Massimo S. Fiandaca

picture of Massimo S. Fiandaca

Associate Professor in Residence - UCI, Neurology
School of Medicine
Associate Professor in Residence - UCI, Neurological Surgery
School of Medicine
Associate Professor on the Adjunct Track - Georgetown University, Neurology
School of Medicine
Associate Research Scientist WOS - UCSF, Neurological Surgery
School of Medicine
Associate Professor in Residence - UCI, Anatomy & Neurobiology
School of Medicine

M.D., Oregon Health & Sciences University, 1981, Medicine

M.B.A., Loyola University of Maryland, 2001, Management

B.S., Oregon State University, 1977, Zoology

Phone: (949) 824-5579

University of California, Irvine
314 Sprague Hall
Mail Code: 3910
Irvine, CA 92697
Research Interests
biomarkers, Alzheimer's disease, Parkinson's disease, convection enhanced delivery, gene therapy
- Collaborative Scientist, Division of Neurobiology, Yerkes Regional Primate Research Center of Emory University, Atlanta, Georgia 30322, 07/1986-06/1987
- Assistant Professor
Division of Neurosurgery, Department of Surgery University of Massachusetts Medical Center, Worcester, Massachusetts 01655, 07/1988-06/1991
- Consultant Neurosurgeon, Boston Red Sox, American League, Major League Baseball, Boston, Massachusetts 02215, 01/1990-06/1991
- Assistant Professor, Adjunct Appointment, Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, 01/1991-06/1991
- Assistant Professor, Chief of Neurosurgical Oncology Service, Division of Neurosurgery, Department of Surgery, University of Maryland Medical Systems, Baltimore, Maryland 21201, 07/1991-08/1993
- Medical Director, Gamma Knife Center, University of Maryland Medical Systems, Baltimore, Maryland 21201, 01/1992-07/1993
- Attending Neurosurgeon/Chief of Neurosurgery Service, Church Home and Hospital, Baltimore, Maryland 21231, 07/1996-05/2000
- Assistant Professor, Part-time, Department of Neurological Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, 05/1994-05/2001
- Assistant Clinical Professor, Department of Neurological Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, 06/1994-05/2001
- President, Co-owner (Entrepreneurial Venture), Radiosurgery Consultants, Ltd., Severna Park, Maryland 21146, 07/1998-08/2001
- Attending Neurosurgeon, Mercy Medical Center, Baltimore, MD 21202, 07/2001-06/2005
- Assistant Research Scientist, Bankiewicz Laboratory, Department of Neurosurgery, UCSF, San Francisco CA 94143, 01/2007-02/2007
- Attending Neurosurgeon, Sinai Hospital of LifeBridge Health, Baltimore, MD 21215, 07/2005-09/2008
- Acting Director of Medical Research, LifeBridge Health Brain & Spine Institute, Baltimore, Maryland 21215, 08/2007-08/2008
- Director of Performance Improvement, Department of Neurosurgery, LifeBridge Health Brain & Spine Institute, Baltimore, Maryland 21215, 09/2006-09/2008
- Educator/Consultant, Healthcare and Biomedical Council, Gerson Lehrman Group, Inc., Texas 78701, 12/2009-05/2012
- Associate Research Scientist, Bankiewicz Laboratory, Department of Neurosurgery, UCSF, San Francisco CA 94143, 02/2007-08/2012
- Attending Neurosurgeon, Howard County General Hospital, Columbia, MD 21044, 09/1993-9/2012
- Attending Neurosurgeon, Saint Agnes Hospital, Baltimore, MD 21229, 09/1993-09/2012
- Sponsored University Associate, Federoff Laboratory, Georgetown University School of Medicine, Washington, DC 20007, 09/2012-11/01/2012
