## Frederic Y.M. Wan

Professor Emeritus, Mathematics

School of Physical Sciences

School of Physical Sciences

Professor Emeritus, Mechanical & Aerospace Engineering

The Henry Samueli School of Engineering

The Henry Samueli School of Engineering

OTH, Massachusetts Institute of Technology, 1959, Mathematics

S.M., June, 1963 and Ph.D. Mathematics September, 1965, MIT

S.M., June, 1963 and Ph.D. Mathematics September, 1965, MIT

University of California, Irvine

510B Rowland Hall

Mail Code: 3875

Irvine, CA 92697

510B Rowland Hall

Mail Code: 3875

Irvine, CA 92697

**Research Interests**

Applied Mathematics, Solid Mechanics, Resource Economics, Biomathematics

**Academic Distinctions**

Honors and Awards:

**Arthur Beaumont Distinguished Service Award, Canadian Applied Mathematics Society, 1991

**Foreign Member, Russian Academy of Natural Sciences, 1999 -

**Fellow: American Academy of Mechanics (AAM), 1981, American Society of Mechanical Engineers (ASME), 1987; American Association for the Advancement of Science (AAAS), 1995; Society for Industrial and Applied Mathematics (SIAM), 2010.

Appointments:

**University of British Columbia: Director, Institute of Applied Mathematics and Statistics (1974-83)

**University of Washington: Chair, Department of Applied Mathematics (1983-88); Divsional Dean of Natural and Mathematical Sciences, College of Arts & Sciences (1988-92)

**Natural Science and Engineering Council of Canada: Member (1980-83) and Chairman (1982-83), Committee of Pure and Applied Mathematics

**National Science Foundation: Program Officer, Appl. Math. Program, DMS (1986-87); Division Director, DMS (January, 1993 - December, 1994)

**MIT: MIT Educational Council (1974-79) MIT Visiting Committee for Mathematics (1991-93)

**University of California, Irvine: Vice Chancellor for Research and Dean of Graduate Studies (1995-2000)

Chair of Board of Trustees, IPAM, UCLA (1999-2002)

Member of Scientific Committee, ZCAM, Tsinghua University, 2002 -

Member of Advisory Committee, Center for the Mathematical Sciences, Renmin University of China, 2015 -.

Editorial Board Membership: 1) Studies in Appl. Math. 84- ; 2) Canadian Appl. Math. Quarterly, 93- ; 3) International J. Solids & Strucutres 96- ; 4) World Sci. Publ. 95- ; 5) J. Mech. Materials & Structures (JoMMS), 05 - ; 6) International J. Num. Anal. & Modeling, Series B, 10 -16.

Professional Societies: Canadian Applied Mathematics Society (CAMS/SCMA): Council Member 1980-82, President 1983-85, Past President 1985-87. American Mathematical Society (AMS): Committee of Committees (1995-97), Science Policy Committee (1995-97). Society for Industrial and Applied Mathematics (SIAM): Educational Committee (1983-87), Representative on the U.S. National Committee on Theoretical and Applied Mechanics (1991-93, 2001-), Science Policy Committee (1990-92,1995-) Mathematical Association of America (MAA)

**Arthur Beaumont Distinguished Service Award, Canadian Applied Mathematics Society, 1991

**Foreign Member, Russian Academy of Natural Sciences, 1999 -

**Fellow: American Academy of Mechanics (AAM), 1981, American Society of Mechanical Engineers (ASME), 1987; American Association for the Advancement of Science (AAAS), 1995; Society for Industrial and Applied Mathematics (SIAM), 2010.

Appointments:

**University of British Columbia: Director, Institute of Applied Mathematics and Statistics (1974-83)

**University of Washington: Chair, Department of Applied Mathematics (1983-88); Divsional Dean of Natural and Mathematical Sciences, College of Arts & Sciences (1988-92)

**Natural Science and Engineering Council of Canada: Member (1980-83) and Chairman (1982-83), Committee of Pure and Applied Mathematics

**National Science Foundation: Program Officer, Appl. Math. Program, DMS (1986-87); Division Director, DMS (January, 1993 - December, 1994)

**MIT: MIT Educational Council (1974-79) MIT Visiting Committee for Mathematics (1991-93)

**University of California, Irvine: Vice Chancellor for Research and Dean of Graduate Studies (1995-2000)

Chair of Board of Trustees, IPAM, UCLA (1999-2002)

Member of Scientific Committee, ZCAM, Tsinghua University, 2002 -

Member of Advisory Committee, Center for the Mathematical Sciences, Renmin University of China, 2015 -.

Editorial Board Membership: 1) Studies in Appl. Math. 84- ; 2) Canadian Appl. Math. Quarterly, 93- ; 3) International J. Solids & Strucutres 96- ; 4) World Sci. Publ. 95- ; 5) J. Mech. Materials & Structures (JoMMS), 05 - ; 6) International J. Num. Anal. & Modeling, Series B, 10 -16.

