Coleen K Cunningham

picture of Coleen K Cunningham

Chair, Pediatrics
School of Medicine


M.D., SUNY Upstate, Syracuse, NY, 1985

Phone: (714)456-8470
Email: ckcunnin@uci.edu

University of California, Irvine
333 City Boulevard West, Suite 800
Mail Code: 4482
Irvine, CA 92697
Research Interests
HIV, pediatrics, bNAb, vaccine
Publications
most recent
Patel SM, Spees L, Smieja M, Luinstra K, Steenhoff AP, Feemster KA, Arscott-Mills T, Boiditswe S, Patel MZ, Shah SS, Cunningham CK, Kelly MS. Predictors of poor outcomes among infants with respiratory syncytial virus-associated acute lower respiratory infection in Botswana. Pediatr Infect Dis J 2018 Dec 5. doi: 10.1097/INF.0000000000002168. [Epub ahead of print] PMID: 30543564 PMCID: PMC6465100.

Kelly MS, Surette MG, Smieja M, Rossi L, Luinstra K, Steenhoff AP, Goldfarb DM, Pernica JM, Arscott-Mills T, Boiditswe S, Mazhani T, Rawls JF, Cunningham CK, Shah SS, Feemster KA, Seed PC. Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana. Pediatr Infect Dis J. 2018 Nov;3(11):1176-1183. doi: 10.1097/INF.0000000000002174. PMID: 30153231 PMCID: PMC6181769 [Available on 2019-11-01].

Dow DE, Mmbaga BT, Turner EL, Gallis JA, Tabb ZJ, Cunningham CK, O'Donnell KE. Building resilience: a mental health intervention for Tanzanian youth living with HIV. AIDS Care. 2018;30(sup4):12-20. doi: 10.1080/09540121.2018.1527008. Epub 2019 Jan 9. PMID: 30626197; PMCID: PMC6422704.

Brumme ZL, Sudderuddin H, Ziemniak C, Luzuriaga K, Jones BR, Joy JB, Cunningham CK, Greenough T, Persaud D. Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth. AIDS. 2019 Feb 1;33(2):211-218. doi: 10.1097/QAD.0000000000002045. PMID: 30325763 PMCID: PMC6298800.

Dow DE, Shayo AM, Cunningham CK, Mmbaga BT. HIV-1 Drug Resistance and Virologic Outcomes Among Tanzanian Youth Living with HIV. Pediatr Infect Dis J. 2019 Feb 4. doi: 10.1097/INF.0000000000002288. [Epub ahead of print] PMID: 30724834.

Kelly MS, Zheng J, Boiditswe S, Steenhoff AP, Feemster KA, Arscott-Mills T, Seme B, Ratshaa B, Rulaganyang I, Patel MZ, Mantzor S, Shah SS, Cunningham CK. Investigating Mediators of the Poor Pneumonia Outcomes of Human Immunodeficiency Virus-Exposed but Uninfected Children. J Pediatric Infect Dis Soc.2019 Mar 28;8(1):13-20. doi: 10.1093/jpids/pix092. PMID: 29165579; PMCID: PMC6437836.

Cunningham CK, Karron R, Muresan P, McFarland EJ, Perlowski C, Libous J, Thumar B, Gnanashanmugam D, Moye J Jr, Schappell E, Barr E, Rexroad V, Aziz M, Deville J, Rutstein R, Yang L, Luongo C, Collins P, Buchholz U; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2012 Study Team. Live-Attenuated Respiratory Syncytial Virus Vaccine With Deletion of RNA Synthesis Regulatory Protein M2-2 and Cold Passage Mutations Is Over-attenuated. Open Forum Infect Dis. 2019 May 6;6(6) eCollection 2019 Jun https://doi.org/10.1093/ofid/ofz212 PMID: 31211158, PMCID: PMC6559275.

Hurst J, Barrett K, Kelly MS, Staples B, McGann K, Cunningham CK, Reed A, Gbadegesin R, Permar S. Cultivating research skills during clinical training to promote pediatric-scientist development. Pediatrics. 2019 Aug;144(2). pii: e20190745. doi: 10.1542/peds.2019-0745. PMID: 31363070, PMCID: PMC6855830

Patel SM, Jallow S, Boiditswe S, Madhi SA, Feemster KA, Steenhoff AP, Arscott-Mills T, Muthoga C, Ajibola G, Shapiro R, Shah SS, Cunningham CK, Kelly MS. Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants. J Pediatric Infect Dis Soc. 2019 Sep 24. pii: piz056. doi: 10.1093/jpids/piz056. [Epub ahead of print] PMID:31549157

