Magdalene J. Seiler ,Ph.D.

picture of Magdalene J. Seiler

Assistant Professor in Residence, Physical Medicine & Rehabilitation
School of Medicine

M.S., Zoology, University of Munich, Germany, Biology, 1982


Ph.D., Max Planck-Institute for Neurochemistry and University of Munich, Munich, Germany, 1986

Phone: (949) 824-2037
Email: mseiler@uci.edu

University of California, Irvine
2035 Gross Hall
Mail Code: 1705
Irvine, CA 92697
Research Interests
retinal progenitor sheet transplantation and demonstration of vision improvement in models of retinal degeneration and ultimately in retinal degeneration patients (Retinitis Pigmentosa, age-related macular degeneration)
URLs
Academic Distinctions
Dr. Seiler’s Ph.D. in 1985 (LMU University of Munich, Max Planck Institute for Psychiatry, Dept. Neurochemistry) focused on neurotrophic factors in the central nervous system, followed by postdoctoral studies in retinal transplantation in Winston-Salem, NC and Boston, MA. She was Assistant Professor at the University of Louisville, KY from 1993-2002, and at the Doheny Eye Institute, USC Department of Ophthalmology 2002-2006.
In a collaboration lasting more than 30 years with her colleague, Dr. Robert Aramant, they developed and refined a unique procedure of retinal progenitor sheet transplantation, which has demonstrated improvement of visual responses in the superior colliculus in 4 different retinal degeneration models (RCS rats, rd mice, rho S334ter line 3 and line 5 rat models of fast and slow retinal degeneration). Dr. Seiler participated in Phase I and II clinical trials to transplant sheets of fetal retina with its RPE to patients with retinal degeneration (retinitis pigmentosa and age-related macular degeneration). The phase II trial showed improvements of visual acuity (EDTRS) in 7 of 10 patients (reference https://escholarship.org/uc/item/4783d911).

From 2007-2014, she was the lead researcher of the retina project of the Research group of Dr. Hans Keirstead at UC Irvine (now CEO at AiVita Biomedical Inc.). In 2014, she received a 3-year Early Translational grant from CIRM with the goal of developing human embryonic stem cells to transplantable 3-D sheets of retinal progenitor cells for vision restoration. In 2018, she received a 4.7 million TRAN1 grant (2.5 years) entitled “Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models.” that will develop this application towards a treatment for Retinitis Pigmentosa (see press release http://www.som.uci.edu/news_releases/Seiler_CIRM_grant2_06222018.asp)
Appointments
Postdoctorate, Retinal Transplantation, Wake Forest University, Winston-Salem, NC 1986-1987

Postdoctorate, Retinal Transplantation, Eye Research Institute, Boston, MA 1987-1988

Scientific Associate, Retinal Transplantation, Eye Research Institute, Boston, MA, 1989-1992

Assistant Professor, Ophthalmology & Visual Sciences; Anatomy & Neurobiology, University of Louisville School of Medicine, 1993-2002

Assistant Professor, Doheny Eye Institute; Ophthalmology; Cell & Neurobiology, Keck School of Medicine (USC), 2002-2006

Project Scientist, Anatomy & Neurobiology, UC Irvine School of Medicine, 2007 – 2014

Project Scientist, Physical Medicine & Rehabilitation, UC Irvine School of Medicine, 2014-2015

Assistant Professor, Physical Medicine & Rehabilitation, UC Irvine School of Medicine, 2015 -
Research Abstract
The goal of Dr. Seiler’s research is to develop retinal progenitor sheet transplants as a clinical treatment for retinal diseases such a Retinitis Pigmentosa and age-related macular degeneration, which affect both photoreceptors and retinal pigment epithelium (RPE). The current focus of her research is to develop human embryonic stem cells (hESCs) into transplantable sheets of 3D retina and RPE and to demonstrate vision restoration at the level of the superior colliculus and visual cortex in rat models of retinal degeneration. She has also been collaborating with Dr. Cummings to investigate whether human mesenchymal stem cells reverse retinal pathology and functional deficits resulting from repeated brain trauma.
Publications
Lin B, McLelland BT, Mathur A, Aramant RB, Seiler MJ*. Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration. Experimental Eye Research, 174:13-28 (in press). https://doi.org/10.1016/j.exer.2018.05.017

