Mark Mapstone

picture of Mark  Mapstone

HS Clinical Professor, Neurology
School of Medicine
Faculty, Institute for Memory Impairments and Neurological Disorders (UCI MIND)
Fellow, Center for the Neurobiology of Learning and Memory

Ph.D., Northwestern University, 2000, Clinical Psychology

Phone: (949) 824-7184

University of California, Irvine
318 Sprague Hall
839 Health Sciences Road
Mail Code: 3910
Irvine, CA 92697
Research Interests
Cognitive Phenotyping, Biomarkers of Neurological Disease, Cognitive Neuroscience
Academic Distinctions
1996, University Scholar, The Graduate School, Northwestern University
1998, Fellow, Buehler Center on Aging, Northwestern University Medical School
2000, George Yacorzinski Scholar, Northwestern University Medical School
2001, NIH Post-doctoral Fellowship, University of Rochester
2003, NIH Career Development Award (K23)
2004, John Henry Hobart Fellow in Ethics and Social Justice, Hobart College
2000-2002, Post-doctoral Fellow, Clinical Neuropsychology, University of Rochester School of Medicine
2002-2008, Assistant Professor, Neurology, University of Rochester School of Medicine
2008-2015, Associate Professor, Neurology, University of Rochester School of Medicine
2015- present, Adjunct Professor, Neurology, University of Rochester School of Medicine
Research Abstract
I am a translational neuroscientist. My goal is to translate discoveries about the aging brain into practical and implementable approaches for successful cognitive aging at the individual level. My current work is focused on early detection of age-related neurological disease especially Alzheimer’s disease and Parkinson’s disease using careful cognitive phenotyping and biomarkers obtained from blood. We are using this information to develop screening tools that can be used to enrich clinical trials with appropriate subjects for disease modifying interventions. We hope to develop reliable biomarkers for clinical use.
Peer reviewed manuscripts from past 5 years

Selzler K, Burack M, Bender R, and Mapstone M. (2013). Neurophysiological correlates of motor and working memory performance following subthalamic nucleus stimulation. Journal of Cognitive Neuroscience 25(1), 37-48.

Lin F, Chen D, Vance D, Ball K and Mapstone M. (2013). Longitudinal relationships between subjective fatigue, cognitive function, and cognitively demanding everyday functioning in old age. International Psychogeriatrics 25(2), 275-285.

Marras C, Armstrong MJ, Meaney CA, Fox S, Rothberg B, Tang-Wai DF, Gill D, Eslinger PJ, Zadikoff C, Kennedy N, Marshall FJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Gerstenecker AT, Duff-Canning S. (2013). Measuring Mild Cognitive Impairment in Patients with Parkinson’s disease. Movement Disorders, 28(5) 626-33.

Reingold W, Duff-Canning S, , Meaney CA, Armstrong MJ, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger PJ, Marshall FJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Tang-Wai D, Lang AE, and Marras C (2013). Impact of mild cognitive impairment on health-related quality of life in Parkinson’s disease. Dementia and Geriatric Cognitive Disorders,15;36(1-2),67-75.

Chapman RM, Porsteinsson AP, Gardner MN, Mapstone M, McCrary JW, Sandoval TC, Guillily MD, Reilly LA, DeGrush E. (2013). The impact of AD drug treatments on event-related potentials as markers of disease conversion. Current Alzheimer Research. 10(7):732-41.

Lin F, Heffner K, Mapstone M, Chen DG, Porsteinsson A. (2013). Frequency of Mentally Stimulating Activities Modifies the Relationship Between Cardiovascular Reactivity and Executive Function in Old Age. American Journal of Geriatric Psychiatry, 22(11): 1210-21.

Mapstone M, Hilton TN, Yang H, Guido JJ, Luque AE, Hall WJ, Dewhurst, S, and Shah K. (2013). Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging and Disease, 4(6), 311-319..

Lin F, Roiland R, Polesskaya O, Chapman B, Johnson M, Brasch J, Chen D, & Mapstone M. (2013). Fatigability Disrupts Cognitive Processes' Regulation of Inflammatory Reactivity in Old Age. The American Journal of Geriatric Psychiatry, S1064-7481 (13)00423-5.

