sleep, hippocampal volume, and cognition in adults over 90 years old. Aging Clin Exp Res 30:1307-1318, 2018. [Epub Sep 3, 2018]. PMID: 30178444. PMCID: PMC7219089

Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VMY, Kawas CH, Trojanowski JQ. Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study. Acta Neuropathol 136:377-388, 2018. [Epub Jun 18, 2018]. PMID: 29916037. PMCID: PMC7219089

Melikyan ZA, Greenia DE, Corrada MM, Hester MM, Kawas C, Grill JD. Recruiting the oldest-old for clinical research. Alzheimer Dis Assoc Disord [Epub May 4, 2018]. PMID: 29734262. PMCID: PMC7219089

Brookmeyer R, Abdallah N, Kawas CH, Corrada MM. Forecasting the prevalence of pre-clinical and clinical Alzheimer’s disease in the United States. Alzheimers Dement 14:121-129, 2018. [Epub Dec 7, 2017]. PMID: 29233480. PMCID: PMC5803316.

Nolen SC, Evans MA, Fischer A, Corrada MM, Kawas CH, Bota DA. Cancer - Incidence, prevalence and mortality in the oldest-old: A comprehensive review. Mech Aging Dev 164:113-126, 2017. [Epub May 11, 2017]. PMID: 28502820.

Bennett IJ, Greenia D, Maillard P, Sajaadi SA, DeCarli C, Corrada MM, Kawas CH. Age-related white matter integrity differences in oldest-old without dementia. Neurobiol Aging 56: 108-114, 2017. [Epub Apr 26, 2017]. PMID: 28527525. PMCID: PMC5647141.

Paganini-Hill A, Greenia DE, Perry SM, Sajjadi SA, Kawas CH, Corrada MM. Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study. Age Ageing. 46(6):951-957, 2017. [Epub Mar 21, 2017]. PMID: 28369185. PMCID: PMC7219089

Corrada MM, Hayden KM, Paganini-Hill A, Bullain SS, DeMoss J, Aguirre C, Brookmeyer R, Kawas CH. (2017). Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study. Alzheimers Dement.

Corrada MM, Sonnen JA, Kim RC, Kawas CH. (2016). Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study. Alzheimers Dement. 12(8):900-908.

Bullain SS, Corrada MM, Perry SM, Kawas CH. (2016). Sound Body Sound Mind? Physical Performance and the Risk of Dementia in the Oldest-Old: The 90+ Study. J Am Geriatr Soc. 64(7):1408-1415.

Brookmeyer R, Kawas CH, Abdallah N, Paganini-Hill A, Kim RC, Corrada MM. (2016). Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old. Alzheimers Dement. 12(3):225-232.

Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Vina J, Perls T, Sachdev PS. (2016). ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol. 16:52.

Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, 3rd, Cole GM, Teng E, Gylys KH. (2016). Synaptic Amyloid-beta Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 186(1):185-198.

Paganini-Hill A, Kawas CH, Corrada MM. (2015). Antioxidant vitamin intake and mortality: the Leisure World Cohort Study. Am J Epidemiol. 181(2):120-126.

Paganini-Hill A, Kawas CH, Corrada MM. (2015). Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study. Alzheimer Dis Assoc Disord.

Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM. (2015). Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study. Neurology. 85(6):535-542.

Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. (2014). Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain. 137(Pt 9):2578-2587.

Pensalfini A, Albay R, 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. (2014). Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiol Dis. 71C:53-61.

Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE, Schellenberg GD, Fardo DW. (2014). ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 127(6):825-843.

Guay M, Dubois MF, Corrada M, Lapointe-Garant MP, Kawas C. (2014). Exponential increases in the prevalence of disability in the oldest old: a Canadian national survey. Gerontology. 60(5):395-401.

Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. (2014). 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement. 10(5 Suppl):S430-452.

Grady DL, Thanos PK, Corrada MM, Barnett JC, Jr., Ciobanu V, Shustarovich D, Napoli A, Moyzis AG, Grandy D, Rubinstein M, Wang GJ, Kawas CH, Chen C, Dong Q, Wang E, Volkow ND, Moyzis RK. (2013). DRD4 genotype predicts longevity in mouse and human. J Neurosci. 33(1):286-291.

Corrada MM, Paganini-Hill A, Berlau DJ, Kawas CH. (2013). Apolipoprotein E genotype, dementia, and mortality in the oldest old: The 90+ Study. Alzheimers Dement. 9(1):12-18.

Bullain SS, Corrada MM, Shah BA, Mozaffar FH, Panzenboeck M, Kawas CH. (2013). Poor physical performance and dementia in the oldest old: the 90+ study. JAMA Neurol. 70(1):107-113.

Bullain SS, Corrada MM. (2013). Dementia in the oldest old. Continuum (Minneap Minn). 19(2 Dementia):457-469.

