Keykavous Parang
Division of Nephrology
School of Medicine
School of Medicine
Ph.D., University of Alberta, 1997, Medicinal Chemistry, Pharmaceutical Sciences
Email: kparang@uci.edu
University of California, Irvine
Irvine, CA 92697
Irvine, CA 92697
Research Interests
Peptides, Cancer, Drug Delivery, Nano medicine, Medicinal Chemistry
Websites
Academic Distinctions
July 2013-Present Associate Dean of Research, Graduate Studies and Global Affairs, Full Professor of Medicinal Chemistry and Pharmacology, Chapman University School of Pharmacy
April 2014-Present Full Professor of Chemistry and Biochemistry, Schmid College of Science and Technology, Chapman University
Sept. 2013-Present Member, Chao Family Comprehensive Cancer Center, University of California, Irvine
Nov. 2012-Present Adjunct Faculty, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University
July 2013-2016 Research Professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
July 2008-June 2013 Full Professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
March 2013-Present Adjunct Faculty, International Center for Chemical and Biological Sciences, University of Karachi
May 2012-June 2013 Program Coordinator, Rhode Island IDeA Network of Biomedical Research Excellence (INBRE) sponsored by NIH
January 2010-Dec. 2010 Sabbatical Research, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University
Nov. 1, 2000-Present Visiting scientist (Scholar), Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University
April 2006-July 2008 Associate professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
Oct. 2000-April 2006 Assistant professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University
April 2014-Present Full Professor of Chemistry and Biochemistry, Schmid College of Science and Technology, Chapman University
Sept. 2013-Present Member, Chao Family Comprehensive Cancer Center, University of California, Irvine
Nov. 2012-Present Adjunct Faculty, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University
July 2013-2016 Research Professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
July 2008-June 2013 Full Professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
March 2013-Present Adjunct Faculty, International Center for Chemical and Biological Sciences, University of Karachi
May 2012-June 2013 Program Coordinator, Rhode Island IDeA Network of Biomedical Research Excellence (INBRE) sponsored by NIH
January 2010-Dec. 2010 Sabbatical Research, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University
Nov. 1, 2000-Present Visiting scientist (Scholar), Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University
April 2006-July 2008 Associate professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
Oct. 2000-April 2006 Assistant professor, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University
Appointments
July 1999-Oct. 2000 Postdoctoral fellow, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University (Burrough Welcome Fund) (Dr. Philip A. Cole)
Chemical cross-linking agents for identification of substrates for protein kinases, Bisubstrate ATP-peptide inhibitors of tyrosine kinases.
Jan. 1999-July 1999 Postdoctoral fellow, Department of Bioorganic Chemistry, Rockefeller University (Dr. Philip A. Cole)
Tyrosine analogs as alternative substrates for protein kinase Csk.
Sept. 1997-Jan. 1999 Postdoctoral fellow, Department of Chemistry, University of Alberta (Dr. Ole Hindsgaul)
Sulfation and phosphorylation of carbohydrates and nucleosides using solid phase organic synthesis.
Chemical cross-linking agents for identification of substrates for protein kinases, Bisubstrate ATP-peptide inhibitors of tyrosine kinases.
Jan. 1999-July 1999 Postdoctoral fellow, Department of Bioorganic Chemistry, Rockefeller University (Dr. Philip A. Cole)
Tyrosine analogs as alternative substrates for protein kinase Csk.
Sept. 1997-Jan. 1999 Postdoctoral fellow, Department of Chemistry, University of Alberta (Dr. Ole Hindsgaul)
Sulfation and phosphorylation of carbohydrates and nucleosides using solid phase organic synthesis.
Research Abstract
The emphasis of Parang's research lies at the interface between chemistry and biology with specific proposals being focused in the fields of organic chemistry, medicinal chemistry, nanomedicine, and drug delivery. Our research can be appropriately described as "the application of synthetic organic chemistry to problems in biology". Specific areas currently under investigation include (1) using peptides as cell-penetrating molecular transporters in drug delivery; (2) designing protein kinase inhibitors; (3) development of multifunctional anti-HIV, anticancer, and antibacterial agents; and (4) designing peptide nanomaterials for nanomedicine. One major area currently under investigation is to design peptide nanomaterials for applications in drug delivery
Parang research is focused on using cyclic peptides as cell-penetrating molecular transporters in drug delivery. His laboratory has discovered a number of cyclic peptides that enhanced delivery of anticancer and antiviral drugs, siRNA, and phosphopeptides. It is expected that this strategy will lead to a broadly applicable platform for carrier-mediated selective delivery of cell-impermeable compounds.
Parang laboratory is designing and evaluating peptides, peptide nanomaterials, and peptide-capped metal nanoparticles as cell-penetrating nuclear targeting agents, molecular transporters of bioactive cell-impermeable compounds, or self-assembled scaffolds for drug delivery applications. We have discovered a number of amphiphilic cyclic peptides that enhanced cellular delivery of anticancer and antiviral drugs, siRNA, and phosphopeptides. Cyclic peptides offered several advantages including stability, nuclear delivery, endocytosis-independent uptake, low cytotoxicity, biocompatibility, hydrophobic drug entrapment through non-covalent interactions, selective targeting of tumor tissues. It is envisioned that cellular delivery by functionalized cyclic peptides will improve the stability, cellular uptake, biological activities, and active targeting of cell-impermeable compounds, such as anticancer and antiviral drugs and siRNA, with limited solubility, permeability, or stability.
Parang research is focused on using cyclic peptides as cell-penetrating molecular transporters in drug delivery. His laboratory has discovered a number of cyclic peptides that enhanced delivery of anticancer and antiviral drugs, siRNA, and phosphopeptides. It is expected that this strategy will lead to a broadly applicable platform for carrier-mediated selective delivery of cell-impermeable compounds.
Parang laboratory is designing and evaluating peptides, peptide nanomaterials, and peptide-capped metal nanoparticles as cell-penetrating nuclear targeting agents, molecular transporters of bioactive cell-impermeable compounds, or self-assembled scaffolds for drug delivery applications. We have discovered a number of amphiphilic cyclic peptides that enhanced cellular delivery of anticancer and antiviral drugs, siRNA, and phosphopeptides. Cyclic peptides offered several advantages including stability, nuclear delivery, endocytosis-independent uptake, low cytotoxicity, biocompatibility, hydrophobic drug entrapment through non-covalent interactions, selective targeting of tumor tissues. It is envisioned that cellular delivery by functionalized cyclic peptides will improve the stability, cellular uptake, biological activities, and active targeting of cell-impermeable compounds, such as anticancer and antiviral drugs and siRNA, with limited solubility, permeability, or stability.
Publications
1. Shafiee, A., Pirouzzadeh, B., Ghasemian, F., Parang, K. Synthesis of 2-acetyl-1-methyl -5-nitroimidazole. J. Heter. Chem. (1992) 29, 1021-1023 and Cheminform (1992) 23, 50.
2. Shafiee, A., Parang, K., Khazen, M., Ghasemian, F. Synthesis of substituted 2-(1-methyl-5- nitro-2-imidazolyl)quinolines. J. Heter. Chem. (1992) 29, 1859-1861.
3. Sharifan, A., Parang, K., Zorrieh-Amirian, H., Nazarinia, M., Shafiee, A. Synthesis of 1-substituted 1,2,4-triazoles, imidazoles and benzimidazoles. J. Heter. Chem. (1994) 31, 1421-1423.
4. Parang, K., Knaus, E. E., Wiebe, L. I., Sardari, S., Daneshtalab, M., Csizmadia, F. Synthesis and antifungal activities of myristic acid analogs. Arch. Pharm.-Pharm. Med. Chem. (1996) 329, 475-482.
5. Parang, K., Wiebe, L. I., Knaus, E. E., Huang, J. S., Tyrrell, D. L., Csizmadia, F. In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis viruses. Antiviral Research (1997) 34, 75-90.
6. Parang, K., Wiebe, L. I., Knaus, E. E. Syntheses and biological evaluation of 5?-O-myristoyl derivatives of thymidine against human immunodeficiency virus (HIV-1). Antiviral. Chem. Chemother. (1997) 8, 417-427.
7. Parang, K., Knaus, E. E., Wiebe, L. I. Synthesis, in vitro anti-HIV structure-activity relationships and stability of 5?-O-myristoyl analogue derivatives of 3'-azido-2',3'-dideoxythymidine as potential prodrugs of 3'-azido-2',3'-dideoxythymidine (AZT). Antiviral. Chem. Chemother. (1998) 9, 311-323.
8. Parang, K., Wiebe, L. I., Knaus, E. E. In vivo pharmacokinetic parameters, liver and brain uptake of (±)-3'-azido-2',3'-dideoxy-5'-O-(2-bromomyristoyl)thymidine as potential prodrug of 3'-azido-3'-deoxythymidine. J. Pharm. Pharmacol. (1998) 50, 989-996.
9. Parang, K., Knaus, E. E., Wiebe, L. I. Synthesis, in vitro anti-HIV activity, and biological stability of 5'-O-myristoyl analogue derivatives of 3'-fluoro-2',3'-dideoxythymidine (FLT) as potential prodrugs of FLT. Nucleosides & Nucleotides (1998) 17, 987-1008.
10. Parang, K., Wiebe, L. I., Knaus, E. E., Huang, J. S., Tyrrell, D. L. In vitro anti-hepatitis B virus activities of 5'-O-myristoyl analogue derivatives of 3'-fluoro-2',3'-dideoxythymidine (FLT) and 3'-azido-2',3'-dideoxythymidine (AZT). J. Pharm. Pharmaceut. Sci. (1998) 1, 107-113.
11. Ablooglu, A. J., Till, J. K., Kim, K., Parang, K., Cole, P. A., Hubbard, S. R., Kohanski, R. A. Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate. J. Biol. Chem. (2000) 275, 30394-30398.
12. Kim, K., Parang, K., Lau, O. D., Cole, P. A. Tyrosine analogs as alternative substrates for protein tyrosine kinase Csk: insights into substrate selectivity and catalytic mechanism. Bioorg. Med. Chem. (2000) 8, 1263-1268.
13. Parang, K., Wiebe, L. I., Knaus, E. E. Novel approaches in designing prodrugs of AZT. Current Med. Chem. (2000) 7, 995-1039.