- Chief Executive Officer (Entrepreneurial Venture), sequelAE2.0, Inc., Bethesda, MD 20817, 09/2012-12/2014
- Associate Professor on the Research Track, Departments of Neurology and Neuroscience, Co-Director, Biomarker Laboratory and Biorepository, Georgetown University Medical Center, Washington DC 20007, 11/01/2012-06/30/2015
(Peer-reviewed since 2008)
- Fiandaca, M., Forsayeth, J., and Bankiewicz, K. (2008) Current status of gene therapy trials for Parkinson’s disease. Exp Neurol 209(1): 51-57.
- Fiandaca, M.S., Forsayeth, J.R., Dickinson, P.J., and Bankiewicz, K.S. (2008) Image-guided convection-enhanced delivery platform in the treatment of neurological diseases. Neurotherapeutics 5(1): 123-127.
- Varenika, V., Dickenson, P., Bringas, J., LeCouteur, R., Higgins, R., Park, J., Fiandaca, M., Berger, M., Sampson, J., and Bankiewicz, K. (2008) Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. J Neurosurg 109:874-880.
- Yin, D., Valles, F.E., Fiandaca, M.S., Forsayeth, J., Larson, P., Starr, P., and Bankiewicz, K.S., (2009) Striatal volume differences between non-human and human primates. J Neurosci Methods 176: 200-205.
- Fiandaca, M.S., Varenika, V., Eberling, J., McKnight, T., Bringas, J., Pivirotto, P., Beyer, J., Hadaczek, P., Forsayeth, J., Bowers, W.J., Park, J., Federoff, H.J., and Bankiewicz, K.S., (2009) Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. NeuroImage 47: T27-T35.
- Valles, F., Fiandaca, M.S., Bringas, J., Dickinson, P., LeCouteur, R., Higgins, R., Berger, M., Forsayeth, J., and Bankiewicz, K.S. (2009) Anatomical compression caused by high-volume convection-enhanced delivery to the brain. Neurosurgery 65: 579-586.
- Yin, D., Richardson, M., Fiandaca, M.S., Bringas, J., Forsayeth, J., Berger, M.S., and Bankiewicz, K.S., (2010) Cannula placement for effective convection-enhanced delivery in the non-human primate thalamus and brainstem: implications for clinical delivery of therapeutics. J Neurosurg 113: 240-248.
- Aguilar Salegio, E., Kells, A.P. , Richardson, R.M., Hadaczek, P. , Forsayeth, J. , Bringas, J., Pablo Sardi, S., Passini, M., Shihabuddin L., Fiandaca, M.S., Bankiewicz, KS. (2010) MRI-controlled delivery of AAV2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther 21:1093-1103.
- Valles, F., Fiandaca, M.S., Eberling, J.L, Starr, P.A., Larson, P., Christine, C.W., Forsayeth, J., Richardson, R.M., Su, X., Aminoff, M.J., and Bankiewicz, K.S., (2010) Imaging of AAV2-hAADC gene therapy infusion in a Phase I study for the treatment of Parkinson’s disease. Neurosurgery 67(5): 1377-1385.
- Fiandaca, M.S., and Bankiewicz, K.S. (2010) Gene therapy for Parkinson’s disease: From nonhuman primates to humans. Curr Opin Mol Ther 12:519-529.
- Yin, D., Valles, F.E., Fiandaca, M.S., Bringas, J., Gimenez, F., Berger, M.S., Forsayeth, J., and Bankiewicz, K.S., (2011) Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates. NeuroImage 54S1: S196-S203.
- Fiandaca, M.S., Aguilar Salegio, E., Yin, D., Richardson, R.M., Valles, F.E., Larson, P.S., Starr, P.A., Lonser, R.R., and Bankiewicz, K.S. (2011) Human/nonhuman primate AC-PC ratio – considerations for translational brain measurements. J Neurosci Methods 196: 124-130.
