Kei M Igarashi

picture of Kei M Igarashi

Assistant Professor, Anatomy & Neurobiology
School of Medicine

Ph.D., University of Tokyo, 2007

Phone: (949) 824-4673
Email: kei.igarashi@uci.edu

University of California, Irvine
Irvine Hall Rm 112
Mail Code: 3950
Irvine, CA 92697
Research Interests
memory, olfaction, Alzherimer's disease, hippocampus, entorhinal cortex
URL
Academic Distinctions
2018 Ando Momofuku Award, Ando Foundation
2017 Mishima Kaiun Prize, Mishima Kaiun Memorial Foundation
2016 PRESTO Career Development Award, Japan Science and Technology Agency
2014 Young Investigator Award, Japan Neuroscience Society
2013 Research Grant, Mishima Kaiun Memorial Foundation
2012 Norwegian Research Council Post-doctoral Fellowship
2007 – 2009 Post-doctoral Fellowship, Japan Society for the Promotion of Science
2004 – 2007 Graduate Fellowship, Japan Society for the Promotion of Science
Research Abstract
The Igarashi laboratory at University of California Irvine investigates:

(i) circuit mechanisms for associative memory in entorhinal cortex and hippocampus, and
(ii) how these mechanisms in the memory circuit are affected and can be manipulated to restore memory in Alzheimer’s disease models.

To this end, we use in vivo tetrode/silicon probe recordings from behaving mice, optogenetics, memory behavioral tasks, and single-cell anatomy.
Publications
Original Research Articles

11. Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM* (2017)
Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model
Frontiers in Systems Neuroscience, 11:48

10. Watanabe H, Rajagopalan UM, Nakamichi Y, Igarashi KM, Kadono H, Tanifuji M. (2016)
Functional optical coherence tomography of rat olfactory bulb with periodic odor stimulation.
Biomed Opt Express. 7:841-5

9. Lu L, Igarashi KM, Witter MP, Moser EI, Moser MB (2015)
Topography of Place Maps along the CA3-to-CA2 Axis of the Hippocampus.
Neuron. 87:1078-92

8. Igarashi KM*, Lu L, Colgin LL, Moser MB, Moser EI* (2014)
Coordination of entorhinal-hippocampal ensemble activity during associative learning.
Nature. 510: 143-7 (*Co-corresponding authors)

Featured by: Rangel LM, Eichenbaum H (2014)
Brain Rhythms: Towards a Coherent Picture of Ensemble Development in Learning.
Curr Biol. 24:R620-1

7. Igarashi KM*, Ieki N, An M, Yamaguchi Y, Nagayama S, Kobayakawa K, Kobayakawa R, Tanifuji M, Sakano H, Chen WR, Mori K* (2012)
Parallel mitral and tufted cell pathways route distinct odor information to different targets in the
olfactory cortex.
Journal of Neuroscience. 32:7970-85 (*Co-corresponding authors)

6. Mitsui S, Igarashi KM, Mori K and Yoshihara Y (2011)
Genetic visualization of the secondary olfactory pathway in Tbx21 transgenic mice.
Neural Systems & Circuits. 1:5

5. Watanabe H, Rajagopalan UM, Nakamichi Y, Igarashi KM, Kadono H, Tanifuji M (2011)
Swept source optical coherence tomography as a tool for real time visualization and localization of electrodes used in electrophysiological studies of brain in vivo.
Biomedical Optics Express. 2:3129-3134

4. Watanabe H, Rajagopalan UM, Nakamichi Y, Igarashi KM, Madjarova VD, Kadono H, Tanifuji M (2011)
In vivo layer visualization of rat olfactory bulb by a swept source optical coherence tomography and its confirmation through electrocoagulation and anatomy.
Biomedical Optics Express. 2:2279-2287

3. Tsuboi A, Imai T, Kato HK, Matsumoto H, Igarashi KM, Suzuki M, Mori K, Sakano H (2011)
Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes respond
differently to phenyl ethers.
European Journal of Neuroscience. 33:205-13

2. Nagayama S, Enerva A, Fletcher ML, Masurkar AV, Igarashi KM, Mori K, Chen WR (2010)
Differential axonal projection of mitral and tufted cells in the mouse main olfactory system.
Frontiers in Neural Circuits. 4. Pii120

1. Igarashi KM, Mori K (2005)
Spatial representation of hydrocarbon odorants in the ventrolateral zones of the rat olfactory bulb.
Journal of Neurophysiology. 93:1007-1019

Review articles
7. Nakazono T, Jun H, Blurton-Jones, M, Green KN, Igarashi KM (2018)
Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia
Neurosci Res, 129:40-46

6. Igarashi KM* (2016)
Entorhinal map of space
Brain Research, 1637:177-87 (*Corresponding author)

5. Igarashi KM* (2015)
Plasticity in oscillatory coupling between hippocampus and cortex
Curr Opin Neurobiol. 35:163-168 (*Corresponding author)

4. Igarashi KM*, Ito HT, Moser EI, Moser, M-B (2014)
Functional diversity along the transverse axis of hippocampal area CA1.
FEBS Lett. 588:2470-2476 (*Corresponding author)

3. Mori K, Matsumoto H, Tsuno Y, Igarashi KM (2009)
Dendrodendritic synapses and functional compartmentalization in the olfactory bulb.
Ann N Y Acad Sci. 1070:255-258

2. Mori K, Takahashi YK, Igarashi KM, Yamaguchi M (2006)
Maps of odorant molecular features in the Mammalian olfactory bulb.
Physiol Rev.86:409-433

1. Mori K, Takahashi YK, Igarashi K, and Nagayama S (2005)
Odor Maps in the Dorsal and Lateral Surfaces of the Rat Olfactory Bulb.
Chemical Senses. 30:i103-i104


Book Chapters

1. Nagayama S, Igarashi KM, Manabe H, Mori K (2014)
Parallel tufted cell and mitral cell pathways from the olfactory bulb to the olfactory cortex.
In: Olfactory System: From Odor Molecules to Motivational Behaviors. Springer
Grants
PRESTO Career Development Award, Japan Science and Technology Agency
Whitehall Foundation Research Grant
Alzheimer’s Association Research Grant
Brain Research Foundation Fay-Frank Grant
Professional Societies
Society for Neuroscience
Federation of European Neuroscience Societies
Japan Neuroscience Society
Norwegian Neuroscience Society
Other Experience
Postdoc/Research Associate
Edvard and May-Britt Moser lab, NTNU 2009—2015

Postdoc
Kensaku Mori lab, Univ of Tokyo 2007—2009

Graduate Programs
Interdepartmental Neuroscience Program

Research Centers
Center for the Neurobiology of Learning and Memory
UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND)
Last updated
03/15/2018