Warren A Chow
Clinical Professor, Division of Hematology/Oncology, Medicine
School of Medicine
School of Medicine
Associate Director for Clinical Sciences, Chao Family Comprehensive Cancer Center
M.D., Chicago Medical School, 1986, Medicine
B.S., University of Southern California, 1981, Psychobiology
B.S., University of Southern California, 1981, Psychobiology
University of California, Irvine
101 The City Drive South
Building 23, Room 405
Mail Code: 2675
Orange, CA 92868
101 The City Drive South
Building 23, Room 405
Mail Code: 2675
Orange, CA 92868
Research Interests
Sarcoma, melanoma
Academic Distinctions
Fellow, American College of Physicians
Awards and Honors
Melanoma Research Foundation Anita Ashby Memorial Research Award
The Margaret E. Early Medical Research Trust recipient
Fellow, American College of Physicians
Castle Connolly America’s Top Doctors
Castle Connolly America’s Top Doctors for Cancer
The Margaret E. Early Medical Research Trust recipient
Fellow, American College of Physicians
Castle Connolly America’s Top Doctors
Castle Connolly America’s Top Doctors for Cancer
Short Biography
Dr. Warren A. Chow is a board-certified UCI Health oncologist who specializes in melanoma and sarcomas. He will serve as associate director for cancer clinical sciences at the UCI Health Chao Family Comprehensive Cancer Center.
He received his medical degree from Chicago Medical School at Rosalind Franklin University of Medicine and Science in North Chicago, Ill. He completed an internship and residency in internal medical at Cedars-Sinai Medical Center in Los Angeles. Next he received fellowship training in medical oncology, hematology and bone marrow transplantation at the City of Hope in Duarte, Calif., where he served nearly 30 years as a clinician and research conducting bench-to-bedside research in both bone and soft-tissue sarcomas.
He received his medical degree from Chicago Medical School at Rosalind Franklin University of Medicine and Science in North Chicago, Ill. He completed an internship and residency in internal medical at Cedars-Sinai Medical Center in Los Angeles. Next he received fellowship training in medical oncology, hematology and bone marrow transplantation at the City of Hope in Duarte, Calif., where he served nearly 30 years as a clinician and research conducting bench-to-bedside research in both bone and soft-tissue sarcomas.
Publications
Chow WA. Chondrosarcoma: biology, genetics, and epigenetics. F1000Res. 2018 Nov 20;7:F1000 Faculty Rev-1826. doi: 10.12688/f1000research.15953.1. PMID: 30519452; PMCID: PMC6248264.
Chow W, Frankel P, Ruel C, Araujo DM, Milhem M, Okuno S, Hartner L, Undevia S, Staddon A. Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma. Cancer. 2020 Jan 1;126(1):105-111. doi: 10.1002/cncr.32515. Epub 2019 Sep 11. PMID: 31509242.
Ramachandran I, Lowther DE, Dryer-Minnerly R, Wang R, Fayngerts S, Nunez D, Betts G, Bath N, Tipping AJ, Melchiori L, Navenot JM, Glod J, Mackall CL, D'Angelo SP, Araujo DM, Chow WA, Demetri GD, Druta M, Van Tine BA, Grupp SA, Abdul Razak AR, Wilky B, Iyengar M, Trivedi T, Winkle EV, Chagin K, Amado R, Binder GK, Basu S. Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma. J Immunother Cancer. 2019 Oct 24;7(1):276. doi: 10.1186/s40425-019-0762-2. PMID: 31651363; PMCID: PMC6813983.
Chow WA, Yee JK, Tsark W, Wu X, Qin H, Guan M, Ross JS, Ali SM, Millis SZ. Recurrent secondary genomic alterations in desmoplastic small round cell tumors. BMC Med Genet. 2020 May 11;21(1):101. doi: 10.1186/s12881-020-01034-w. PMID: 32393201; PMCID: PMC7216377.
Chawla SP, Goel S, Chow W, Braiteh F, Singh AS, Olson JEG, Osada A, Bobe I, Riedel RF. A Phase 1b Dose Escalation Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft-tissue Sarcoma. Clin Cancer Res. 2020 Aug 15;26(16):4225-4232. doi: 10.1158/1078-0432.CCR-20-0591. Epub 2020 May 7. PMID: 32381487.
