Assistant Professor, Developmental & Cell Biology
School of Biological Sciences
Ph.D., University of Texas at Austin, 2010
M.S., Yonsei University, 2003
B.S., Yonsei University, 2000
Phone: (949) 824-3086
University of California, Irvine
4111 Natural Sciences II
Mail Code: 2300
Irvine, CA 92697
Airineme-mediated intercellular communication, airinemes, cytonemes, macrophages, zebrafish
2017-2018 Dept. of Biology, University of Virginia, Charlottesville, VA, USA
2011-2017 Dept. of Biology, University of Washington, Seattle, WA, USA
Long distance communication between cells is essential for development and homeostasis. Such signaling depends on the diffusion of secreted factors, yet additional modes of communication have been uncovered including direct contacts between cells mediated by long, specialized filopodia. We found that stripes in zebrafish require a novel class of thin, fast projection with vesicles at their tips named “airinemes” that contribute to transducing a Delta-Notch signal over long distances from precursor cells of yellow-orange xanthophores to target melanophores. Interestingly, pigment cells are not the only cell type that extends airinemes. We have found them from many other cell types.
Also, we show that macrophages play critical role in airineme-mediated signaling by relaying the airineme vesicles to the target cells. Our study reveals a novel mechanism of cellular communication and, suggest airinemes are widely used in various tissues during normal development and disease.
1. Eom DS, Parichy DM. (2017) A macrophage relay for long distance signaling during post-embryonic tissue remodeling. Science 355(6331):1317-1320.
2. Eom DS, Bain EJ, Patterson LB, Grout M, Parichy DM. (2015) Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLife 10.7554/eLife.12401.
3. McMenamin SK, Bain EJ, McCann AE, Patterson LB, Eom DS, Waller ZP, Hamill JC, Kuhlman JA, Eisen JS, Parichy DM. (2014) Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science 345(6202):1358-1361.
4. Eom DS, Amarnath S, Agarwala S. (2013) Apicobasal polarity and neural tube closure. Dev Growth Differ. 55(1):164-172.
5. Eom DS*, Inoue S*, Patterson LB, Gordon TN, Slingwine R, Kondo S, Watanabe M, Parichy DM. (2012) Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule, igsf11. PLoS Genet. 8(8) e1002899 (*co-first author)
6. Eom DS, Amarnath S, Fogel LJ, Agarwala S. (2012) The dynamic regulation of neural tube closure by bone morphogenetic proteins. Birth Defects Res A Clin Mol Teratol. 94(10):804-816.
7. Brown CY, Eom DS, Amarnath S, Agarwala S. (2012) In vivo electroporation of E1 chick embryos. Cold Spring Harb Protoc. 2012(8).
8. Brown CY*, Eom DS*, Amarnath S, Agarwala S. (2012) A simple technique for early in vivo electroporation of chick embryos. Dev Dyn (241) 545-552. (*co-first author)
9. Eom DS, Smita A, Fogel LJ, Agarwala S. (2011) Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway. Development (138) 3179-3188.
10. Eom DS*, Choi WS*, Ji S, Cho JW, Oh YJ. (2005) Activation of c-Jun N-terminal kinase is required for neurite outgrowth in dopaminergic neurons. NeuroReport 16(8):823-828. (*co-first author)
11. Choi WS, Eom DS, Kim WK, Han BS, Oh TH, Markelonis GJ and Oh YJ. (2004) Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8 and -9-mediated apoptotic pathways in dopaminergic neurons. J Biol Chem. 279(19):20451-20460.
12. Eom DS, Choi WS, and Oh YJ. (2004) Bcl-2 enhances neurite extension via activation of c-Jun N-terminal Kinase. Biochem Biophys Res Commun. 314(2):377-381.
13. Kim JE, Han BS, Choi WS, Eom DS, Lee EH, Oh TH, Markelonis GJ, Saido TC, Lee GE, Chung IK and Oh YJ. (2001) Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death : role of antiapoptotic protein Bcl-X(L). J Neurosci Res. 66(6):1074-1082.
Cellular and Molecular Biosciences