Fabio Cappuccini

picture of Fabio  Cappuccini

Clinical Professor, Obstetrics & Gynecology
School of Medicine


Fellowship, University of California, Irvine, CA, 2002, Gynecologic Oncology
Residency, University of California, Irvine, CA, 1998, Obstetrics and Gynecology
Residency, University of Bologna, Italy, 1990, Obstetrics and Gynecology
Undergraduate and Graduate Doctor of Medicine, University of Bologna School of Medicine and Surgery, 1985

Phone: (714) 456-7971
Email: fcappucc@uci.edu

University of California, Irvine
333 City Boulevard West
Suite 1400
Mail Code: 3200
Orange, CA 92868
Research Interests
Early immunotherapy research for ovarian cancer and the treatment pathways of cervical cancer
URLs
Appointments
CURRENT APPOINTMENTS

Clinical Professor
Division of Gynecologic Oncology
Department of Obstetrics & Gynecology
University of California, Irvine
2017 - Present

Director, Gynecologic Oncology, Todd Cancer Institute
Long Beach Memorial Medical Center
Long Beach, CA
2019 - present

PREVIOUS APPOINTMENTS

Physician of Gynecologic Oncology
Compass Oncology
Portland, OR
2015-2017

Adjunct Professor
Department of Obstetrics & Gynecology
Division of Gynecologic Oncology
Oregon Health and Science University
Portland, OR
2008-2017

Chief of Gynecologic Oncology Division
Department of Obstetrics & Gynecology
Kaiser Permanente Northwest
Portland, OR
2003-2015

Assistant Professor
Chief of the Division of Gynecologic Oncology
Department of Obstetrics & Gynecology
Oregon Health Sciences University
Portland, OR
2002-2008

Chief of the Gynecologic Chemotherapy Infusion Center
Oregon Health Sciences University
Portland, OR
2002-2008
Publications
BOOKS
TRANSLATION: DiSaia PJ, Creasman WT. Clin Gyn Oncol, Fourth Edition, Mosby 1993. Translated to Italian, Utet, Turin, 199.

BOOK CHAPTERS, PEER REVIEWED
1. Bulletti C, Jasonni VM, Cappuccini F, Ciotti P, Fuschini G, Flamigni C. Extraction of 17-ß estradiol from normal and abnormal endometrium. In: Castagnetta L, Nenci I, eds. Biology and Biochemistry of Normal and Cancer Cell Growth. London: Harwood Academic Publisher, 1988.

2. Bulletti C, Jasonni VM, Cappuccini F, Di Cosmo E, Polli V, Flamigni C. Differential permeability of human endometrium to ovarian steroids. In: Gennazzani AR, Petraglia F, Volpe A, Facchinetti F, eds. Advances in Gynecological Endocrinology. New York: The Parthenon Publishing Group, 1988.

3. Flamigni C, Jasonni VM, Bulletti C, Cappuccini F, Ciotti P. Valutazione del trasporto degli estrogeni dal lume vascolare ai tessuti bersaglio, con l'applicazione di un modello per la perfusione extracorporea dell'utero umano. In: Massi GB, Scarselli G, eds. Attualita' di Oncologia Ginecologica, Edizioni Riviste Scientifiche, 1988.

4. Jasonni VM, Bulletti C, Naldi S, Cappuccini F, Flamigni C. Pain and Danazol. In: Gennazzani AR, Nappi G, Facchinetti F, Martignoni E, eds. Pain and Reproduction. New York: The Parthenon Publishing Group, 1988.

5. Jasonni VM, Bulletti C, Naldi S, Di Cosmo E, Cappuccini F, Fuschini G. Benefici della contraccezione in premenopausa. Terza eta' deIla donna. In: Zicchella L, Valente M, eds. Prevenzione e Terapia del Climaterio. Monduzzi Publisher, 1989.

6. Granger GA, Gatanaga T, Yamamoto RS, Abe Y, Grosen EA, Cappuccini F, Jeffes EWB, Jakowatz J, DiSaia PJ. Studies on the action of human TNFILT and their blocking factors in cancer patients. In: Mantovani G, Bonavida B, Del Giacco GS, Granger GA, Kirkwood JM, eds. New Frontiers in the Therapy of Malignancies: From Biological Approaches to Clinical Trial. Areas-Serano Symposia Publisher, 1991.