Riedel RF, Ballman KV, Lu Y, Attia S, Loggers ET, Ganjoo KN, Livingston MB, Chow W, Wright J, Ward JH, Rushing D, Okuno SH, Reed DR, Liebner DA, Keedy VL, Mascarenhas L, Davis LE, Ryan C, Reinke DK, Maki RG. A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study. Oncologist. 2020 Nov;25(11):e1655-e1662. doi: 10.1634/theoncologist.2020-0679. Epub 2020 Aug 20. PMID: 32701199; PMCID: PMC7648334.
Yu C, Huang F, Chow WA, Cook-Wiens G, Cui X. Single Protein Encapsulated Doxorubicin as an Efficacious Anticancer Therapeutic. Adv Ther (Weinh). 2020 Nov;3(11):2000135. doi: 10.1002/adtp.202000135. Epub 2020 Oct 12. PMID: 33709014; PMCID: PMC7941910.
Frankel P, Ruel C, Uche A, Choi E, Okuno S, Somiah N, Chow WA. Pazopanib in Patients with Osteosarcoma Metastatic to the Lung: Phase 2 Study Results and the Lessons for Tumor Measurement. J Oncol 2022. doi.org/10.1155/2022/3691025.
Rock A, Ali S, Chow WA. Systemic therapy for chondrosarcoma. Curr Treat Options in Oncol 2022. DOI 10.1007/s11864-022-00951-7.
Kumar P, Brazel D, DeRogatis J, Valerin JBG, Whiteson K, Chow WA, Tinoco R, Moyers JT. The cure from within? a review of the microbiome and diet in melanoma. Cancer Metast Rev 2022. doi.org/10.1007/s10555-022-10029-3.
Gyurdieva A, Zajic S, Chang YF, Houseman EA, Zhong S, Kim J, Nathenson M, Faitg T, Woessner M, Turner DC, Hasan AN, Glod J, Kaplan RN, D'Angelo SP, Araujo DM, Chow WA, Druta M, Demetri GD, Van Tine BA, Grupp SA, Fine GD, Eleftheriadou I. Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma. Nat Commun. 2022 Sep 8;13(1):5296. doi: 10.1038/s41467-022-32491-x. PMID: 36075914; PMCID: PMC9458750.
Patel SP, Othus M, Chen Y, Wright GP, Jr., Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Troung TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Gossman KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sonak VK, Ribas A. Neoadjuvant-adjuvant or adjuvant-only pembrolizumab in advanced melanoma. N Engl J Med 2023;388:813-823. https://doi.org/10.1056/NEJMoa2211437.
Fatllah MMJ, Law FV, Chow WA, Kaiser P. Small-molecule correctors and stabilizers to target p53. Trends Pharm Sci. 2023.44:274-289. https://doi.org/10.1016/j.tips.2023.02.007.
Rock A, Uche A, Yoon J, Agulnik M, Chow W, Millis S. Bioinformatic analysis of recurrent genomic alterations and corresponding pathway alterations in Ewing sarcoma. J Pers Med. 2023;13:1499. https://doi.org/10.3390/jpm13101499.
Yu C, Huang F, Wang K, Liu M, Chow WA, Ling X, Li F, Causey JL, Huang X, Cook-Wiens G, Cui X. Single protein encapsulated SN38 for tumor-targeting treatment. J Transl Med. 2023 Dec 10;21(1):897. doi: 10.1186/s12967-023-04778-0. PMID: 38072965; PMCID: PMC10712105.
Hagopian G, Jiang X, Grant C, Brazel D, Kumar P, Yamamoto M, Jakowatz J, Chow W, Tran T, Shen W, Moyers J. Survival impact of post-operative immunotherapy in resected stage III cutaneous melanomas in the checkpoint era. ESMO Open. 2024; 9:1-10. http://creativecommons.org/licenses/by-nc-nd/4.0/.