Berlau DJ, Corrada MM, Robinson JL, Geser F, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. (2013). Neocortical beta-amyloid area is associated with dementia and APOE in the oldest-old. Alzheimers Dement.

Peltz CB, Corrada MM, Berlau DJ, Kawas CH. (2012). Cognitive impairment in non-demented oldest-old: Prevalence and relationship to cardiovascular risk factors. Alzheimers Dement. 8(2):87-94.

Kawas CH, Greenia DE, Bullain SS, Clark CM, Pontecorvo MJ, Joshi AD, Corrada MM. (2012). Amyloid imaging and cognitive decline in nondemented oldest-old: The 90+ Study. Alzheimers Dement. 9(2):199-203.

Corrada MM, Berlau DJ, Kawas CH. (2012). A population-based clinicopathological study in the oldest-old: the 90+ study. Curr Alzheimer Res. 9(6):709-717.

Berlau DJ, Corrada MM, Peltz CB, Kawas CH. (2012). Disability in the oldest-old: incidence and risk factors in the 90+ study. Am J Geriatr Psychiatry. 20(2):159-168.

Balasubramanian AB, Kawas CH, Peltz CB, Brookmeyer R, Corrada MM. (2012). Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia. Neurology. 79(9):915-921.

Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA, Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC. (2011). Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 7(1):35-52.

Robinson JL, Geser F, Corrada MM, Berlau DJ, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. (2011). Neocortical and hippocampal amyloid-beta and tau measures associate with dementia in the oldest-old. Brain. 134(Pt 12):3708-3715.

Peltz CB, Corrada MM, Berlau DJ, Kawas CH. (2011). Incidence of dementia in oldest-old with amnestic MCI and other cognitive impairments. Neurology. 77(21):1906-1912.

Paganini-Hill A, Kawas CH, Corrada MM. (2011). Activities and mortality in the elderly: the Leisure World cohort study. J Gerontol A Biol Sci Med Sci. 66(5):559-567.

Brumback-Peltz C, Balasubramanian AB, Corrada MM, Kawas CH. (2011). Diagnosing dementia in the oldest-old. Maturitas. 70(2):164-168.

Berlau DJ, Corrada MM, Peltz CB, Kawas CH. (2011). Bathing as a potential target for disability reduction in the oldest old. Am J Public Health. 101(2):200-201.

Corrada MM, Paganini-Hill A. (2010). Being overweight in adults aged 70-75 is associated with a reduction in mortality risk compared with normal BMI. Evid Based Med. 15(4):126-127.

Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. (2010). Dementia incidence continues to increase with age in the oldest-old: The 90+ Study. Ann Neurol. 67(1):114-121.

Kravitz BA, Corrada MM, Kawas CH. (2009). Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old. Alzheimers Dement. 5(4):318-323.

Kravitz BA, Corrada MM, Kawas CH. (2009). High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from The 90+ Study. J Am Geriatr Soc. 57(4):641-646.

Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. (2009). Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiol Aging. 30(7):1125-1134.

Berlau DJ, Corrada MM, Kawas CH. (2009). The prevalence of disability in the oldest-old is high and continues to increase with age: findings from The 90+ Study. Int J Geriatr Psychiatry. 24:1217-1225.

Berlau DJ, Corrada MM, Head E, Kawas CH. (2009). APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology. 72(9):829-834.

Szekely CA, Green RC, Breitner JC, Ostbye T, Beiser AS, Corrada MM, Dodge HH, Ganguli M, Kawas CH, Kuller LH, Psaty BM, Resnick SM, Wolf PA, Zonderman AB, Welsh-Bohmer KA, Zandi PP. (2008). No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology. 70(24):2291-2298.

Corrada MM, Brookmeyer R, Berlau D, Paganini-Hill A, Kawas CH. (2008). Prevalence of dementia after age 90: results from The 90+ Study. Neurology. 71(5):337-343.

Whittle C, Corrada MM, Dick M, Ziegler R, Kahle-Wrobleski K, Paganini-Hill A, Kawas CH. (2007). Neuropsychological data in nondemented oldest-old: The 90+ Study. J Clin Exp Neuropsychol. 29(3):290-299.

Paganini-Hill A, Kawas CH, Corrada MM. (2007). Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study. Prev Med. 44(4):305-310.

Paganini-Hill A, Kawas CH, Corrada MM. (2007). Type of alcohol consumed, changes in intake over time and mortality: the Leisure World Cohort Study. Age Ageing. 36(2):203-209.

Kahle-Wrobleski K, Corrada MM, Li B, Kawas CH. (2007). Sensitivity and specificity of the mini-mental state examination for identifying dementia in the oldest-old: The 90+ Study. J Am Geriatr Soc. 55(2):284-289.

