Sanghyuk Shin
Professor
Sue & Bill Gross School of Nursing
Sue & Bill Gross School of Nursing
Ph.D.
Email: ssshin2@uci.edu
University of California, Irvine
854 Health Sciences Quad
Mail Code: 3959
Irvine, CA 92697
854 Health Sciences Quad
Mail Code: 3959
Irvine, CA 92697
Research Interests
Infectious disease epidemiology, COVID-19, tuberculosis, TB/HIV co-infection, genomic epidemiology, molecular diagnostics, community-based intervention trials, social determinants, global health
Publications
Shin SS, Ghannam J, Taha AA. US public health resistance must include Palestine. The Lancet 2025;406:2625. https://doi.org/10.1016/S0140-6736(25)02017-3.
Quansah N, Arriaga MB, Calderon RI, Shin S, Molldrem S, Niemann S, Ugarte-Gil C. Flying blind: urgency for drug-resistant testing for new tuberculosis drugs. The Lancet Microbe. 2025 Mar 6;:101106. doi: 10.1016/j.lanmic.2025.101106.
Deb D, Heidari ME, Kizito B, Kesamang M, Matila T, Matsheka M, Niemann S, Shin SS, Modongo C. HIV status is not associated with SARS-CoV-2 viral load and longer duration of infection among people with well-controlled HIV and high COVID-19 vaccine coverage. International Journal of Infectious Diseases 2025:108142. https://doi.org/10.1016/j.ijid.2025.108142.
Medina-Marino A, Bezuidenhout D, Bezuidenhout C, Facente SN, Fourie B, Shin SS, et al. In-home TB Testing Using GeneXpert Edge is Acceptable, Feasible, and Improves the Proportion of Symptomatic Household Contacts Tested for TB: A Proof-of-Concept Study. Open Forum Infectious Diseases. 2024 Jun 1;11(6):ofae279. PMCID: PMC11167660.
Molldrem S, Bagani S, Subrahmanyam V, Permar R, Matsiri O, Caiphus C, Kizito B, Modongo C, Shin SS. Botswana Tuberculosis (TB) Stakeholders Broadly Support Scaling up next-Generation Whole Genome Sequencing: Ethical and Practical Considerations for Botswana and Global Health. PLOS Global Public Health 2023;3(11): e0002479. https://doi.org/10.1371/journal.pgph.0002479. PMCID: PMC10651001
Modongo C, Barilar I, Wang Q, Molefi T, Makhondo T, Niemann S, Shin SS. Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana. Emerg Infect Dis. 2023 Nov;29(11):2403-2406. doi: 10.3201/eid2911.230987. PMCID: PMC10617350.
Goldstein I*, Bayer D, Barilar I, Kizito B, Matsiri O, Modongo C, Zetola NM, Niemann S*, Minin VN*, Shin SS. Investigating methods for using genetic data to estimate the association between host factors and being an infection source with application to probing the association between HIV infection and tuberculosis transmission [Internet]. 2021 Dec; doi:10.1101/2021.12.12.21267687. Available from: https://www.medrxiv.org/content/10.1101/2021.12.12.21267687v1
Wang Q, Dima M, Ho-Foster A, Molebatsi K, Modongo C, Zetola NM, Shin SS. The association of household food insecurity and HIV infection with common mental disorders among newly diagnosed tuberculosis patients in Botswana. Public Health Nutrition; 2020: 1–22. 10.1017/S1368980020004139. NIHMSID 1638137.
Baik Y*, Modongo C, Moonan PK, Click ES, Tobias JL, Boyd R, Finlay A, Oeltmann JE, Shin SS(Co-Senior Author), Zetola NM. Possible Transmission Mechanisms of Mixed Mycobacterium tuberculosis Infection in High HIV Prevalence Country, Botswana. Emerging Infectious Diseases. 2020 May;26(5):953–60.
Shin SS, Carpenter C, Ekstrand M, Wang Q*, Yadav K, Sinha S, Nyamathi AM. The effect of integrated nutritional interventions on children of women living with HIV in rural India: A 2 x 2 factorial intervention trial. Clin Infect Dis 2019 Oct 14;. doi: 10.1093/cid/ciz1009.
Mupfumi L*, Wang Q*, Moyo S, Shin SS, Zetola NM, Nnawa N, Kgwaadira BT, Chebani T, Iketleng T, Mogashoa T, Musonda R, Kasvosve I, Gaseitsiwe S. High Incidence of tuberculosis in the first six months in HIV-infected adults registered in the Botswana National Antiretroviral therapy programme between 2011 and 2016. AIDS 2019;33(15):2415-2422.
