Marcelo Wood

Picture of Marcelo Wood
Professor, Department of Neurobiology and Behavior, School of Biological Sciences
Chair, Department of Neurobiology and Behavior, School of Biological Sciences
Ph.D., Princeton University, 2000, Molecular Biology
Phone: (949) 824-2259, 2356
University of California, Irvine
301 Qureshey Research Lab
Mail Code: 3800
Irvine, CA 92697
Selected Publications (more complete list at:

Kwapis JL, Alaghband Y, Kramar EA, Lopez AJ, Vogel Ciernia A, White AO, Shu G, Rhee D, Michael CM, Montellier E, Liu Y, Magnan CN,Chen S, Sassone-Corsi P, Baldi P, Matheos DP, Wood MA (2018) Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. Nature Commun. v9:3323. PMCID6102273.
Shu G, Kramar EA, Lopez AJ, Huynh G, Wood MA, Kwapis JL (2018) Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b. Learning & Memory, In Press. doi:10.1111/adb.12605
Lopez AJ, Jia Y, White AO, Kwapis JL, Espinoza M, Hwang P, Campbell R, Alaghband Y, Matheos DP, Lynch G, Wood MA (2018) The medial habenula as a novel epithalamic regulator of cocaine action. Addiction Biology, In Press.
Malvaez M, Greenfield VY, Matheos DP, Angelilis NA, Murphy MD, Kennedy PJ, Wood MA, Wassum K (2018) Habits are negatively regulated by histone deacetylase 3 in the dorsal striatium. Biological Psychiatry, In Press.
Alaghband Y, Kwapis JL, Lopez AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory. Neurobiology of Learning & Memory. Sep 7. pii: S1074-7427(17)30146-6. doi: 10.1016/j.nlm.2017.09.001.
Vogel Ciernia A, Kramar EA, Matheos DP, Havekes R, Hemstedt TJ, Magnan CN, Sakata K, Tran A, Azzawi S, Lopez AJ, Dang RT, Wang W, Trieu B, Tong J, Barrett RM, Post RJ, Baldi P, Abel T, Lynch G, and Wood MA (2017) Mutation of neuron-specific chromatin remodeling subunit BAF53b: Rescue of plasticity and memory by manipulating actin remodeling. Learning & Memory, v24(5):199-209. PMCID5397687
White AO, Kramar EA, Lopez AJ, Doan J, Saldana D, Davatolhagh MF, Alaghband Y, Blurton-Jones M, Matheos DP, and Wood MA (2016) BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens. Nature Commun, v7:11725-. PMCID4894971
Lopez AJ, Kramar E, Matheos DP, White A, Kwapis J, Vogel-Ciernia A, Sakata K, Espinoza M, and Wood MA (2016) Promoter specific effects of DREADD modulation on hippocampal synaptic plasticity and memory formation. J Neurosci, v36:3588-99. PMCID4804014
Bieszczad KM, Bechay K, Rusche JR, Jacques V, Kudugunti S, Miao W, Weinberger NM, McGaugh JL, and Wood MA (2015) Histone deacetylase inhibition via RGFP966 releases the brakes on sensory cortical plasticity and the specificity of memory formation. J Neurosci, v35:13124-32.
Bharadwaj R, Peter C, Jiang Y, Roussos P, Vogel-Ciernia A, Shen E, Mitchell A, Mao W, Whittle C, Dincer A, Jakovcevski M, Pthula V, Rasmussen T, Giakoumaki SG, Bitsios P, Gardner PD, Ernst PA, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, and Akbarian S (2014) Conserved higher order chromatin regulates NMDA receptor gene expression and cognition. Neuron, v84:997-1008.
Kwapis, JL and Wood MA (2014) Epignetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder. Trends in Neurosciences, v37:706-720.
Vogel-Ciernia A, Matheos DP, Barrett RM, Kramar E, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan A, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, and Wood MA (2013) The Neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nature Neuroscience, v16:552-561.
Lattal KM and Wood MA (2013) Epigenetics and persistent memory: Implications for reconsolidation and silent extinction beyond the zero. Nature Neuroscience, v16:124-129.
Rogge GA, Singh H, Dang R, and Wood MA (2013) HDAC3 is a negative regulator of cocaine- context associated memory formation. Journal of Neuroscience, v33:6623-6632.
Malvaez M, McQuown SC, Rogge GA, Astarabadi M, Jacques V, Carreiro S, Rusche J, and Wood MA (2013) HDAC3 selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. PNAS, v110:2647-52.
Malvaez M, Mhillaj E, Matheos DP, Palmery M, and Wood MA (2011) CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors. J Neurosci, v31:16941-8.
McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones
S, Rusche JR, Lazar MA, and Wood MA (2011) HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci, v31:764-774.
Barrett RM, Malvaez M, Kramar E, Matheos DP, Arrizon A, Cabrera SM, Lynch G, Greene RW, and Wood MA (2011) Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology, v36:1545-56.
McQuown SC and Wood MA (2011) HDAC3 and the molecular brake pad hypothesis. Neurobio Learning & Memory, v96:27-34.
Roozendaal B, Hernandez A, Cabrera S, Hagewoud R, Malvaez M, Stefanko D, Haettig J, and Wood MA (2010) Glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification. J Neurosci v30:5037-46.
Malvaez M, Sanchis-Segura C, Vo D, Lattal KM, and Wood MA (2010) Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference. Biol Psychiatry, v67:36-43.
Stefanko DP, Barrett RM, Ly AR, Reolon GK, and Wood MA (2009) Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci v106:9447-9452.
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Graduate Programs
Interdepartmental Neuroscience Program
Research Centers
Center for the Neurobiology of Learning and Memory
Institute for Memory Impairments and Neurological Disorders
Center for Epigenetics and Metabolism
UC Irvine Center for Addiction Neuroscience
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