McLelland BT, Lin B, Mathur A, Aramant RB, Thomas BB, Nistor G, Keirstead HS, Seiler MJ*. Transplanted hESC-retina organoid sheets differentiate, integrate and improve visual function in retinal degenerate rats. Invest Ophthalmol Vis Sci, 59:2586-2603. doi:10.1167/iovs.17-23646. PMC5968836. ? = equivalent contribution; * - corresponding author

Seiler MJ. hESC-derived photoreceptors survive and integrate better in immunodeficient retina. Invited Editorial. Stem Cell Investigation, 2017;4:70; doi: 10.21037/sci.2017.08.05. PMID 28920063; PMC5590018

Lin T-C, Seiler MJ, Zhu D, Falabella P, Hinton DR, Clegg DO, Humayun MS, Thomas BB*. Assessment of safety and functional effect of stem cell-based therapeutic approaches using retinal degenerative animal models. Stem Cells International, 2017, https://doi.org/10.1155/2017/9428176. PMID 28928775; PMC5592015. Invited review (peer-reviewed)

Seiler MJ*, Lin R, McLelland BT, Mathur A, Lin B, Sigman J, De Guzman A, Kitzes LM, Aramant RB, Thomas BB. Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model. Invest. Ophthalmol Vis Sci, 58:614-630 (2017). DOI 10.1167/iovs.15-19028. PMID 28129425. ? = equivalent contribution; * - corresponding author

Seiler MJ, Aramant RB, Jones MK, Ferguson D, Bryda E, Keirstead HS*. A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Graefe’s Arch Clin Exp Ophthalmol, 252:1079-1092 (2014). DOI 10.1007/s00417-014-2638-y * - corresponding author

Seiler MJ, Aramant RB. Cell replacement and visual restoration by retinal sheet transplants. Prog Retin Eye Res, 31:661-687 (2012). Invited review (peer-reviewed)

Seiler MJ*, Jones BW*, Aramant RB, Yang PB, Keirstead HS, Marc RE. Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration. Eur J. Neurosci, 35:1692–1704 (2012) (Figure 9A selected for cover of EJN's Virtual Issue: Disorders of the Nervous System)
* - equal contribution

Martinez-Navarrete G, Seiler MJ, Aramant RB, Fernandez-Sanchez L, Pinilla I, Cuenca N. Retinal Degeneration in Two Lines of Transgenic S334ter Rats. Exp Eye Res 92: 227-237 (2011)

Yang PB*, Seiler MJ*, Aramant RB, Yan F, Mahoney MJ, Kitzes LM, Keirstead HS. Trophic Factors GDNF and BDNF Improve Function of Retinal Sheet Transplants. Exp Eye Res 91: 727-738 (2010)

Nistor G*, Seiler MJ*, Yan F, Ferguson D, Keirstead HS. Three-Dimensional Early Retinal Progenitor 3D Tissue Constructs Derived from Human Embryonic Stem Cells. J. Neurosci. Methods, 190:63–70 (2010)
* - equal contribution

Seiler MJ*, Rao B*, Aramant RB, Yu L, Wang Q, Kitayama E, Pham S, Yan F, Chen Z, Keirstead HS. Three-dimensional Optical Coherence Tomography Imaging of Retinal Sheet Implants in Live Rats. J. Neurosci. Methods, 188: 250–257 (2010)
* - equal contribution

Seiler MJ, Aramant RB, Thomas BB, Peng Q, Sadda SR, Keirstead HS. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. Eur J. Neurosci, 31(3):508-520 (2010)

Seiler MJ, Aramant RB, Seeliger M, Bragadottir R, Mahoney M, Narfstrom K. Functional and structural assessment of retinal sheet allograft transplantation in feline hereditary retinal degeneration. Veterinary Ophthalmology, 12(3):158–169 (2009)

Seiler MJ, Thomas BB, Chen Z, Wu R, Sadda SR, Aramant RB. Retinal transplants restore visual responses - Transsynaptic tracing from visually responsive site in the superior colliculus (SC) labels transplant neurons. Eur J. Neurosci, 28:208-220 (2008) (selected for journal cover)

Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium. Am J Ophthalmol, 146:172-182 (2008)
Research Center
Sue & Bill Gross Stem Cell Research Center (SCRC)
Last updated
07/26/2018