Masese RV., Ramos JV., Rugalabamu L, Luhanga S, Shayo AM., Stewart Kearsley A, Cunningham CK., Dow DE. Challenges and Facilitators of Transition from Adolescent to Adult HIV Care Among Youth Living with HIV in Moshi, Tanzania. J International AIDS Society 2019, https://doi.org/10.1002/jia2.25406 PMID: 31651089, PMCID: PMC6813636

Cunningham CK, McFarland EJ, Morrison RL, Capparelli EV, Safrit JT, Mofenson LM, Mathieson B, Valentine ME, Perlowski C, Smith B, Hazra R, Purdue L, Muresan P, Harding PA, Mbengeranwa T, Robinson LG, Wiznia A, Theron G, Lin B, Bailer RT, Mascola JR, and Graham BS for the IMPAACT P1112 team. Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants. J Infect Dis. 2019 Nov 4. pii: jiz532. doi: 10.1093/infdis/jiz532. [Epub ahead of print] PMID: 31681963

Abu-Raya B, Goldfarb DM, Smieja M, Luinstra K, Richard-Greenblatt M, Steenhoff AP, Feemster KA, Arscott-Mills T, Cunningham CK, Shah SS, Patel MZ, Kelly MS, Sadarangani M. The prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana. BMC Pediatr. 2019 Nov 16;19(1):444. doi: 10.1186/s12887-019-1820-0. PMID: 31733643, PMCID: PMC6858628

McFarland EJ, Karron RA, Muresan P, Cunningham, CK, Libous J, Perlowski C, Thumar B, Gnanashanmugam D, Moye J, Schappell E, Barr E, Rexroad V, Fearn L, Spector SA, Aziz M, Cielo M, Beneri C, Wiznia A, Luongo C, Collins PL, Buchholz UJ and the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2011 Study Team. Live respiratory syncytial virus attenuated 1 by M2-2 deletion and stabilized temperature sensitivity mutation 1030s is a promising vaccine candidate in children. J Infect Dis. 2020 Feb 3;221(4):534-543. doi:10.1093/infdis/jiz603.PMID: 31758177, PMCID: PMC6996856

McFarland EJ, Karron RA, Muresan P, Cunningham CK, Perlowski C, Libous J, Oliva J, Jean-Philippe P, Moye J, Schappell E, Barr E, Rexroad V, Fearn L, Cielo M, Wiznia A, Deville JG, Yang L, Luongo C, Collins PL, Buchholz UJ; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2013 Study Team. Live-attenuated respiratory syncytial virus vaccine with M2-2 deletion and with SH non-coding region is highly immunogenic in children. J Infect Dis. 2020 Feb 1. pii: jiaa049. doi: 10.1093/infdis/jiaa049. [Epub ahead of print] PMID: 32006006, PMCID: PMC7289559

Karron R, Atwell J, MacFarland E, Cunningham C, Muresan P, Perlowski C, Libous J, Yogev R, Aziz M, Woods S, Wanionek K, Collins P, Buchholz U; Live-attenuated vaccines prevent respiratory syncytial virus-associated illness in young children. Am J Respir Crit Care Med. 2020 Sep 1. doi: 10.1164/rccm.202005-1660OC. Online ahead of print. PMID: 32871092

Thomas S, Kilgore J, Becken B, Cunningham CK, Thompson A; Raltegravir-associated DRESS syndrome. 2021 J Pediatr Infect Dis Society (10) 363-366.

Shane AL, Sato AI, Kao C, Adler-Shohet FC, Vora SB, Auletta JJ, Nachman S, Raabe VN, Inagaki K, Akinboyo IC, Woods C, Alsulami AO, Kainth MK, Santos RP, Espinosa CM, Burns JE, Cunningham CK, Dominguez SR, Martinez BL, Zhu F, Crews J, Kitano T, Saiman L, Kotloff K. A Pediatric Infectious Disease Perspective of SARS-CoV-2 and COVID-19 in Children. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):596-608. doi: 10.1093/jpids/piaa099. PMID: 32840614

Li J, Nikanjam M, Cunningham CK, McFarland E, Coates E, Houser K, Lin B, McDermott A, Flach B, Gama L, Koup R, Graham B, Mascola J, Ledgerwood J, Capparelli E. Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach. Clin Pharmacol Ther. 2020 Aug 31. doi: 10.1002/cpt.2026. Online ahead of print. PMID: 32866318

