Mohammad Riazi Esfahani

picture of Mohammad Riazi Esfahani

HS Clinical Professor, Ophthalmology
School of Medicine

M.D., Tehran University of Medical Sciences - Tehran, Iran, 1990

Phone: For Appointments: (949) 824-2020 Academic Office:(949) 824-7944

University of California, Irvine
850 Health Sciences Rd.
Mail Code: 4375
Irvine, CA 92697
Research Interests
Retinopathy of Prematurity, Childhood Retinal Detachment, Age-Related Macular Degeneration, Diabetic Retinopathy
1. Khojasteh H, Riazi H, Khalili E, Faghihi H, Ghassemi F, Bazvand F, Mahmoudzadeh R, Salabati M, Mirghorbani M, Riazi Esfahani M. Multifocal Electroretinogram in Diabetic Macular Edema and its Correlation with Different Optical Coherence Tomography Features. Int Ophthalmol. 2020 Mar; 40: 571-581.
2. Ebrahimiadib N, Lashay A, Riazi H, Jamali S, Khodabandeh A, Zarei M, Roohipoor R, Khojasteh H, Bazvand F, Ojani M, Shahabinejad M, Yaseri M, Mojtahedi M, Davoudi S, Riazi Esfahani M. Intravitreal Ziv-Aflibercept in Patients with Diabetic Macular Edema Refractory to Intravitreal Bevacizumab. Ophthalmic Surg Lasers Imaging Retina. 2020; Vol 51: 3.
3. Salimiaghdam N, Riazi-Esfahani M, Fukuhara P, Schneider K, Kenney Cristina. Age-related Macular Degeneration (AMD): A Review on its Epidemiology and Risk Factors. The Open Ophthalmology Journal, 2019; Vol 13: 90-99.
4. Ghiam BK, Israelsen P, Wang A, Grob S, Riazi Esfahani M. Klebsiella pneumoniae endogenous endophthalmitis presenting as orbital cellulitis. GMS Ophthalmol Cases. 2019 Aug 20; 9:Doc30. doi: 10.3205/oc000119. eCollection 2019
5. Riazi Esfahani M, Kenney MC, Kuppermann BD. Mitochondrial Repair in Dry Age-Related Macular Degeneration. Retinal Physician. 2019 Apr; 48-54.
6. Karkhaneh R, Ahmadraji A, Riazi Esfahani M, et al. The Accuracy of Digital Imaging in Diagnosis of Retinopathy of Prematurity in Iran: A Pilot Study. Journal of Ophthalmic Vis Res. 2019; 14 (1): 38-41.
7. Azadi P, Khodabande A, Riazi Esfahani M, Ghassemi F, Aliabadi N. Bilateral Choroidal Osteoma associated with Langerhans Cell Histiocytosis, a Coincidense? Journal of Current Ophthalmology. 2019 Mar; 31(1): 109–112.
8. Roohipoor R, Karkhaneh R, Riazi Esfahani M, et al. Comparison of Intravitreal Bevacizumab and Laser Photocoagulation in the Treatment of Retinopathy of Prematurity. Ophthalmology Retina. 2018 Sep;2(9):942-948.
9. Karkhaneh R, Torabi H, Khodabandeh A, Roohipour R, Riazi Esfahani M, Efficacy of intravitreal bevacizumab for the treatment of zone I type 1 retinopathy of prematurity. J Ophthalmic Vis Res. 2018; 13(1): 29-33.
10. Khalilipoor E, Pourreza H, Zamani KA, Mahmoudi A, Sadeghi AM, Shadravan M, Karkhaneh R, Roohipoor R, Riazi Esfahani M. Retinopathy of prematurity-assist: Novel software for detecting plus disease. Korean J Ophthalmol. 2017 Dec; 31(6): 524–532.
11. Riazi Esfahani M, Kuppermann BD, Kenney MC. The role of Mitochondria in AMD: Current knowledge and future applications. J Ophthalmic Vis Res. 2017 Oct-Dec; 12(4):424-8.
12. Torabi H, Riazi Esfahani M, Tabatabai SA. Endophthalmitis in the tertiary referral center in Iran; Etiology and causative organisms. Hosp Pract Res. 2017 Sep;2(3):79-83.
