Xiaoying Lu

Assistant Clinical Professor
School of Medicine

M.D., Shandong Medical University, 1993
Ph.D., University of Southern California, 2002, Neuroscience

Phone: 7144566203
Email: xlu22@uci.edu

University of California, Irvine
200 S. Manchester Ave. Ste 206
Mail Code: 4280
Irvine, CA 92697
Research Interests
Management of medically refractory epilepsy
1. Howe J*, Lu X*, Thompson Z*, Peterson GW, Losey TE (2016) Intraoperative seizures during craniotomy under general anesthesia. Seizure 2016; 38:23-6. *equal contribution.
2. Bajo M, Madamba SG, Lu X, Sharkey LM, Bartfai T, Siggins GR (2012) Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmitter and ethanol responses in the central amygdala. Addict Biol 2012; 17(4):694-705.
3. Lu X, Roberts E, Xia F, Sanchez-Alavez M, Liu T, Baldwin R, Wu S, Chang J, Wasterlain CG, Bartfai T (2010) GalR2 positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A 2007;107(34):15229-34.
4. Mitsukawa K, Lu X, and Bartfai T (2009) Bidirectional regulation of stress responses by galanin in mice: Involvement of galanin receptor subtype 1. Neuroscience 2009; 160: 837-46.
5. Lu X and Bartfai T (2009) Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice. Naunyn Schmiedebergs Arch Pharmacol 2009; 379: 417-20.
6. Lu X, Ross B, Sanchez-Alavez M, Zorrillla EP, Bartfai T (2008) Phenotypic analysis of GalR2 knockout mice in anxiety- and depression related behavioral tests. Neuropeptides 2008; 42: 387-97.
7. Conti B, Maier R, Barr AM, Morale MC, Lu X, Sanna PP, Bilbe G, Hoyer D, Bartfai T (2007) Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. Mol Psychiatry 2007; 12(2): 167-89.
8. Zorrilla EP, Brennan M, Sabino V, Lu X, Bartfai T (2007) Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge. Physiol Behav 2007; 91(5): 479-85.
9. Lu X, Sharkey L, Bartfai T (2007) The Brain galanin receptors: targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets 2007; 6(3): 183-92.
10. Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hokfelt T (2006) Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci 2006; 23(3): 627-36.
11. Malkmus S, Lu X, Bartfai T, Yaksh TL, Hua XY (2005) Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice. Neuropeptides 2005; 39(3):217-21.
12. Lu X, Lundstrom L, Langel U, Bartfai T (2005) Galanin receptor ligands. Neuropeptides 2005; 39(3):143-46.
13. Lu X, Mazarati A, Sanna P, Shinmei S, Bartfai T (2005) Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity. Neuropeptides 2005; 39:147-52.
14. Lu X, Lundstrom L, Bartfai T (2005) Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 2005; 39(3): 165-67.
15. Jourdi H, Lu X, Yanagihara T, Lauterborn JC, Bi X, Gall CM, Baudry M (2005) Prolonged positive modulation of AMPA receptors induces calpain-mediated PDZ protein degradation and AMPA receptor down-regulation in cultured hippocampal slices. J Pharmacol Exp Ther 2005; 314(1): 16-26.
16. Lu X, Barr AM, Bartfai T (2005) Galanin receptors as novel drug targets for the treatment of depression and anxiety. Drug Development Research, 2005; 65:227-36.
17. Lu X, Barr AM, Kinney JW, Sanna P, Conti B, Behrens MM, Bartfai T (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc Natl Acad Sci U S A. 2005; 102(3): 874-79.
18. Badie-Mahdavi H., Lu X, Behrens MM, Bartfai, T (2005) Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3',5'-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: Studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice. Neuroscience 2005; 133(2): 591-604.
19. Mazarati A, Lu X, Langel U, Wasterlain CG, Bartfai T (2004) Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in dentate gyrus. European Journal of Neuroscience 2004; 19:3235-44.
20. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua X, Yaksh T, Haberhauer G, Trembleau L, Conde S, Rebek J Jr (2004) GALMIC, a non peptide galanin receptor agonist, affects behaviors in seizure, pain and forced swim tests. Proc Natl Acad Sci U S A 2004; 101:10470-75.
21. Mazarati A, Lu X, Shinmei S, Badie-Mahdavi H, Bartfai T (2004) Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1(GalR1) knockout mice. Neuroscience 2004; 128:441-51.
22. Rong Y, Lu X, Bernard A, Khrestchatisky M, Baudry M (2001) Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn and Src selectively modulates their susceptibility to calpain. Journal of Neurochemistry 2001; 79:382-90.
23. Lu X, Rong Y, Baudry M (2000) Calpain-mediated degradation of PSD-95 in developing and adult rat brain. Neuroscience Letters 2000; 286:149-53.
24. Lu X, Rong Y, Bi R, Baudry M (2000) Calpain-mediated truncation of rat brain AMPA receptors increases their Triton X-100 solubility. Brain Research 2000; 863:143-50.
25. Lu X, Wyszynski M, Sheng M, Baudry M (2000) Proteolysis of glutamate receptor interacting protein (GRIP) by Calpain in rat brain: implications for synaptic plasticity. Journal of Neurochemistry 2001; 77:1553-60.
26. Pong Z, Lu X, Zhang G (1997) Spinal cord ischemia secondary to a dissecting aortic aneurysm. Journal of Shandong Medicine 1997; 37:30-31.
27. Pong Z, Lu X (1997) Pontine lacunar infarction in elderly: a clinical study of 28 cases. Chinese Journal of Gerontology 1997; 17:40-41.
28. Liu Z, Huan Y, Lu X (1996) Pontine hemorrhage: clinical and CT features. Journal of Medical Imaging 1996; 6:37-39.

B. Books and/or Chapters
Xu D. and Lu X. Biochemical Laboratory Tests in Neurological Diseases. Practical Guide to Neurological Disorders: Diagnosis and Treatment. Ed. Xu D. pp361-377, 2001. Shandong Science and Technology Publisher.
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