7. Granger GA, Yamaumoto RS, Gatanaga T, Cappuccini F, Jeffes EWB, Jakowatz J. Lymphotoxin, macrophage toxins, tumor necrosis factor and cachectin. In: Osawa T, Bonavida B, eds. Tumor Necrosis Factor: Structure Function Relationship and Clinical Application. Switzerland: Karger, Basel, 1991.

JOURNAL ARTICLES, PEER REVIEWED
1. Jasormi VM, Bulletti C, Bonavia M, Franceschetti F, Ciotti P, Bolelli GF, La Marca L, Cappuccini F, Flamigni C. Metabolismo dell'estrone solfato nelle donne in post-menopausa. Fisiopatologia della Riproduzione 1:53-56, 1983.

2. Bulletti C, Jasom1i VM, Franceschetti F, Bolelli GF, Bonavia M, Ciotti P, Cappuccini F, Flamigni C. Estrone solfato ed adenocarcinoma dell'endometrio. Oncologia Ginecologica 2:29- 35, 1983.

3. Bulletti C, Jasonni VM, Naldi S, Tabanelli S, Cappuccini F, Fuschini G, Flamigni C. Riduzione della conversione de] deidroepiandrosterone in estrogeni nella condizione di ipogonadismo ipogonadotropo. Fisiopatologia della Riproduzione 3:165-169, 1986.

4. Jasonni VM, Bulletti C, Cappuccini F, Fuschini G, Naldi S, Borini A, Flamigni C. La veralipride nel trattamento degli hot flushes; valutazione durante e dopa il trattamento. Giomale Italiano di Ostetricia e Ginecologia 10:733-738, 1988.

5. Bulletti C, Jasonni VM, Tabanelli S, Ciotti P, Cappuccini F, Borini A, Flamigni C. Increased extraction of estrogens in human endometrial hyperplasia and carcinoma. Cancer Detect Prev. 1998; 13(2):123-130. PMID: 3242821

6. Ciotti PM, Jasonni VM, Bulletti C, Cappuccini F, Bolelli G. Evaluation of fractional distribution of estradiol and estrone by centrifugal ultrafiltration-dialysis. Steroids. 1988;52(4):425-426. PMID: 3250045

7. Gatanaga T, Hwang CD, Kohr W, Cappuccini F, Lucci JA 3rd, Jeffes EW, Lentz R, Tomich J, Yamamoto RS, Granger GA. Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients. Proc Natl Acad Sci USA 1990 Nov;87(22):8781-4. PMCID: PMC55043

8. Dett CA, Gatanaga M, lninns EK, Cappuccini F, Yamamoto RS, Granger GA, Gatanaga T. Enhancement of lymphokine-activated T killer cell tumor necrosis factor receptor mRNA transcription, tumor necrosis factor receptor membrane expression, and tumor necrosis factor/lymphotoxin release by IL-1ß, IL-4, and IL-6 in vitro. J Immunol 1991 Mar 1;146(5):1522-6. PMID: 1847164

9. Jasonni VM, Bulletti C, Naldi S, DiCosmo E, Cappuccini F, Flamigni C. Treatment of hirsutism by an association of oral cyproterone acetate and transdermal 17-ß estradiol. Fertil Steril. 1991 Apr;55(4):742-5. PMID: 1826278

10. Bullctti C, Jasonni VM, Polli V, Cappuccini F, Galassi A, Flamigni C. Basement membrane in human endometrium: possible role of proteolytic enzymes in developing hyperplasia and carcinoma. Annals N Y Acad Sci. 1991;622:376-382. PMID: 1648321

11. Cappuccini F, Yamamoto RS, DiSaia PJ, Grosen EA, Gatanaga M, Lucci JA, Ininns EK, Gatanaga T, Granger GA. Identification of tumor necrosis factor and lymphotoxin blocking factor(s) in the ascites of patients with advanced and recurrent ovarian cancer. Lymphokine Cytokine Res. 1991 Jun;10(3):225-9. PMID: 1653048