- Richardson, R.M., Kells, A.P., Rosenbluth, K.H., Aguilar Salegio, E., Fiandaca, M.S., Larson, P.S., Starr, P.A., Martin, A., Lonser, R.R., Federoff, H.J., Forsayeth, J.R., and Bankiewicz, K.S. (2011) Interventional MRI-guided delivery of AAV2-GDNF for a planned clinical trial in Parkinson’s disease. Mol Ther 19: 1048-1057.
- Fiandaca, M.S., Berger, M.S., and Bankiewicz, K.S. (2011) The use of convection-enhanced delivery with liposomal toxins in neurooncology. Review. Toxins 3: 369-397.
- Ziegler, R.J., Aguilar Salegio, E., Dodge, J.C., Bringas, J., Trealeaven, C.M., Bercury, S.D., Tamsett, T.J., Shihabuddin, L., Hadaczek, P., Fiandaca, M., Bankiewicz, K., and Scheule, R.K. (2011) Distribution of acid sphingomyelinase in rodent and primate brain after intracerebroventricular infusion. Exp Neurol 231: 261-271.
- Fiandaca, M.S., Bankiewicz, K.S., and Federoff, H.J. (2012) Gene therapy for the treatment of Parkinson’s disease: The nature of the biologic expands the future indications. Pharmaceuticals 5: 553-590.
- Fiandaca, M.S., Padilla, R.M., Conteh, I., and Federoff, H.J. (2013) Can population genomics guide future therapeutic gene transfer strategies for Parkinson’s disease? OJGen 3: 19-29.
- Burger, E.W., Federoff, H.J., Fiandaca, M.S., Frieder, O., Goharian, N., and Yates, A. (2013) Social Media Communications Networks and Pharmacovigilance: SequelAE-2.0, Fifteenth IEEE International Conference on e-Health Networking, Applications and Services (Healthcom), Lisbon, Portugal, October 2013.
- Mapstone, M., Cheema, A.K., Fiandaca, M.S., Zhong, X., Mhyre, T.R., MacArthur, L.H., Hall, W.J., Fisher, S.G., Petersen, D.R., Haley, J.M., Nazar, M.D., Rich, S.A, Berlau, D.J., Peltz, C.B., Tan, M.T., Kawas, C.H., and Federoff, H.J. (2014) Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med 20: 415-418.
- Fiandaca, M.S. and Federoff, H.J. (2014) Using viral-mediated gene delivery to model Parkinson's disease: Do nonhuman primate investigations expand our understanding? Exp Neurol 256: 117-125.
- Fiandaca, M.S., Mapstone, M.E., Cheema, A.K., and Federoff, H.K. (2014) The critical need for defining preclinical biomarkers of Alzheimer’s disease. Alzheimers Dement 10 (3 Suppl): S196-S212 (Military risk supplement).
- Passini, M.A., Bu, J., Richards, A.M., Treleaven, C.M., Sullivan, J.A., O’Riordan, C.R., Scaria, A., Kells, A.P., Samaranch, L., Sebastian, W.S., Federici, T., Fiandaca, M.S., Boulis, N.M., Bankiewicz, K.S., Shihabuddin, L.S., and Cheng, S.H. (2014) Translational fidelity of intrathecal delivery of scAAV9-SMN1 for spinal muscular atrophy. Hum Gene Ther 25: 1-12, doi: 10.1089/hum.2014.011.
- Fiandaca, M.S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J.B., Abner, E.L., Petersen, R.C., Federoff, H.J., Miller, B.L., and Goetzl, E.J. (2015) Identification of preclinical Alzheimer’s disease by a profile of pathogenic proteins in neurally derived blood exosomes:?A case-control study. Alzheimers Dement 11: 600-607.
- Dromerick, A.W., Edwardson, M.A., Edwards, D.F., Giannetti, M.L., Barth, J., Brady, K.P., Chan, E., Tan, M.T., Tamboli, I., Chia, R., Orquiza, M., Padilla, R.M., Cheema, A.K., Mapstone, M.E., Fiandaca, M.S., Federoff, H.J., Newport, E.L. (2015) Critical Periods after Stroke Study: Translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci 9: 1-13.
