Jessica Shiu

picture of Jessica  Shiu

Assistant Professor, Dermatology
School of Medicine

Master of Health Science, Johns Hopkins Bloomberg School of Public Health, 2007, Biochemistry
Ph.D., University of Maryland School of Medicine, 2013, Microbiology & Immunology
M.D., University of Maryland School of Medicine, 2015

Phone: (949) 824-5515

University of California, Irvine
118 Med Surge I
Mail Code: 2400
Irvine, CA 92697
Research Interests
Vitiligo, Melanocytic nevi, Melanoma
Awards and Honors
2020 UC Irvine Institute of Clinical and Translational Science KL-2 Scholar
2019 Pan American Society for Pigment Cell Research Travel Award
2017 CalDerm Symposium Resident Symposium Presenter
2017 Society of Investigative Dermatology’s Resident Retreat
2015 Eugene Sydney Bereston Award for Excellence in Dermatology
2015 Charles L. Wisseman, Jr. Award for Excellence in Microbiology & Immunology
(University of Maryland School of Medicine)
2013 Graduate Program in Life Sciences Molecular Microbiology & Immunology program Ollie Eylar Award Winner
2011 University of Maryland GPILS Outstanding PhD Scholar Award Winner
2011 Biolegend Travel Award Recipient
2008 Medical Student Research Day Oral Presentation Winner
2008 American Gatroenterological Association Student Research Fellowship
2007 John Hopkins University Masters Scholarship
Short Biography
I am a Dermatology trained physician scientist interested in understanding tissue homeostatic mechanisms in melanocyte-related disorders in the skin. I was in the Medical Scientist Training Program at the University of Maryland School of Medicine where I completed my PhD training studying the gut immune response to Helicobacter pylori in Dr. Thomas Blanchard’s laboratory. I completed my Dermatology Residency training at UCI and Board Certification in July 2019. Currently, I am an assistant professor and the first fellow in the Physician Scientist Fellowship Track in the Department of Dermatology. I am a KL-2 scholar at the University of California Irvine Institute of Clinical and Translational Research with protected research time and funding.
1. Choi FD, Kraus CN, Elsensohn AN, Carley SK, Lehmer LM, Nguyen RT, Linden KG, Shiu J. PD-1 and PD-
L1 inhibitors in the treatment of non-melanoma skin cancer: a systematic review. J Am Acad Dermatol. 2020 Feb; 82(2):440-459.

2. Choi FD, Hosking AM, Shiu J, Bergheim T, Kassira S, de Feraudy, Barr R, Elsensohn A. (In press). Rare Malignant Melanomas with Neural Differentiation p53 Positive. Pigment Cell Melanoma Res.

3. Lee K, Pouldar D, Shiu J, Elsensohn A, de Feraudy S. The histological spectrum of Talimogene laherparepvec (TVEC) injections—neutrophilic and chronic granulomatous dermatitis. J Cutan Path. 2019 Feb;46(2):165-7

4. Hosking AM, Kraus CN, Elsensohn AN, Shiu J, de Feraudy S, Smith J. Ulcerated nodules in a sporotrichoid distribution. J Am Acad Dermatol. 2019;5(10):925-927. doi: 10.1016/j.jdcr.2019.05.020.

5. Elsensohn A, de Feraudy S. The histological spectrum of talimogene laherparepvec(TVEC) injections- Neutrophilic and chronic granulomatous dermatitis. J Cutan Pathol. 2019;46(2):165-16.

6. Yale K, Elsensohn A, Shiu J, Amber K, Smith J. Erythematous papular rash with sparing of folds. JAAD Case Rep. 2019 Jan 25;5(2):135-7.

7. Elsensohn AN, Shiu J, Grove N, Hosking AM, Barr R, de Feraudy S. Distinguishing neurofibroma from desmoplastic melanoma: the value of p53. Am J of Surg Path. 2018; 42(3):372-75.

8. Shiu J, Thai M, Elsensohn AN, Nguyen NQ, Lin KY, Cassarino DS. A case series of primary cutaneous coccidioidomycosis after a record-breaking rainy season. JAAD Case Rep. 2018; 4(5): 412-414.

9. Chiang A, Shiu J, Elsensohn AN, Chapman L, Smith J. Classic Autoimmune Type 1 Diabetes Mellitus Following a case of drug reaction with eosinophilia and systemic symptoms (DRESS). JAAD Case Rep. 2018; 4(4): 295-297.

10. Thomas LW, Elsehsohn AN, Bergheim T, Shiu J, Ganesan A. Intramuscular steroids in the treatment of dermatologic disease: a systemic review. J Drugs in Dermatol. 2018; 17(3): 323-329.

