Selma Masri

Assistant Professor, Biological Chemistry, Center for Epigenetics and Metabolism
School of Medicine

Ph.D., Beckman Research Institute of the City of Hope, 2009, Cancer Biology

Phone: (949) 824-3855

University of California, Irvine
Sprague Hall 328
Mail Code: 1700
Irvine, CA 92697

picture of Selma  Masri

Cancer Biology, Circadian Rhythms, Epigenetics and Metabolism
Research in the Masri lab is aimed at understanding the relationship between disruption of circadian rhythms and tumorigenesis. We are interested in two research questions. The first question relates to how genetic disruption of the circadian clock in mouse models alters tumorigenesis both at the level of initiation and disease progression. The second question is aimed at elucidating the systemic crosstalk between tumors and peripheral tissues and how cancer cells are able to rewire circadian metabolism at a distance. The Masri lab utilizes genetic mouse models, basic molecular and cell biology, as well as genome-wide ‘omics’ approaches to determine changes in gene expression programs, histone modifications, and alterations in metabolites using metabolomics.
Publications Selected Publications:

**Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell. 2016 May 5;165(4):896-909.

** Previews in Science, Cell Metabolism and Nature Reviews Cancer

Masri S. Sirtuin-dependent clock control: new advances in metabolism, aging and cancer. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):521-7.

Masri S, Kinouchi K, Sassone-Corsi P. Circadian clocks, epigenetics, and cancer. Curr Opin Oncol. 2015 Jan;27(1):50-6.

Masri S and Sassone-Corsi P. Sirtuins and the circadian clock: Bridging chromatin and metabolism. Sci Signaling. 2014 Sep 9; 7(342).

***Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014 Jul 31;158(3):659-72.

*** Highlighted in Science

Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A and Sassone-Corsi P. Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. 

Masri S and Sassone-Corsi P. The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci. 2013 Jan;14(1):69-75. 

Masri S and Sassone-Corsi P. Plasticity and Specificity of the Circadian Epigenome. Nature Neuroscience. 2010 Nov;13(11):1324-9.

Masri S, Phung S, Wang X, Wu X, Yuan Y, Wagman L and Chen S. Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant and long-term estrogen deprived cells reveals a role for estrogen receptor. Cancer Res. 2008 Jun 15;68(12):4910-8.
Grant K22 Transition Career Development Award - NIH/NCI
Graduate Programs Cellular and Molecular Biosciences

Research Centers Center for Epigenetics and Metabolism
Chao Family Comprehensive Cancer Center
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Last updated 10/20/2017