Yongen Chang

picture of Yongen  Chang

Assistant Clinical Professor, Medicine
School of Medicine

Fellowship Program Director, Nephrology

M.D., Fudan University Medical Center, 2001
Ph.D., Cornell University, 2007

Phone: (Office) 714-456-5142; (Clinic) 714-456-7720; (Fellowship) 714-456-5413
Fax: 714-456-6034
Email: cyongen@uci.edu

University of California, Irvine
333 City Blvd West
Suite 400
Mail Code: 4088
Orange, CA 92868
Research Interests
Chronic Kidney Disease, Renal Fibrosis, Tissue injury and repair, Integrin biology
Research Abstract
Dr. Chang completed her fellowship in Nephrology at the University of California, San Francisco. Her clinical interests include refractory/resistant hypertension, chronic kidney disease, kidney diseases in pregnancy and malignancy and rare glomerulonephritis. Dr. Chang has also conducted translational research focusing on the molecular mechanisms of renal fibrosis and chronic kidney disease in animal models. She was awarded the Ben J. Lipps Research Fellowship from the American Society of Nephrology and the Ruth L. Kirschstein National Research Service Award (F32 NRSA) from the National Institutes of Health. Dr. Chang has presented her work at various international meetings and has published in several high-impact, peer-reviewed journals.

Dr. Chang is board certified in Internal Medicine and Nephrology, and an active member of the American Society of Nephrology. She is also fluent in Mandarin Chinese.
Hingdi S.M., Wang Y., Jones K.D., Nussbaum J.C., Chang Y., Masharani U., Bikle D., Shoback D.M., Hsiao E.C., A case of hypercalcemia and overexpression of CYP27B1 in skeletal muscle lesions in a patient with HIV infection after cosmetic injections with polymethylmethacrylate (PMMA) for wasting. Calcif Tissue Int, 2015

Chang Y., Mbeo G., Littman S.J., Reversible posterior leukoencephalopathy syndrome associated with concurrent bevacizumab, gemcitabine, and oxaliplatin for cholangiocarcinoma. J. Gastrointest. Cancer, 2011

Nandrot E.F., Chang Y., Finnemann S.C., avß5 integrin receptors at the apical surface of the RPE: one receptor, two functions. Adv. Exp. Med. Biol., 2008

Chang Y., Finnemann S.C., Photoreceptor-RPE interactions: physiology and molecular mechanisms. Visual Transduction and Non-Visual Light Perception, Vol. 4. 2008, The Humana Press Inc.

Chang Y., Finnemann S.C., Tetraspanin CD81 is required for the avß5 integrin-dependent particle binding step of RPE phagocytosis. Journal of Cell Science, 2007

Chang Y., Jiang Y., The definition of glomerulonephritis. Nephritis and Urinary Infection. Shanghai Science & Technology Publishing Co., Ltd. 1999
Professional Society
American Society of Nephrology
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