Ping H. Wang

Picture of Ping H. Wang
Professor, Medicine
School of Medicine
Biological Chemistry
School of Medicine
Director, Center for Diabetes Research and Treatment
Chief, Division of Endocrinology, Diabetes and Metabolism, Medicine
School of Medicine
M.D., Kaohsiung Medical College
OTH, Harvard University
Phone: (949) 824-6887
Fax: (949) 824-2200
University of California, Irvine
845 Health Science Rd
Gross Hall 2014
Mail Code: 4086
Irvine, CA 92697
Research Interests
Diabetes, Diabetes Complications, Stem Cell
Available Technologies
Yang J, Yeh H, Lin, K, Wang PH. Insulin Stimulates Akt Translocation to Mitochondria: Implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium. Journal of Molecular and Cellular Cardiology, 2009;46: 919–926.
Siegrist J, Kazarian T, Ensor C, Joel S, Madou M, Wang P, Daunert S. Continuous glucose sensor using novel genetically engineered binding polypeptides towards in vivo applications. Sensors and Actuators B: Chemical, 2010;149:51-58.
Nguyen NT, Nguyen XM, Lane J, Wang P. Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999-2006. Obes Surg. 2011;21(3):351-5.
Garcia A, Mirbolooki M, Constantinescu C, Pan M, Sevrioukov E, Milne N, Wang P, Lakey J, Chandy G, Mukherjee J. 18F-Fallypride PET Imaging of Pancreatic Islets Cells: In Vitro and In Vivo Rodent Studies. J Nucl Medicine 2011;52:1125-32.
Su CC, Yang JY, Leu HB, Chen Y, Wang PH. Mitochondrial Akt Regulated Mitochondrial Apoptosis Signaling in Cardiac Muscle Cells. Am J Physiol 2012;302:H716-23.
Ji F, Sharpley MS, Derbeneva O, Alves LS, Qian P, Wang Y, Chalkia D, Lvova M, Xu J, Yao W, Simon M, Platt J, Xu S, Angelin A, Davila A, Huang T, Wang PH, Chuang LM, Moore LG, Qian G, Wallace DC. Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans. Proc Natl Acad Sci USA. 2012 May 8;109(19):7391-6.
Yang J, Deng W, Chen Y, Fan W, Baldwin KM, Jope RJ, Wallace DC, Wang PH. Impaired Translocation and Activation of Mitochondrial Akt1 Mitigated Mitochondria Oxidative Phosphorylation Complex V Activity in Diabetic Myocardium. Journal of Molecular and Cellular Cardiology 2013;59:167-75.
Kalantari-Dehaghi M, Chen Y, Deng W, Chernyavsky A, Marchenko S, Wang PH*, Grando SA* (*co-corresponding authors). Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies. J Biol Chem. 2013;288(23):16916-25.
Upadhyay S, Eckel-Mahan K, Mirbolooki M, Tjong I, Griffey S, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG.Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci USA. 2013;110(24):E2239-48.
Yazdi PG, Moradi H, Yang JY, Wang PH, Vaziri ND. Skeletal muscle mitochondrial depletion and dysfunction in chronic kidney disease. Int J Clin Exp Med. 2013;6(7):532-9.
Deng W, Leu HB, Chen Y, Chen YH, Epperson CM, Juang C, Wang PH. Protein Kinase B (PKB/Akt1) Formed Signaling Complexes with Mitochondrial Proteins and Protected against Glycolytic Energy Impairment in Stressed Cardiomyocytes. Endocrinology. 2014;155(5):1618-28.
Ke C, Tran K, Chen Y, Di Donato AT, Yu L, Hu Y, Linskey ME, Wang PH, Limoli C, Zhou YH. Linking differential radiation responses to glioma heterogeneity. Oncotarget. 2014; 5(6): 1657–1665.
Chernyavsky A, Chen Y, Wang PH, Grando SA. Pemphigus vulgaris antibodies target the mitochondrial nicotinic acetylcholine receptors that protect keratinocytes from apoptolysis. Int Immunopharmacol. 2015; pii: S1567-5769(15)00210-6.
Yazdi A, Pedersen BA, Taylor JF, Khattab O, Chen Y-H, Chen Y, Jacobsen SE, Wang PH. Nucleosome organization in human embryonic stem cells. PLoS One 2015; 10 (8): e0136314.
Yazdi A, Pedersen BA, Taylor JF, Khattab O, Chen Y-H, Chen Y, Jacobsen SE, Wang PH. Increasing nucleosome occupancy is correlated with an increasing mutation rate so long as DNA repair machinery is intact. PLoS One 2015; 10(8):e0136574.
Ke C, Ru N, Chen Y, Yu L, Siegel ER, Linskey ME, Wang PH, Xing J, Zhou YH. Cell context-dependent dual effects of EFEMP1 stabilizes subpopulation equilibrium in responding to changes of in vivo growth environment. Oncotarget 2015; 6(31):30762-72.
Chen Y, Chernyavsky A, Weber R, Grando SA, Wang PH. Critical role of FcRn in the pathogenic action of anti-mitochondrial autoantibodies synergizing with anti-desmoglein autoantibodies in pemphigus vulgaris. J Biol Chem. 2015; 290:23826-37.
Pedersen BA, Wang W, Yazdi A, Taylor JF, Khattab O, Chen Y-H, Chen Y, Wang PH. Novel remodeling of the mouse heart mitochondrial proteome in response to acute insulin stimulation. Nutr Metab Cardiovasc Dis. 2015; 25(12):1152-8.
Pedersen BA, Wang W, Taylor JF, Khattab O, Chen Y-H, Edwards RA, Yazdi, P, Wang PH. Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1+/-/Akt2-/- mice. Metabolism 2015; 64(12):1694-703.
Graduate Programs
Cellular and Molecular Biosciences
Research Centers
Center for Diabetes Research and Treatment
Last updated