- Nalls, M.A., McLean, C.Y., Rick, J., Eberly, S., Hutten, S.J., Gwinn, K., Sutherland, M., Martinez, M., Heutink, P., Williams, N., Hardy, J., Gasser, T., Brice, A., Price, T.R., Keller, M.F., Malony, C., Gibbs, J.R., Chen-Plotkin, A., Suh, E., Letson, C., Fiandaca, M.S., Mapstone, M., Federoff, H.J., Noyce, A., Van Deerlin, V.M., Weintraub, D., Zabetian, C., Hernandez, D.G., Lesage, S., Mullins, M., Northover, C., Cannon, P., Frasier, M., Marek, K., Day-Williams, A.G., Stone, D.J., Ioannidis, J.P.A., Singleton, A.B. (2015) Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modeling study. Lancet Neurol 14(10): 1002-1009.
- Fiandaca, M.S., Zhong, X., Cheema, A.K., Orquiza, M.H., Chidambaram, S., Tan, M.T., Gresenz, C.R., FitzGerald, K.T., Nalls, M.A., Singleton, A.B., Mapstone, M., Federoff, H.J. (2015) Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease. Front Neurol 6:237.
- Mapstone, M., Lin, F., Nalls, M.A., Cheema, A.K., Singleton, A.B., Fiandaca, M.S., Federoff, H.J. (2017) What success can teach us about failure: The plasma metabolome of older adults with superior memory and lessons for Alzheimer’s disease. Neurobiol Aging 51: 148-155.
- Mapstone, M., Cheema, A.K., Zhong, X., Fiandaca, M.S., and Federoff, H.J. (2017) Biomarker Validation: Methods and Matrix Matter (Letter). Alzheimers Dement. 13: 608-609.
- Mehta, K.Y., Wu, H-J, Menon, S.S., Fallah, Y., Zhong, X., Rizk, N., Unger, K., Mapstone, M., Fiandaca, M.S., Federoff, H.J., Cheema, A.K. (2017) Metabolomic Biomarkers of Pancreatic Cancer – a Meta-Analysis Study. Oncotarget 8: 68899-68915.
- Lehrich, Brandon M., Khosravi, P., Fiandaca, M.S. (2017) MathWorks® MATLAB App (Code): BPM Plot, Sep 26, 2017, BPM Plot, DOI:10.13140/RG.2.2.17778.40642 (
- Fiandaca, M.S., Mapstone, M., Connors, N., Jacobson, M., Monuki, E.M., Malik, S., Macciardi, F., Federoff, H.J. (2017) Systems Healthcare: A Holistic Paradigm for Tomorrow. BMC Systems Biology 11:142.
-Hampel, H., Vergallo, A., Aguilar, L.F., Benda, N., Broich, K., Cuello, C., Cummings, J., DUBOIS, B., Federoff, H.J., Fiandaca, M., Genthon, R., Haberkamp, M., Karran, E., Mapstone, M., Perry, G., Schneider, L., Welikovitch, L.A., Woodcock, J., Baldacci, F., Lista, S. (2018) Precision Pharmacology for Alzheimer’s Disease. Pharmacological Research 130: 331-365,
-Fiandaca, M.S., Mapstone, M., Mahmoodi, A., Gross, T., Macciardi, F., Cheema, A.K., Merchant-Borna, K., Bazarian, J., Federoff, H.J. (2017) Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLOS ONE 13(4): e0195318. https://doi. org/10.1371/journal.pone.0195318.
-Gross, T., Mapstone, M., Miramontes, R., Padilla, R., Cheema, A.K., Macciardi, F., Federoff, H.J., Fiandaca, M.S. (2018) Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives and a Basis for Analytic Pipeline Development. Curr Topics Med Chem 18 (11): 883-895. (Epub Ahead of Print) DOI: 10.2174/1568026618666180711144323.
- Edwardson, M.A., Zhong, X., Fiandaca, M.S., Federoff, H.J., Cheema, A.K., Dromerick, A.W. (2018) Plasma microRNA markers of upper limb recovery following human stroke. Scientific Reports 8:12558. DOI:10.1038/s41598-018-31020-5.
Other Experience
Partner/Neurological Surgeon
Lancelotta, Soliman, Jamaris, and Fiandaca, PA 1993—2001

Owner/Neurological Surgeon
Massimo S. Fiandaca, MD, PA 2001—2012

Graduate Programs

Neurological Surgery


Master of Business Administration (MBA)

Research Center
UCI Translational Laboratory and Biorepository (TLaB)
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