12. Gatanaga T, Hwang CD, Gatanaga M, Cappuccini F, Yamamoto RS, Granger GA. The regulation of TNF receptor mRNA synthesis, membrane expression, and release by PMA- and LPS­stimulated human monocytic THP-1 cells in vitro. Cell Immunol. 1991 Nov;138(1):1-10. PMID: 1655285

13. Ininns EK, Gatanaga M, Cappuccini F, Dett CA, Yamamoto RS, Granger GA, Gatanaga T. Growth of the endometrial adenocarcinoma cell line AN3 CA is modulated by tumor necrosis factor and its receptor is up-regulated by estrogen in vitro. Endocrinology. 1992 Apr;130(4):1852-6. PMID: 1312427

14. Lucci JA 3rd, Manetta A, Cappuccini F, lninns EK, Dett CA, DiSaia P, Yamamoto RS, Bennan ML, Soopikian J, Granger GA. Immunotherapy of ovarian cancer. II. In vitro generation and characterization of lymphokine-activated killer T cells from the peripheral blood of recurrent ovarian cancer patients. Gynecol Oncol. 1992 May;45(2):129-35. PMID: 1592279

15. Cappuccini F, Lucci JA 3rd, Dett CA, Gatanaga M, Ininns EK, Gatanaga T, Yamamoto RS, Manetta A, DiSaia PJ, Granger GA. Trafficking of synergic murine lymphokine activated killer T cells following intraperitoneal administration in normal and tumor bearing mice. Gynecol Oncol. 1992 Aug;46(2):163-9. PMID: 1500017

16. DiSaia PJ, Dorion GE, Cappuccini F, Carpenter PM. Case report. A report of two cases of recurrent Paget's disease of the vulva in a split-thickness graft and its possible pathogenesis-labeled "retrodissemination". Gynecol Oncol 1995 Apr;57(1): 109-12. PMID: 7705692

17. Cappuccini F, Tewari K, Rogers LW, DiSaia PJ. Extramammary Paget's disease of the vulva: metastases to the bone marrow in the absence of an underlying adenocarcinoma - Case report and literature review. Gynecol Oncol. 1997 Jul;66(1):146-50. PMID: 9234936

18. Tewari K, Brewer C, Cappuccini F, Macri C, Rogers LW, Berman ML. Advanced-stage small cell carcinoma of the ovary in pregnancy: long term survival after surgical debulking and multi­ agent chemotherapy. Case report. Gynecol Oncol. 1997 Sep;66(3):531-4. PMID: 9299272

19. Tewari K, Cappuccini F, Gambino A, Kohler M, Pecorelli S, DiSaia PJ. Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma in pregnancy. Cancer. 1998 Apr 15;82(8):1529-34. PMID: 9554531

20. Cappuccini F, Tewari K, Fuller P, Pindur A, DiSaia PJ. Aggressive clinical behavior of a rare uterine sarcoma. Case report. Gynecol Oncol. 1998 Jul;70(1):147-151, 1998. PMID: 9698494

21. Tewari K, Cappuccini F, Balderston KD, Rose GS, Porto M, Berman ML. Pregnancy in a Jehovah's Witness with cervical cancer and anemia. Gynecol Oncol. 1998 Nov;71(2):330-2. PMID: 9826482

22. Tewari K, Cappuccini F, Syed AM, DiSaia PJ, Berman ML, Manetta A, Monk BJ. Interstitial brachythearpy in the treatment of advanced and recurrent vulvar cancer. Am J Obstet Gynecol. 1999 Jul;181(1):91-8. PMID: 10411801

23. Tewari K, Cappuccini F, Rosen RB, Rosenthal J, Asrat T , Kohler MF. Relapse of acute lymphoblastic leukemia in pregnancy: Survival following chemoirradation and autologous transfer of interleukin-2 activated stem cells. Gynecol Oncol. 1999 Jul;74(1):143-6. PMID: 10385569

