Catherine S. Sassoon

Picture of Catherine S. Sassoon
Professor in Residence, Medicine
School of Medicine
Chief, Pulmonary & Critical Care Medicine VALB
Phone: 562-826-5831
Fax: 562-826-5832
University of California, Irvine
101 The City Drive
Mail Code: 4100
Orange, CA 92668
Research Interests
Mechanical ventilation, Work of breathing, Diaphragm muscle, Sepsis, Thiamin
Academic Distinctions
Member of the Editorial Board, American Journal of Respiratory and Critical Care Medicine, American Thoracic Society 2010 - present
Member of the Editorial Board, CHEST, American College of Chest Physicians 2010 - present
VA Merit Review Research Awardee 1984 - 2013
America’s Top Physicians - 2005
Research Abstract
My research focuses on the physiological aspects of mechanical ventilation, the effects of diaphragm inactivity with mechanical ventilation on diaphragm muscle function, and the role of diaphragm muscle fatigue as a contributor to acute respiratory failure. I am also interested in the interactions between mechanical ventilation, short-term high-dose corticosteroid, and paralytics in producing criticall-illness myopathy in patients receiving these treatment in the intensive care unit.
Sassoon CSH. Intermittent Mandatory Ventilation. In: Tobin MJ ed.; Principal and practice of mechanical ventilation. 3rd Edition. McGraw Hill, New York, NY 2013; pp 175-198
Lecuona E, Sassoon CS, Barreiro E. Lipid Overload: Trigger or Consequence of Mitochondrial Oxidative Stress in Ventilator-induced Diaphragmatic Dysfunction? (Editorial). Am J Crit Care Med 2012; 186:1074-1076.
Wilcox ME, Rivera MP, Sassoon CS, Ware LB, Wunsch H, Herridge MS. Clinical Year in Review II: Mechanical Ventilation, Acute Respiratory Distress Syndrome, Critical Care, and Lung Cancer. Proc Am Thorac Soc 2012; 9:190-196
Sassoon CSH, Zhu E, Fang L, Ramar K, Jiao G, Caiozzo VJ. Interactive effects of corticosteroid and mechanical ventilation on diaphragm muscle function. Muscle Nerve 2011; 43:103-111.
Sassoon CSH. Triggering of the ventilator in patient-ventilator interaction. Respir Care 2011; 56:39-48
Baydur A, Sassoon CSH. Respiratory dysfunction in spinal cord disorders. In: Lin VW, Chief Ed; Spinal Cord Medicine, Principles and Practice. 2nd Edition, Demos Publishing, New York, NY. 2010; pp 215-229.
Bose AA, Le P, Sassoon CSH. Asincronia tra paziente a ventilatore. In: Romano E, Chief Editor; Medicina Critica. UTET, Torino, Italy. 2010; pp 1005-1015.
Tom LR, Sassoon CSH†. Patient-ventilator interactions. In: MacIntyre N and Branson R eds.: Mechanical Ventilation. 2nd Edition. Elsevier, Philadelphia, 2009, pp 182-197.
Sassoon CSH, Caiozzo VJ. Bench-to-Bedside: Diaphragm muscle functions in disuse and acute high-dose corticosteroid treatment. Critical Care 2009; 13:221 (doi:10.1186/cc7971)
Zhu E, Sassoon CSH. The silenced diaphragm: The good and the bad. Réanimation 2008; 17: 631-638.
Moon M, Sassoon CSH†. Patient-ventilator asynchrony. In: Esquinas A, Volsko T eds: Yearbook Respiratory Care Clinics and Applied Technologies. World Federation of Respiratory Care and Applied. Murcia, Spain. 2008; pp 240-247.
Sassoon CSH, Zhu E, Pham HT, Nelson RS, Fang L, Baker MJ, Caiozzo VJ. Acute effects of high-dose corticosteroid on diaphragm contractile properties. Muscle Nerve 2008; 38: 1161-1172.
Murgu SD, Sassoon CSH. New Invasive Ventilatory Strategy. In: Parsons PE and Heffner JE eds.; Pulmonary / Respiratory Therapy Secrets. 3rd Edition. Hanley & Belfus Inc., Philadelphia, PA 2006, pp 511-521.
Zhu E, Sassoon CSH, Nelson RS, Pham HT, Zhu L, Baker MJ, Caiozzo VJ. The early effects of mechanical ventilation on isotonic contractile properties and MAF-box gene expression in the diaphragm. J Appl Physiol 2005; 99:747-756.
Sassoon CSH, Zhu E, Caiozzo VJ. Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004; 170: 626-632 (doi:10.1164/rccm.200401-042OC).
Sassoon CSH. Ventilator-associated diaphragm dysfunction (Editorial). Am J Respir Crit Care Med 2002; 166: 1017-1018.
Sassoon CSH, Caiozzo VJ, Manka A, Sieck GC. Altered diaphragm contractile properties with controlled mechanical ventilation. J Appl Physiol 2002; 92: 2585-2595.
Foster GT, Vaziri ND, Sassoon CSH. Respiratory alkalosis. Respir Care 2001; 46: 384-391
Gallacher TS, Sassoon CSH†. New Invasive Ventilatory Strategy. In: Parsons PE and Heffner JE eds.; Pulmonary / Respiratory Therapy Secrets. 2nd Edition. Hanley & Belfus Inc., Philadelphia, PA 2001; pp 437-443
Sassoon CSH, Mahutte CK. Airway occlusion pressure and breathing pattern as predictors of weaning outcome. Am Rev Respir Dis 1993; 148:860-866
Sassoon CSH, Light RW, O'Hara VS, Moritz TE. Iatrogenic pneumothorax: etiology and morbidity. Results of a Department of Veterans Affairs Cooperative Study. Respiration 1992; 59: 215-220
Professional Societies
American College of Chest Physicians
American Physiological Society
American Thoracic Society
European Respiratory Society
Society of Critical Care Medicine
American Academy of Sleep Medicine
Other Experience
Faculty Pulmonary & Critical Care Section
VAMCLB 1983—pres
Graduate Programs
Internal Medicine
Pulmonary Disease and Critical Care Medicine (IM)
Sleep Medicine
Research Centers
VAMC Long Beach
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