Cholsoon Jang

picture of Cholsoon  Jang

Assistant Professor, Biological Chemistry
School of Medicine

Ph.D., Harvard University, 2015
Postdoc, Princeton University, 2020

Phone: (949) 824-6052

University of California, Irvine
Sprague Hall, Room 122
Irvine, CA 92697
Research Interests
Nutrient metabolism, Metabolic disease, Cancer metabolism
Research Abstract
My research aims to understand how dietary nutrients are metabolized by host organs and gut microbiota and contribute to health and disease. I focus on disease-associated nutrients such as branched-chain amino acids, fructose and alcohol and study their metabolic fates and inter-organ exchange in diverse physiological and pathological conditions (diabetes and cancer). To achieve this goal, I use the state-of-the-art liquid chromatography mass spectrometry (LC-MS) and stable isotope tracing in disease animal models and human patients. My technical expertise and knowledge in mass spectrometry, metabolic flux analysis, analytical chemistry, and pathophysiology will expand our understanding of the fundamental link between diets, health and disease.
Awards and Honors
2009 - 2013 LOTTE Scholarship (full stipend), LOTTE foundation, Korea
2013 - 2015 AHA Pre-doctoral Fellowship
2017 - 2019 ADA Post-doctoral Fellowship
2017.1 Selected Oral Presentation and Travel Award, Keystone Symposia – Diabetes
2017.10 Selected Oral Presentation, Cell Symposia – Metabolic disease therapies
2018.5 Best poster Award, NEBS annual conference, Boston
2018.10 Selected Oral Presentation and Travel Award, Keystone Symposia – Type II Diabetes
2018.12 Selected Oral Presentation, Cell Symposia – Metabolites as signaling molecules
2019.11 Invited Talk, NEBS monthly seminar, Boston
2020 - 2023 AASLD Pinnacle Research Award in Liver Disease
2020 - 2023 Edward Mallinckrodt Jr Foundation Grant
Short Biography
Assistant Professor at UC Irvine (2020.5-)
Postdoc in Rabinowitz lab at Princeton University (2016.6-2020.4)
PhD in Arany lab at Harvard Medical School (2009.9-2015.11)
Military Service in a biotech company (2006.3-2009.2)
BS and MS in Biological Sciences at Korea Advanced Institute of Science and Technology (KAIST) (2000.3-2006.2)
1. Jang C*, Oh SF*, Wada S, Rowe GC, Liu L, et al. (2016) A branched chain amino acid metabolite drives vascular fatty acid transport and insulin resistance. Nature Medicine 22:421-6.

2. Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, et al. (2018) The small intestine converts dietary fructose into glucose and organic acids. Cell Metabolism. 27:351-361.

3. Jang C, Li C, Rabinowitz JD. (2018) Metabolomics and isotope tracing. Cell 173:822-837. (Primer)

4. Neinast M*, Jang C*, Hui S, Murashige DS, Chu Q, et al. (2019). Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids. Cell Metabolism. 29:417-429.

5. Jang C, Hui S, Zeng X, Cowan AJ, Wang L, et al. (2019). Metabolite exchange between mammalian organs quantified in pigs. Cell Metabolism. 30:596-606.

6. Zhao S*, Jang C*, Liu J, Uehara K, Gilbert M, et al. (2020). Dietary fructose feeds hepatic lipogenesis via microbiome-derived acetate. Nature 579:586-591.

7. Jang C*,#, Wada S*, Yang S, Gosis B, Zeng X, et al. (2020) The small intestine shields the liver from fructose-induced steatosis. Nature Metabolism 2:586-593. *equal contribution, #co-correspondence.

8. Murashige D*, Jang C*, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z. (2020). Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science 370:364-368.
AASLD Pinnacle Award
Edward Mallinckrodt Jr. Award
Graduate Programs
Cellular and Molecular Biosciences

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