Aileen J Anderson,PhD

picture of Aileen J Anderson,PhD

Professor, Physical Medicine & Rehabilitation
School of Medicine

Director, Sue and Bill Gross Stem Cell Research Center


B.S., University of Illinois, Urbana, 1987, Bioengineering
Ph.D., University of California, Irvine, 1996, Biology, Neurobiology

Phone: (949) 824-6750
Email: aja@uci.edu

University of California, Irvine
Sue & Bill Gross Stem Cell Research Center
Building 845, Room 2030
Mail Code: 1705
Irvine, CA 92697
Research Interests
stem cell biology, spinal cord injury, glioblastoma, Role of inflammatory mechanisms in degeneration and regeneration in the injured CNS. Human CNS stem cell engraftment in the injured CNS, and mechanisms for promotion of neurological recovery.
Academic Distinctions
UCI Chancellor's Award for Excellence in Research Mentorship. (2006).
Harvard Medical School Clinical Neuroscience Training Program Fellowship. (1996 - 1997).
5th Conference on Alzheimer's Disease Young Investigator Award. (1996).
Appointments
Postdoctoral Fellow, University of California Irvine, (1996).
Postdoctoral Fellow, Harvard University, (1996-1998).

Postdoctoral Fellow, Harvard University, (1996 - 1998).
Neurobiology

Researcher, University of California Irvine, (1998 - 2001).
Research Abstract
Pre-clinical and translational work from my laboratory has directly supported an IND filing for an FDA-approved phase I trial of human neural stem cells in the myelination disorder Pelizaeus-Merzbacher disease (PMD), and a phase I/II clinical trial for human neural stem cells in thoracic spinal cord injury (SCI). These translational milestones reflect over 15 years of work from my laboratory on human-derived neural stem cell (hNSC) populations and spinal cord injury mechanisms. In these studies, we have investigated the intrinsic and extrinsic factors defining the migration and differentiation potential of these cells both in vitro and after transplantation into the spinal cord. In parallel, we have investigated nontraditional roles for the innate inflammatory system in the pathophysiology of spinal cord injury, mechanisms controlling stem cell fate and migration, and potential for implanted biomaterial scaffolds to provide an environment supporting robust axonal regeneration. This work has led us to the discovery of a role for complement C1q and C3a/C3b as single molecules in the CNS, controlling mouse and human NSC behavior, including self-renewal. Recently, we have extended these novel findings to investigate whether endogenous NSC in the subventricular and subgranular zone brain neurogenic niches share common mechanisms with the hNSC we have used in transplantation. These studies have identified a key role for both innate immune cells and autocrine / paracrine complement signaling in survival, self-renewal, and differentiation in the adult brain, as well as a role for these proteins in age-related neurogenesis declines and glioblastoma.
Awards and Honors
UCI Chancellor's Award for Excellence in Research Mentorship. (2006).
Harvard Medical School Clinical Neuroscience Training Program Fellowship. (1996 - 1997).
5th Conference on Alzheimer's Disease Young Investigator Award. (1996).
National Research Service Award Individual Fellowship. (1992 - 1994).
Short Biography
Director, Sue & Bill Gross Stem Cell Research Facility UC Irvine (2017-present).
Associate Director, Sue & Bill Gross Stem Cell Research Facility UC Irvine (2013-2017).
Professor, Physical Medicine & Rehab, Anatomy & Neurobiology, and Neurosurgery UC Irvine (2014-present).
Associate Professor, Physical Medicine & Rehab and Anatomy & Neurobiology, UC Irvine (2007-2014).
Assistant Professor, Physical Medicine & Rehab and Anatomy & Neurobiology, UC Irvine (2001-2007).
Visiting Scholar in Writing, Brandeis University. (1997).
Publications
Selected from over 90.

Benavente F, Piltti K, Hooshmand, M, Nava, A, Feld, B, Gershon, P, Anderson, A. Complement C1q Interacts with Novel Transmembrane Receptors to control Neural Stem Cell Behavior. eLife. 2020 Sep 7;9:e55732. doi: 10.7554/eLife.55732.

Nguyen H.X., Hooshmand, M.J., Saiwai, H., Maddox, J., Salehi, A., Salazar, D., Uchida, N., Anderson, A.J. (2017). Systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescue functional repair. Journal of Neuroscience. 37(38):9269-9287.

Hooshmand, M.J., Nguyen, H.X. #, Piltti, K.M. #, Benavente, F.#, Hong, S., Flanagan, L., Uchida, N, Cummings, B.J. , and Anderson, A. J. (2017). Neutrophils induce astroglial differentiation and migration of human neural stem cells via C1q and C3a synthesis. Journal of Immunology. 199(3):1069-1085. PMCID: PMC5523578

Piltti K.M., Funes G.M., Avakian S.N., Salabian A.A., Huang K., Carta K., Kamei N., Flanagan L., Monuki E.S., Uchida N., Cummings B.J., Anderson A.J. (2017, online May 4). Increasing human neural stem cell transplantation dose alters oligodendroglial and neuronal differentiation after spinal cord injury. Stem Cell Reports. 6;8(6):1534-1548

Anderson, A. J., Piltti, K. M., Hooshmand, M. J., Nishi, R. A., and Cummings B. J. (2017). Efficacy failure of human central nervous system derived stem cells (HuCNS-SC) for use in the “Pathway Study™” of cervical spinal cord injury. Stem Cell Reports. 14;8(2):249-263.

Pawar, K., Cummings, B. J., Thomas, A., Shea, L. D., Levine, A., Pfaff, S., Anderson, A. J. (2015). Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function. Biomaterials, 65, 1-12. 0142-9612. doi: 10.1016/j.biomaterials.2015.05.032. PMC4523232.

Sontag, C. J., Uchida, N., Cummings, B. J., Anderson, A. J. (2014). Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Reports, 2(5), 620–632. Cell Press.

Beck, K. D., Nguyen, H. X., Galvan, M. D., Salazar, D. L., Woodruff, T. M., Anderson, A. J. (2010). Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain, 133(2), 433–447. Oxford Univ Press.

Galvan, M. D., Luchetti, S., Burgos, A. M., Nguyen, H. X., Hooshmand, M. J., Hamers, F. P., Anderson, A. J. (2008). Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. Journal of Neuroscience, 28(51), 13876–13888.

Cummings, B. J., Uchida, N., Tamaki, S. J., Salazar, D. L., Hooshmand, M., Summers, R., Gage, F. H., Anderson, A. J. (2005). Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proceedings of the National Academy of Sciences of the United States of America, 102(39), 14069–14074.
Professional Societies
Society for Neuroscience
American Association for the Advancement of Science
International Society for Stem Cell Research
Graduate Programs
Interdepartmental Neuroscience Program

Research Centers
UCI Institute for Memory Impairment & Neurological Disorders
UCI Center for Immunology
UCI Sue & Bill Gross Stem Cell Research Center
Last updated
03/10/2021