Magdalene J. Seiler, PhD

Assistant Professor in Residence, Physical Medicine & Rehabilitation
School of Medicine

M.S., Inst. Zoology, University of Munich, FRG, 1982, Biology


Ph.D., Max Planck-Institute for Psychiatry, Munich, Germany, 1985, Neurochemistry

Phone: (949) 824-2037
Email: mseiler@uci.edu

University of California, Irvine
2035 Gross Hall
Mail Code: 1705
Irvine, CA 92697

picture of Magdalene J. Seiler, PhD

Research
Interests
retinal progenitor sheet transplants, Retinitis Pigmentosa and age-related macular degeneration
   
URLs Magdalene Seiler
   
Seiler Lab
   
Academic
Distinctions
Dr. Seiler’s Ph.D. in 1985 (Ludwig-Maximilians University of Munich, Max Planck Institute for Psychiatry, Dept. Neurochemistry) focused on neurotrophic factors in the central nervous system, followed by postdoctoral studies in retinal transplantation in Winston-Salem, NC and Boston, MA. She was Assistant Professor at the University of Louisville, KY from 1993-2002, and at the Doheny Eye Institute, USC Department of Ophthalmology 2002-2006.
Along with her colleague, Dr. Aramant, she developed and refined a unique procedure of retinal progenitor sheet transplantation, which has demonstrated improvement of visual responses in the superior colliculus in 4 different retinal degeneration models (RCS rats, rd mice, rho S334ter line 3 and line 5 rat models of fast and slow retinal degeneration). She participated in Phase I and II clinical trials to transplant sheets of fetal retina with its RPE to patients with retinal degeneration (retinitis pigmentosa and age-related macular degeneration). The phase II trial showed improvements of visual acuity (EDTRS) in 7 of 10 patients.

From 2007-2014, she was the lead researcher of the retina project of the Research group of Dr. Hans Keirstead at UC Irvine (now CEO at AiVita Biomedical Inc.). In 2014, she received a 3-year Early Translational grant from CIRM with the goal of developing human embryonic stem cells to transplantable 3-D sheets of retinal progenitor cells for vision restoration.

Hobbies/Outside Interests
Gardening, hiking, photography
   
Appointments Postdoctorate, Retinal Transplantation, Wake Forest University, Winston-Salem, NC 1986-1987
Postdoctorate, Retinal Transplantation, Eye Research Institute, Boston, MA 1987-1988
   
Research
Abstract
The goal of Dr. Seiler’s research is to develop retinal progenitor sheet transplants as a clinical treatment for retinal diseases such a Retinitis Pigmentosa and age-related macular degeneration, which affect both photoreceptors and retinal pigment epithelium (RPE). The current focus of her research is to develop human embryonic stem cells (hESCs) into transplantable sheets of 3D retina and RPE and to demonstrate vision restoration at the level of the superior colliculus and visual cortex in rat models of retinal degeneration. She is also collaborating with Dr. Cummings to investigate whether human mesenchymal stem cells reverse retinal pathology and functional deficits resulting from repeated brain trauma.
   
Publications Publications (selected from 56 publications in journals and 20 reviews).
Seiler MJ, Aramant RB, Jones MK, Ferguson D, Bryda E, Keirstead HS. A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefe’s Arch Clin Exp Ophthalmol, 252:1079-1092 (2014). DOI 10.1007/s00417-014-2638-y

Seiler MJ, Aramant RB. Cell replacement and visual restoration by retinal sheet transplants. Prog Retin Eye Res, 31:661-687 (2012). Invited review (peer-reviewed)

Seiler MJ*, Jones BW*, Aramant RB, Yang PB, Keirstead HS, Marc RE. Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration. Eur J. Neurosci, 35:1692–1704 (2012) (Figure 9A selected for cover of EJN's Virtual Issue: Disorders of the Nervous System)
* - equal contribution

Martinez-Navarrete G, Seiler MJ, Aramant RB, Fernandez-Sanchez L, Pinilla I, Cuenca N. Retinal Degeneration in Two Lines of Transgenic S334ter Rats. Exp Eye Res 92: 227-237 (2011)

Yang PB*, Seiler MJ*, Aramant RB, Yan F, Mahoney MJ, Kitzes LM, Keirstead HS. Trophic Factors GDNF and BDNF Improve Function of Retinal Sheet Transplants. Exp Eye Res 91: 727-738 (2010)

Nistor G*, Seiler MJ*, Yan F, Ferguson D, Keirstead HS. Three-Dimensional Early Retinal Progenitor 3D Tissue Constructs Derived from Human Embryonic Stem Cells. J. Neurosci. Methods, 190:63–70 (2010)
* - equal contribution

Seiler MJ*, Rao B*, Aramant RB, Yu L, Wang Q, Kitayama E, Pham S, Yan F, Chen Z, Keirstead HS. Three-dimensional Optical Coherence Tomography Imaging of Retinal Sheet Implants in Live Rats. J. Neurosci. Methods, 188: 250–257 (2010)
* - equal contribution

Seiler MJ, Aramant RB, Thomas BB, Peng Q, Sadda SR, Keirstead HS. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. Eur J. Neurosci, 31(3):508-520 (2010)

Seiler MJ, Aramant RB, Seeliger M, Bragadottir R, Mahoney M, Narfstrom K. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration. Veterinary Ophthalmology, 12(3):158–169 (2009)

Seiler MJ, Thomas BB, Chen Z, Wu R, Sadda SR, Aramant RB. Retinal transplants restore visual responses - Transsynaptic tracing from visually responsive site in the superior colliculus (SC) labels transplant neurons. Eur J. Neurosci, 28:208-220 (2008) (selected for journal cover)

Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium. Am J Ophthalmol, 146:172-182 (2008)
   
Research Center Sue & Bill Gross Stem Cell Research Center (SCRC)
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=6226
   
Last updated 09/02/2016