Wang Q, Modongo C, Baik Y, Allender C, Engelthaler DM, Warren RM, Zetola NM, Shin SS. Utility of targeted, amplicon-based deep sequencing to detect resistance to first-line tuberculosis drugs in Botswana. Antimicrobial Agents and Chemotherapy AAC.00982-19 (2019). doi:10.1128/AAC.00982-19.
Shin SS, Modongo C, Zetola NM. Twice-Daily vs. Once-Daily Dolutegravir in Patients With Human Immunodeficiency Virus–Tuberculosis Coinfection Receiving Rifampicin-Based Tuberculosis Therapy. Clin Infect Dis 2020. doi:10.1093/cid/ciz917.
Molebatsi K, Wang Q, Dima M, Ho-Foster A, Modongo C, Zetola NM, Shin SS. Depression and delayed tuberculosis treatment initiation among newly diagnosed patients in Botswana. Global Public Health. 2020 Sep 29;0(0):1–11.
Modongo
C,
Wang
Q,
Dima
M,
Ogopotse
M,
Kgwaadira
B,
Rankgoane
-
Pono
G,
Shin SS
,
Zetola
NM.
Clinical and virological outcomes of TB/HIV co
-
infected patients treated with dolutegravir
-
based HIV
antiretroviral regimens: Early programmatic experience from Botswana
.J Acquir Immune Dec Syndr. 2019;82(2):5.
Baik Y*, Fane O, Wang Q, Modongo C, Caiphus C, Zetola NM,
Shin SS
. Undetected tuberculosis
at enrollment and after hospitalization in medical and oncology wards in Botswana.
PLOS
ONE
.
2019;14(7):e0219678. doi:10.1371/journal.pone.0219678
Shin SS, Carpenter C, Ekstrand M, Wang Q, Grover S, Zetola NM, Yadav K, Sinha S, Nyamathi AM. Cervical cancer screening and awareness survey among women living with HIV/AIDS in Rural Andhra Pradesh, India. Int J STD AIDS 2019 Feb 27:956462419825950. doi: 10.1177/0956462419825950. NIHMS1005234.
Shin SS
, Modongo
C, Baik Y, Allende
r C, Engelthaler DM, Warren RM
, Zetola NM.
Mixed
infections are associated with poor treatment outcomes among newly diagnosed tuberculosis
patients independent of pre
-
treatment heteroresistance
.
Journal of Infectious Diseases
2
018;
218(12
):1974
-
1982.
doi: 10.1093/infdis/jiy480.
PMCID:
PMC6217728
Shin SS, Carpenter CL, Ekstrand ML, et al. Household Food Insecurity as Mediator of the Association Between Internalized Stigma and Opportunistic Infections. AIDS Behav. June 2018:1-8. doi:10.1007/s10461-018-2193-3. NIHMSID 973811.
Shin SS, Modongo C, Zetola NM, Wang Q, Phologolo T, Kestler M, Ho-Foster A. High rates of exposure to tuberculosis patients among HIV-infected healthcare workers in Botswana. Int J Tuberc Lung Dis 2018;22(4):366-370. PMCID: PMC5868425.
Shin SS, Modongo C, Boyd R, Caiphus C, Kuate L, Kgwaadira B, Zetola NM. High Treatment Success Rates among HIV-infected Multidrug-resistant Tuberculosis Patients after Expansion of Antiretroviral Therapy in Botswana, 2006–2013. J Acquir Immune Defic Syndr. 2017;74(1):65-71. PMCID: PMC5140728.
Shin SS, Modongo C, Boyd R, Caiphus C, Kuate L, Kgwaadira B, Zetola NM. High Treatment Success Rates among HIV-infected Multidrug-resistant Tuberculosis Patients after Expansion of Antiretroviral Therapy in Botswana, 2006–2013. J Acquir Immune Defic Syndr. 2017;74(1):65-71. PMCID: PMC5140728.
Grants
R01AI147336
National Institute of Allergy and Infectious Diseases - NIH (PI: Shin)
Improved understanding of TB transmission by accounting for within-host heterogeneity of M. tuberculosis: A population-based molecular epidemiology study in a high HIV prevalent setting
2/01/2020 – 1/31/2025
Role: Principal Investigator https://reporter.nih.gov/project-details/10327709
R01 AI170204-01A1 National Institute of Allergy and Infectious Diseases - NIH (PI: Shin)
The effect of HIV on SARS-CoV-2 transmission and emergence of variants of concern
07/05/2022 – 6/30/2026
Role: Principal Investigator
https://reporter.nih.gov/project-details/10548494
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6338
https://faculty.uci.edu/profile/?facultyId=6338
Last updated
12/14/2025
12/14/2025