24. Tewari K, Cappuccini F, Brewster WR, DiSaia PJ, Berman ML, Manetta A Syed, AMN, Kohler MF. Interstitial brachytherapy for vaginal recurrences of endometrial cancer. Gynecol Oncol. 1999 Sep;74(3):416-22. PMID: 10479502

25. Tewari K, Cappuccini F, DiSaia PJ, Berman ML, Manetta A, Kohler MF. Malignant germ cell tumors of the ovary. Obstet Gynecol. 2000 Jan;95(1):128-33. PMID: 10636515

26. Tewari KS, Cappuccini F, Asrat T, Flamm BL, Carpenter SE, DiSaia PJ, Quilligan EJ. Obstetrical emergencies precipitated by malignant brain tumors. Am J Obstet Gynecol. 2000 May;182(5):1215-21. PMID: 10819861

27. Tewari KS, Cappuccini F, Puthawala AA, Kuo JV, Burger RA, Monk BJ, Manetta A, Berman ML, DiSaia PJ, Nisar AM. Primary invasive carcinoma of the vagina: Treatment with interstitial brachytherapy. Cancer. 2001 Feb;91(4):758-70. PMID: 11241244

28. Loizzi V, Cappuccini F, Berman ML. An unusual presentation of struma ovarii mimicking a malignant process. Obstet Gynecol. 2002 Nov;100(5 Pt 2):1111-2. PMID: 12423825

29. Loizzi V, Chan J, Osann K, Cappuccini F, DiSaia P, Berman ML. The Efficacy of Individualized Chemotherapy Selected by In Vitro Drug Resistance Testing for Women with Recurrence Epithelial Ovarian Cancer. Am J Ob/Gyn 2003, June 166-172.

30. Loizzi V, Cormio G, Loverro G, Selvaggi L, Disaia PJ, Cappuccini F. Chemoradiation: A new approach for the treatment of cervical cancer. Int J Gynecol Cancer. 2003 Sep-Oct;13(5):580-6. PMID: 14675339

31. Loizzi V, Chan JK, Osann K, Cappuccini F, DiSaia PJ, Berman ML. Survival outcomes in patients with recurrent ovarian cancer who were treated with chemoresistance assay-guided chemotherapy. Am J Obstet Gynecol. 2003 Nov;189(5):1301-7. PMID: 14634558

32. Cappuccini F, Petty W, Cain J. Palliative care: a critical component of care for women. Current Obstetrics & Gynecology. 2003 13(3):166-72.

33. Pejovic T, Yates JE, Liu HY, Hays LE, Akkari Y, Torimaru Y, Keeble W, Rathbun RK, Rodgers WH, Bale AE, Ameziane N, Zwaan CM, Errami A, Thuillier P, Cappuccini F, Olson SB, Cain JM, Bagby GC Jr. Cytogenetic Instability in ovarian epithelial cells from women at risk of ovarian cancer. Cancer Res. 2006 Sep 15;66(18):9017-25. PMID: 16983743

34. Calkins A, Stehman FB, Bundy B, Bendas JA, Mannel RS, Seago P, Cappuccini F, Alvarez RD, Monk BJ, Maiman M. Human immunodeficendy virus testing in patients with invasive cervical carcinoma: a prospective trial of the gynecologic oncology group. Intl J Gynecol Cancer. 2006 Mar-Apr;16(2):660-3. PMID: 16681743

35. Hauser A, Cappuccini F, Cain J, Rodgers W, Pejovic T (2004): Neuroendocrine tumors of the female genital tract: a case series and review of the literature. European Journal of Oncology, submitted

36. Pejovic T, Pande N, Mori M, Mhawech-Fauceglia P, Harrington C, Mogoue-Tchokote S, Dim D, Andrews C, Beck A, Tarumi Y, Djilas J, Cappuccini F, Caballero O, Huang J, Levy S, Tsiamouri A, Cain J, Bagby G, Strausberg R, Simpson A, Odunsi K. Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes. Transl Oncol. 2009 Dec;2(4): 341-9. PMCID: PMC2781076
Professional Societies
Fellow, American Congress of Obstetricians and Gynecologists
Fellow, American College of Surgeons
International Gynecologic Cancer Society
Society of Gynecologic Oncology
Other Experience
Last updated
07/16/2021