Kei M Igarashi

picture of Kei M Igarashi

Assistant Professor, Anatomy & Neurobiology
School of Medicine


Ph.D., University of Tokyo, 2007
B.S., University of Tokyo, 2001

Phone: (949) 824-4673
Email: kei.igarashi@uci.edu

University of California, Irvine
Irvine Hall 112
Mail Code: 3950
Irvine, CA 92697
Research Interests
memory, olfaction, Alzherimer's disease, hippocampus, entorhinal cortex
URLs
Appointments
2009 - 2015 Postdoc/Research Associate
Edvard and May-Britt Moser lab
Norwegian University of Science and Technology, Trondheim, Norway

2007- 2009 Postdoc
Kensaku Mori lab, Univ of Tokyo
Research Abstract
The Igarashi laboratory at University of California Irvine investigates:

(i) circuit mechanisms for associative memory in entorhinal cortex and hippocampus, and
(ii) how these mechanisms in the memory circuit are affected and can be manipulated to restore memory in Alzheimer’s disease models.

To this end, we use in vivo tetrode/silicon probe recordings from behaving mice, optogenetics, memory behavioral tasks, and single-cell anatomy.
Awards and Honors
2019 BrightFocus Foundation Alzheimer’s Disease Award
2019 New Vision Scholar on Alzheimer’s Disease Research, New Vision Research Foundation
2018 Ando Momofuku Award, Ando Foundation
2017 Mishima Kaiun Prize, Mishima Kaiun Memorial Foundation
2017 Fay/Frank Seed Award, Brain Research Foundation
2016 PRESTO Career Development Award, Japan Science and Technology Agency
2015 Excellence in Teaching Award, Norwegian University of Science and Technology
2014 Young Investigator Award, Japan Neuroscience Society
2013 Research Grant, Mishima Kaiun Memorial Foundation
2012 Norwegian Research Council Post-doctoral Fellowship
2007 – 2009 Post-doctoral Fellowship, Japan Society for the Promotion of Science
2004 – 2007 Graduate Fellowship, Japan Society for the Promotion of Science
Publications
Original Research Articles

13. Jun H, Bramian A, Soma S, Saito T, Saido TC, Igarashi KM (2020)
Disrupted place cell remapping and impaired grid cells in a knockin model of Alzheimer’s disease
Neuron, 107:1-18

12. Cavarretta F, Burton SD, Igarashi KM, Shepherd GM, Hines ML, Migliore M (2018)
Parallel odor processing by mitral and middle tufted cells in the olfactory bulb
Scientific Reports. 8:7625

11. Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM* (2017)
Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model
Frontiers in Systems Neuroscience, 11:48

10. Watanabe H, Rajagopalan UM, Nakamichi Y, Igarashi KM, Kadono H, Tanifuji M. (2016)
Functional optical coherence tomography of rat olfactory bulb with periodic odor stimulation.
Biomed Opt Express. 7:841-5

9. Lu L, Igarashi KM, Witter MP, Moser EI, Moser MB (2015)
Topography of Place Maps along the CA3-to-CA2 Axis of the Hippocampus.
Neuron. 87:1078-92

8. Igarashi KM*, Lu L, Colgin LL, Moser MB, Moser EI* (2014)
Coordination of entorhinal-hippocampal ensemble activity during associative learning.
Nature. 510: 143-7 (*Co-corresponding authors)

7. Igarashi KM*, Ieki N, An M, Yamaguchi Y, Nagayama S, Kobayakawa K, Kobayakawa R, Tanifuji M, Sakano H, Chen WR, Mori K* (2012)
Parallel mitral and tufted cell pathways route distinct odor information to different targets in the
olfactory cortex.
Journal of Neuroscience. 32:7970-85 (*Co-corresponding authors)

6. Mitsui S, Igarashi KM, Mori K and Yoshihara Y (2011)
Genetic visualization of the secondary olfactory pathway in Tbx21 transgenic mice.
Neural Systems & Circuits. 1:5

5. Watanabe H, Rajagopalan UM, Nakamichi Y, Igarashi KM, Kadono H, Tanifuji M (2011)
Swept source optical coherence tomography as a tool for real time visualization and localization of electrodes used in electrophysiological studies of brain in vivo.
Biomedical Optics Express. 2:3129-3134

