Massimo S. Fiandaca

Associate Professor in Residence - UCI, Neurology
School of Medicine

Associate Professor in Residence - UCI, Neurological Surgery
School of Medicine

Associate Professor on the Adjunct Track - Georgetown University, Neurology
School of Medicine

Associate Research Scientist WOS - UCSF, Neurological Surgery
School of Medicine

Associate Professor in Residence - UCI, Anatomy & Neurobiology
School of Medicine

M.D., Oregon Health & Sciences University, 1981, Medicine

M.B.A., Loyola University of Maryland, 2001, Management

B.S., Oregon State University, 1977, Zoology

Phone: (949) 824-5579

University of California, Irvine
314 Sprague Hall
Mail Code: 3910
Irvine, CA 92697

picture of Massimo S. Fiandaca

biomarkers, Alzheimer's disease, Parkinson's disease, convection enhanced delivery, gene therapy
Publications (Peer-reviewed since 2008)
- Fiandaca, M., Forsayeth, J., and Bankiewicz, K. (2008) Current status of gene therapy trials for Parkinson’s disease. Exp Neurol 209(1): 51-57.
- Fiandaca, M.S., Forsayeth, J.R., Dickinson, P.J., and Bankiewicz, K.S. (2008) Image-guided convection-enhanced delivery platform in the treatment of neurological diseases. Neurotherapeutics 5(1): 123-127.
- Varenika, V., Dickenson, P., Bringas, J., LeCouteur, R., Higgins, R., Park, J., Fiandaca, M., Berger, M., Sampson, J., and Bankiewicz, K. (2008) Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. J Neurosurg 109:874-880.
- Yin, D., Valles, F.E., Fiandaca, M.S., Forsayeth, J., Larson, P., Starr, P., and Bankiewicz, K.S., (2009) Striatal volume differences between non-human and human primates. J Neurosci Methods 176: 200-205.
- Fiandaca, M.S., Varenika, V., Eberling, J., McKnight, T., Bringas, J., Pivirotto, P., Beyer, J., Hadaczek, P., Forsayeth, J., Bowers, W.J., Park, J., Federoff, H.J., and Bankiewicz, K.S., (2009) Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. NeuroImage 47: T27-T35.
- Valles, F., Fiandaca, M.S., Bringas, J., Dickinson, P., LeCouteur, R., Higgins, R., Berger, M., Forsayeth, J., and Bankiewicz, K.S. (2009) Anatomical compression caused by high-volume convection-enhanced delivery to the brain. Neurosurgery 65: 579-586.
- Yin, D., Richardson, M., Fiandaca, M.S., Bringas, J., Forsayeth, J., Berger, M.S., and Bankiewicz, K.S., (2010) Cannula placement for effective convection-enhanced delivery in the non-human primate thalamus and brainstem: implications for clinical delivery of therapeutics. J Neurosurg 113: 240-248.
- Aguilar Salegio, E., Kells, A.P. , Richardson, R.M., Hadaczek, P. , Forsayeth, J. , Bringas, J., Pablo Sardi, S., Passini, M., Shihabuddin L., Fiandaca, M.S., Bankiewicz, KS. (2010) MRI-controlled delivery of AAV2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther 21:1093-1103.
- Valles, F., Fiandaca, M.S., Eberling, J.L, Starr, P.A., Larson, P., Christine, C.W., Forsayeth, J., Richardson, R.M., Su, X., Aminoff, M.J., and Bankiewicz, K.S., (2010) Imaging of AAV2-hAADC gene therapy infusion in a Phase I study for the treatment of Parkinson’s disease. Neurosurgery 67(5): 1377-1385.
- Fiandaca, M.S., and Bankiewicz, K.S. (2010) Gene therapy for Parkinson’s disease: From nonhuman primates to humans. Curr Opin Mol Ther 12:519-529.
- Yin, D., Valles, F.E., Fiandaca, M.S., Bringas, J., Gimenez, F., Berger, M.S., Forsayeth, J., and Bankiewicz, K.S., (2011) Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates. NeuroImage 54S1: S196-S203.
- Fiandaca, M.S., Aguilar Salegio, E., Yin, D., Richardson, R.M., Valles, F.E., Larson, P.S., Starr, P.A., Lonser, R.R., and Bankiewicz, K.S. (2011) Human/nonhuman primate AC-PC ratio – considerations for translational brain measurements. J Neurosci Methods 196: 124-130.
- Richardson, R.M., Kells, A.P., Rosenbluth, K.H., Aguilar Salegio, E., Fiandaca, M.S., Larson, P.S., Starr, P.A., Martin, A., Lonser, R.R., Federoff, H.J., Forsayeth, J.R., and Bankiewicz, K.S. (2011) Interventional MRI-guided delivery of AAV2-GDNF for a planned clinical trial in Parkinson’s disease. Mol Ther 19: 1048-1057.
- Fiandaca, M.S., Berger, M.S., and Bankiewicz, K.S. (2011) The use of convection-enhanced delivery with liposomal toxins in neurooncology. Review. Toxins 3: 369-397.
- Ziegler, R.J., Aguilar Salegio, E., Dodge, J.C., Bringas, J., Trealeaven, C.M., Bercury, S.D., Tamsett, T.J., Shihabuddin, L., Hadaczek, P., Fiandaca, M., Bankiewicz, K., and Scheule, R.K. (2011) Distribution of acid sphingomyelinase in rodent and primate brain after intracerebroventricular infusion. Exp Neurol 231: 261-271.
