Assistant Professor, Pediatric Neurology, Pediatrics
School of Medicine
Joint Faculty, Physiology & Biophysics
School of Medicine
Joint Faculty, Anatomy & Neurobiology
School of Medicine
Joint Faculty, Neurobiology and Behavior
School of Biological Sciences
M.D., University of California, Irvine School of Medicine, 2012
Ph.D., University of California, Irvine, 2010
Child Neurology Residency, Lucile Packard Children's Hospital - Stanford Hospitals and Clinics, 2017
Phone: (949) 824-0570
University of California, Irvine
Med Sci 1, C237
Mail Code: 4475
Irvine, CA 92697
early-life exercise, epigenetics, neurology, learning and memory, developmental disorders
The Ivy Lab uses mouse models to study how early-life exercise can influence the development of cognitive functions.
*Ivy AS, Yu T, Kramar E, Parievsky S, Sohn F, Vu T. “A Unique Mouse Model of Early-Life Exercise Enables Hippocampal Memory and Synaptic Plasticity.” www.nature.com/articles/s41598-020-66116-4. Scientific Reports, May 2020
Short AK, Maras PM, Pham AL, Ivy AS, Baram TZ. “Blocking CRH receptors in adults mitigates age-related memory impairments provoked by early-life adversity.” Neuropsychopharm 2020 Feb; 45(3):515-523.
Johnstone DL, Al-Shekaili HH, Tarailo-Graovac M, Wolf NI, Ivy AS, et al. “PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights.” Brain. 2019 Mar 1;142(3):542-559.
Bolton JL, Molet J, Ivy AS, Baram TZ. "New insights into early-life stress and behavioral outcomes." Curr Opin Behav Sci. 2017 Apr;14:133-139
Ivy AS, Clark C, Baum S, Wusthoff C. "Improving the Identification of Neonatal Encephalopathy: Utility of a Web-Based Video Tool" Am. Journal Perinat. 2017 Apr;34(5):520-522
Molet J, Maras PM, Kinney-Lang E, Harris NG, Rashid F, Ivy AS, Solodkin A, Obenaus A, Baram TZ. “MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity.” Hippocampus 2016 Dec 26(12); 1618-1632.
Dube CM, Molet J, Singh-Taylor A, Ivy AS, Maras PM, Baram TZ. “Hyperexcitability and epilepsy generated by chronic early-life stress.” Neurobiol Stress 2015; 2:10-19.
McClelland S, Korosi A, Cope J, Ivy AS, Baram TZ. “Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory.” Neurobiol Learn Mem. 2011 Jul;96(1):79-88.
Ivy AS, Rex CS, Chen Y, Dubé C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ. “Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors.” J Neurosci. 2010 Sep 29;30(39):13005-15.
Ivy AS, Brunson KL, Sandman C, Baram TZ. “Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress.” Neurosci 2008 April 19; (154):1132-1142.
Chen MJ, Ivy AS, Russo-Neustadt AA. “Nitric Oxide synthesis is required for exercise-induced increases in hippocampal BDNF and phophatidylinositol 3’ kinase expression.” Brain Res Bull 2006 Jan 15; 68(4):257-68.
Russo-Neustadt AA, Alejandre H, Garcia C, Ivy AS, Chen MJ. “Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise.” Neuropsychopharm 2004 Dec 2; 9(12):2189-99.
Ivy AS, Rodriguez FG, Garcia C, Chen MJ, Russo-Neustadt AA. “Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant.” Pharm Biochem Behav. 2003 April; 75(1):81-85.
NIH-NINDS Child Neurologist Career Development Program (CNCDP-K12), Hugo W. Moser Research Institute at Kennedy Krieger (2017-2020)
Robert Wood Johnson Foundation- Amos Medical Faculty Development Program (Career Development Award; 2020-2024)
Conte Center @ UCI Seed Grant
UCI Institute for Clinical and Translational Sciences Pilot Project Award
Children's Hospital Orange County CSO Pilot Projects Grant
Child Neurology Foundation PERF Elterman Research Award
Child Neurology Society
American Academy of Neurology
Society for Neuroscience
American Board of Psychiatry and Neurology, special qualification in Child Neurology 2017
Child Neurology (N)
UCI Pediatric Exercise Research Center (UCI-PERC)
UCI Center for the Neurobiology of Learning and Memory