14. Parang, K., Till, J. H., Ablooglu, A. J., Kohanski, R. A., Hubbard, S. R., Cole, P. A. Mechanism-based design of a protein kinase inhibitor. Nature Structural Biology (2001) 8, 37-41.
15. Parang, K., Fournier, E. J.-L., Hindsgaul, O. A solid phase reagent for the capture phosphorylation of carbohydrate and nucleosides. Org. Lett. (2001) 3, 307-309.
16. Parang, K., Preface, Anti-HIV design, Bentham Science Publishers, Hilversum, Current Pharmaceutical Design (2002) 8, 8.
17. Parang, K., Miri, R. Review of Organic Chemistry Principals, Kushamehr Publications, First Edition, Shiraz, 2002, Persian.
18. Parang, K., Kohn, J. A., Saldahna, A., Cole, P. A. Development of photo-crosslinking reagents for protein kinase-substrate interactions. Febs Letters (2002) 520, 156-160.
19. Parang, K. Polymer-supported reagents for methylphosphorylation and phosphorylation of Carbohydrates. Bioorg. Med. Chem. Lett. (2002) 12, 1863-1866.
20. Parang, K., Cole, P. A. Bisubstrate inhibitors of protein kinases. Pharmacology and Therapeutics (2002) 93, 145-157.
21. Nam, N. H., Parang, K. Current Drug Targets for Anticancer Drug Discovery. Current Drug Targets (2003), 4, 159-179.
22. Parang, K., Preface, Anti-HIV design, Bentham Science Publishers, Hilversum, Current Pharmaceutical Design (2003) 9, 22.
23. Nam, N. H., Sardari, S., Parang, K. Reactions of solid supported reagents and solid supports with alcohols and phenols through their hydroxyl functional group. J. Comb. Chem. (2003) 5, 479-546 and ChemInform (2003), 34, 49.
24. Sardari, S., Pourmorad, F., Tiemo, A., Nam, H., Parang, K. Protein kinases and their modulation in the central nervous system. Current Medicinal Chemistry-CNS (2003) 3, 341-364.
25. Lee, S., Lin, X., Nam, N. H., Parang, K., Sun G. Determination of the substrate-docking site of protein tyrosine kinase Csk. Proc. Nat. Acad. Sci. U.S.A. (2003) 100, 14707-14712.
26. Force, T., Kuida, K., Parang, K., Kyriakis, J. M. Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease. Circulation (2004) 109, 1196-1205.
27. Carballeira, N. M., Ortiz, D., Parang, K., Sardari, S. Total synthesis and in vitro antifungal activity of 2-methoxytetradecanoic acid. Arch. Pharm.-Pharm. Med. Chem. (2004) 337, 152-155.
28. Nam, N.-H., Ye, G., Sun, G., Parang, K. Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain binding. J. Med. Chem. (2004) 47, 3131-3141.
29. Nam, N. H., Pitts, R., Sun, G., Sardari, S., Tiemo, A., Xie, M., Yan, B., Parang, K. Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. Bioorg. Med. Chem. (2004) 12, 779-787.
30. Schmidt, B., Jiricek, J., Titz, A., Ye, G., Parang, K. Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain. Bioorg. Med. Chem. Lett. (2004) 14, 4203-4206.
31. Nam, N. H., Sardari, S., Selecky, M., Parang, K. Carboxylic acids and phosphate ester derivatives of fluconazole: synthesis and antifungal activities. Bioorg. Med. Chem. (2004) 12, 6255-6269.
32. Nam, N. H., Lee, S., Ye, G., Sun, G., Parang, K. ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases. Bioorg. Med. Chem. (2004) 12, 5753-5766.
33. Parang, K., Sun, G. Design strategies for protein kinases inhibitors. Current Opinions In Drug Discovery (2004) 7, 630-638.
34. Ahmadibeni, Y., Parang, K. Solid-phase reagents for selective monophosphorylation of carbohydrates and nucleosides. J. Org. Chem. (2005) 70, 1100-1103.
35. Parang, K., Sun, G. Protein kinase inhibitors in drug discovery. Drug Discovery Handbook, 2005, Wiley-Interscience, New Jersey, Ed. Gad, S. C. 1191-1257.
36. Lin, X., Ayrapetov, M. K., Lee, S., Parang, K., Sun G. Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk. Biochemistry (2005) 44, 1561-1567.
37. Hines, A. C., Parang, K., Kohanski, R. A., Hubbard, S. R., Cole, P. A. Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: Molecular yardsticks for analyzing catalytic mechanism and inhibitor design. Bioorg. Chem. (2005) 33, 285-297.
38. Carballeira, N. M., O’Neill, R., Parang K. Racemic and optically active 2-methoxy-4-oxatetradecanoic acids: Novel synthetic fatty acids with selective antifungal properties. Chem. Phys. Lipids (2005) 136, 47-54.
39. Ahmadibeni, Y., Parang, K. Polymer-bound oxathiaphospholane: A solid-phase reagent for regioselective monothiophosphorylation and monophosphorylation of unprotected nucleosides and carbohydrates. Org. Lett. (2005) 7, 1955-1958.
40. Ayrapetov, M. K., Nam, N. H., Ye, G. Kumar, A., Parang, K., Sun, G. Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation. J. Biol. Chem. (2005) 280, 25780-25787.
41. Carballeira, N. M., O’Neill, R., Parang, K. Total synthesis and further scrutiny of the in vitro antifungal activity of 6-nonadecynoic acid. Arch. Pharm.-Pharm. Med. Chem. (2005) 338, 441-443.
42. Ye, G., Ayrapetov, M., Nam, N. H., Sun, G., Parang, K. Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain. Bioorg. Med. Chem. Lett. (2005) 15, 4994-4997.
43. Parang, K., Sun, G. Recent advances in the discovery of Src kinases inhibitors. Expert Opin. Ther. Patents (2005) 15, 1183-1207.
44. Ahmadibeni, Y., Parang, K. Selective diphosphorylation, dithiodiphosphorylation, triphosphorylation, and trithiotriphosphorylation of unprotected carbohydrates and nucleosides. Org. Lett. (2005) 7, 5589-5592.
45. Parang, K. Editor. Novel approaches in designing anti-HIV microbicides and anti-HIV Agents. Curr. Pharm. Des. (2005) 11, 123 pp.
46. Lin, X., Wang, Y., Ahmadibeni, Y., Parang, K., Sun, G. Structural basis for domain-domain communication in a protein tyrosine kinase, Csk. J. Mol. Biol. (2006) 357, 1263-1273.
47. Lee, S., Ayrapetov, M. K., Kemble, D., Parang, K., Sun, G. Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, the C-terminal Src kinase. J. Biol. Chem. (2006) 281, 8183-8189.
48. Ahmadibeni, Y., Parang, K. Solid-phase synthesis of dinucleoside and nucleoside-carbohydrate phosphodiesters and thiophosphodiesters. J. Org. Chem. (2006) 71, 6693-6696.
49. Ahmadibeni, Y., Parang, K. Application of a solid-phase ß-triphosphitylating reagent in the synthesis of nucleoside ß-triphosphates. J. Org. Chem. (2006) 71, 5837-5839.
50. Kumar, A., Ye, G., Wang, Y., Lin, X., Sun, G., Parang, K. Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogs of CIYKYY as Src tyrosine kinase inhibitors. J. Med. Chem. (2006) 49, 3395-3401.
51. Carballeira, N. M., Sanabria, D., Cruz, C., Parang, K., Wan, B., Franzblau, S. 2,6-Hexadecadiynoic acid and 2,6-nondecadiynoic acid – Novel synthesized acetylenic fatty acids as potent antifungal agents. Lipids (2006) 41, 507-511.
52. Ayrapetov, M. K., Wang, Y.-H., Xiaofeng, L., Gu X., Parang, K., Sun G. Conformational basis for SH2-pTYR527 binding in SRC inactivation. J. Biol. Chem. (2006) 281, 23776-23784.
53. Kumar, A., Ye, G., Ahmadibeni, Y., Parang, K. Synthesis of polymer-bound 4-acetoxy-3-phenylbenzaldehyde derivatives: Applications in solid-phase organic synthesis. J. Org. Chem. (2006) 71, 7915-7918.
54. Gu, X., Wang, Y., Kumar, A., Ye, G., Parang, K., Sun, G. Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase. J. Med. Chem. (2006) 49, 7532-7539.
55. Agarwal, H. K., Parang, K. Application of solid-phase chemistry for the synthesis of 3?-fluoro-3?-deoxythymidine. Nucleosides, Nucleotides& Nucleic Acids (2007) 26, 317-322.
56. Ahmadibeni, Y., Parang, K., Synthesis and evaluation of oligodeoxynucleotides containing diphosphodiester internucleotide linkages. Angew. Chem. Int. Ed. (2007) 46, 4739-4743.
57. Kumar, A., Wang, Y., Lin, X., Sun, G., Parang, K. Synthesis and evaluation of 3-phenylpyrazolopyrimidine-peptide conjugates as Src tyrosine kinase inhibitors. ChemMedChem (2007) 2, 1346-1360.
58. Carballeira, N. M., O’Neil, R., Parang, K. Synthesis and antifungal properties of alpha-methoxy and alpha-hydroxyl substituted 4-thiatetradecanoic acids. Chem. Phys. Lipids (2007) 150, 82-88.
59. Ahmadibeni, Y., Hanley, M., White, M., Ayrapetov, M., Lin, X., Sun, G., Parang, K. Metal-binding properties of a dicysteine-containing motif in protein tyrosine kinases. ChemBioChem (2007) 8, 1592-1605.
60. Ye, G., Nam, N. H., Saleh, A., Kumar, A., Sun, G., Shenoy, D. B., Amiji, M. M., Parang, K. Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptides. J. Med. Chem. (2007) 50, 3604-3617.
61. Chimalakonda, C., Agarwal, H., Kumar, A., Parang, K., Mehvar, R. Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver. Bioconj. Chem. (2007) 18, 2097-2108.
62. Bhandari, R., Saiardi, A., Ahmadibeni, Y., Snowman, A. M., Resnick, A. C., Kristiansen, T. Z., Molina, H., Pandey, A., Werner, Jr. J. K., Juluri, K. R., Xu, Y., Prestwich, G. D., Parang, K., Snyder, S. H. Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc. Nat. Acad. Sci. U.S.A. (2007) 104, 15305-15310.
