Aileen J Anderson, PhD

picture of Aileen J Anderson, PhD

Professor, Physical Medicine & Rehabilitation
School of Medicine

Director, Sue and Bill Gross Stem Cell Research Center

B.S., University of Illinois, Urbana, 1987, Bioengineering
Ph.D., University of California, Irvine, 1996, Biology, Neurobiology

Phone: (949) 824-6750

University of California, Irvine
Sue & Bill Gross Stem Cell Research Center
Building 845, Room 2030
Mail Code: 1705
Irvine, CA 92697
Research Interests
stem cell biology, spinal cord injury, glioblastoma
Academic Distinctions
UCI Chancellor's Award for Excellence in Research Mentorship. (2006).
Harvard Medical School Clinical Neuroscience Training Program Fellowship. (1996 - 1997).
5th Conference on Alzheimer's Disease Young Investigator Award. (1996).
Postdoctoral Fellow, University of California Irvine, (1996).

Postdoctoral Fellow, Harvard University, (1996 - 1998).

Researcher, University of California Irvine, (1998 - 2001).
Publications. Most recent 10 from more than 90.

Piltti KM, Cummings BJ, Carta K, Manughian-Peter A, Worne CL, Singh K, Ong D, Maksymyuk Y, Khine M, Anderson AJ. (2018) Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection. Methods. 15;133:81-90.

Nguyen H.X., Hooshmand, M.J., Saiwai, H., Maddox, J., Salehi, A., Salazar, D., Uchida, N., Anderson, A.J. (2017). Systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescue functional repair. Journal of Neuroscience. 37(38):9269-9287.

Hooshmand, M.J., Nguyen, H.X. #, Piltti, K.M. #, Benavente, F.#, Hong, S., Flanagan, L., Uchida, N, Cummings, B.J. , and Anderson, A. J. (2017). Neutrophils induce astroglial differentiation and migration of human neural stem cells via C1q and C3a synthesis. Journal of Immunology. 199(3):1069-1085. PMCID: PMC5523578

Piltti K.M., Funes G.M., Avakian S.N., Salabian A.A., Huang K., Carta K., Kamei N., Flanagan L., Monuki E.S., Uchida N., Cummings B.J., Anderson A.J. (2017, online May 4). Increasing human neural stem cell transplantation dose alters oligodendroglial and neuronal differentiation after spinal cord injury. Stem Cell Reports. 6;8(6):1534-1548

Anderson, A. J., Piltti, K. M., Hooshmand, M. J., Nishi, R. A., and Cummings B. J. (2017). Efficacy failure of human central nervous system derived stem cells (HuCNS-SC) for use in the “Pathway Study™” of cervical spinal cord injury. Stem Cell Reports. 14;8(2):249-263.

Peterson S.L., Nguyen H.X., Mendez O.A., Anderson A.J. (2017). Complement protein C3 suppresses axon growth and promotes neuron loss. Scientific Reports. 10:7(1):12904.

Haus, D. L., López-Velázquez, L., Gold, E. M., Cunningham, K. M., Perez, H., Anderson, A. J., Cummings, B. J. (2016). Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury. Experimental Neurology, 281, 1-16. 0014-4886. doi: 10.1016/j.expneurol.2016.04.008.

Peterson, S. L., Nguyen, H. X., Mendez, O. A., Anderson, A. J. (2015). Complement protein C1q modulates neurite outgrowth in vitro and spinal cord axon regeneration in vivo. Journal of Neuroscience, 35(10), 4332-49. 0270-6474. doi: 10.1523/JNEUROSCI.4473-12.2015. PMC4355202.

Pawar, K., Cummings, B. J., Thomas, A., Shea, L. D., Levine, A., Pfaff, S., Anderson, A. J. (2015). Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function. Biomaterials, 65, 1-12. 0142-9612. doi: 10.1016/j.biomaterials.2015.05.032. PMC4523232.

Piltti, K. M., Avakian, S. N., Funes, G. M., Hu, A., Uchida, N., Anderson, A. J., Cummings, B. J. (2015). Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury. Stem Cell Research, 15(2), 341-53. 1873-5061. doi: 10.1016/j.scr.2015.07.001. PMC4600655.
Professional Societies
Society for Neuroscience
American Association for the Advancement of Science
International Society for Stem Cell Research
Graduate Programs
Interdepartmental Neuroscience Program

Research Centers
UCI Institute for Memory Impairment & Neurological Disorders
UCI Center for Immunology
UCI Sue & Bill Gross Stem Cell Research Center
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