- Fiandaca, M.S., Bankiewicz, K.S., and Federoff, H.J. (2012) Gene therapy for the treatment of Parkinson’s disease: The nature of the biologic expands the future indications. Pharmaceuticals 5: 553-590.
- Fiandaca, M.S., Padilla, R.M., Conteh, I., and Federoff, H.J. (2013) Can population genomics guide future therapeutic gene transfer strategies for Parkinson’s disease? OJGen 3: 19-29.
- Burger, E.W., Federoff, H.J., Fiandaca, M.S., Frieder, O., Goharian, N., and Yates, A. (2013) Social Media Communications Networks and Pharmacovigilance: SequelAE-2.0, Fifteenth IEEE International Conference on e-Health Networking, Applications and Services (Healthcom), Lisbon, Portugal, October 2013.
- Mapstone, M., Cheema, A.K., Fiandaca, M.S., Zhong, X., Mhyre, T.R., MacArthur, L.H., Hall, W.J., Fisher, S.G., Petersen, D.R., Haley, J.M., Nazar, M.D., Rich, S.A, Berlau, D.J., Peltz, C.B., Tan, M.T., Kawas, C.H., and Federoff, H.J. (2014) Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med 20: 415-418.
- Fiandaca, M.S. and Federoff, H.J. (2014) Using viral-mediated gene delivery to model Parkinson's disease: Do nonhuman primate investigations expand our understanding? Exp Neurol 256: 117-125.
- Fiandaca, M.S., Mapstone, M.E., Cheema, A.K., and Federoff, H.K. (2014) The critical need for defining preclinical biomarkers of Alzheimer’s disease. Alzheimers Dement 10 (3 Suppl): S196-S212 (Military risk supplement).
- Passini, M.A., Bu, J., Richards, A.M., Treleaven, C.M., Sullivan, J.A., O’Riordan, C.R., Scaria, A., Kells, A.P., Samaranch, L., Sebastian, W.S., Federici, T., Fiandaca, M.S., Boulis, N.M., Bankiewicz, K.S., Shihabuddin, L.S., and Cheng, S.H. (2014) Translational fidelity of intrathecal delivery of scAAV9-SMN1 for spinal muscular atrophy. Hum Gene Ther 25: 1-12, doi: 10.1089/hum.2014.011.
- Fiandaca, M.S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J.B., Abner, E.L., Petersen, R.C., Federoff, H.J., Miller, B.L., and Goetzl, E.J. (2015) Identification of preclinical Alzheimer’s disease by a profile of pathogenic proteins in neurally derived blood exosomes:?A case-control study. Alzheimers Dement 11: 600-607.
- Dromerick, A.W., Edwardson, M.A., Edwards, D.F., Giannetti, M.L., Barth, J., Brady, K.P., Chan, E., Tan, M.T., Tamboli, I., Chia, R., Orquiza, M., Padilla, R.M., Cheema, A.K., Mapstone, M.E., Fiandaca, M.S., Federoff, H.J., Newport, E.L. (2015) Critical Periods after Stroke Study: Translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci 9: 1-13.
- Nalls, M.A., McLean, C.Y., Rick, J., Eberly, S., Hutten, S.J., Gwinn, K., Sutherland, M., Martinez, M., Heutink, P., Williams, N., Hardy, J., Gasser, T., Brice, A., Price, T.R., Keller, M.F., Malony, C., Gibbs, J.R., Chen-Plotkin, A., Suh, E., Letson, C., Fiandaca, M.S., Mapstone, M., Federoff, H.J., Noyce, A., Van Deerlin, V.M., Weintraub, D., Zabetian, C., Hernandez, D.G., Lesage, S., Mullins, M., Northover, C., Cannon, P., Frasier, M., Marek, K., Day-Williams, A.G., Stone, D.J., Ioannidis, J.P.A., Singleton, A.B. (2015) Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modeling study. Lancet Neurol 14(10): 1002-1009.
- Fiandaca, M.S., Zhong, X., Cheema, A.K., Orquiza, M.H., Chidambaram, S., Tan, M.T., Gresenz, C.R., FitzGerald, K.T., Nalls, M.A., Singleton, A.B., Mapstone, M., Federoff, H.J. (2015) Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease. Front Neurol 6:237.
  - Yin, D., Fiandaca, M.S., Forsayeth, J., and Bankiewicz, K.S. (2016) Real-time convection delivery of therapeutics to the primate brain. In M. Janowski (ed.), Experimental Neurosurgery in Animal Models (Neuromethods Series-Book 116), 1st Edition, Humana Press, New York, pp. 175-194.
- Mahmoodi Amin, Sahyouni R, Fiandaca MS: MathWorks® MATLAB App: MSFmetabolomics, Dec 7, 2016, MSFmetabolomics, DOI:10.13140/RG.2.2.27777.86886 (
- Mapstone, M., Lin, F., Nalls, M.A., Cheema, A.K., Singleton, A.B., Fiandaca, M.S., Federoff, H.J. (2017) What success can teach us about failure: The plasma metabolome of older adults with superior memory and lessons for Alzheimer’s disease. Neurobiol Aging 51: 148-155.
- Mapstone, M., Cheema, A.K., Zhong, X., Fiandaca, M.S., and Federoff, H.J. (2017) Biomarker Validation: Methods and Matrix Matter (Letter). Alzheimers Dement. 13: 608-609.
Other Experience Partner/Neurological Surgeon
Lancelotta, Soliman, Jamaris, and Fiandaca, PA 1993—2001

Owner/Neurological Surgeon
Massimo S. Fiandaca, MD, PA 2001—2012

Graduate Programs Surgery-General

Neurological Surgery


Research Center UCI Translational Laboratory and Biorepository (TLaB)
Link to this profile
Last updated 07/18/2017