63. Ahmadibeni, Y., Parang, K. Solid-phase synthesis of symmetrical 5?,5?-dinucleoside mono-, di-, tri-, and tetraphosphodiesters. Org. Lett. (2007) 9, 4483-4486.
64. Penugonda, S., Kumar, A., Agarwal, H. K., Parang, K., Mehvar, R. Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: Effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates. J. Pharm. Sci. (2008) 97, 2649-2664.
65. Ahmadibeni, Y., Parang, K. Solid-supported diphosphitylating and triphosphitylating reagents for nucleoside modification. Current Protocols in Nucleic Acid Chemistry (2008) Chapter 13:Unit13.8.1-13.8.29.
66. Ye, G., Tiwari, R., Parang K. Development of Src tyrosine kinase substrate binding site inhibitors. Current Opinions Investigational Drugs (2008) 9, 605-613.
67. Agarwal, H. K., Doncel, G., Parang, K. Synthesis and anti-HIV activities of phosphate triester derivatives of 3'-fluoro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine. Tetrahedron Lett. (2008) 49, 4905-4907.
68. Ahmadibeni, Y., Parang K. Symmetrical dinucleosides. Synfacts (2008) 2, 0207 (highlight publication).
69. Ahmadibeni, Y., Parang, K. Solid-supported reagents for synthesis of nucleoside monothiophosphates, dithiodiphosphates, and trithiotriphosphates. Current Protocols in Nucleic Acid Chemistry (2009) Chapter 13:Unit13.9.
70. Ahmadibeni, Y., Tiwari, R., Sun, G., Parang, K. Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cycloSaligenyl phosphitylating reagents. Org. Lett. (2009) 11, 2157-2160.
71. Ye, G., Schuler, A., Ahmadibeni, Y., Morgan, J. R., Faruqui, A., Huang, K., Sun, G., Zebala, J. A., Parang, K. Synthesis and evaluation of peptides containing iminodiacetate groups as binding ligands of the Src SH2 domain. Bioorg. Chem. (2009) 37, 133-142.
72. Carballeira, N. M., Miranda, C., Parang, K. The first total synthesis of the (?)-4-methoxydecanoic acid: a novel antifungal fatty acid. Tetrahedron Lett. (2009) 50, 5699-5700.
73. Tiwari, R., Parang K. Protein conjugates of SH3 domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases. ChemBioChem (2009) 10, 2445-2448.
74. Ahmadibeni, Y., Dash, C., Grice, S. F., Parang, K. 5?-O-?,?-Methylenetriphosphate derivatives of nucleoside. Synfacts (2010) 8, 0961 (highlight publication).
75. Penugonda, S., Agarwal, H. K., Parang, K., Mehvar, R. Plasma pharmacokinetics and tissue disposition of novel dextran-methylprednisolone conjugates with peptide linkers in rats. J. Pharmaceutical Sci. (2010), 99, 1627-1637.
76. Ye, G., Gupta, A., DeLuca, R., Parang, K., Bothun, G. D. Bilayer disruption and liposome restructuring by a homologous series of small Arg. Rich synthetic peptides. Colloids and Surfaces B.: Biointerfaces (2010) 76, 76-81.
77. Ahmadibeni, Y., Dash, C., Hanley, M. J., Le Grice, S. F. J., Agarwal, H. K., Parang K. Synthesis of nucleoside 5'-O-a,ß-methylene-ß-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase. Org. Biomol. Chem. (2010) 8, 1271-1274.
78. Tiwari, R., Brown, A., Narramaneni, S., Sun, G., Parang, K. Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands. Biochimie (2010) 92, 1153-1163.
79. Ahmadibeni, Y., Dash, C., Le Grice, S. F. J., Parang K. Solid-phase synthesis of 5'-O-ß,?-methylenetriphosphate derivatives of nucleosides and evaluation of their inhibitory activity against HIV-1 reverse transcriptase. Tetrahedron Lett. (2010) 51, 3010-3013.
80. Sharma, D., Bhatia, S., Sharma, R. K., Tiwari, R., Olsen, C. E., Mandal, D., Lehmann, J., Parang, K., Parmar, V. S., Prasad, A. S. Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3-(N-alkyl-N-phenylamino)propane-2-ols. Biochimie (2010) 92, 1164-1172.
81. Chhikara, B. S., Mandal, D., Parang, K. Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents. Eur. J. Med. Chem. (2010) 45, 4601-4608.
82. Agarwal, H. K., Kumar, A., Doncel, G. F., Parang K. Synthesis, antiviral and contraceptive activities of nucleoside-sodium cellulose sulfate acetate and succinate conjugates. Bioorg. Med. Chem. Lett. (2010) 20, 6993-6997.
83. Chhikara, B. S., Parang, K. Development of cytarabine prodrugs and delivery systems for leukemia treatment. Expert Opin. Drug Del. (2010) 7, 1399-1414.
84. Parang, K., Sun, G. Protein kinase inhibitors in drug discovery. Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing (2010) John Wiley & Sons, Inc.
85. Kumar, D., Buchi Reddy, V., Kumar, A., Mandal, D., Tiwari, R., Parang, K. Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity. Bioorg. Med. Chem. Lett. (2011) 2, 449-452.
86. Kumar, A., Ahmad, I., Chhikara, B. S., Tiwari, R., Mandal, D., Parang, K. Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities. Bioorg. Med. Chem. Lett. (2011) 21, 1342-1346.
87. Ahmadibeni, Y., Tiwari, R., Swepson, C., Pandhare, J., Dash, C., Doncel, G. F., Parang, K. Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine. Tetrahedron Lett. (2011) 52, 802-805.
88. Agarwal, H. K., Loethan, K., Mandal, D., Doncel, G. F., Parang, K. Synthesis and anti-HIV activities of fatty acyl ester derivatives of 2',3'-didehydro-2',3'-dideoxythymidine. Bioorg. Med. Chem. Lett. (2011) 21, 1917-1921.
89. Fallah-Tafti, A., Tiwari, R., Shirazi, A. N., Akbarzadeh, T., Mandal, D., Shafiee, A., Parang, K., Foroumadi, A. 4-Aryl-4H-chromene-3-carbonitrile derivatives: Evaluation of Src kinase inhibitory and anticancer activities. Med. Chem. (2011) 7, 466-472.
90. Chhikara, B. S., St. Jean, N., Mandal, D., Kumar, A., Parang, K. Fatty-acyl amide derivatives of doxorubicin: Synthesis and in vitro anticancer activities. Eur. J. Med. Chem. (2011) 46, 2037-2042.
91. Gupta, A., Mandal, D., Ahmadibeni, Y., Parang, K., Bothun, G. Hydrophobicity drives the non-specific cellular uptake of short cationic peptide ligands. Eur. Biophysics J. (2011) 40, 727-736.
92. Rao, V. K., Chhikara, B. S., Nasrolahi Shirazi, A. N., Tiwari, R., Parang, K., Kumar, A. 3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities. Bioorg. Med. Chem. Lett. (2011) 21, 3511-3514.
93. Dash, C., Ahmadibeni, Y., Hanley, M. J., Pandhare, J., Gotte, M., Le Grice, S. F. J., Parang, K. Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside ß-triphosphates. Bioorg. Med. Chem. Lett. (2011) 21, 3519-3522.
94. Kathuria, A., Jalal, S., Tiwari, R., Nasrolahi Shirazi, A., Gupta, S., Kumar, S., Parang, K., Harma, S. K. Substituted coumarin derivatives: Synthesis and evaluation of antiproliferative and Src kinase inhibitory activities. Chemistry Biology Interface (2011) 1 (2), 279-296.
95. Fallah-Tafti, A., Foroumadi, A., Tiwari, R., Shirazi, A. N., Hangauer, D. G., Bu, Y., Akbarzadeh, T., Parang, K., Shafiee, A. Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities. Eur. J. Med. Chem. (2011) 46, 4853-4858.
96. Mandal, D., Nasrolahi Shirazi, A., Parang, K. Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew. Chem. Int. Ed. (2011) 50, 9633-9637.
97. Rao, M. S., Chhikara, B. S., Tiwari, R., Nasrolahi Shirazi, A., Parang, K., Kumar, A. Greener synthesis of 2-aminochromenes in ionic liquid and evaluation of their antiproliferative activities. Chemistry & Biology Interface (2012) 2, 362-372.
98. Rafinejad, A., Fallah-Taftia, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Shafiee, A., Parang, K., Foroumadi, A., Akbarzadeh, T. 4-Aryl-4H-naphthopyrans derivatives: One-pot synthesis, Evaluation of Src kinase inhibitory and anti-proliferative activities. DARU Journal of Pharmaceutical Sciences, 2012, 20, 100.
99. Muthyala, M. J., Chhikara, B. S., Parang, K., Kumar, A. Ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene— An efficient and recyclable organocatalyst for Michael addition to a,ß-unsaturated ketones. Can. J. Chem. (2012) 90, 290-297.
100. Agarwal, H. K., Doncel, G. F., Parang K. Synthesis and anti-HIV activities of Suramin conjugates of 3'-fluoro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine. Med. Chem. 2012, 8, 193-197.
101. Rao, M. S., Chhikara, B. S., Tiwari, R., Shirazi, A. N., Parang, K., Kumar, A. Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones. Monatsh. Chem. (2012) 143, 263-268.
102. Rao, V. K., Chhikara, B.S., Tiwari, R., Nasrolahi Shirazi, A., Parang, K., Kumar, A. One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their anti-proliferative and Src kinase inhibitory activities. Bioorg. Med. Chem. Lett. (2012) 22, 410-414.
103. Munthayala, M., Chhikara, B., Parang, K., Kumar, A. Ionic liquid-supported synthesis of sulfonamides and carboxamides. ACS Combinatorial Science (2012) 14, 60-65.
104. Chhikara, B. S., Mandal, D., Parang, K. Synthesis, anticancer activities, and cellular uptake studies of lipophilic derivatives of doxorubicin succinate. J. Med. Chem. (2012) 55, 1500-1510.
105. Agarwal, H. K., Chhikara, B. S., Quiterio, M., Doncel, G. F., Parang, K. Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors. J. Med. Chem. (2012) 55, 2672-2687.
