Peter Kaiser

Picture of Peter Kaiser
Professor & Chair, Biological Chemistry
School of Medicine
PH.D., University of Innsbruck (Austria), 1994
Phone: (949) 824-9442 & 9441
Fax: (949) 824-2688
University of California, Irvine
D251 Medical Sciences I
Irvine, CA 92697
Research Interests
Cell cycle control; regulation of proteins by ubiquitylation, reactivation of p53 in cancer, cancer drug target discovery
Research Abstract
Research in the Kaiser laboratory aims to (i) investigate fundamental mechanistic questions about cell cycle control and the ubiquitin-proteasome pathway, (ii) discover molecular pathways that link key cellular metabolites to cell cycle control for the development of novel strategies in cancer therapy, and (iii) develop novel approaches to directed drug design, which we apply to develop small molecules to reactivate mutant p53 in human cancer.
Available Technologies
Yanchang Li#, Eric B. Dammer#, Yuan Gao#, Qiuyan Lan#, Chengpu Zhang#, Duc M. Duong#, Mark A. Villamil#, Lingyan Ping, Linda Lauinger, Karin Flick, Zhongwei Xu, Wei Wei, Xiaohua Xing, Lei Chang, Xuechuan Hong, Yunping Zhu, Junzhu Wu, Fuchu He*, Peter Kaiser*, Ping Xu* (2019). Proteomics links ubiquitin chain topology change to transcription factor activation. Molecular Cell.
Lin, D.-W., Chung, B.P., Huang, J.-W., Wang, X., Huang, L., and Kaiser, P. (2019). Microhomology based CRISPR tagging tools for protein tracking, purification, and depletion. J. Biol. Chem.
Yu C., Yang Y., Wang X., Guan S., Fang L., Liu F., Walters KJ., Kaiser P. and Huang L. (2016). Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation. Mol Cell Proteomics.
Mathur R., Yen L.J. and Kaiser P. (2015). Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis. PLOS Genetics. 11(12):e1005727. PMC3483439.
Faezeh Salehi*, Roberta Baronio, Ryan Idrogo-Lam, Huy Vu, Linda V. Hall, Peter Kaiser2*, and Richard H. Lathrop. (2014). CHOPER filters enable rare mutation detection in complex mutagenesis populations by next generation sequencing. PLOS One. (Salehi and Kaiser co-corresponding authors).
Lin DW, Chung BP. and Kaiser P. (2014). S-adenosylmethionine limitation induces p38 mitogen activated protein kinase and triggers cell cycle arrest in G1. J. Cell. Sci., 127, 50-59.
Wassman C.D.*, Baronio R.*, Demir Ö.*, Wallentine B.D., Chen C.K., Hall L.V., Salehi F., Lin D.W., Chung B.P., Hatfield G.W., Chamberlin A.R., Luecke H. , Lathrop R.H., Kaiser P.*, Amaro R.E.* (2013). Computational Identification of a Transiently Open L1/S3 Pocket for p53 Cancer Mutant Reactivation. Nature Communications. 4, 1407.
Booher K., Lin DW., Borrego SL and Kaiser P. (2012). Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells. Cell Cycle, 11, 4414 - 4423.
Yen J. L.*, Flick K.*, Papagiannis C. V., Mathur R., Tyrrell A., Ouni I., Kaake R., Huang L. and Kaiser P., (2012) Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Molecular Cell. 48, 288-297.
Ikram Ouni, Karin Flick and Peter Kaiser. (2010). A transcriptional activator is part of an SCF ubiquitin ligase to control degradation of its co-factors. Molecular Cell, 40, 954-964.
An Tyrrell, Karin Flick, Gary Kleiger, Hongwei Zhang, Raymond J. Deshaies and Peter Kaiser (2010). A physiologically relevant and portable tandem ubiquitin-binding domain that stabilizes polyubiquitylated protein. Proc Natl Acad Sci U S A. 107, 19796-801.
Wang X., Yen J., Kaiser P.* and Huang L*. (2010) Unraveling the Regulation of the 26S Proteasome Complex upon H2O2-induced Oxidative Stress. Science Signaling. 3, ra88.
Aghajan M#., Jonai N. #, Flick K. #, Fu F., Luo M., Cai X., Ouni I.,Pierce N., Lomenick B. ,Damoiseaux R.,Hao R.,Verma R., Li Y., Houk K. N., Jung M. E., Huang L., Deshaies R. J., Kaiser P.* and Huang J.* (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nature Biotechnology. 7, 738-742.
