Devon A Lawson

picture of Devon A Lawson

Assistant Professor, Physiology & Biophysics
School of Medicine

B.S., University of California, Davis, 2002, Genetics
Ph.D., University of California, Los Angeles, 2008, Microbiology and Molecular Genetics

Phone: (949) 824-4113

University of California, Irvine
112 Sprague Hall
Mail Code: 4560
Irvine, CA 92697
Research Interests
cancer, stem cells, genomics, intratumor heterogeneity, metastasis, systems biology
Postdoctoral fellow, University of California, San Francisco
Research Abstract
Dr. Lawson's lab is interested in understanding the cellular and molecular mechanisms underlying the metastatic spread of cancer cells to peripheral tissues. They take a systems-level approach, using cutting edge single-cell technologies to study intratumor heterogeneity in human patient-derived xenograft (PDX) models and identify pre-metastatic cells within primary tumors. Their work is aimed at defining the key genetic and transcriptomic programs that confer special fitness for metastasis in rare cancer cells, and understand how the interplay between intracellular signals within those cancer cells, and extracellular stimuli from the microenvironment (e.g. immune cells) influence the metastatic potential of individual cancer cells. The overarching goals are to identify new therapeutic strategies to prevent progression to lethal metastatic disease in cancer patients.
Graduate Programs
Cellular and Molecular Biosciences

Mathematical and Computational Biology

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