106. Agarwal, H. K., Chhikara, B. S., Hanley, M. J., Ye, G., Doncel, G. F., Parang, K. Synthesis and biological evaluation of fatty acyl ester derivatives of (-)-2',3'-dideoxy-3'-thiacytidine. J. Med. Chem. (2012) 55, 4861-4871.
107. Agarwal, H. K., Buckheit, K. W., Buckheit, R. W. Jr, Parang, K. Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. (2012) 22, 5451-5454.
108. Shaik, I. H., Agarwal, H. K., Parang, K., Mehvar, R. Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats. J. Pharm. Sci. (2012) 101, 4003-4012.
109. Tiwari R. K., Parang, K. Conformationally constrained peptides as protein tyrosine kinase inhibitors. Curr. Pharm. Des. (2012) 18, 2852-2866.
110. Chhikara, B. S., Tiwari, R., Parang, K. N-Myristoylglutamic acid derivative of 3'-fluoro-3'-deoxythymidine as an organogel. Tetrahedron Lett. (2012) 53, 5335-5337.
111. Sharma, R. K., Singh, S., Tiwari, R., Mandal, D., Olsen, C. E., Parmar, V. S., Parang, K., Prasad, A. K. O-Aryl ?,?-D-ribofuranoside: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity. Bioorg. Med. Chem. (2012) 20, 6821-6830.
112. Kumar, A., Muthyala, M. K., Choudhary, S., Tiwari, R. K., Parang, K. Ionic liquid as soluble support for synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles. J. Org. Chem. (2012) 77, 9391-9396.
113. Nasrolahi Shirazi, A., Mandal, D., Tiwari, R. K., Guo, L., Lu, W., Parang, K. Cyclic peptide-capped gold nanoparticles as drug delivery systems. Molecular Pharmaceutics (2013), 10, 500-511.
114. Agarwal, H. K., Chhikara, B. S., Bhavaraju, S., Mandal, D., Doncel, G. F., Parang, K. Emtricitabine prodrugs with improved anti-HIV activity and cellular uptake. Molecular Pharmaceutics (2013) 10, 467-476.
115. Nasrolahi Shirazi, A., Tiwari, R. K., Chhikara, B. S., Mandal, D., Parang, K. Design and evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. Molecular Pharmaceutics (2013) 10, 488-499.
116. Chand, K., Nasrolahi Shirazi, A., Yadav, P., Tiwari, R. K., Kumari, M., Parang K., Sharma, S. K. Synthesis, antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives. Can. J. Chem. (2013) 91, 741-754.
117. Cao, C., Rioult-Pedotti, M. S., Migani, P., Yu, C. J., Tiwari, R., Parang, K., Spaller, M. R., Goebel, D. J., Marshall, J., Impairment of TrkB-PSD-95 signaling in Angelman syndrome, PLoS Biology, (2013) 11, e1001478.
118. Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D, Banerjee, A, Yadav, A, Parang, K. Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine. Mol. Pharm. (2013) 10, 2008-2020.
119. Nasrolahi Shirazi, A., Tiwari, R. K., Brown, A., Mandal, D., Sun, G., Parang, K. Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors. Bioorg. Med. Chem. Lett. (2013) 23, 3230-3234.
120. Kameshwara Rao V., Shelke, G. M., Tiwari, R., Parang, K., Kumar A. A simple and efficient synthesis of 2,3-diarynaphthofurans using sequential hydroarylation/Heck oxyarylation. Org. Lett. (2013) 15, 2190-2193.
121. Kumar, A., Ye, G., Gu, X., Wang, Y., Sun, G., Parang K. Synthesis of pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their Src kinase inhibitory activities. Chemistry & Biology Interface (2013) 3, 264-269.
122. Kumar, A., Rao, V. K., Tiwari, R., Chhikara, B. S., Shirazi, A. N., Parang, K. Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities. RSC Adv. (2013), 3, 15396-15403.
123. Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D., Sullivan, B., McCaffrey, K., Mandal. D., Parang, K. Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters. Molecular Pharmaceutics. (2013) 10, 3137-3151.
124. Pericherla, K., Nasrolahi Shirazi, Rao, A. V. K., Tiwari, R., DaSilva, N., Mccaffrey, K. T. Seeram, N., Parang, K., Kumar A., Synthesis and antiproliferative activities of Quebecol and its analogs. Bioorg. Med. Chem. Lett. (2013) 23, 5329-5331.
125. Mandal, D., Tiwari, R. K., Nasrolahi Shirazi, A., Ye, G., Banerjee, A., Yadav, A., Parang, K. Self-assembled surfactant cyclic peptide nanostructures as stabilizing agents. Soft Matter. (2013) 9. 9465-9475.
126. Pericherla, K., Poonam Khedar, P., Khungar, B., Parang, K., Kumar, A. Copper catalyzed tandem oxidative C–H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines. RSC Adv. (2013) 3, 18923-18930.
127. Shelke, G. M., Rao, V. K., Tiwari, R., Chhikara, B. S., Parang K., Kumar A. Bismuth triflate-catalyzed condensation of indoles with acetone. RSC Adv. (2013) 3, 22346-22352.
128. Suresh, N., Nagesh, H. N., Sekhar, K., V. G. C., Kumar, A., Shirazi, A. N., Parang K. Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines. Bioorg. Med. Chem. Lett. (2013) 23, 6292-6295.
129. Nasrolahi Shirazi, A., Oh, D., Tiwari, R. K., Sullivan, B., Gupta, A., Bothun, G. D., Parang, K. Peptide amphiphile containing arginine and fatty acyl chains as molecular transporters. Mol. Pharmaceutics (2013) 10, 4717-4727.
130. Yoon, Y. K., Ali, M., A., Wei, A. C., Choon, T. S., Osman, H., Parang, K., Shirazi, A. M. Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities. Bioorg. Med. Chem. (2014) 22, 703-710.
131. El-Sayed, N.S., Shirazi, N. A., El-Meligy, M. G., El-Ziaty, A. K., Nagib, Z. A., Parang, K. Synthesis of 4-aryl-6-indolylpyridine-3-carbonitriles and evaluation of their antiproliferative activity. Tetrahedron Lett. (2014) 55, 1154-1158.
132. Motavallizadeh, S., Fallah-Tafti, A., Maleki, S., Nasrolahi Shirazi, A., Pordeli, M., Safavi, M., Kabudanian Ardestani, S., Asd, S., Tiwari, R., Oh, D., Shafiee, A., Foroumadi, A., Parang, K., Akbarzadeh T., Synthesis and evaluation of cytotoxic activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides. Tetrahedron Lett. (2014) 55, 373-375.
133. Ghasemi Pirbalouti, A, Sajjadi, S. E., Parang, K. A review (research and patents) on jasmonic acid and its derivatives. Arch Pharm (Weinheim). (2014) 347, 229-239.
134. Pemmaraju, B., Agarwal, H. K., Oh, D., Buckheit, K. W., Buckheit Jr. R. W., Tiwari, R., Parang, K. Synthesis and biological evaluation of 5'-O-dicarboxylic fatty acyl monoester derivatives of anti-HIV nucleoside reverse transcriptase inhibitors. Tetrahedron Lett. (2014) 55, 1983-1986.
135. Chand, K., Prasad, S., Tiwari, R. K., Shirazi, A. N., Kumar, S., Parang, K., Sharma, S. K. Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorganic Chem. (2014) 53, 75-82.
136. Mandal, D., Nasrolahi Shirazi, A., Parang, K. Self-assembly of peptides to nanostructures. Org. Biomol. Chem. (2014) 12, 3544-3561.
137. Choudhary, S., Muthyala, M. K., Parang, K., Kumar A. Ionic liquid-supported sulfonyl hydrazine: A useful reagent for traceless synthesis of pyrazoles. Frontiers in Organic Chemistry (2014) 1, 683-688.
138. Sayeh, N., Nasrolahi Shirazi, A., Oh, D., Sun, J., Rowley, D., Banerjee, A., Yadav, A., Tiwari, R. K., Parang, K.. Amphiphilic triazolyl peptides: Synthesis and evaluation as nanostructures. Current Org. Chem. (2014) 18, 2665-2671.
139. Muthyala, M. K. Velisetti, K., Parang, K., Kumar, A. K. Advances in functionalized ionic liquids as reagents and scavengers in organic synthesis. Current Org. Chem. (2014) 18, 2530-2554.
140. Almansour, A. I., Kumar, R. S., Beevi, F., Shirazi, A. N., Osman, H., Ismail, R., Choon, T. S., Sullivan, B., McCaffrey, K., Nahhas, A., Parang, K., Ali, M. A. Facile, regio- and diastereoselective synthesis of spiro-pyrrolidine and pyrrolizine derivatives and evaluation of their antiproliferative activities. Molecules (2014) 19, 10033-10055.
141. Yoon, Y. K., Ali, M. A., Wei, A. C., Shirazi, A. N., Parang, K., Choon, T. S. Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. Eur J Med Chem. (2014) 83C, 448-454.
142. Verma, A. K., Patel, M., Joshi, M., Likhar, P. R., Tiwari, R. K., Parang, K. Base-mediated chemo- and stereoselective addition of 5-aminoindole/tryptamine and histamines onto alkynes. J. Org. Chem. (2014) 79, 172-186.
143. Oh, D., Darwish, S. A., Nasrolahi Shirazi, A., Tiwari, R. K., Parang, K. Amphiphilic bicyclic peptides as cellular delivery agents. ChemMedChem (2014) 9, 2449-2453.
144. Oh, D., Nasrolahi Shirazi, A., Northup, K., Sullivan, B., Tiwari, R. K., Bisoffi, M., Parang, K. Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization. Mol. Pharmaceutics (2014) 11, 2845-2854.
145. Nasrolahi Shirazi, A., Paquin, K. L., Howlett, N. G., Mandal, D., Parang, K. Cyclic peptide-capped gold nanoparticles for enhanced siRNA delivery. Molecules (2014), 19, 13319-13331.
146. Oh, D., Sun, J., Nasrolahi Shirazi, A., LaPlante, K. L., Rowley, D. C., Parang, K. Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug resistant pathogens. Mol. Pharmaceutics (2014) 11, 3528-3536.
