Sanghyuk Shin

picture of Sanghyuk  Shin

Associate Professor
Sue & Bill Gross School of Nursing

Director, UCI Infectious Disease Science Initiative


Phone: (949) 576-8675

University of California, Irvine
106F Berk Hall
Mail Code: 3959
Irvine, CA 92697
Research Interests
Infectious disease epidemiology, drug-resistant tuberculosis, TB/HIV co-infection, molecular diagnostics, community-based intervention trials, molecular epidemiology, social determinants
Wang Q, Dima M, Ho-Foster A, Molebatsi K, Modongo C, Zetola NM, Shin SS. The association of household food insecurity and HIV infection with common mental disorders among newly diagnosed tuberculosis patients in Botswana. Public Health Nutrition; 2020: 1–22. 10.1017/S1368980020004139. NIHMSID 1638137.
Baik Y*, Modongo C, Moonan PK, Click ES, Tobias JL, Boyd R, Finlay A, Oeltmann JE, Shin SS(Co-Senior Author), Zetola NM. Possible Transmission Mechanisms of Mixed Mycobacterium tuberculosis Infection in High HIV Prevalence Country, Botswana. Emerging Infectious Diseases. 2020 May;26(5):953–60.
Mupfumi L*, Mpande C, Reid T Moyo S, Shin SS, Zetola NM, Mogashoa T, Musonda RM, Kasvosve I, Scriba TJ, Gaseitsiwe S. Immune phenotype and functionality of Mtb-specific T-cells in HIV/TB co-infected patients with controlled HIV-infection. Pathogens 2020;19.
Shin SS, Carpenter C, Ekstrand M, Wang Q*, Yadav K, Sinha S, Nyamathi AM. The effect of integrated nutritional interventions on children of women living with HIV in rural India: A 2 x 2 factorial intervention trial. Clin Infect Dis 2019 Oct 14;. doi: 10.1093/cid/ciz1009.
Mupfumi L*, Wang Q*, Moyo S, Shin SS, Zetola NM, Nnawa N, Kgwaadira BT, Chebani T, Iketleng T, Mogashoa T, Musonda R, Kasvosve I, Gaseitsiwe S. High Incidence of tuberculosis in the first six months in HIV-infected adults registered in the Botswana National Antiretroviral therapy programme between 2011 and 2016. AIDS 2019;33(15):2415-2422.
Wang Q, Modongo C, Baik Y, Allender C, Engelthaler DM, Warren RM, Zetola NM, Shin SS. Utility of targeted, amplicon-based deep sequencing to detect resistance to first-line tuberculosis drugs in Botswana. Antimicrobial Agents and Chemotherapy AAC.00982-19 (2019). doi:10.1128/AAC.00982-19.
Shin SS, Modongo C, Zetola NM. Twice-Daily vs. Once-Daily Dolutegravir in Patients With Human Immunodeficiency Virus–Tuberculosis Coinfection Receiving Rifampicin-Based Tuberculosis Therapy. Clin Infect Dis 2020. doi:10.1093/cid/ciz917.
Zetola NM, Shin SS, Modongo C. Co-administration of dolutegravir and rifampicin under programmatic conditions. J Acquir Immune Defic Syndr. 2020 Jul 1;84(3):e20
Molebatsi K, Wang Q, Dima M, Ho-Foster A, Modongo C, Zetola NM, Shin SS. Depression and delayed tuberculosis treatment initiation among newly diagnosed patients in Botswana. Global Public Health. 2020 Sep 29;0(0):1–11.
Tawe L, MacDuffie E, Narasimhamurthy M, Wang Q*, Gaseitsiwe S, Moyo S, Kasvosve I, Shin SS, Zetola NM, Paganotti GM, Grover S. Human Papillomavirus (HPV) Genotypes in Women with Invasive Cervical Cancer with and without Human Immunodeficiency Virus (HIV) Infection in Botswana. International Journal of Cancer 2020;146(6):1667–73.