Professional Societies: Canadian Applied Mathematics Society (CAMS/SCMA): Council Member 1980-82, President 1983-85, Past President 1985-87. American Mathematical Society (AMS): Committee of Committees (1995-97), Science Policy Committee (1995-97). Society for Industrial and Applied Mathematics (SIAM): Educational Committee (1983-87), Representative on the U.S. National Committee on Theoretical and Applied Mechanics (1991-93, 2001-), Science Policy Committee (1990-92,1995-) Mathematical Association of America (MAA)

**Appointments**

Instructor of Mathematics, MIT, 1965-67

**Research Abstract**

**Copyrights on Books: 1) Mathematical Models and Their Analysis, Harper and Row, February, 1989. 2) Introduction to the Calculus of Variations and Its Applications, Chapman & Hall, January, 1995. 3) Dynamical System Models in the Life Sciences, World Scientific, 2018. 4) Mathematical Models and Their Analysis, SIAM Classics in Applied Math, SIAM, 2018. 5) Stochastic Models in the Life Sciences, World Scientific, 2019.

**Short Biography**

Frederic Wan has been a Professor of Mathematics at the University of California, Irvine (UCI) since 1995 where he was also Vice Chancellor for Research and Dean of Graduate Studies, 1995–2000. Prior to UCI, Professor Wan received S.B., S.M. and Ph.D. in Mathematics at MIT (1955 – 1965) and was on the Faculty of that Mathematics Department (1965–1974). He was appointed Professor of Mathematics and the founding Director of the Institute of Applied Mathematics and Statistics at the University of British Columbia (1974–1983). In 1983, Professor Wan relocated to the University of Washington as Professor (1983–1995), the founding Chair of Department of Applied Mathematics (1983–1988) and later the Divisional Dean of Natural and Mathematical Sciences (1988–1992). At the request of the National Science Foundation (NSF), Professor Wan was re-assigned by the University to serve as the Director of the Foundation’s Division of Mathematical Sciences (1992–1994). For his research contributions (supported by both NSF and the National Institute of Health (NIH)), Professor Wan was elected a Fellow of ASME, AAAS, SIAM and a Foreign Member of the Russian Academy of Natural Sciences among others.

**Publications**

Progressive decrease in Chlamydia cell size precedes differentiation, Nature Communications, Vol. 9, 2018, Article # 45, doi:10.1038/s41467-017-02432-0. ( J.K. Lee, G.A. Enciso, D. Boassa, C.N. Chander, T.H. Lou, S.S. Pairawan. M.C. Guo, F.Y.M.Wan, M.J. Ellisman, C. Suetterlin and Ming Tan)

Optimal Proliferation and Differentiation of Chlamydia Trachomatis, Studies in Applied. Math. 139 (1), 2017, 129-178 (DOI: 10.1111/sapm.12175). (F.Y.M. Wan and G.A. Enciso).

Dynamical System Models in the Life Sciences and their scientific issues, World Scientific, Singapore, New Jersey, etc. , 2017

Timing of CD8 T cell effector responses in viral infections, Royal Society Open Science (2016) 3.2: 150661: 140. (with S.R. Stipp, A. Iniguez, and D. Wodarz)

Transient Feedback and Robust Signaling Gradients, Int. J. Num. Anal. & Modeling, Series B, 13 (2), 2016, Pgs.175-200. (with A. Simonyan)

Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms, Interface, J. Royal Soc. 12 . 2014, Pgs. 1014-26. (with W.-C. Lo, S. Zhou, A.D. Lander and Q. Nie)

A new approach to feedback for robust signaling gradients, Studies in Appl. Math. 133, 2014, 18-51. (with T. Kushner abd A. Simonyan)

Fastest time to cancer by loss of tumor suppressor genes, Bull. Math Bio.. 76. 2014, 2737-2784. (with C. Sanchez-Tapia)

Robustness of signaling gradient in Drosophila wing imaginal disc, J. DCDS-B (Discrete and Continuous Dynamical Systems, Series B) Vol. 16 (3) 2011, Pgs. 835-866. (with J. Lei, A.D. Lander, and Q. Nie)

Size-normalized robustness of Dpp gradient in Drosophila wing imaginal disc, JoMMS Vol. 6 (1-4), 2011, Pgs. 321-350. (with A.D. Lander, Q, Nie, and B. Vargas)

Timing of CD8 T cell effector responses in viral infections, Royal Society Open Science (2016) 3.2: 150661: 140. (with S.R. Stipp, A. Iniguez, and D. Wodarz)