147. Chhikara, B. S., Rao, M. S., Rao, V. K., Kumar, A., Buckheit, K. W., Buckheit Jr. R. W., Parang, K. Carbocyclodipeptides as modified nucleosides: Synthesis and anti-HIV activities. Can. J. Chem. (2014) 10.1139/cjc-2014-0356.
148. Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D., Sullivan, B., Kumar, A., Beni, Y. A., Parang K. Cyclic peptide-selenium nanoparticles as drug transporters. Mol. Pharmaceutics (2014) 11, 3631-3641.
149. Fowler, B. J., Gelfand,B. D.., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., Amarnath, S. Fowler, D. H., Radwan, M., Young, M. T., Pittman, K., Kubes, P., Agarwal, H. K., Parang, K., Hinton,D. R., Bastos-Carvalho, A., Li, S., Yasuma, T., Mizutani, T., Yasuma, R. Wright, C., Ambati, J. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (2014) 346, 1000-1003.
150. Pemmaraju, B. P., Malekar, S., Agarwal, H. K., Tiwari, R. K., Oh, D., Doncel, G. F., Worthen, D. R., Parang,, K., Design, synthesis, antiviral activity, and pre-formulation development of poly-L-arginine-fatty acyl derivatives of nucleoside reverse transcriptase inhibitors. Nucleosides, Nucleotides and Nucleic Acids (2015) 34, 1-15.
151. Saunthwal, R. K., Patel, M., Tiwari, R. K., Parang, K., Verma, A. K. On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate. Green Chemistry (2015) 17, 1434–1441.
152. Beni, Y., Dash C., Parang K. Synthesis of ?-triphosphotriester pronucleotides. Tetrahedron Lett. (2015) 56, 2247–2250.
153. Mokhtari, S,, Shirazi, A. N., Tiwari, R. K., Parang, K., Kobarfard, F. Synthesis of 3-arylidene and 3-arylimine oxindole derivatives and evaluation of their Src kinase inhibitory and antiproliferative activities. Med. Chem. (2015) 5, 242-252.
154. Ramos-Molina, B., Lick, A. N., Nasrolahi Shirazi, A., Oh, D., Tiwari, R., El-Sayed, N. S., Parang, K., Lindberg, I. Cationic cell-penetrating peptides are potent furin inhibitors. PLos One (2015) 10(6): e0130417.
155. Marshall, J., Wong, K., Parang, K., Tiwari, R., Spaller, M., Rupasinghe, C., Berberoglu, E. D., Zhao, X., Sinkler, C., Lie, J., Lee, I., Hüttemann, M., Goebel, D. J. Inhibition of N-methyl-D-aspartate induced retinal neuronal death by polyArginine peptides is linked to the attenuation of stress-induced hyperpolarization of the inner mitochondrial membrane potential. J. Biol. Chem. (2015) 290, 22030-22048.
156. Chand, K., Tiwari, R. K., Kumar, S., Shirazi, A. N., Sharma, S., Eycken, E. V. V. D, Parmar, V. S., Parang, K., Sharma, S. K. Synthesis, antiproliferative, and c-Src kinase inhibitory activities of 4-oxo-4H-1-benzopyran derivatives. J. Heterocyclic Chemistry (2015) 52, 562-572.
157. Banerjee, A., Patel, P. B., Beni, Y., Shirazi, A. N., Parang, K., Yadav, A. Biocompatible, biodegradable peptides for heavy metal toxicity removal. Journal of Applied Chemical Science International (2015) 4, 144-153.
158. Kameshwara Rao V., Kaswan, P., Parang, K., Kumar, A. Indium triflate catalyzed microwave-assisted alkenylation of methoxyphenols: Synthesis of indenes and chromenes. Organic and Biomolecular Chem. (2015) 13, 11072-11077.
159. Yoon, Y. K., Ali, M. A., Wei, A. C., Choon, T. S., Shirazi, A. N., Parang, K. Discovery of a potent and highly fluorescent sirtuin inhibitor. Med. Chem. Commun. (2015) 6, 1857-1863.
160. Rafinejad, A., Fallah-Tafti, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Parang, K., A. Foroumadi, A., Akbarzadeh, T. Synthesis and Evaluation of Ethyl 2,4-dioxo-4- arylbutanoate Derivatives as Src Kinase Inhibitors. Journal of Sciences, 2015, 26, 321-325.
161. Nasrolahi Shirazi, A., El-Sayed, N. S., Tiwari, .R. K., Tavakoli, K., Parang K. Cyclic peptide containing hydrophobic and positively charged residues as a drug delivery system for curcumin. Curr. Drug Deliv. (2016), 13, 409-417.
162. Nasrolahi Shirazi, A., El-Sayed, N. S., Mandal, D., Tiwari, R. K., Tavakoli, K., Etesham, M., Parang, K. Cysteine and arginine-rich peptides as molecular carriers. Bioorg. Med. Chem. Lett. (2016) 26, 651-656.
163. Banerjee, A., Sayeh, N., Nasrolahi Shirazi, A., Tiwari, A., Parang, K., Yadav, A. Arginine-rich cyclic peptides enhance nuclear targeted delivery of anti-cancer agents: Molecular insights. Letters in Drug Design & Discovery, 2016, 13, 591-604.
164. El-Sayed, N. S., Shirazi, A. N., El-Meligy, M. G., El-Ziaty, A. K., Nagieb, Z. A., Parang, K., Tiwari, R. K. Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter. Int. J. Biol. Macromol. 2016 87, 611-622.
165. Weerakkody, D., Moshnikova, A., El-Sayed, N. S., Adochite, R. C., Slaybaugh, G., Golijanin, J., Tiwari, R. K. Andreev, O. A., Parang, K., Reshetnyak, Y. K., Novel pH-sensitive cyclic peptides, Scientific Reports 2016, 6, 31322 doi:10.1038/srep31322.
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32. Nam, N. H., Lee, S., Ye, G., Sun, G., Parang, K. ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases. Bioorg. Med. Chem. (2004) 12, 5753-5766.
33. Parang, K., Sun, G. Design strategies for protein kinases inhibitors. Current Opinions In Drug Discovery (2004) 7, 630-638.
34. Ahmadibeni, Y., Parang, K. Solid-phase reagents for selective monophosphorylation of carbohydrates and nucleosides. J. Org. Chem. (2005) 70, 1100-1103.
35. Parang, K., Sun, G. Protein kinase inhibitors in drug discovery. Drug Discovery Handbook, 2005, Wiley-Interscience, New Jersey, Ed. Gad, S. C. 1191-1257.
36. Lin, X., Ayrapetov, M. K., Lee, S., Parang, K., Sun G. Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk. Biochemistry (2005) 44, 1561-1567.
37. Hines, A. C., Parang, K., Kohanski, R. A., Hubbard, S. R., Cole, P. A. Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: Molecular yardsticks for analyzing catalytic mechanism and inhibitor design. Bioorg. Chem. (2005) 33, 285-297.
38. Carballeira, N. M., O’Neill, R., Parang K. Racemic and optically active 2-methoxy-4-oxatetradecanoic acids: Novel synthetic fatty acids with selective antifungal properties. Chem. Phys. Lipids (2005) 136, 47-54.
39. Ahmadibeni, Y., Parang, K. Polymer-bound oxathiaphospholane: A solid-phase reagent for regioselective monothiophosphorylation and monophosphorylation of unprotected nucleosides and carbohydrates. Org. Lett. (2005) 7, 1955-1958.
40. Ayrapetov, M. K., Nam, N. H., Ye, G. Kumar, A., Parang, K., Sun, G. Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation. J. Biol. Chem. (2005) 280, 25780-25787.
41. Carballeira, N. M., O’Neill, R., Parang, K. Total synthesis and further scrutiny of the in vitro antifungal activity of 6-nonadecynoic acid. Arch. Pharm.-Pharm. Med. Chem. (2005) 338, 441-443.
42. Ye, G., Ayrapetov, M., Nam, N. H., Sun, G., Parang, K. Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain. Bioorg. Med. Chem. Lett. (2005) 15, 4994-4997.
43. Parang, K., Sun, G. Recent advances in the discovery of Src kinases inhibitors. Expert Opin. Ther. Patents (2005) 15, 1183-1207.
44. Ahmadibeni, Y., Parang, K. Selective diphosphorylation, dithiodiphosphorylation, triphosphorylation, and trithiotriphosphorylation of unprotected carbohydrates and nucleosides. Org. Lett. (2005) 7, 5589-5592.
45. Parang, K. Editor. Novel approaches in designing anti-HIV microbicides and anti-HIV Agents. Curr. Pharm. Des. (2005) 11, 123 pp.
46. Lin, X., Wang, Y., Ahmadibeni, Y., Parang, K., Sun, G. Structural basis for domain-domain communication in a protein tyrosine kinase, Csk. J. Mol. Biol. (2006) 357, 1263-1273.
47. Lee, S., Ayrapetov, M. K., Kemble, D., Parang, K., Sun, G. Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, the C-terminal Src kinase. J. Biol. Chem. (2006) 281, 8183-8189.
48. Ahmadibeni, Y., Parang, K. Solid-phase synthesis of dinucleoside and nucleoside-carbohydrate phosphodiesters and thiophosphodiesters. J. Org. Chem. (2006) 71, 6693-6696.
49. Ahmadibeni, Y., Parang, K. Application of a solid-phase ß-triphosphitylating reagent in the synthesis of nucleoside ß-triphosphates. J. Org. Chem. (2006) 71, 5837-5839.
50. Kumar, A., Ye, G., Wang, Y., Lin, X., Sun, G., Parang, K. Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogs of CIYKYY as Src tyrosine kinase inhibitors. J. Med. Chem. (2006) 49, 3395-3401.
51. Carballeira, N. M., Sanabria, D., Cruz, C., Parang, K., Wan, B., Franzblau, S. 2,6-Hexadecadiynoic acid and 2,6-nondecadiynoic acid – Novel synthesized acetylenic fatty acids as potent antifungal agents. Lipids (2006) 41, 507-511.
52. Ayrapetov, M. K., Wang, Y.-H., Xiaofeng, L., Gu X., Parang, K., Sun G. Conformational basis for SH2-pTYR527 binding in SRC inactivation. J. Biol. Chem. (2006) 281, 23776-23784.