Modongo C, Wang Q, Dima M, Ogopotse M, Kgwaadira B, Rankgoane - Pono G, Shin SS , Zetola NM. Clinical and virological outcomes of TB/HIV co - infected patients treated with dolutegravir - based HIV antiretroviral regimens: Early progra mmatic experience from Botswana .J Acquir Immune De?c Syndr. 2019;82(2):5.
Baik Y*, Fane O, Wang Q, Modongo C, Caiphus C, Zetola NM, Shin SS . Undetected tuberculosis at enrollment and after hospitalization in medical and oncology wards in Botswana. PLOS ONE . 2019;14(7):e0219678. doi:10.1371/journal.pone.0219678
Shin SS, Carpenter C, Ekstrand M, Wang Q, Grover S, Zetola NM, Yadav K, Sinha S, Nyamathi AM. Cervical cancer screening and awareness survey among women living with HIV/AIDS in Rural Andhra Pradesh, India. Int J STD AIDS 2019 Feb 27:956462419825950. doi: 10.1177/0956462419825950. NIHMS1005234.
Shin SS , Modongo C, Baik Y, Allende r C, Engelthaler DM, Warren RM , Zetola NM. Mixed infections are associated with poor treatment outcomes among newly diagnosed tuberculosis patients independent of pre - treatment heteroresistance . Journal of Infectious Diseases 2 018; 218(12 ):1974 - 1982. doi: 10.1093/infdis/jiy480. PMCID: PMC6217728
Nyamathi AM, Shin SS, Carpenter C, Garfin D, Yadav K, Sinha S, Ekstrand M. Title: Sustained Effect of a Community-based Behavioral and Nutrition Intervention on HIV-related Outcomes among Women living with HIV in Rural India: A Quasi-experimental Trial. J Acquir Immune Defic Syndr. 2019;81(4):429–438. PMCID: PMC6594881.
Sweetland AC, Galea J, Shin SS , Driver C, Dlodlo R, Karpati A, Wainberg ML on behalf of The Union TB & Mental Health Working Group. Global receptivity to TB and mental health service integration: A survey of National TB Program Directors. Int J Tuberc Lung Dis 2019 May 1;23(5):600 - 605. PMCID: PMC6558966
Shin SS, Carpenter CL, Ekstrand ML, et al. Household Food Insecurity as Mediator of the Association Between Internalized Stigma and Opportunistic Infections. AIDS Behav. June 2018:1-8. doi:10.1007/s10461-018-2193-3. NIHMSID 973811.
Shin SS, Modongo C, Zetola NM, Wang Q, Phologolo T, Kestler M, Ho-Foster A. High rates of exposure to tuberculosis patients among HIV-infected healthcare workers in Botswana. Int J Tuberc Lung Dis 2018;22(4):366-370. PMCID: PMC5868425.

Shin SS, Modongo C, Boyd R, Caiphus C, Kuate L, Kgwaadira B, Zetola NM. High Treatment Success Rates among HIV-infected Multidrug-resistant Tuberculosis Patients after Expansion of Antiretroviral Therapy in Botswana, 2006–2013. J Acquir Immune Defic Syndr. 2017;74(1):65-71. PMCID: PMC5140728.
65328 CRDF Global Indo-US Joint Program on HIV/AIDS and STI Prevention Research Collaboration Award (PI: Shin, Shrinivasa) The effect of HIV infection on molecular diagnostics for drug-resistant tuberculosis in India 10/08/2019 – 10/7/2021 Role: Co-PI
R01AI147336 National Institute of Allergy and Infectious Diseases - NIH (PI: Shin) Improved understanding of TB transmission by accounting for within-host heterogeneity of M. tuberculosis: A population-based molecular epidemiology study in a high HIV prevalent setting 2/01/2020 – 1/31/2025 Role: PI
Professional Society
Co-Chiar, TB-Mental Health Working Group, IUATLD
Research Center
UCI Infectious Disease Science Initiative
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