Robert F. Phalen

Picture of Robert F. Phalen
Professor, Medicine
School of Medicine
Air Pollution Health Effects Laboratory, Medicine
School of Medicine
Phone: (949) 824-4758
Fax: (949) 824-4763
University of California, Irvine
Mail Code: 1825
Irvine, CA 92697
Research Interests
Air Pollution; Aerosol medicine; Inhalation Toxicology; Pulmonary Anatomy; Research Ethics; Bioterror Aerosols
Academic Distinctions
Fellow -- Academy of Toxicological Sciences; Fellow -- Southern California Academy of Sciences; Board of Directirs -- California Society for Biomedical Research; Member -- U.S. EPA Clean Air Scientific Advisory Committee; Former Chair -- UCI Human Subjects Medical Review Committee; Former Chair -- Animal Research Committee; Former Member -- U.C. Office of the President's Health Sciences Committee; Lifetime Achievement Award -- Society of Toxicology, Inhalation Specialty Section; Public Education Award -- California Biomedical Research Association.
Lovelace Foundation, Inhalation Toxicology Research Institute (now The Lovelace Respiratory Research Institute), Albuquerque, New Mexico
Research Abstract
The aerodynamics of particle deposition in the developing lung and in the adult lung is one major focus of the research program; another is assessment of lung defense mechanisms using aerosol inhalation challenges. Quantitative morphometry by hand and video image analysis is being used to study the mechanism of interference with organogenesis and possible long-term consequences for lung disease due to toxic inhalation exposure. Additional studies are evaluating the tolerance of animals to air pollution mixtures as a mechanism that may protect humans against ambient pollutants, and the doses related to environmental tobacco smoke and bioterror agents.
Recent Publications Only, # Refers to Total List in Each Category

A. Books
#9. Phalen, R.F., "The Particulate Air Pollution Controversy", Kluwer Academic Publishers, Boston, 2002,128 pp
#10. Phalen, R.F., et al. (editors), "Frontiers in Aerosol Dosimetry Research" (conference proceedings), APHEL Report #06-01, U.C. Irvine,
Irvine, CA, 2006, 223 pp
#11. Hobbs, C.H., et al., "Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents", National Research Council (NAS), Washington, D.C., 2006
#12. Phalen, R.F., "Inhalation Studies: Foundations and Techniques, second edition", Informa Healthcare, New York, 2008, 257pp

B. Papers & Chapters
#122. Phalen, R.F., Oldham, M.J., and Nel, A.E., Tracheobronchial dose considerations for in-vitro toxicology studies, Tox Sci.,192:126-132, 2006
#125. Phalen, R.F., and Oldham, M.J., Aerosol dosimetry considerations, Clinics in Occupational and Environmental Medicine, 5:773-784, 2006
#129. Phalen, R.F., Oldham, M.J., and Wolff, R.K., The relevance of animal models for aerosol studies, J Aerosol Med Pulm Drug Delivery, 21:125-144, 2008
#130. Phalen, R.F., and Mendez, L.B., Dosimetry considerations for animal inhalation studies, Biomarkers (submitted)
#131. Phalen, R.F., Ethical issues related to animal welfare in the toxicology laboratory, In "General and Applied Toxicology", edited by Ballantyne, et al., John Wiley and Sons, Chichester, (accepted, in press)
NIH #AI065359 P.I, Dr Alan Barbour
C.S. Stocking Fund, endowment, "Children at Risk: Air Pollution Hazards", P.I. Dr. Robert Phalen
Professional Societies
Academy of Toxicological Sciences (Fellow)
American Association for Aerosol Science (charter member)
American Industrial Hygiene Association
Gessellschaft fur Areosolforschung
International Society for Aerosols in Medicine
Society of Toxicology
Southern California Academy of Sciences (Fellow)
The Aerosol Society (European)
Other Experience
Graduate Programs
Environmental Toxicology
Research Centers
AIR UCI, Organized Research Center
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