11. Elsensohn AN, Getty S, Shiu J, de Feraudy S. Intradermal proliferative fasciitis on the ear occurring with chrondrodermatitis nodularis helicis. Am J of Dermatopath. 2018; 17(3):323-29.

12. Thomas LW, Elsensohn AN, Shiu J, de Feraudy S, Segal, F. Blaschkoid hyperkeratotic plaques in a hemi- distribution since infancy. JAAD Case Rep. 2018; 4(5):412-14.

13. Pouldar, D, Elsensohn AN, Ortenzio F, Shiu J, de Feraudy, S. Nodular vasculitis in a Crohn's disease patient on vedolizumab. Am J of Dermatopath.2018; 40(2): 139-141.

14. Wang L, Ni X, Yang BY, Shiu J, Zhang X, Xi L, Covington KR, Drummond J, Donehower LA, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Duvic M. Genomic profiling of Sézary Syndrome reveals alteration of key T-cell signaling and differentiation genes. Nature Genetics. 2015; 47:1426-34.

15. Shiu J, Wang CL, Ellis RM, Duvic M. Hyper-IgE, Dermatitis and Staphylococcus aureus in an HIV-positive man. Journal of Infectious Diseases and Therapy 2015; 3(2).

16. Zawahir S, Li G, Banerjee A, Shiu J, Blanchard TG, Okogbule-Wonodi AC. Inflammatory and immune activation in intestinal myofibroblasts is developmentally regulated. J Interferon Cytokine Res. 2015 Jun 23.

17. Shiu J, Gaitens J, Squibb KS, Gucer PW, McDiarmid MA, Gaspari AA. Significance of Dermatologic Findings in a Cohort of Depleted Uranium Exposed Veterans of Iraqi Conflicts. Dermatitis 2015 May/June; 26(3):142-8.

18. Shiu J, Piazuelo BM, Ding H, Czinn S, Drakes ML, Basappa N, Banerjee A, Kobayashi KS, Fricke WF, Blanchard T. Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth. Mucosal Immunology 2015 Jan 21. doi:10.1038/mi.2014.132.

19. Shiu J, Czinn S, Kobayashi KS, Sun Y, Blanchard T.IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori. PLoS One 2013 Jun 11;8(6):e66914.

20. Ding H, Negrud JG, Blanchard TG, Zagorski BM, Li G, Shiu J, Xu J, Czinn SJ. Th1-mediated immunity against Helicobacter pylori can compensate for lack of Th17 cells and can protect mice in the absence of immunization. PLoS One 2013 Jul 11;8(7):e69384

21. Shiu J, Harberts E, Gaspari AA, Nickoloff BJ. Skin: Immunological Defense Mechanisms. (April 2013) Skin: Immunological Defence Mechanisms. In: eLS. John Wiley & Sons Ltd: Chichester

22. Shiu J, Blanchard T. Dendritic Cell Function in the Host Response to H. pylori in the Gastric Mucosa. Pathogens & Disease. 2013 Feb. 67(1): 46-53.

23. Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH. Antibacterial autophagy uccors at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPAse. Autophagy. 2011 Jan 4;7(1).

24. Shahnazari S, Yen WL, Birmingham CL, Shiu J, Namolovan A, Zheng YT, Nakayama K, Klionsky DJ, Brumell JH. A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe. 2010 Aug 18; 8 (2): 137-46.

25. Cully M, Shiu J, Muller WJ, Done S, Mak TW. TACC1 is an anti-apoptotic oncogene that promotes transformation and mammary tumorigenesis. Cancer Res. 2005 Nov 15;65(22):10363-70.

1. Shiu J, Chen JK, Smith J. Angular Cheilitis. In: Treatment of Skin Disease. M Lebwohl, W Heymann, J Berth-Jones, I Coulson eds., Elsevier, 2020

2. Shiu J, Chen JK, Smith J. Geographic Tongue. In: Treatment of Skin Disease. M Lebwohl, W Heymann, J
Berth-Jones, I Coulson eds., Elsevier

3. Amber KT, Shiu J, Ferris K, Grando SA. Role of Intravenous Immunoglobulin in Dermatologic Disorders, In: Biologic and Systemic Agents in Dermatology. PS Yamauchi ed., Springer International Publishing, 401- 423, 2018.

4. Shiu J, Gaspari AA. Toll-like Receptors, In: Clinical and Basic Immunodermatology. AA Gaspari, SK Tyring, D Kaplan eds., Springer International Publishing, 11-34, 2017.
Professional Societies
American Academy of Dermatology
Women’s Dermatologic Society
Society of Investigative Dermatology
Medical Dermatologic Society
PanAmerican Society for Pigment Cell Research
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