Barbara Jusiak

picture of Barbara  Jusiak

Assistant Professor, Physiology & Biophysics
School of Medicine


Ph.D., Baylor College of Medicine, 2012, Developmental Biology

ORCiD: 0000-0001-6439-0456

Phone: 281-979-2584
Email: bjusiak@uci.edu

University of California, Irvine
UCI CAMPUS:Med Sci D, 825 Health Sciences Rd., Room D351
Mail Code: 4560
Irvine, CA 92697
Research Interests
synthetic biology, gene circuits, macrophages, cancer, Drosophila
Appointments
Lu lab, Synthetic Biology Center, MIT, 2013-2020
Publications
Wu MR, Jusiak B, Lu TK. Engineering advanced cancer therapies with synthetic biology. Nat Rev Cancer 2019 Apr; 19(4):187-195. doi: 10.1038/s41568-019-0121-0.
 
Jusiak B, Jagtap K, Gaidukov L, Duportet X, Bandara K, Chu J, Zhang L, Weiss R, Lu TK. Comparison of Integrases Identifies Bxb1-GA as the Most Efficient Site-Specific Integrase System in Mammalian Cells. ACS Synth Biol 2019 Jan 18; 8(1):16-24. doi: 10.1021/acssynbio.8b00089. Epub 2019 Jan 9.
 
Inniss MC, Bandara K, Jusiak B, Lu TK, Weiss R, Wroblewska L, Zhang L. A novel Bxb1 integrase RMCE system for high fidelity site-specific integration of mAb expression cassette in CHO cells. Biotechnol Bioeng 2017 Aug; 114(8):1837-1846. doi: 10.1002/bit.26268. Epub 2017 Mar 14.
 
Jusiak B, Cleto S, Perez-Pinera P, Lu TK. Engineering Synthetic Gene Circuits in Living Cells with CRISPR Technology. Trends Biotechnol 2016 Jul; 34(7):535-547. doi: 10.1016/j.tibtech.2015.12.014. Epub 2016 Jan 22.
 
Jusiak B, Wang F, Karandikar UC, Kwak SJ, Wang H, Chen R, Mardon G. Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster. Genom Data 2014 Dec 1; 2:153-155. doi: 10.1016/j.gdata.2014.06.016.
 
Karandikar UC, Jin M, Jusiak B, Kwak S, Chen R, Mardon G. Drosophila eyes absent is required for normal cone and pigment cell development. PLoS One 2014 Jul 24; 9(7):e102143. doi: 10.1371/journal.pone.0102143. eCollection 2014.
 
Jusiak B, Karandikar UC, Kwak SJ, Wang F, Wang H, Chen R, Mardon G. Regulation of Drosophila eye development by the transcription factor Sine oculis. PLoS One 2014 Feb 25; 9(2):e89695. doi: 10.1371/journal.pone.0089695. eCollection 2014.
 
Atkins M, Jiang Y, Sansores-Garcia L, Jusiak B, Halder G, Mardon G. Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation. PLoS Genet 2013 Aug; 9(8):e1003731. doi: 10.1371/journal.pgen.1003731. Epub 2013 Aug 29.
 
Jin M, Jusiak B, Bai Z, Mardon G. Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival. PLoS One 2013; 8(3):e58818. doi: 10.1371/journal.pone.0058818. Epub 2013 Mar 12.
 
Jusiak B, Abulimiti A, Haelterman N, Chen R, Mardon G. MAPK target sites of eyes absent are not required for eye development or survival in Drosophila. PLoS One 2012; 7(12):e50776. doi: 10.1371/journal.pone.0050776. Epub 2012 Dec 12.
 
Padash-Barmchi M, Browne K, Sturgeon K, Jusiak B, Auld VJ. Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia. J Cell Sci 2010 Dec 1; 123(Pt 23):4052-62. doi: 10.1242/jcs.066605. Epub 2010 Nov 2.
Professional Society
Genetics Society of America
Graduate Programs
Cellular and Molecular Biosciences

Mathematical and Computational Biology

Research Centers
Chao Family Comprehensive Cancer Center
Center for Complex Biological Systems
Last updated
09/02/2022