Matthew F Rose

picture of Matthew F Rose

Assistant Professor, Pathology
School of Medicine

-Clinical Scientist Postdoctoral Training, Harvard Medical School, Brigham & Women's Hospital, Boston Children's Hospital, The Broad Institute of MIT and Harvard, 2021, Neurodevelopment, Imaging, & Bioinformatics
-Fellowship, Harvard Medical School, Brigham & Women's Hospital, Boston Children's Hospital, 2014, Neuropathology
-Residency, Harvard Medical School, Brigham & Women's Hospital, 2012, Anatomic Pathology
M.D., Baylor College of Medicine, 2009, Medicine
Ph.D., Baylor College of Medicine, 2008, Developmental Neurogenetics
B.S., University of Virginia, 2000, Chemistry

ORCiD: 0000-0002-1148-4130

Phone: (713)294-7416

University of California, Irvine
Medical Sciences I D440
825 Health Sciences Road
Mail Code: 4800
Irvine, CA 92697
Research Interests
neurodevelopment, brainstem, motor neuron, gene expression patterns, axon targeting, congenital cranial dysinnervation disorders (CCDDs), amyotrophic lateral sclerosis (ALS), neuropathology, imaging, bioinformatics, single cell approaches, transcriptomics
-Collaborator-POI, Pathology, Brigham & Women's Hospital (2021-Present)
-Instructor, Harvard Medical School (2016-Present)
-Associated Scientist, Klarman Cell Observatory, The Broad Institute of MIT and Harvard (2016-Present)
-Affiliated Non-Clinical Staff, Engle Lab, F.M. Kirby Neurobiology Center, Boston Children’s Hospital (2021-Present)
-Affiliated Non-Clinical Staff, Engle Lab, Pathology, Boston Children’s Hospital (2014-2020)
-Associate Pathologist, Pathology (Neuropathology), Brigham and Women’s Hospital (2016-2021)
-Research/Clinical Fellow, Pathology, Laboratory of Elizabeth Engle, Boston Children's Hospital and Brigham and Women’s Hospital (2014-2016)
-Affiliated Fellow, Pathology, Boston Children’s Hospital (2014)
-Neuropathology Fellow, Pathology (Neuropathology), Brigham & Women's Hospital, Boston Children’s Hospital, & Beth Israel Deaconess Medical Center (2012-2014)
-Resident, Pathology, Brigham and Women's Hospital (2010-2012)
Research Abstract
We study the gene networks driving neuronal diversity during brainstem development to uncover why only specific subsets are differentially affected in a given human neurologic disease. The brainstem controls multiple critical motor and sensory functions, including eye movements, facial expression, speech, hearing, proprioception, arousal, and breathing. Disruption of these functions can lead to profound deficits including in childhood social interaction. The anatomy and gene circuits in the brainstem are highly conserved in mice, providing an ideal model system to investigate neuronal specification and axon growth and guidance in both health and disease. We combine neurodevelopmental tools, 3D imaging, multi-omics/bioinformatic approaches, molecular/synthetic biology, and mouse models of human disease to define developmental differences among various neuronal populations. Through a single cell and spatial transcriptomic atlas of developing motor neurons, we have identified unique genetic fingerprints of each motor neuron population, including novel markers of spatially and temporally distinct subpopulations that contribute to specific aberrant nerve branches in mouse models of childhood disorders. This work provides a new toolbox to study differential neuronal vulnerability in disease.
Short Biography
I’ve pursued research since an early age, supported by many wonderful mentors and teachers along the way, and I consider mentoring and training the next generation of scientists one of my primary goals. I have progressively developed approaches in critical thinking, imaging, cell culture, animal work, bioinformatics, and neuropathology through work in the laboratories of Jeff Corwin, PhD (University of Virginia), Huda Zoghbi, MD and Hugo Bellen, PhD (Baylor College of Medicine), Jeff Lichtman, MD/PhD (The Marine Biological Laboratory), Elizabeth Engle, MD (Harvard Medical School), & Aviv Regev, PhD (The Broad Institute of MIT & Harvard), among many others. I’m also a clinical neuropathologist and look for areas to apply our research findings to medicine.
Mapping Brainstem Motor Neuron Subtypes and Genetic Pathways Involved in their Differential Susceptibility to Disease NIHK08NS099502; Dec 1, 2016 - Nov 30, 2022; Role: Principal Investigator
Role of Math1 in brain stem &cerebellar development NIHF31NS051046; Sep 30, 2004 - Oct 31, 2007; Role: Principal Investigator
Graduate Programs
Interdepartmental Neuroscience Program

Cellular and Molecular Biosciences

Experimental Pathology (PTH)

Neuropathology (PTH)

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