Dwabe S, Chow WA. Phosphaturic mesenchymal tumor with de novo liver metastases: A case report and literature review. Therapeutic Advances in Medical Oncology. 2024;16: 1-5. doi: 10.1177/17588359241232092
Yu C, Huang F, Wang L, Liu M, Chow WA, Ling X, Li F, Cook-Wiens G, Li L, Cui X. Targeted Treatment of Soft Tissue Sarcomas by Single Protein Encapsulated Doxorubicin with Undetectable Cardiotoxicity and Superior Efficacy. Cancers. 2025; 17(5), 881; https://doi.org/10.3390/cancers17050881
Mahadevan A, Vosooghi A, Arora J, Jones J, Moslehyazdi M, Chow WA. Associations between pre-existing cardiovascular disease and survival in patients on immune checkpoint inhibitor therapy. Cancer Med. 2025; 2025 May;14(9):e70846. doi: 10.1002/cam4.70846.
Chow W, Frankel P, Ruel C, Araujo DM, Milhem M, Okuno S, Hartner L, Undevia S, Staddon A. Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma. Cancer. 2020 Jan 1;126(1):105-111. doi: 10.1002/cncr.32515. Epub 2019 Sep 11. PMID: 31509242.
Ramachandran I, Lowther DE, Dryer-Minnerly R, Wang R, Fayngerts S, Nunez D, Betts G, Bath N, Tipping AJ, Melchiori L, Navenot JM, Glod J, Mackall CL, D'Angelo SP, Araujo DM, Chow WA, Demetri GD, Druta M, Van Tine BA, Grupp SA, Abdul Razak AR, Wilky B, Iyengar M, Trivedi T, Winkle EV, Chagin K, Amado R, Binder GK, Basu S. Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma. J Immunother Cancer. 2019 Oct 24;7(1):276. doi: 10.1186/s40425-019-0762-2. PMID: 31651363; PMCID: PMC6813983.
Chow WA, Yee JK, Tsark W, Wu X, Qin H, Guan M, Ross JS, Ali SM, Millis SZ. Recurrent secondary genomic alterations in desmoplastic small round cell tumors. BMC Med Genet. 2020 May 11;21(1):101. doi: 10.1186/s12881-020-01034-w. PMID: 32393201; PMCID: PMC7216377.
Chawla SP, Goel S, Chow W, Braiteh F, Singh AS, Olson JEG, Osada A, Bobe I, Riedel RF. A Phase 1b Dose Escalation Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft-tissue Sarcoma. Clin Cancer Res. 2020 Aug 15;26(16):4225-4232. doi: 10.1158/1078-0432.CCR-20-0591. Epub 2020 May 7. PMID: 32381487.
Riedel RF, Ballman KV, Lu Y, Attia S, Loggers ET, Ganjoo KN, Livingston MB, Chow W, Wright J, Ward JH, Rushing D, Okuno SH, Reed DR, Liebner DA, Keedy VL, Mascarenhas L, Davis LE, Ryan C, Reinke DK, Maki RG. A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study. Oncologist. 2020 Nov;25(11):e1655-e1662. doi: 10.1634/theoncologist.2020-0679. Epub 2020 Aug 20. PMID: 32701199; PMCID: PMC7648334.
Yu C, Huang F, Chow WA, Cook-Wiens G, Cui X. Single Protein Encapsulated Doxorubicin as an Efficacious Anticancer Therapeutic. Adv Ther (Weinh). 2020 Nov;3(11):2000135. doi: 10.1002/adtp.202000135. Epub 2020 Oct 12. PMID: 33709014; PMCID: PMC7941910.
Frankel P, Ruel C, Uche A, Choi E, Okuno S, Somiah N, Chow WA. Pazopanib in Patients with Osteosarcoma Metastatic to the Lung: Phase 2 Study Results and the Lessons for Tumor Measurement. J Oncol 2022. doi.org/10.1155/2022/3691025.
Rock A, Ali S, Chow WA. Systemic therapy for chondrosarcoma. Curr Treat Options in Oncol 2022. DOI 10.1007/s11864-022-00951-7.
Kumar P, Brazel D, DeRogatis J, Valerin JBG, Whiteson K, Chow WA, Tinoco R, Moyers JT. The cure from within? a review of the microbiome and diet in melanoma. Cancer Metast Rev 2022. doi.org/10.1007/s10555-022-10029-3.