53. Kumar, A., Ye, G., Ahmadibeni, Y., Parang, K. Synthesis of polymer-bound 4-acetoxy-3-phenylbenzaldehyde derivatives: Applications in solid-phase organic synthesis. J. Org. Chem. (2006) 71, 7915-7918.
54. Gu, X., Wang, Y., Kumar, A., Ye, G., Parang, K., Sun, G. Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase. J. Med. Chem. (2006) 49, 7532-7539.
55. Agarwal, H. K., Parang, K. Application of solid-phase chemistry for the synthesis of 3?-fluoro-3?-deoxythymidine. Nucleosides, Nucleotides& Nucleic Acids (2007) 26, 317-322.
56. Ahmadibeni, Y., Parang, K., Synthesis and evaluation of oligodeoxynucleotides containing diphosphodiester internucleotide linkages. Angew. Chem. Int. Ed. (2007) 46, 4739-4743.
57. Kumar, A., Wang, Y., Lin, X., Sun, G., Parang, K. Synthesis and evaluation of 3-phenylpyrazolopyrimidine-peptide conjugates as Src tyrosine kinase inhibitors. ChemMedChem (2007) 2, 1346-1360.
58. Carballeira, N. M., O’Neil, R., Parang, K. Synthesis and antifungal properties of alpha-methoxy and alpha-hydroxyl substituted 4-thiatetradecanoic acids. Chem. Phys. Lipids (2007) 150, 82-88.
59. Ahmadibeni, Y., Hanley, M., White, M., Ayrapetov, M., Lin, X., Sun, G., Parang, K. Metal-binding properties of a dicysteine-containing motif in protein tyrosine kinases. ChemBioChem (2007) 8, 1592-1605.
60. Ye, G., Nam, N. H., Saleh, A., Kumar, A., Sun, G., Shenoy, D. B., Amiji, M. M., Parang, K. Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptides. J. Med. Chem. (2007) 50, 3604-3617.
61. Chimalakonda, C., Agarwal, H., Kumar, A., Parang, K., Mehvar, R. Synthesis, analysis, in vitro characterization, and in vivo disposition of a lamivudine-dextran conjugate for selective antiviral delivery to the liver. Bioconj. Chem. (2007) 18, 2097-2108.
62. Bhandari, R., Saiardi, A., Ahmadibeni, Y., Snowman, A. M., Resnick, A. C., Kristiansen, T. Z., Molina, H., Pandey, A., Werner, Jr. J. K., Juluri, K. R., Xu, Y., Prestwich, G. D., Parang, K., Snyder, S. H. Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc. Nat. Acad. Sci. U.S.A. (2007) 104, 15305-15310.
63. Ahmadibeni, Y., Parang, K. Solid-phase synthesis of symmetrical 5?,5?-dinucleoside mono-, di-, tri-, and tetraphosphodiesters. Org. Lett. (2007) 9, 4483-4486.
64. Penugonda, S., Kumar, A., Agarwal, H. K., Parang, K., Mehvar, R. Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: Effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates. J. Pharm. Sci. (2008) 97, 2649-2664.
65. Ahmadibeni, Y., Parang, K. Solid-supported diphosphitylating and triphosphitylating reagents for nucleoside modification. Current Protocols in Nucleic Acid Chemistry (2008) Chapter 13:Unit13.8.1-13.8.29.
66. Ye, G., Tiwari, R., Parang K. Development of Src tyrosine kinase substrate binding site inhibitors. Current Opinions Investigational Drugs (2008) 9, 605-613.
67. Agarwal, H. K., Doncel, G., Parang, K. Synthesis and anti-HIV activities of phosphate triester derivatives of 3'-fluoro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine. Tetrahedron Lett. (2008) 49, 4905-4907.
68. Ahmadibeni, Y., Parang K. Symmetrical dinucleosides. Synfacts (2008) 2, 0207 (highlight publication).
69. Ahmadibeni, Y., Parang, K. Solid-supported reagents for synthesis of nucleoside monothiophosphates, dithiodiphosphates, and trithiotriphosphates. Current Protocols in Nucleic Acid Chemistry (2009) Chapter 13:Unit13.9.
70. Ahmadibeni, Y., Tiwari, R., Sun, G., Parang, K. Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cycloSaligenyl phosphitylating reagents. Org. Lett. (2009) 11, 2157-2160.
71. Ye, G., Schuler, A., Ahmadibeni, Y., Morgan, J. R., Faruqui, A., Huang, K., Sun, G., Zebala, J. A., Parang, K. Synthesis and evaluation of peptides containing iminodiacetate groups as binding ligands of the Src SH2 domain. Bioorg. Chem. (2009) 37, 133-142.
72. Carballeira, N. M., Miranda, C., Parang, K. The first total synthesis of the (?)-4-methoxydecanoic acid: a novel antifungal fatty acid. Tetrahedron Lett. (2009) 50, 5699-5700.
73. Tiwari, R., Parang K. Protein conjugates of SH3 domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases. ChemBioChem (2009) 10, 2445-2448.
74. Ahmadibeni, Y., Dash, C., Grice, S. F., Parang, K. 5?-O-?,?-Methylenetriphosphate derivatives of nucleoside. Synfacts (2010) 8, 0961 (highlight publication).
75. Penugonda, S., Agarwal, H. K., Parang, K., Mehvar, R. Plasma pharmacokinetics and tissue disposition of novel dextran-methylprednisolone conjugates with peptide linkers in rats. J. Pharmaceutical Sci. (2010), 99, 1627-1637.
76. Ye, G., Gupta, A., DeLuca, R., Parang, K., Bothun, G. D. Bilayer disruption and liposome restructuring by a homologous series of small Arg. Rich synthetic peptides. Colloids and Surfaces B.: Biointerfaces (2010) 76, 76-81.
77. Ahmadibeni, Y., Dash, C., Hanley, M. J., Le Grice, S. F. J., Agarwal, H. K., Parang K. Synthesis of nucleoside 5'-O-a,ß-methylene-ß-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase. Org. Biomol. Chem. (2010) 8, 1271-1274.
78. Tiwari, R., Brown, A., Narramaneni, S., Sun, G., Parang, K. Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands. Biochimie (2010) 92, 1153-1163.
79. Ahmadibeni, Y., Dash, C., Le Grice, S. F. J., Parang K. Solid-phase synthesis of 5'-O-ß,?-methylenetriphosphate derivatives of nucleosides and evaluation of their inhibitory activity against HIV-1 reverse transcriptase. Tetrahedron Lett. (2010) 51, 3010-3013.
80. Sharma, D., Bhatia, S., Sharma, R. K., Tiwari, R., Olsen, C. E., Mandal, D., Lehmann, J., Parang, K., Parmar, V. S., Prasad, A. S. Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3-(N-alkyl-N-phenylamino)propane-2-ols. Biochimie (2010) 92, 1164-1172.
81. Chhikara, B. S., Mandal, D., Parang, K. Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents. Eur. J. Med. Chem. (2010) 45, 4601-4608.
82. Agarwal, H. K., Kumar, A., Doncel, G. F., Parang K. Synthesis, antiviral and contraceptive activities of nucleoside-sodium cellulose sulfate acetate and succinate conjugates. Bioorg. Med. Chem. Lett. (2010) 20, 6993-6997.
83. Chhikara, B. S., Parang, K. Development of cytarabine prodrugs and delivery systems for leukemia treatment. Expert Opin. Drug Del. (2010) 7, 1399-1414.
84. Parang, K., Sun, G. Protein kinase inhibitors in drug discovery. Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing (2010) John Wiley & Sons, Inc.
85. Kumar, D., Buchi Reddy, V., Kumar, A., Mandal, D., Tiwari, R., Parang, K. Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity. Bioorg. Med. Chem. Lett. (2011) 2, 449-452.
86. Kumar, A., Ahmad, I., Chhikara, B. S., Tiwari, R., Mandal, D., Parang, K. Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities. Bioorg. Med. Chem. Lett. (2011) 21, 1342-1346.
87. Ahmadibeni, Y., Tiwari, R., Swepson, C., Pandhare, J., Dash, C., Doncel, G. F., Parang, K. Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine. Tetrahedron Lett. (2011) 52, 802-805.
88. Agarwal, H. K., Loethan, K., Mandal, D., Doncel, G. F., Parang, K. Synthesis and anti-HIV activities of fatty acyl ester derivatives of 2',3'-didehydro-2',3'-dideoxythymidine. Bioorg. Med. Chem. Lett. (2011) 21, 1917-1921.
89. Fallah-Tafti, A., Tiwari, R., Shirazi, A. N., Akbarzadeh, T., Mandal, D., Shafiee, A., Parang, K., Foroumadi, A. 4-Aryl-4H-chromene-3-carbonitrile derivatives: Evaluation of Src kinase inhibitory and anticancer activities. Med. Chem. (2011) 7, 466-472.
90. Chhikara, B. S., St. Jean, N., Mandal, D., Kumar, A., Parang, K. Fatty-acyl amide derivatives of doxorubicin: Synthesis and in vitro anticancer activities. Eur. J. Med. Chem. (2011) 46, 2037-2042.
91. Gupta, A., Mandal, D., Ahmadibeni, Y., Parang, K., Bothun, G. Hydrophobicity drives the non-specific cellular uptake of short cationic peptide ligands. Eur. Biophysics J. (2011) 40, 727-736.
92. Rao, V. K., Chhikara, B. S., Nasrolahi Shirazi, A. N., Tiwari, R., Parang, K., Kumar, A. 3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities. Bioorg. Med. Chem. Lett. (2011) 21, 3511-3514.
93. Dash, C., Ahmadibeni, Y., Hanley, M. J., Pandhare, J., Gotte, M., Le Grice, S. F. J., Parang, K. Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside ß-triphosphates. Bioorg. Med. Chem. Lett. (2011) 21, 3519-3522.
94. Kathuria, A., Jalal, S., Tiwari, R., Nasrolahi Shirazi, A., Gupta, S., Kumar, S., Parang, K., Harma, S. K. Substituted coumarin derivatives: Synthesis and evaluation of antiproliferative and Src kinase inhibitory activities. Chemistry Biology Interface (2011) 1 (2), 279-296.