Mapstone M, Cheema AK, Fiandaca, MS, Zhong X, Mhyre TR, Macarthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. (2014). Plasma phospholipids identify antecedent memory impairment in older adults. Nature Medicine. 20, 415–418.

Lin. F, Roiland, R., Heffner, K., Johnson, M., Chen, DG, & Mapstone, M. (2014). Evaluation of objective and perceived mental fatigability in older adults with vascular risk. Journal of Psychosomatic Research, 76(6): 458-64.

Fiandaca MS, Mapstone M, Cheema AK, Federoff HJ. (2014). The critical need for defining preclinical biomarkers in Alzheimer’s disease. Alzheimer’s & Dementia. 10(3S):S196-S212.

Lin F, Lo R, Cole D, Ducharme S, Mapstone M, Porsteinsson A, & ADNI group. (2014). Longitudinal Effects of Metabolic Syndrome on Alzheimer and Vascular-Related Brain Pathology. Dementia and Geriatric Cognitive Disorders EXTRA, 4(2): 184-94.

Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, and Goetzl EJ. (2014). Identification of pre-clinical Alzheimer’s disease by a profile of pathogenic proteins in neurally-derived blood exosomes: a case-control study. Alzheimer’s & Dementia, S1552-5260(14)02469-8.

Chapman RM, Gardner MN, Mapstone M, Dupree HM, and Antonsdottir IM. (2015). Memory Timeline: Brain ERP C250 (not P300) is an Early Biomarker of Short-Term Storage. Brain Research.1604:74-83.

Dromerick, A.W., Edwardson, M.A., Edwards, D.F., Giannetti, M.L., Barth, J., Brady, K.P., Chan, E., Tan, M.T., Tamboli, I., Chia, R., Orquiza, M., Padilla, R.M., Cheema, A.K., Mapstone, M.E., Fiandaca, M.S., Federoff, H.J., Newport, E.L. (2015) Critical Periods after Stroke Study: Translating animal stroke recovery experiments into a clinical trial. Frontiers in Human Neuroscience. 9; 231.

Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams N, Hardy J, Gasser T, Brice A, Price TR, Keller MF, Molony C, Gibbs JR, Chen-­Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce A,Van Deerlin VM, Weintraub W, Zabetian C, Hernandez DG, Lesage S, Mullins M, Northover C, Cannon P, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JPA, Singleton AB, on behalf of the Parkinson’s Disease Biomarkers Program (PDBP) and the Parkinson’s Progression Marker Initiative (PPMI) investigators. (2015). Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurology.14(10), 1002-1009.

Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M and Federoff HJ (2015). Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease. Frontiers in Neurology. 6:237.

Lin F, Heffner KL, Ren P, Tivarus ME, Brasch J, Chen D-G, Mapstone M, Porsteinsson A, and Tadin D. (2016). Cognitive and Neural Effects of Vision-based Speed of Processing Training in Older Adults with Mild Cognitive Impairment: A Pilot Study. Journal of the American Geriatrics Society 64(6): 1293-1298.

Lin F, Ren P, Cotton K, Tivarus ME, Hasselberg M, Schifitto G, Porsteinsson A, Mapstone M, and Heffner K. (2016). Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment. American Journal of Geriatric Psychiatry, 24(5): 374-378.

Chapman RM, Gardner MN, Mapstone M, Klorman R, Porsteinsson AP, Dupree HM, Antonsdottir I, & Kamalyan L. (2016). ERP C250 shows the elderly (cognitively normal, Alzheimer’s disease) store more stimuli in short-term memory than Young Adults do. Clinical Neurophysiology 127(6), 2423-2435.

Wasserman EB, Bazarian JJ, Mapstone M, Block R, & van Wijngaarden E. (2016). Academic dysfunction following a concussion in high school and college students. American Journal of Public Health. 106(7): 1247-1253.

Ren P, Lo R, Chapman B, Mapstone M, Porsteinsson A, and Lin F. (2016). Longitudinal alteration of intrinsic brain activity in the striatum in Mild Cognitive Impairment. Journal of Alzheimer’s Disease. P 1-10.