Genetic instability in cancer: an optimal control problem, Studies in Appl. Math., Vol. 125(1), 2010, Pgs. 1 - 10. (with A. Sadovsky and N. L. Komarova)

Spatial dynamics of multi-state cell lineages in tissue stratification, Biophysical J. Vol. 99 (10), 2010, Pgs. 3145-3154. (with C.-S. Chiou, W. Lo, K. Gokoffski,Y.-T.Zhang, A.D. Lander, A.L. Calof, and Q. Nie)

Spatial dynamics of multi-state cell lineages in tissue stratification, Biophysical J. Vol. 99 (10), 2010, Pgs. 3145-3154. (with C.-S. Chiou, W. Lo, K. Gokoffski,Y.-T.Zhang, A.D. Lander, A.L. Calof, and Q. Nie)

Feedback regulation in multistage cell lineages, Math. Biosci. & Eng., 6(1), 2009, Pgs. 59-82. (W.-C. Lo, C.-S. Chou, K. Gokoffski, A.D. Lander, A.L. Calof and Q. Nie)

Compact integration factor methods in high spatial dimension, J. Comp. Phys., 227, 2008, Pgs. 5238-5525. (with Q. Nie, F.Y.M. Wan, Y.-T. Zhang and X.-F. Liu)

Selective pressures for and against genetic instability in cancer: a time-dependent problem, J. Royal Society, Interface, 2007, Online, June 19, 2007, doi: 10.1098/rsif.2007.1054. (with N. Komarova and A. Sadovsky)

Elastodynamics of embryonic epidermal wound closure, Studies in Appl. Math., 118, 2007, Pgs. 365-395. (with A. Sadovsky)

Time to first spike in Hodgkin-Huxley stochastic systems, Physica A - Stat. Mech. Applic., 351 (2-4), 2005, Pgs. 427-438. (with H.C. Tuckwell)

Effects of Sog on Dpp-receptor binding, SIAM J. Appl. Math., 65, 2005, Pgs. 1748 - 1771. (with Y. Lou and Q. Nie)

Formation of the BMP activity gradient in the Drosophila embryo, Dev. Cell, 8, 2005, Pgs. 519-5?? [plus supplement]. (with C.M. Mizutani, Q. Nie, Y.-T. Zhang, P. Vilmos, E. Bier, J.L. Marsh and A.D. Lander)

Spatially distributed morphogen synthesis and morphogen gradient formation, Math. Biosci. & Eng. (MBE), 2 , 2005, Pgs. 239 – 262. (with A.D. Lander and Q. Nie)

Stress boundary conditions for plate bending, Int. J. Solids Structure Vol. 40, 2003, 4107-4123. (A Special Issue in honour of Arthur. W. Leissa on his 70th Birthday)

Determination of Firing Times for the Stochastic Fitzhugh-Nagumo Neuronal Model, Neural Comp., vol. 15, 2003, 143-159. (with H.C. Tuckwell and Rodriguez)

Do morphogen gradients arise by diffusion? Dev. Cell, vol. 2, 2002, 785-796. (with A.D. Lander and Q. Nie)

Nature of equilibria and effects of drug treatments in some viral population dynamical models, IMA J. Math. Appl. Med. & Biol. vol. 17, 2000, Pgs. 311-327. (with H.C. Tuckwell)

Locational equilibrium models for publicly owned residential land, Natural Resource Modeling vol. 13(2), 2000, 219-246.

A thick hollow sphere compressed by equal and opposite concentrated axial loads, an asymptotic solution, SIAM J. Appl. Math., vol. 59, 1999, 1080-1097. (with R. D. Gregory & T. I. Milac)

**Grants**

NIH grant R01GM67247 (PI), 2002-2006, 2006-2010; 2010-2014; NIH grant R25GM-096989 (PI), 2011 - 2016;
NIH grant P50GM-066051 (Co-PI), 2007-2012, 2013-2018;
NSF DMS (SCREMS) grant DMS-0112416 (PI), 2001-2003, DMS (UBM) grant DMS-1129008 (PI), 2011 - 2016

**Professional Societies**

American Academy of Mechanics

American Society for Mechanical Engineers (ASME)

Canadian Applied Mathematical Society (CAMS/SCMA)

Society for Industrial and Applied Mathematics (SIAM)

American Mathematical Society (AMS)

Mathematical Association of America (MAA)

**Other Experience**

Assistant Professor of Applied Mathematics

MIT 1967—1969

MIT 1967—1969

Associate Professor of Applied Mathematics

MIT 1969—1974

MIT 1969—1974

Professor of Mathematics

University of British Columbia 1974—1983

University of British Columbia 1974—1983

Professor of Applied Mathematics and Mathematics

University of Washington 1983—1995

University of Washington 1983—1995

**Research Centers**

Center for Research on Complex Biological Systems

**Last updated**

02/03/2022