13. Soleimannejad M, Ebrahimi-Barough S, Soleimani M, Nadri S, Tavangar SM, Tavangar SM, Roohipoor R, Yazdankhan N, Bayat M, Riazi-Esfahani M, Ai J. Fibrin gel as a scaffold for photoreceptor cells differentiation from conjunctiva mesenchymal stem cells in retina tissue engineering. Artif Cells Nanomed Biotechnol. 2017 Jul; 10:1-10.
14. Soleimannejad M, Ebrahimi-Barough S, Nadri S, Riazi-Esfahani M, et al. Retina tissue engineering by conjunctival mesenchymal stem cells encapsulated in fibrin gel: Hypotheses on novel approach to Retinal diseases treatment. Medical Hypotheses. 2017 Apr;101:75-77.
15. Riazi Esfahani M, Riazi Esfahani H, Ahmadraji A et al. Intravitreal bevacizumab alone or combined with 1 mg triamcinolone in diabetic macular edema: a randomized clinical trial. Int Ophthalmol. 2017 Mar 27.
16. Estrago Franco F, Tarek M, Riazi Esfahani M, Sapkal A, Piche-Lopez R, Patil A, Sharma A, Falatoonzadeh P, Chwa M, Luczy-Bachman G, Kuppermann B, Kenney C. Effects of benzo (e)pyrene on ROS/RNS and inflammatory cytokines induction in human RPE cells and attenuation by mitochondrial-involved mechanism. J Ophthalmic Vis Res. 2016 Oct-Dec; 11(4):385-93.
17. Roohipoor R, Sharifian E, Ghassemi F, Riazi Esfahan M, et al. Choroidal thickness changes in proliferative diabetic retinopathy treated with panretinal photocoagulation versus panretinal photocoagulation with intravitreal bevacizumab. Retina. 2016 Oct; 36(10):1997-2005.
18. EbrahimiAdib N, Roohipour R, Karkhaneh R, Farahani A, Riazi Esfahani M, et al. Internet-based versus conventional referral system for retinopathy of prematurity screening in Iran. Ophthalmic Epidemiology. 2016 Oct 6; 23(5):292-7.
19. Roohipoor R, Karkhaneh R, Farahani A, Ebrahimiadib N, Mojtahedi B, Fotouhi A, Yaseri M, Khodabande A, Zarei M, Imani M, Taheri A, Riazi Esfahani M, Loewenstein J. Retinopathy of prematurity screening criteria in Iran: new screening guideline. Arch Dis Child Fetal Neonatal Ed. 2016 Jul 12;101(4):288-93.
20. Karkhaneh R, Khodabande A, Riazi Esfahan M, et al. Efficacy of intravitreal bevacizumab for zone-II retinopathy of prematurity. Acta Ophthalmol. 2016 Sep;94(6):e417-20.
21. Karkhaneh R, Ahmadraji A, Riazi Esfahani M, et al. Complement factor H and LOC387715/ARMS2/HTRA1 variant's frequencies and phenotypic associations in neovascular age-related macular degeneration, a pilot study. J Curr Ophthalmol. 2016 March; 8(28): 32-6.
22. Roohipoor R, Karkhaneh R, Riazi Esfahani M, et al. Comparison of refractive error changes in ROP patients treated with diode and green LASER. Ophthalmologica. 2016 26; 235(3):173-8.
23. Beheshtian M, Saeerad S, Babanejad M, Mohseni M, Hashemi H, Eshghabadi A, Hajizadeh F, Akbari MR, Kahrizi K, Riazi Esfahani M, Najmabadi H. Impact of whole exome sequencing among Iranian patients with autosomal recessive RP. Arch Iran Med. 2015 Nov; 18(11):776-85.
24. Riazi Esfahani M, Khademi MR, Mazloumi M, Khodabandeh A, Riazi Esfahani H. Macular surgery using spectral domain OCT. J Ophthalmic Vis Res. 2015; 10 (3):309-15.
25. Mazaheri N, Riazi Esfahani H, Jafarzadehpoor E, Mirzajani A, Talebi H, Aminii A, Mazloumi M, Roohipoor R, Riazi Esfahani M. Multifocal ERG in diabetic macular edema; Correlation with visual acuity and OCT. J Ophthalmic Vis Res. 2015; 10(2):165-71.