95. Fallah-Tafti, A., Foroumadi, A., Tiwari, R., Shirazi, A. N., Hangauer, D. G., Bu, Y., Akbarzadeh, T., Parang, K., Shafiee, A. Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities. Eur. J. Med. Chem. (2011) 46, 4853-4858.
96. Mandal, D., Nasrolahi Shirazi, A., Parang, K. Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew. Chem. Int. Ed. (2011) 50, 9633-9637.
97. Rao, M. S., Chhikara, B. S., Tiwari, R., Nasrolahi Shirazi, A., Parang, K., Kumar, A. Greener synthesis of 2-aminochromenes in ionic liquid and evaluation of their antiproliferative activities. Chemistry & Biology Interface (2012) 2, 362-372.
98. Rafinejad, A., Fallah-Taftia, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Shafiee, A., Parang, K., Foroumadi, A., Akbarzadeh, T. 4-Aryl-4H-naphthopyrans derivatives: One-pot synthesis, Evaluation of Src kinase inhibitory and anti-proliferative activities. DARU Journal of Pharmaceutical Sciences, 2012, 20, 100.
99. Muthyala, M. J., Chhikara, B. S., Parang, K., Kumar, A. Ionic-liquid-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene— An efficient and recyclable organocatalyst for Michael addition to a,ß-unsaturated ketones. Can. J. Chem. (2012) 90, 290-297.
100. Agarwal, H. K., Doncel, G. F., Parang K. Synthesis and anti-HIV activities of Suramin conjugates of 3'-fluoro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine. Med. Chem. 2012, 8, 193-197.
101. Rao, M. S., Chhikara, B. S., Tiwari, R., Shirazi, A. N., Parang, K., Kumar, A. Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones. Monatsh. Chem. (2012) 143, 263-268.
102. Rao, V. K., Chhikara, B.S., Tiwari, R., Nasrolahi Shirazi, A., Parang, K., Kumar, A. One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their anti-proliferative and Src kinase inhibitory activities. Bioorg. Med. Chem. Lett. (2012) 22, 410-414.
103. Munthayala, M., Chhikara, B., Parang, K., Kumar, A. Ionic liquid-supported synthesis of sulfonamides and carboxamides. ACS Combinatorial Science (2012) 14, 60-65.
104. Chhikara, B. S., Mandal, D., Parang, K. Synthesis, anticancer activities, and cellular uptake studies of lipophilic derivatives of doxorubicin succinate. J. Med. Chem. (2012) 55, 1500-1510.
105. Agarwal, H. K., Chhikara, B. S., Quiterio, M., Doncel, G. F., Parang, K. Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors. J. Med. Chem. (2012) 55, 2672-2687.
106. Agarwal, H. K., Chhikara, B. S., Hanley, M. J., Ye, G., Doncel, G. F., Parang, K. Synthesis and biological evaluation of fatty acyl ester derivatives of (-)-2',3'-dideoxy-3'-thiacytidine. J. Med. Chem. (2012) 55, 4861-4871.
107. Agarwal, H. K., Buckheit, K. W., Buckheit, R. W. Jr, Parang, K. Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett. (2012) 22, 5451-5454.
108. Shaik, I. H., Agarwal, H. K., Parang, K., Mehvar, R. Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats. J. Pharm. Sci. (2012) 101, 4003-4012.
109. Tiwari R. K., Parang, K. Conformationally constrained peptides as protein tyrosine kinase inhibitors. Curr. Pharm. Des. (2012) 18, 2852-2866.
110. Chhikara, B. S., Tiwari, R., Parang, K. N-Myristoylglutamic acid derivative of 3'-fluoro-3'-deoxythymidine as an organogel. Tetrahedron Lett. (2012) 53, 5335-5337.
111. Sharma, R. K., Singh, S., Tiwari, R., Mandal, D., Olsen, C. E., Parmar, V. S., Parang, K., Prasad, A. K. O-Aryl ?,?-D-ribofuranoside: Synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity. Bioorg. Med. Chem. (2012) 20, 6821-6830.
112. Kumar, A., Muthyala, M. K., Choudhary, S., Tiwari, R. K., Parang, K. Ionic liquid as soluble support for synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles. J. Org. Chem. (2012) 77, 9391-9396.
113. Nasrolahi Shirazi, A., Mandal, D., Tiwari, R. K., Guo, L., Lu, W., Parang, K. Cyclic peptide-capped gold nanoparticles as drug delivery systems. Molecular Pharmaceutics (2013), 10, 500-511.
114. Agarwal, H. K., Chhikara, B. S., Bhavaraju, S., Mandal, D., Doncel, G. F., Parang, K. Emtricitabine prodrugs with improved anti-HIV activity and cellular uptake. Molecular Pharmaceutics (2013) 10, 467-476.
115. Nasrolahi Shirazi, A., Tiwari, R. K., Chhikara, B. S., Mandal, D., Parang, K. Design and evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. Molecular Pharmaceutics (2013) 10, 488-499.
116. Chand, K., Nasrolahi Shirazi, A., Yadav, P., Tiwari, R. K., Kumari, M., Parang K., Sharma, S. K. Synthesis, antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives. Can. J. Chem. (2013) 91, 741-754.
117. Cao, C., Rioult-Pedotti, M. S., Migani, P., Yu, C. J., Tiwari, R., Parang, K., Spaller, M. R., Goebel, D. J., Marshall, J., Impairment of TrkB-PSD-95 signaling in Angelman syndrome, PLoS Biology, (2013) 11, e1001478.
118. Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D, Banerjee, A, Yadav, A, Parang, K. Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine. Mol. Pharm. (2013) 10, 2008-2020.
119. Nasrolahi Shirazi, A., Tiwari, R. K., Brown, A., Mandal, D., Sun, G., Parang, K. Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors. Bioorg. Med. Chem. Lett. (2013) 23, 3230-3234.
120. Kameshwara Rao V., Shelke, G. M., Tiwari, R., Parang, K., Kumar A. A simple and efficient synthesis of 2,3-diarynaphthofurans using sequential hydroarylation/Heck oxyarylation. Org. Lett. (2013) 15, 2190-2193.
121. Kumar, A., Ye, G., Gu, X., Wang, Y., Sun, G., Parang K. Synthesis of pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their Src kinase inhibitory activities. Chemistry & Biology Interface (2013) 3, 264-269.
122. Kumar, A., Rao, V. K., Tiwari, R., Chhikara, B. S., Shirazi, A. N., Parang, K. Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities. RSC Adv. (2013), 3, 15396-15403.
123. Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D., Sullivan, B., McCaffrey, K., Mandal. D., Parang, K. Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters. Molecular Pharmaceutics. (2013) 10, 3137-3151.
124. Pericherla, K., Nasrolahi Shirazi, Rao, A. V. K., Tiwari, R., DaSilva, N., Mccaffrey, K. T. Seeram, N., Parang, K., Kumar A., Synthesis and antiproliferative activities of Quebecol and its analogs. Bioorg. Med. Chem. Lett. (2013) 23, 5329-5331.
125. Mandal, D., Tiwari, R. K., Nasrolahi Shirazi, A., Ye, G., Banerjee, A., Yadav, A., Parang, K. Self-assembled surfactant cyclic peptide nanostructures as stabilizing agents. Soft Matter. (2013) 9. 9465-9475.
126. Pericherla, K., Poonam Khedar, P., Khungar, B., Parang, K., Kumar, A. Copper catalyzed tandem oxidative C–H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines. RSC Adv. (2013) 3, 18923-18930.
127. Shelke, G. M., Rao, V. K., Tiwari, R., Chhikara, B. S., Parang K., Kumar A. Bismuth triflate-catalyzed condensation of indoles with acetone. RSC Adv. (2013) 3, 22346-22352.
128. Suresh, N., Nagesh, H. N., Sekhar, K., V. G. C., Kumar, A., Shirazi, A. N., Parang K. Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines. Bioorg. Med. Chem. Lett. (2013) 23, 6292-6295.
129. Nasrolahi Shirazi, A., Oh, D., Tiwari, R. K., Sullivan, B., Gupta, A., Bothun, G. D., Parang, K. Peptide amphiphile containing arginine and fatty acyl chains as molecular transporters. Mol. Pharmaceutics (2013) 10, 4717-4727.
130. Yoon, Y. K., Ali, M., A., Wei, A. C., Choon, T. S., Osman, H., Parang, K., Shirazi, A. M. Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities. Bioorg. Med. Chem. (2014) 22, 703-710.
131. El-Sayed, N.S., Shirazi, N. A., El-Meligy, M. G., El-Ziaty, A. K., Nagib, Z. A., Parang, K. Synthesis of 4-aryl-6-indolylpyridine-3-carbonitriles and evaluation of their antiproliferative activity. Tetrahedron Lett. (2014) 55, 1154-1158.
132. Motavallizadeh, S., Fallah-Tafti, A., Maleki, S., Nasrolahi Shirazi, A., Pordeli, M., Safavi, M., Kabudanian Ardestani, S., Asd, S., Tiwari, R., Oh, D., Shafiee, A., Foroumadi, A., Parang, K., Akbarzadeh T., Synthesis and evaluation of cytotoxic activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides. Tetrahedron Lett. (2014) 55, 373-375.
133. Ghasemi Pirbalouti, A, Sajjadi, S. E., Parang, K. A review (research and patents) on jasmonic acid and its derivatives. Arch Pharm (Weinheim). (2014) 347, 229-239.
134. Pemmaraju, B., Agarwal, H. K., Oh, D., Buckheit, K. W., Buckheit Jr. R. W., Tiwari, R., Parang, K. Synthesis and biological evaluation of 5'-O-dicarboxylic fatty acyl monoester derivatives of anti-HIV nucleoside reverse transcriptase inhibitors. Tetrahedron Lett. (2014) 55, 1983-1986.
135. Chand, K., Prasad, S., Tiwari, R. K., Shirazi, A. N., Kumar, S., Parang, K., Sharma, S. K. Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorganic Chem. (2014) 53, 75-82.
136. Mandal, D., Nasrolahi Shirazi, A., Parang, K. Self-assembly of peptides to nanostructures. Org. Biomol. Chem. (2014) 12, 3544-3561.
137. Choudhary, S., Muthyala, M. K., Parang, K., Kumar A. Ionic liquid-supported sulfonyl hydrazine: A useful reagent for traceless synthesis of pyrazoles. Frontiers in Organic Chemistry (2014) 1, 683-688.