4. Watanabe H, Rajagopalan UM, Nakamichi Y, Igarashi KM, Madjarova VD, Kadono H, Tanifuji M (2011)
In vivo layer visualization of rat olfactory bulb by a swept source optical coherence tomography and its confirmation through electrocoagulation and anatomy.
Biomedical Optics Express. 2:2279-2287

3. Tsuboi A, Imai T, Kato HK, Matsumoto H, Igarashi KM, Suzuki M, Mori K, Sakano H (2011)
Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes respond
differently to phenyl ethers.
European Journal of Neuroscience. 33:205-13

2. Nagayama S, Enerva A, Fletcher ML, Masurkar AV, Igarashi KM, Mori K, Chen WR (2010)
Differential axonal projection of mitral and tufted cells in the mouse main olfactory system.
Frontiers in Neural Circuits. 4. Pii120

1. Igarashi KM, Mori K (2005)
Spatial representation of hydrocarbon odorants in the ventrolateral zones of the rat olfactory bulb.
Journal of Neurophysiology. 93:1007-1019

Review articles
7. Nakazono T, Jun H, Blurton-Jones, M, Green KN, Igarashi KM (2018)
Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia
Neurosci Res, 129:40-46

6. Igarashi KM* (2016)
Entorhinal map of space
Brain Research, 1637:177-87 (*Corresponding author)

5. Igarashi KM* (2015)
Plasticity in oscillatory coupling between hippocampus and cortex
Curr Opin Neurobiol. 35:163-168 (*Corresponding author)

4. Igarashi KM*, Ito HT, Moser EI, Moser, M-B (2014)
Functional diversity along the transverse axis of hippocampal area CA1.
FEBS Lett. 588:2470-2476 (*Corresponding author)

3. Mori K, Matsumoto H, Tsuno Y, Igarashi KM (2009)
Dendrodendritic synapses and functional compartmentalization in the olfactory bulb.
Ann N Y Acad Sci. 1070:255-258

2. Mori K, Takahashi YK, Igarashi KM, Yamaguchi M (2006)
Maps of odorant molecular features in the Mammalian olfactory bulb.
Physiol Rev.86:409-433

1. Mori K, Takahashi YK, Igarashi K, and Nagayama S (2005)
Odor Maps in the Dorsal and Lateral Surfaces of the Rat Olfactory Bulb.
Chemical Senses. 30:i103-i104


Book Chapters

1. Nagayama S, Igarashi KM, Manabe H, Mori K (2014)
Parallel tufted cell and mitral cell pathways from the olfactory bulb to the olfactory cortex.
In: Olfactory System: From Odor Molecules to Motivational Behaviors. Springer
Grants
Whitehall Foundation Research Grant 9/1/17 – 8/31/21 Total: $225,000 Role: PI
Alzheimer’s Association Research Grant 10/1/17 – 9/30/21 Total: $150,000 Role: PI
NIH / NIA R01 AG063864 8/1/19 – 5/31/24 Total: $1,931,250 Role: PI
BrightFocus Foundation Research grant 7/1/19 – 6/31/22 Total: $300,000 Role: PI
NIH / NIMH R01 MH121736 9/12/19 – 6/30/24 Total: $1,981,219 Role: PI
NIH / NIA R01 AG066806 5/1/20 – 1/31/25 Total: $1,962,500 Role: PI
Professional Societies
Society for Neuroscience
Federation of European Neuroscience Societies
Japan Neuroscience Society
Norwegian Neuroscience Society
Other Experience
Ad-hoc Reviewer
NIH Neurobiology of Learning and Memory study section (LAM)

Ad-hoc Reviewer
NIH Brain Initiative study section ZRG1 IFCN-T(55)

Ad-hoc Reviewer
Wellcome Trust (UK)

Ad-hoc Reviewer
Nature, Nature Neuroscience, Neuron, Journal of Neuroscience, eLife

Graduate Programs
Interdepartmental Neuroscience Program

Research Centers
Center for the Neurobiology of Learning and Memory
UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND)
Last updated
10/16/2020