Gyurdieva A, Zajic S, Chang YF, Houseman EA, Zhong S, Kim J, Nathenson M, Faitg T, Woessner M, Turner DC, Hasan AN, Glod J, Kaplan RN, D'Angelo SP, Araujo DM, Chow WA, Druta M, Demetri GD, Van Tine BA, Grupp SA, Fine GD, Eleftheriadou I. Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma. Nat Commun. 2022 Sep 8;13(1):5296. doi: 10.1038/s41467-022-32491-x. PMID: 36075914; PMCID: PMC9458750.
Patel SP, Othus M, Chen Y, Wright GP, Jr., Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Troung TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Gossman KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sonak VK, Ribas A. Neoadjuvant-adjuvant or adjuvant-only pembrolizumab in advanced melanoma. N Engl J Med 2023;388:813-823. https://doi.org/10.1056/NEJMoa2211437.
Fatllah MMJ, Law FV, Chow WA, Kaiser P. Small-molecule correctors and stabilizers to target p53. Trends Pharm Sci. 2023.44:274-289. https://doi.org/10.1016/j.tips.2023.02.007.
Rock A, Uche A, Yoon J, Agulnik M, Chow W, Millis S. Bioinformatic analysis of recurrent genomic alterations and corresponding pathway alterations in Ewing sarcoma. J Pers Med. 2023;13:1499. https://doi.org/10.3390/jpm13101499.
Yu C, Huang F, Wang K, Liu M, Chow WA, Ling X, Li F, Causey JL, Huang X, Cook-Wiens G, Cui X. Single protein encapsulated SN38 for tumor-targeting treatment. J Transl Med. 2023 Dec 10;21(1):897. doi: 10.1186/s12967-023-04778-0. PMID: 38072965; PMCID: PMC10712105.
Hagopian G, Jiang X, Grant C, Brazel D, Kumar P, Yamamoto M, Jakowatz J, Chow W, Tran T, Shen W, Moyers J. Survival impact of post-operative immunotherapy in resected stage III cutaneous melanomas in the checkpoint era. ESMO Open. 2024; 9:1-10. http://creativecommons.org/licenses/by-nc-nd/4.0/.
Dwabe S, Chow WA. Phosphaturic mesenchymal tumor with de novo liver metastases: A case report and literature review. Therapeutic Advances in Medical Oncology. 2024;16: 1-5. doi: 10.1177/17588359241232092
Yu C, Huang F, Wang L, Liu M, Chow WA, Ling X, Li F, Cook-Wiens G, Li L, Cui X. Targeted Treatment of Soft Tissue Sarcomas by Single Protein Encapsulated Doxorubicin with Undetectable Cardiotoxicity and Superior Efficacy. Cancers. 2025; 17(5), 881; https://doi.org/10.3390/cancers17050881
Mahadevan A, Vosooghi A, Arora J, Jones J, Moslehyazdi M, Chow WA. Associations between pre-existing cardiovascular disease and survival in patients on immune checkpoint inhibitor therapy. Cancer Med. 2025; 2025 May;14(9):e70846. doi: 10.1002/cam4.70846.
Professional Societies
American Society of Clinical Oncology
American Association for Cancer Research
Connective Tissue Oncology Society
Sarcoma Alliance for Research through Collaboration
Other Experience
Internship, Internal Medicine
Cedars-Sinai Medical Center 1986—1987
Cedars-Sinai Medical Center 1986—1987
Resident, Internal Medicine
Cedars-Sinai Medical Center 1987—1989
Cedars-Sinai Medical Center 1987—1989
Chief Resident, Internal Medicine
Cedars-Sinai Medical Center 1989—1990
Cedars-Sinai Medical Center 1989—1990
Fellow, Medical Oncology
City of Hope 1990—1991
City of Hope 1990—1991
Fellowship, Hematology/Bone Marrow Transplantation
City of Hope 1991—1992
City of Hope 1991—1992
Research Fellow, Molecular Genetics
City of Hope 1992—1994
City of Hope 1992—1994
Research Centers
Chao Family Comprehensive Cancer Center
Link to this profile
https://faculty.uci.edu/profile/?facultyId=7006
https://faculty.uci.edu/profile/?facultyId=7006
Last updated
09/08/2025
09/08/2025