138. Sayeh, N., Nasrolahi Shirazi, A., Oh, D., Sun, J., Rowley, D., Banerjee, A., Yadav, A., Tiwari, R. K., Parang, K.. Amphiphilic triazolyl peptides: Synthesis and evaluation as nanostructures. Current Org. Chem. (2014) 18, 2665-2671.
139. Muthyala, M. K. Velisetti, K., Parang, K., Kumar, A. K. Advances in functionalized ionic liquids as reagents and scavengers in organic synthesis. Current Org. Chem. (2014) 18, 2530-2554.
140. Almansour, A. I., Kumar, R. S., Beevi, F., Shirazi, A. N., Osman, H., Ismail, R., Choon, T. S., Sullivan, B., McCaffrey, K., Nahhas, A., Parang, K., Ali, M. A. Facile, regio- and diastereoselective synthesis of spiro-pyrrolidine and pyrrolizine derivatives and evaluation of their antiproliferative activities. Molecules (2014) 19, 10033-10055.
141. Yoon, Y. K., Ali, M. A., Wei, A. C., Shirazi, A. N., Parang, K., Choon, T. S. Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. Eur J Med Chem. (2014) 83C, 448-454.
142. Verma, A. K., Patel, M., Joshi, M., Likhar, P. R., Tiwari, R. K., Parang, K. Base-mediated chemo- and stereoselective addition of 5-aminoindole/tryptamine and histamines onto alkynes. J. Org. Chem. (2014) 79, 172-186.
143. Oh, D., Darwish, S. A., Nasrolahi Shirazi, A., Tiwari, R. K., Parang, K. Amphiphilic bicyclic peptides as cellular delivery agents. ChemMedChem (2014) 9, 2449-2453.
144. Oh, D., Nasrolahi Shirazi, A., Northup, K., Sullivan, B., Tiwari, R. K., Bisoffi, M., Parang, K. Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization. Mol. Pharmaceutics (2014) 11, 2845-2854.
145. Nasrolahi Shirazi, A., Paquin, K. L., Howlett, N. G., Mandal, D., Parang, K. Cyclic peptide-capped gold nanoparticles for enhanced siRNA delivery. Molecules (2014), 19, 13319-13331.
146. Oh, D., Sun, J., Nasrolahi Shirazi, A., LaPlante, K. L., Rowley, D. C., Parang, K. Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug resistant pathogens. Mol. Pharmaceutics (2014) 11, 3528-3536.
147. Chhikara, B. S., Rao, M. S., Rao, V. K., Kumar, A., Buckheit, K. W., Buckheit Jr. R. W., Parang, K. Carbocyclodipeptides as modified nucleosides: Synthesis and anti-HIV activities. Can. J. Chem. (2014) 10.1139/cjc-2014-0356.
148. Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D., Sullivan, B., Kumar, A., Beni, Y. A., Parang K. Cyclic peptide-selenium nanoparticles as drug transporters. Mol. Pharmaceutics (2014) 11, 3631-3641.
149. Fowler, B. J., Gelfand,B. D.., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., Amarnath, S. Fowler, D. H., Radwan, M., Young, M. T., Pittman, K., Kubes, P., Agarwal, H. K., Parang, K., Hinton,D. R., Bastos-Carvalho, A., Li, S., Yasuma, T., Mizutani, T., Yasuma, R. Wright, C., Ambati, J. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (2014) 346, 1000-1003.
150. Pemmaraju, B. P., Malekar, S., Agarwal, H. K., Tiwari, R. K., Oh, D., Doncel, G. F., Worthen, D. R., Parang,, K., Design, synthesis, antiviral activity, and pre-formulation development of poly-L-arginine-fatty acyl derivatives of nucleoside reverse transcriptase inhibitors. Nucleosides, Nucleotides and Nucleic Acids (2015) 34, 1-15.
151. Saunthwal, R. K., Patel, M., Tiwari, R. K., Parang, K., Verma, A. K. On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate. Green Chemistry (2015) 17, 1434–1441.
152. Beni, Y., Dash C., Parang K. Synthesis of ?-triphosphotriester pronucleotides. Tetrahedron Lett. (2015) 56, 2247–2250.
153. Mokhtari, S,, Shirazi, A. N., Tiwari, R. K., Parang, K., Kobarfard, F. Synthesis of 3-arylidene and 3-arylimine oxindole derivatives and evaluation of their Src kinase inhibitory and antiproliferative activities. Med. Chem. (2015) 5, 242-252.
154. Ramos-Molina, B., Lick, A. N., Nasrolahi Shirazi, A., Oh, D., Tiwari, R., El-Sayed, N. S., Parang, K., Lindberg, I. Cationic cell-penetrating peptides are potent furin inhibitors. PLos One (2015) 10(6): e0130417.
155. Marshall, J., Wong, K., Parang, K., Tiwari, R., Spaller, M., Rupasinghe, C., Berberoglu, E. D., Zhao, X., Sinkler, C., Lie, J., Lee, I., Hüttemann, M., Goebel, D. J. Inhibition of N-methyl-D-aspartate induced retinal neuronal death by polyArginine peptides is linked to the attenuation of stress-induced hyperpolarization of the inner mitochondrial membrane potential. J. Biol. Chem. (2015) 290, 22030-22048.
156. Chand, K., Tiwari, R. K., Kumar, S., Shirazi, A. N., Sharma, S., Eycken, E. V. V. D, Parmar, V. S., Parang, K., Sharma, S. K. Synthesis, antiproliferative, and c-Src kinase inhibitory activities of 4-oxo-4H-1-benzopyran derivatives. J. Heterocyclic Chemistry (2015) 52, 562-572.
157. Banerjee, A., Patel, P. B., Beni, Y., Shirazi, A. N., Parang, K., Yadav, A. Biocompatible, biodegradable peptides for heavy metal toxicity removal. Journal of Applied Chemical Science International (2015) 4, 144-153.
158. Kameshwara Rao V., Kaswan, P., Parang, K., Kumar, A. Indium triflate catalyzed microwave-assisted alkenylation of methoxyphenols: Synthesis of indenes and chromenes. Organic and Biomolecular Chem. (2015) 13, 11072-11077.
159. Yoon, Y. K., Ali, M. A., Wei, A. C., Choon, T. S., Shirazi, A. N., Parang, K. Discovery of a potent and highly fluorescent sirtuin inhibitor. Med. Chem. Commun. (2015) 6, 1857-1863.
160. Rafinejad, A., Fallah-Tafti, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Parang, K., A. Foroumadi, A., Akbarzadeh, T. Synthesis and Evaluation of Ethyl 2,4-dioxo-4- arylbutanoate Derivatives as Src Kinase Inhibitors. Journal of Sciences, 2015, 26, 321-325.
161. Nasrolahi Shirazi, A., El-Sayed, N. S., Tiwari, .R. K., Tavakoli, K., Parang K. Cyclic peptide containing hydrophobic and positively charged residues as a drug delivery system for curcumin. Curr. Drug Deliv. (2016), 13, 409-417.
162. Nasrolahi Shirazi, A., El-Sayed, N. S., Mandal, D., Tiwari, R. K., Tavakoli, K., Etesham, M., Parang, K. Cysteine and arginine-rich peptides as molecular carriers. Bioorg. Med. Chem. Lett. (2016) 26, 651-656.
163. Banerjee, A., Sayeh, N., Nasrolahi Shirazi, A., Tiwari, A., Parang, K., Yadav, A. Arginine-rich cyclic peptides enhance nuclear targeted delivery of anti-cancer agents: Molecular insights. Letters in Drug Design & Discovery, 2016, 13, 591-604.
164. El-Sayed, N. S., Shirazi, A. N., El-Meligy, M. G., El-Ziaty, A. K., Nagieb, Z. A., Parang, K., Tiwari, R. K. Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter. Int. J. Biol. Macromol. 2016 87, 611-622.
165. Weerakkody, D., Moshnikova, A., El-Sayed, N. S., Adochite, R. C., Slaybaugh, G., Golijanin, J., Tiwari, R. K. Andreev, O. A., Parang, K., Reshetnyak, Y. K., Novel pH-sensitive cyclic peptides, Scientific Reports 2016, 6, 31322 doi:10.1038/srep31322.
Grants
“Synthesis of Molybdopterin and its Analogs”, $213,179 Alexion, (8/1/13-Present) (Role: PI).
36. “Synthesis of Cyclic Pyranopterin Monophosphate (cPMP) and the Prodrugs”, Alexion (Total grant $139,656) (4/01/2012-10/01/2013) (Role: PI).
35. “Synthesis of Organophosphorus Compounds Using Solid-Phase Reagents”, NSF, CHE 0748555, $300,000, 02/01/2008-02/01/2013 (Role: PI).
30. “Development of Src Kinase Inhibitors as Anticancer Agents”. American Cancer Society, RSG-07-290-01-CDD, $627,000, 07/01/2007-07/01/2012 (Role: PI).
27. “The Tick-Bite Patch”, Rhode Island Science & Technology Advisory Council (STAC), RIRA-CA-2011, (Total grant $199,479) (01/01/2011-12/31/2012) (PI. Dr. Thomas Mather) (Role: PI, Multiple PI grant).
21. (Co-PI, 20% effort, $172,800), “Mechanism of PTK Substrate Recognition and Specificity”, NIH, 1R01CA111687 (Total grant $864,000) March 2005-December 2009 (PI: Dr. Gongqin Sun).
20. (Co-PI, 15% effort, $130,000), “Local Immunosuppression for Liver Transplantation”, NIH, 1R01 GM069869 (Total grant $866,980) 04/01/05-04/01/09, (PI. Dr. Reza Mehvar).
(Co-PI, 25% effort, $178,635), “Mechanistic Studies and Inhibitor Design for Protein Tyrosine Kinases”, American Cancer Society, RSG CDD-106966 (Total grant $714,543) 08/01/04-08/01/09 (P.I.: Dr. Gongqin Sun).
Graduate Programs
Medicinal Chemistry and Pharmacology
Research Centers
Chao Family Cancer Center
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6295
https://faculty.uci.edu/profile/?facultyId=6295
Last updated
11/05/2016
11/05/2016