26. Roohipoor R, Riazi Esfahani M, Ebrahimiadib N, et al. Predictive value of pupillary response to mydriatic agents for diagnosis of retinopathy of prematurity. J Ophthalmic Vis Res. 2015 Oct-Dec; 10(4):417-23.
27. Tamaddon L, Mostafavi SA, Karkhaneh R, Riazi Esfahani M, Rafiee-Tehrani M. Thermo-analytical characterization of clindamycin loaded implants prepared by hot melt extrusion. Adv Biomed Res. 2015; 27(4):147.
28. Riazi Esfahani M, Riazi Esfahani H, Mahmoudi A, Johari MK, Hemati K. Focal choroidal excavation in best vitteliform macular dystrophy: A case report. Journal of Clinical and Diagnostic Research. 2015 May; 9(5):ND01-ND02.
29. Tabatabaei SA, Soleimani M, Mansouri MR, Ebrahimi M, Abdi P, Riazi Esfahani M. Exogenous endophthalmitis due to ellicit drug injection in an IV drug abuser. Open J Ophthalmology. 2015; 5:155-7.
30. Varshochian R, Riazi Esfahani M, Jeddi-Tehrani M, Mahmoudi AR, Aghazadeh S. et al. Albuminated PLGA nanoparticles containing Bevacizumab intended for ocular neovascularization treatment. J Biomed Mater Res A. 2015 Oct;103(10):3148-56.
31. Tamaddon L, Mostafavi SA, Karkhaneh R, Riazi Esfahani M. Et al. Design and development of intraocular polymeric implant system for long-term controlled-release of clindamycin phosphate for toxoplasmic retinochoroiditis. Adv Biomed Res. 2015 Jan 30;4:32.
32. Piri N, Ahmadieh H, Taei R, Soheilian M, Karkhaneh R, Lashay A, Golbafian F, Yaseri M, Riazi-Esfahani M. Photodynamic therapy and intravitreal bevacizumab with vs. without triamcinolone for neovascular AMD: A randomized clinical trial. Journal of Ophthalmic and Vision Research. 2014: 9(4):469-77.
33. Maghami MH, Sodagar AM, Lashay A, Riazi H, Riazi-Esfahani M. Visual prostheses: the enabling technology to give sight to the blind. Journal of Ophthalmic and Vision Research. 2014; 9(4):494-505.
34. Tamaddon L, Mostafavi A, Riazi-Esfahani M, et al. Development, characterization, and biocompatibility evaluations of intravitreal lipid implants. Jundishapur J Nat Pharm Prod. 2014 May; (9)2:e16414.
35. Kabir FR, Fattahian HR, Riazi-Esfahani M, The protective role of silymarine on selenium induced cataract in rabbit model. Kafkas Univ Vet Fak Derg. 2014; 20(1):143-7.
36. Ghassemi F, Ghadimi H, Asadi Amoli F, Riazi Esfahani M, Diffuse infiltrating retinoblastoma coexisting with ocular toxoplasmosis. Int Ophthalmol. 2014 Feb 16; 34(1):137-40.
37. Riazi-Esfahani M, Jafarzadehpoor E, Hashemi H, Ghaffari E. Evaluation of corneal biomechanical properties following scleral buckling using ORA. Iranian Journal of Ophthalmology 2013; 5(2):151-4.
38. Varshochian R, Jeddi-Tehrani M, Mahmoudi AR, Khoshayand MR, Atyabi F, Sabzevari A, Riazi Esfahani M, Dinarvand R. The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retina and choroidal neovascularization treatments. Eur J Pharm Sci. 2013 Aug 8; 50(3-4):341-52.
39. Roohipour R, Tabassomi F, Riazi Esfahani M et al. Preliminary Efficacy of Autologous Plasmin Injection in Pediatric Vitrectomy. Iranian Journal of Ophthalmology. 2013; 25(1):53-8.
40. Tamaddon L, Mostafavi1S A, Dorkoosh F.A, Karkhaneh R, Riazi-Esfahani M, Rafiee-Tehrani M. A novel design of a biodegradable intravitreal implant for the sustained release of clindamycin. Research in Pharmaceutical Sciences, 2012;7(5):S308.