Hurst JH, Heston SM, Chambers HN, Cunningham HM, Price MJ, Suarez L, Crew CG, Bose S, Aquino JN, Carr ST, Griffin SM, Smith SH, Jenkins K, Pfeiffer TS, Rodriguez J, DeMarco CT, De Naeyer NA, Gurley TC, Louzao R, Zhao C, Cunningham CK, Steinbach WJ, Denny TN, Lugo DJ, Moody MA, Permar SR, Rotta AT, Turner NA, Walter EB, Woods CW, Kelly MS. SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study. Clin Infect Dis. 2020 Nov 3:ciaa1693. doi: 10.1093/cid/ciaa1693. Online ahead of print. PMID: 33141180

Dow DE, Mmbaga BT, Gallis JA, Turner EL, Gandhi M, Cunningham CK, O'Donnell KE. A group-based mental health intervention for young people living with HIV in Tanzania: results of a pilot individually randomized group treatment trial. BMC Public Health. 2020 Sep 4;20(1):1358. doi: 10.1186/s12889-020-09380-3. PMID: 32887558

Congdon M, Hong H, Young RR, Cunningham CK, Enane LA, Arscott-Mills T, Banda FM, Chise M, Motlhatlhedi K, Feemster K, Patel SM, Boiditswe S, Leburu T, Shah SS, Steenhoff AP, Kelly MS. Effect of Haemophilus influenzae type b and 13-valent pneumococcal conjugate vaccines on childhood pneumonia hospitalizations and deaths in Botswana. Clin Infect Dis. 2020 Jul 8:ciaa919. doi: 10.1093/cid/ciaa919. Online ahead of print. PMID: 32634831

McFarland EJ, Karron RA, Muresan P, Cunningham CK, Perlowski C, Libous J, Oliva J, Jean-Philippe P, Moye J, Schappell E, Barr E, Rexroad V, Fearn L, Cielo M, Wiznia A, Deville JG, Yang L, Luongo C, Collins PL, Buchholz UJ. Live-Attenuated Respiratory Syncytial Virus Vaccine With M2-2 Deletion and With Small Hydrophobic Noncoding Region Is Highly Immunogenic in Children. J Infect Dis. 2020 Jun 11;221(12):2050-2059. doi: 10.1093/infdis/jiaa049. PMID: 32006006

Li J, Nikanjam M, Cunningham CK, McFarland EJ, Coates EE, Houser KV, Lin BC, McDermott AB, Flach B, Gama L, Koup RA, Graham BS, Ledgerwood JE, Caparelli EV. Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach. Clinical Pharmacology & Therapeutics 2020 Aug 31 https://doi.org/10.1002/cpt.2026

Patel SM, Jallow S, Boiditswe S, Madhi SA, Feemster KA, Steenhoff AP, Arscott-Mills T, Muthoga C, Ajibola G, Shapiro R, Shah SS, Cunningham CK, Kelly MS. Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):349-356. doi: 10.1093/jpids/piz056
Renaud de Armas L, George V, Filali-Mouhim A, Steel C, Parmigiani A, Cunningham CK, Weinberg A, Trautmann L, Sekaly RP, Cameron M, Pahwa S. Transcriptional and Immunologic Correlates of Response to Pandemic Influenza Vaccine in Aviremic, HIV-Infected Children. Frontiers in Immunology 2021. https://doi.org/10.3389/fimmu.2021.639358.

McFarland, J.E., Cunningham CK, Muresan, P, Capparelli E, Perlowski C, Morgan P, Smith B, Hazra R, Purdue L, Harding P, Theron G, Mujuru H, Agwu A, Purswani M, Rathore M, Flach B, Taylor A, Lin B, McDermott AB, Mascola JR, Graham BS. Safety, Tolerability and Pharmacokinetics of a Long-Acting Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01LS in HIV-1 Exposed Newborn Infants. J Infect Dis. 2021 https://doi.org/10.1093/infdis/jiab229

Dan M Cooper, Behnoush Afghani, Carrie L Byington, Coleen K Cunningham, Sidney Golub, Kim D Lu, Shlomit Radom-Aizik, Lainie Friedman Ross, Jasjit Singh, William E Smoyer, Candice Taylor Lucas, Jessica Tunney, Frank Zaldivar, Erlinda R Ulloa. SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges. Pediatr Res (2021). https://doi.org/10.1038/s41390-021-01402-z
Professional Societies
Pediatric Infectious Diseases Society
Infectious Diseases Society of America
Last updated
02/02/2022