Lin F, Ren P, Mapstone M, Meyers S, Porsteinsson A, Baran T. (2017). The cingulate cortex of older adults with excellent memory capacity. Cortex 86, 83-92.

Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. (2017). What Success Can Teach Us About Failure: The Plasma Metabolome of Older Adults with Superior Memory and Lessons for Alzheimer's Disease. Neurobiology of Aging. 51, 148-155.

Mapstone M. Cheema AK, Zhong X, Fiandaca MS, Federoff HJ. (2017). Biomarker Validation: Methods and Matrix Matter. Alzheimer’s and Dementia. 13(5), 608–609.

Grill, J, Apostolova L, Bullain S, Burns J, Cox C, Dick M, Hartley D, Kawas C, Kremen S, Lingler J, Lopez O, Mapstone M, Pierce A, Rabinovici G, Roberts JS, Sajjadi SA, Teng E, Karlawish J. (2017). Communicating Mild Cognitive Impairment diagnoses with and without amyloid imaging. Alzheimer’s Research and Therapy, 9:35.

Chapman BP, Benedict RHB, Lin F, Roy S, Federoff HJ, Mapstone M. (2017). Personality and performance in specific cognitive domains among older persons. American Journal of Geriatric Psychiatry. 25(8): 900-908.

Chapman BP, Benedict RHB, Lin F, Roy S, Szigeti K, Federoff HJ, Mapstone M. (2017). Apolipoprotein E genotype impact on memory and attention in older persons: The moderating role of personality phenotype. International Journal of Geriatric Psychiatry. Jun 14. DOI 10.1002/gps.4748.

Zhuang Y, Qiu X, Wang L, Qing MA, Mapstone M, Luque A, Weber MT, Tivarus M, Miller E, Arduino RC, Zhong J, and Schifitto G. (2017). Combination anti-retroviral therapy improves cognition and functional connectivity in treatment naïve HIV-infected individuals. Journal of Neurovirology. 23(5): 704–712.

Mehta K, Wu H-J, Menon S, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, and Cheema AK. (2017). Metabolomic biomarkers of pancreatic cancer - a meta-analysis study. Oncotarget, 8(40): 68899–68915.

Wang XX, Ren P, Mapstone M, Conwell Y, Porsteinsson A, Foxe J, Raizada R, Lin F, for the Alzheimer’s Disease Neuroimaging Initiative. (2017). Identifying a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer’s Pathology. Brain Imaging and Behavior. Sep 15. DOI: 10.1007/s11682-017-9767-y.

Wang XX, Ren P, Baran T, Raizada R, Mapstone M, Lin F. (2017). Longitudinal functional brain mapping in Supernormals. Cerebral Cortex, 23:1-11.

Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki E, Malik S, Macciardi F, and Federoff HJ. (2017). Systems Healthcare: A Holistic Paradigm for Tomorrow. BMC Systems Biology. 11: 142.

Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S.(2018). Precision pharmacology for Alzheimer's disease. Pharmacological Research. PMID: 29458203

Fiandaca MS, Mapstone M, Mahmoodi A, Gross TJ*, Macciardi F, Cheema A, Merchant-Borna K, Bazarian J, Federoff HJ. (2018). Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS ONE 13(4): e0195318. DOI: 10.1371/journal.pone.0195318.

Zimmerman J, Perry A, Breakspear M, Schirner M, Sachdev P, Wen W, Kochan N, Mapstone M, Ritter P, McIntosh AR, Solodkin A. (2018). Differentiation of Alzheimer’s disease based on local and global parameters in personalized Virtual Brain models. NeuroImage: Clinical 19:240-251. DOI: 10.1016/j.nicl.2018.04.017.

Gross T*, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS (2018). Toward reproducible results from targeted metabolomic studies: Perspectives for data pre-processing and a basis for analytic pipeline development. Current topics in Medicinal Chemistry. DOI: 10.2174/1568026618666180711144323.
R01 AG058644-01 (Mapstone, PI) Multi-omic Investigation of Exercise Effects in MCI
Professional Societies
Society for Neuroscience
International Neuropsychology Society
International Society for Behavioral Neuroscience
American Academy of Neurology
Graduate Programs
Interdepartmental Neuroscience Program


Research Center
Translational Laboratory and Biorepository (TLaB)
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