41. Ebrahimiadib N, Riazi- Esfahani M. Autofluorescence imaging for diagnosis and follow-up of cystoid macular edema. Journal of Ophthalmic & Vision Research. 2012; 7(3):261-7.
42. Noori J, Riazi-Esfahani M, Hajizadeh F, Zaferani MM. Choroidal mapping; a novel approach for evaluating choroidal thickness and volume. Journal of Ophthalmic & Vision Research. 2012; 7(2):180-5.
43. Hajizadeh F, Faghihi H, Riazi Esfahani M. Branch retinal vein occlusion as a coincident ocular sign of systemic primary CMV infection: A case report. Iranian Journal of Ophthalmology. 2012; 24(3):62-4.
44. Hodjatjalali K, Riazi M, Faghihi H, Khorami A. Ultrasound biomicroscopic study of vitreous incarceration subsequent to intravitreal injections. Can J Ophthalmol. 2012 Feb;47(1):24-7.
45. Esfahani MR, Harandi ZA, Movasat M, Nikdel M, Memantine for axonal loss of optic neuritis. Graefes Arch Clin Exp Ophthalmol. 2012 Jun; 250(6):863-9.
46. Bigdeli H, Roohipoor R, Karkhaneh R, Riazi-Esfahani, et al, structural outcome of treated retinopathy of prematurity Patients. Iranian Journal of Ophthalmology. 2012; 24(1):56-65.
47. Hajizadeh F, Riazi-Esfahani M, Faghihi H et al, Optical Coherence Tomography Findings in Highly Myopic Eyes following Cataract Surgery. Iranian Journal of Ophthalmology 2011; 23(4):49-54.
48. Faghihi H, Hajizadeh F, Riazi Esfahani M, et al. Post-traumatic endophthalmitis: Report No. 2. Retina. 2012 Jan; 32(1):146-51.
49. Ahmadieh H, Taei R, Riazi-Esfahani M, Piri N, Homayouni M, Daftarian N, Yaseri M. Intravitreal bevacizumab versus combined intravitreal bevacizumab and triamcinolone for neovascular age-related macular degeneration: six-month results of a randomized clinical trial. Retina. 2011 Oct; 31(9):1819-26.
50. Roohipoor R, Ghasemi H, Ghassemi F, Karkhaneh R, Riazi-Esfahani M, Nili-Ahmadabadi M. Intravitreal bevacizumab in retinopathy of prematurity: an interventional case series. Graefes Arch Clin Exp Ophthalmol. 2011 Sep; 249(9):1295-301.
51. Moradian S, Faghihi H, Sadeghi B, Piri N, Ahmadieh H, Soheilian M, Dehghan MH, Azarmina M, Riazi Esfahani M. Intravitreal bevacizumab vs. sham treatment in acute branch retinal vein occlusion with macular edema: results at 3 months (Report 1). Graefes Arch Clin Exp Ophthalmol. 2011 Feb;249(2):193-200.
52. Riazi-Esfahani M, Ghafari E, Alami Z. Optical coherence tomography findings in idiopathic perifoveal telangiectasia. Iranian Journal of Ophthalmology. 2011; 23(3):21-6.
53. Riazi-Esfahani M, Khakbaz M, Alami Z et al. Effects of memantine on visual functions after scleral buckling for retinal detachment. Iranian Journal of Ophthalmology. 2011; 23(2):3-10.
54. Nili M, Rooholamin FS, Riazi-Esfahani M, et al. Association of retinal vascular diameter and vascular branching angle with Diabetic Retinopathy Stage: A cross-sectional study. Iranian Journal of Ophthalmology. 2011; 23(1):21-6.
55. Riazi-Esfahani M, Alami Z, Kiumehr S et al, Memantine Treatment in Acute Nonarteritic Anterior Ischemic Optic Neuropathy: A Randomized Clinical Trial. Iranian Journal of Ophthalmology. 2011; 23(1):11-20.
56. Riazi-Esfahani M, Torabi HR, Alami Z, Zarei M. Ketoconazole in the treatment of central serous chorioretinopathy. Iranian Journal of Ophthalmology. 2010; 22(4):59-65.
57. Riazi-Esfahani M, Kohansal S, Hajizadeh F, Mahmoudi AH. enhanced depth imaging optical coherence tomography, a new method in diagnosis and evaluation for choroidal hemangioma: A case report. Iranian Journal of Ophthalmology. 2010; 22(3):47-52.