Paganini-Hill A, Corrada MM, Kawas CH. (2006). Increased longevity in older users of postmenopausal estrogen therapy: the Leisure World Cohort Study. Menopause. 13(1):12-18.

Kawas CH, Corrada MM. (2006). Alzheimer's and dementia in the oldest-old: a century of challenges. Curr Alzheimer Res. 3(5):411-419.

Corrada MM, Kawas CH, Mozaffar F, Paganini-Hill A. (2006). Association of body mass index and weight change with all-cause mortality in the elderly. Am J Epidemiol. 163(10):938-949.

Yasar S, Corrada MM, Brookmeyer R, Kawas CH. (2005). Calcium channel blockers and risk of AD: the Baltimore Longitudinal Study of Aging. Neurobiol Aging. 26(2):157-163.

Platz EA, Rohrmann S, Pearson JD, Corrada MM, Watson DJ, De Marzo AM, Landis PK, Metter EJ, Carter HB. (2005). Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. Cancer Epidemiol Biomarkers Prev. 14(2):390-396.

Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. (2005). Reduced risk of Alzheimer's disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimers Dement. 1(1):11-18.

Mulnard RA, Corrada MM, Kawas CH. (2004). Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment. Curr Neurol Neurosci Rep. 4(5):368-373.

Kawas CH, Corrada MM, Brookmeyer R, Morrison A, Resnick SM, Zonderman AB, Arenberg D. (2003). Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology. 60(7):1089-1093.

Brookmeyer R, Corrada MM, Curriero FC, Kawas CH. (2002). Survival following a diagnosis of Alzheimer disease. Arch Neurol. 59(11):1764-1767.

Stewart WF, Kawas CH, Corrada MM, Metter EJ. (1997). Risk of Alzheimer's disease and duration of NSAID use. Neurology. 48(3):626-632.

Kawas CH, Resnick S, Morrison A, Brookmeyer R, Corrada MM, Zonderman A, Bacal C, Lingle DD, Metter E. (1997). A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology. 48(6):1517-1521.

Kawas CH, Karagiozis H, Resau L, Corrada MM, Brookmeyer R. (1995). Reliability of the Blessed Telephone Information-Memory-Concentration Test. J Geriatr Psychiatry Neurol. 8(4):238-242.

Corrada M, Brookmeyer R, Kawas CH. (1995). Sources of variability in prevalence rates of Alzheimer's disease. Int J Epidemiol. 24(5):1000-1005.

Kawas CH, Segal J, Stewart WF, Corrada MM, Thal LJ. (1994). A validation study of the Dementia Questionnaire. Arch Neurol. 51(9):901-906.
(MPI: Dr. Claudia Kawas & Dr. María Corrada) Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study. This prospective epidemiologic investigation examines biological, psychological, and social factors associated with functional, cognitive, and behavioral capacities of individuals aged 90 years and older. A particular focus is the relationship of vascular risk factors and vascular disease in cognitive impairment.
(PI): Dr. Frank LaFerla) Alzheimer's Disease Research Center of the University of California, Irvine. The overall objective of this grant is to understand the factors that cause people to transition from normal aging to preclinical Alzheimer's disease (AD) to mild cognitive impairment, and subsequently convert to dementia.
(MPI: Dr. Rachel Whitmer, Dr. María Corrada, Dr. Paola Gilsanz) Epidemiology of Age-related Dementia Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-old.The overall objectives of this application are to estimate incidence of dementia/MCI in a multiracial cohort of oldest-old, identify midlife and late-life risk and protective factors, and understand the pattern of cerebral and brain pathologies in this diverse oldest-old population.
(PI: Dr. Tom Montine) Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer’s disease and related dementias. The overall objectives of the application are to identify common patterns for the singular, concurrent, or sequential development of cognitive and motor impairments in persons with and without dementia.
(PI: Dr. S. Ahmad Sajjadi) Diagnosis and Risk Factors of Hippocampal Sclerosis of Aging; A Common Alzheimer's Mimic in the Oldest-Old. The overarching goal of this project is to apply stochastic multistate models that incorporate biomarkers to determine lifetime risks and population projections of Alzheimer’s disease (AD).
(PI: J O’Connell, L Jiang) Diagnosis and Risk Factors of Hippocampal Sclerosis of Aging; A Common Alzheimer's Mimic in the Oldest-Old. The overall goal of this project is to identify a set of neuropsychological, imaging, and serological markers that enable the diagnosis during life of hippocampal sclerosis, an important and understudied cause of dementia in the oldest-old.
Professional Societies
ISTAART-Alzheimer’s Assoc Intern. Society to Advance Alzheim
American Academy of Neurology
Other Experience
Research Centers
Institute for Memory Impairments and Neurological Disorders (UCI MIND)
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