Baronio R., Danziger S.A., Hall L.V., Salmon K., Hatfield G.W., Lathrop R.H.*, and Kaiser P.*. (2010). All-codon Scanning identifies p53 cancer rescue mutations. Nucleic Acids Research.
Danziger S. A., Baronio R., Ho L., Hall L.V., Salmon K., Hatfield G. W., Kaiser P.* and Lathrop R. H.* Predicting Positive p53 Cancer Rescue Regions Using Most Informative Positive (MIP) Active Learning.(2009). PLoS Computational Biology. 9.
Meierhofer D., Wang X., Huang L. and Kaiser P. (2008). Quantitative Analysis of global Ubiquitination in HeLa Cells by Mass Spectrometry. J. Proteome Res. 7, 4566-4576.
Flick K., Raasi S., Zhang H., Yen J. and Kaiser P.. (2006). A Ubiquitin Interacting Motif Protects Polyubiquitinated Met4 from Degradation by the 26S Proteasome. Nature Cell Biology, 8, 509-515.
Tagwerker C., Flick K., Cui M., Guerrero C., Dou Y., Auer B., Baldi P., Huang L. and Kaiser P. (2006). A tandem-affinity tag for two-step purification under fully denaturing conditions: Application in ubiquitin profiling and protein complex identification combined with in vivo cross-linking. Mol. Cell. Proteomics. 5, 737-48.
Su N., Flick K. and Kaiser P. (2005). The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle. Mol. Cell. Biol. 25, 3875-3885.
Yen, JL., Su, N. and Kaiser P. (2005). The yeast ubiquitin ligase SCFMet30 regulates heavy metal response. Mol. Biol. Cell. 6, 1872-1882.
Flick K., Ouni I., Wohlschlegel J. A., Capati C., McDonald W. H., Yates J. R. and Kaiser P. (2004). Proteolysis-independent Regulation of the Transcription Factor Met4 by a single K48-Linked Ubiquitin Chain. Nature Cell Biology. 6, 634-641.
Morris M., Kaiser P., Rudyak S., Baskerville C., Watson MH. and Reed S. I.. (2003). Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature. 423, 1009-1013.
Borrego SL., Fahrmann J., Datta R., Stringari C., Grapov D., Zeller M., Yumay C., Wang P., Baldi P., Gratton E., Fiehn O. and Kaiser P. (2016). Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells. Cancer&Metabolism.
Strohmaier H., Spruck C. H., Kaiser P., Won K., Sangfelt O. and Reed S. I. (2001). The Human F-Box Protein, hCdc4, Targets Cyclin E for Proteolysis and is Mutated in a Breast Cancer Cell Line. Nature. 413, 316-322
Yanchang Li#, Eric B. Dammer#, Yuan Gao#, Qiuyan Lan#, Chengpu Zhang#, Duc M. Duong#, Mark A. Villamil#, Lingyan Ping, Linda Lauinger, Karin Flick, Zhongwei Xu, Wei Wei, Xiaohua Xing, Lei Chang, Xuechuan Hong, Yunping Zhu, Junzhu Wu, Fuchu He*, Peter Kaiser*, Ping Xu* (2019). Proteomics links ubiquitin chain topology change to transcription factor activation. Molecular Cell.
Kaiser P., Flick K., Wittenberg C. and Reed S. I.. (2000). Regulation of Transcription by Ubiquitination without Proteolysis: Cdc34/SCFMet30-Mediated Inactivation of the Transcription Factor Met4. Cell 102 (3), 303-314.
Xu S., Huang H-K., Kaiser P., Latterich M. and Hunter T.. (2000). Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in Saccharomyces cerevisiae. Current Biology 10, 329-332.
Kaiser P., Moncollin V., Clarke D. J., Watson M. H., Bertolaet B. L., Reed S. I., and Bailly E. (1999). Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes and Dev. 13, 1190-202.
Kaiser P., Sia R. A. L., Bardes E. G. S., Lew D. J., and Reed S. I. (1998). Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. Genes and Dev. 12, 2587-97.
Graduate Programs
Cancer Biology
Cellular and Molecular Biosciences
Research Centers
Chao Family Comprehensive Cancer Center
Center for Epigenetics & Metabolism
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