58. Nili Ahmadabadi M, Azaripour E, Movasat M, Karkhaneh R, Riazi-Esfahani M, et al. Ultrasound biomicroscopy of conventional and sutureless (23, 25 Gauge) sclerotomy sites after Pars Plana vitrectomy. Iranian Journal of Ophthalmology 2010; 22(3) :17-22.
59. Mousavi SZ, Karkhaneh R, Riazi-Esfahani M, et al. Screening for retinopathy of prematurity. The role of educating the parents. Iranian Journal of Ophthalmology 2010; 22(2):13-8.
60. Mousavi SZ, Riazi-Esfahani M, Karkhaneh R. et al. characteristics of advanced stages of retinopathy of prematurity. Iranian Journal of Ophthalmology 2010; 22(2):19-24.
61. Roohipoor R, Riazi-Esfahani M, Karkhaneh R. et al. Anatomical outcome of 25-gauge vitrectomy associated with scleral buckling in Stage 5 retinopathy of prematurity : A case series study. Iranian Journal of Ophthalmology 2010; 22(2):25-31.
62. Faghihi H, Riazi-Esfahani M, Aalami Z, Madani Sh. Intravitreal bevacizumab vs. combination of bevacizumab plus macular photocoagulation in clinically significant macular edema: 6 months results of a randomized clinical trial. Iranian Journal of Ophthalmology 2010; 22(1):21-6.
63. Faghihi H, Hajizadeh F, Riazi-Esfahani M. Optical coherence tomography findings in highly myopic eyes. Journal of Ophthalmic & Vision Research 2010; 5 (2):110-21.
64. Nili Ahmadabadi M, Karkhaneh R, Mirshahi A, Lashay R, Alami Z, Roohipoor R, Riazi-Esfahani M. etal. Premacular hemorrhage in valsalva retinopathy: A Study of 21 Cases. Iranian Journal of Ophthalmology 2009; 3(21):11-6.
65. Roohipoor R. Karkhaneh R. Riazi-Esfahani M. Ghasemi F. Nili-Ahmadabadi M. Surgical management in advanced stages of retinopathy of prematurity; our experience. Journal of Ophthalmic & Vision Research. 2009; 4 (3):185- 90.
66. Hashemian MN, Moghimi S, Kiumehr S, Riazi M, Amoli FA. Prevention and treatment of corneal neovascularization: Comparison of different doses of subconjunctival Bevacizumab with corticosteroid in experimental rats. Ophthalmic Res. 2009: June 18; 42(2):90-5.
67. Lashay AR, Behnia M, Karkhaneh R, Mirshahi A, Riazi-Esfahani M. et al. Surgical outcomes of complicated retinal detachment using heavy silicone oil as an internal tamponade. Iranian Journal of Ophthalmology; 2009; 21(3):25-30.
68. Riazi-Esfahani M, Behnia M, Faghihi H, Aalami Z, Karkhaneh R. et al. Pars plana vitrectomy for retinal detachments associated with chorioretinal coloboma. Iranian Journal of Ophthalmology; 2009; 21(2):36-40.
69. Mousavi SZ, Karkhaneh R, Riazi-Esfahani M, et al. ROP in infants with late retinal examination. Journal of Ophthalmic & Vision Research 2009; 4(1):24-8.
70. Riazi-Esfahani M, Asghari H, Piri N. Advanced proliferative diabetic retinopathy in four young patients with flexion contractures (Rosenbloom syndrome). Int Ophthalmol. 2009; 29:261-5.
71. Riazi-Esfahani M, Kiumehr S, Asadi-Amoli F, Dehpour AR. Effects of intravitreal morphine at different time points after reperfusion in a rabbit model of ischemic retinopathy. Retina. 2009 Feb;29(2):262-8.

Professional Societies:

2017 Association for Research in Vision and Ophthalmology
2013- Present American Society of Retinal Specialists (ASRS)
2008- 2009 European Vitreoretinal Society (EVRS)
2003- Present American Academy of Ophthalmology (AAO)
2003-2004 Association for Research in Vision and Ophthalmology
1993-present Iranian Society of Ophthalmology (IrSO)
1990-Present Iranian Medical Council Organization
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