Shahrdad Lotfipour

picture of Shahrdad  Lotfipour

Assistant Professor, Emergency Medicine
School of Medicine
Joint Appointment, Pharmacology
School of Medicine

Ph.D., University of California, Irvine, 2007, The Role of Monoamine Oxidase Inhibitors in Tobacco Addiction


M.M.Sci., University of Queensland, 2001, Pharmacy: The Relative Potency of Morphine and Oxycodone in Neuropathic Pain


A.B., University of California, Irvine, 2000

Phone: (949) 824-8529
Email: shahrdad@uci.edu

University of California, Irvine
Med Surge II
Laboratory Room #303
Office 310A
Mail Code: 4625
Irvine, CA 92697
Research Interests
Adolescence, Nicotine, Tobacco, Stimulants, Alcohol, Illicit Drugs, nAChRs, Dopamine, Serotonin, Opioids, Marijuana, Addiction, Development, Maternal Drug Exposure, Brain Imaging, Reward, Learning and Memory, Limbic Brain Regions, Drug Seeking, Relapse
URLs
Academic Distinctions
1997 – 1999 Dr. John R. Miltner Annual Academic and Leadership Scholarship, University of California, Irvine
1999 – 2000 Tierney Leadership and Arts Scholarship, University of California, Irvine
2000 Chancellor’s Award for Excellence in Undergraduate Research, University of California, Irvine
2000 Phi Beta Kappa, University of California, Irvine
2000 Valedictorian, University of California, Irvine
2000 – 2001 United States Fulbright Fellowship, University of Queensland, School of Pharmacy, Brisbane, Australia
2002-2003 National Institute of Health Neurobiology Training Fellowship, University of California, Irvine
2004-2006 Tobacco Related Disease Research Program (TRDRP), University of California, Irvine, 13DT 0033
2007 – 2009 Academic Senate, Elected Member, University of Nottingham
2009 American College of Neuropsychopharmacology, Hot Topic Selection, Miami, Florida
2010 American College of Neuropsychopharmacology, Voice E-poster Selection, Miami, Florida
2010 Cold Spring Harbor Laboratory, Advanced Techniques of Molecular Neuroscience Course, New York
2012 Cold Spring Harbor Laboratory, Cellular Biology of Addiction Course, Barcelona, Spain
2015 UC Irvine Director of the Translational Adolescent Addiction Laboratory
2016 UC Irvine ADVANCE Career Development Award
2016 UC Irvine Center for Addiction Neuroscience Executive Committee Member
2016 U See I Write Fall Faculty Retreat Participant
2017 NIH Bootcamp (1st Mentee Selection, UCI School of Medicine)
2017 U See I Write Spring Faculty Retreat Participant
2017 NIH Early Career Reviewer Program, Center for Scientific Review, National Institutes of Health
2018 U See I Write Winter Faculty Retreat Participant
Appointments
2007 – 2009 Brain and Body Center, Post-Doctoral Fellowship, Department of Psychology, University of Nottingham
2009 – 2011 T-32 Post-Doctoral Training Program Fellowship, National Institute of Mental Health, University of California, Los Angeles, Psychobiology of the Major Mental Illnesses
2011 – 2014 Tobacco Related Disease Research Program, University of California, Los Angeles
2012-2015 Assistant Research Neuroscientist, Department of Psychiatry, University of California, Los Angeles
Research Abstract
Research objectives are to understand the mechanisms mediating addictive disorders. Special interest is on how brain and behavior interact with environment (i.e. developmental drug exposure) to influence addiction. Focus is placed on midbrain and limbic brain regions in modulating baseline and drug-induced brain and behavior associations. The goals of the research studies are to further our understanding of the impact of drugs of abuse on the developing brain using animal models, with translational relevance to the human population. The information gathered aims to assist in the promotion of better prevention and intervention strategies for the reduction of addictive disorders in the future.
Publications
Mojica C, Bai Y, Lotfipour, S. Maternal Nicotine Exposure Effects on Adolescent Learning and Memory Are Abolished in Alpha(a)2* Nicotinic Acetylcholine Receptor-Null Mutant Mice, Neuropharmacology, Accepted manuscript available online: 9-APR-2018 DOI information: 10.1016/j.neuropharm.2018.04.010
 
Lotfipour S, Smith MT. Morphine hyposensitivity in streptozotocin-diabetic rats: Reversal by dietary l-arginine treatment. Clin Exp Pharmacol Physiol. 2017 Sep 19. PMID: 28925511
 
Hersman S, Cushman J, Lemelson N, Wassum K, Lotfipour S, and Fanselow MS. Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations. Scientific Reports. 2017 May 24;7(1):2333. PMID: 28539613
 
Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J. a2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice. Learn Mem. 2017 May 15;24(6):231-244. Print 2017 Jun. PMID: 28507032
 
Faulkner P, Ghahremani DG, Tyndale RF, Cox CM, Kazanjian AS, Paterson N, Lotfipour S, Hellemann GS, Petersen N, Vigil C, London ED. Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology. 2017 Feb 15. PMID: 28117337
 
Cross SJ, Lotfipour S, Leslie FM. Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. Am J Drug Alcohol Abuse. 2017 Mar;43(2):171-185. Aug 17. PMID: 27532746
 
Upton M & Lotfipour S. Alpha2-Null Mutant Mice Have Altered Levels of Neuronal Activity in Restricted Midbrain and Limbic Brain Regions During Nicotine Withdrawal as Demonstrated by Cfos Expression. Biochemical Pharmacology. 2015, Oct 15;97(4):558-65, PMID: 26111579
 
Lotfipour S*, Ferguson E*, Leonard G, Miettunen J, Perron M, Pike GB, Richer L, Séguin JR, Veillette S, Jarvelin MR, Moilanen I, Mäki P, Nordström T, Pausova Z, Veijola J, Paus T. Maternal Cigarette Smoking during Pregnancy Predicts Drug Use Via Externalizing Behavior in Two Community-Based Samples of Adolescents. Addiction 2014
Oct;109(10):1718-29. PMID: 24942256 *Equal contributors.
 
Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J. Targeted Deletion of the a2
Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors. Journal of
Neuroscience. 2013, May;33(18):7728-41. PMID: 23637165.
 
Lotfipour S, Mandelkern M, Alvarez-Estrada, M, Brody A. A Single Administration of Low Dose Varenicline Saturates a4ß2* Nicotinic Acetylcholine Receptors in the Human Brain. Neuropsychopharmacology. 2012 Jun;37(7):1738-48. PMID: 22395733
 
Lotfipour S, Paus T. Association Between Prenatal Exposure to Maternal Cigarette Smoking and the Brain and Behaviour of Adolescent Offspring. Invited Review: Wakschlag LS, topic ed. In: Tremblay RE, Boivin M, Peters RDeV, Barr RG, eds. Encyclopedia on Early Childhood Development [online]. Montreal, Quebec: Center of Excellence for Early Childhood
Development. 2011:1-8.
 
Lotfipour S, Mandelkern M, Brody A. Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in
the Human Brain With A-85380 Radiotracers. Current Medical Imaging Review. 2011 May; 7(2):107-112. ISSN: 1573-
4056 PMID:22773924
 
Lotfipour S, Arnold MM, Hogenkamp DJ, Gee KW, Belluzzi JD, Leslie FM. The Monoamine Oxidase (MAO) Inhibitor
Tranylcypromine Enhances Nicotine Self-Administration in Rats Through a Mechanism Independent of MAO Inhibition.
Neuropharmacology. 2011 Jul-Aug;61(1-2):95-104. PMID: 21419142
 
Lotfipour S, Leonard G, Perron M, Pike GB, Richer L, Toro T, Veillette S, Ferguson E, Seguin J, Pausova Z, Paus T.
Prenatal Exposure to Maternal Cigarette Smoking Interacts with a Polymorphism in the a6 Nicotinic Acetylcholine
Receptor Gene to Influence Drug Use and Striatum Volume in Adolescence. Molecular Psychiatry. 2010 Jan;15(1):6-8.
PMID: 20029407
 
Toledo M*, Lotfipour S*, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Maternal Smoking
During Pregnancy is Associated with Epigenetic Modifications of the Brain-Derived Neurotrophic Factor-6 Exon in
Adolescent Offspring. Am J Med Genet B Neuropsychiatr Genet. 2010 Oct;153B(7):1350-4. PMID: 20583129 *Equal
contributors
 
Lotfipour S, Leonard G, Perron M, Pike GB, Richer L, Toro T, Veillette S, Ferguson E, Seguin J, Pausova Z, Paus T.
Orbitofrontal Cortex and Drug Use During Adolescence: Role of Prenatal Exposure to Maternal Smoking and BDNF
Genotype. Archives of General Psychiatry. 2009 Nov;66(11):1244-52. PMID: 19884612
 
Lotfipour S. The Role of Monoamine Oxidase Inhibitors in Tobacco Addiction. Ph.D. Dissertation, University of California,
Irvine, CA. 2008
 
Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. Oxycodone and Morphine Have Distinctly Different
Pharmacological Profiles: Radioligand Binding and Behavioural Studies in Two Rat Models of Neuropathic Pain. Pain.
2007 Dec;132(3):289-300. PMID: 17467904
 
Cao J, Lotfipour S, Loughlin SE, Leslie FM. Adolescent Maturation of Cocaine-Sensitive Neural Mechanisms.
Neuropsychopharmacology. 2007 Nov;32(11):2279-89. PMID: 17299504
 
Villégier AS, Lotfipour S, Belluzzi JD, Leslie FM. Involvement of Alpha1-Adrenergic Receptors in Tranylcypromine
Enhancement of Nicotine Self-Administration in Rats. Psychopharmacology (Berl). 2007 Sep;193(4):457-65. PMID:
17486319
 
Villégier AS, Lotfipour S, McQuown SC, Belluzzi JD, Leslie FM. Tranylcypromine Enhancement of Nicotine SelfAdministration.
Neuropharmacology. 2007 May;52(6):1415-25. PMID: 17412372
 
Leslie FM, Azam L, Gallardo K., O’Leary K., Franke R. and Lotfipour S. Nicotinic Receptor Regulation of Developing
Catecholamine Systems. In: Development of the Mammalian Central Nervous System: Lessons Learned from Studies of
Alcohol and Nicotine, Miller, M.W., ed., Oxford Press, April, 2006
 
Leslie FM, Loughlin SE, Wang R, Perez L, Lotfipour S, Belluzzia JD. Adolescent Development of Forebrain Stimulant
Responsiveness: Insights From Animal Studies. Ann NY Acad Sci. 2004 Jun;1021:148-59. PMID: 15251884
 
Lotfipour S. The Relative Potency of Morphine and Oxycodone in the STZ-Diabetic Rat, School of Pharmacy, University of Queensland, Brisbane, Australia, Aug 2002; (U.S. Fulbright Masters Thesis)
Grants
2001 Transdisciplinary Tobacco Use Research Grant, University of California, Irvine
2003 Hyundai Motor America Award, University of California, Irvine Children’s Hospital
2008 Welcome Trust Travel Grant, Welcome Collection, London, UK
2009 Friends of the Semel Institute, University of California, Los Angeles
2010 Investigator Initiated Research Grant, Pfizer, University of California, Los Angeles and the Veterans Association Greater Los Angeles Healthcare System
2010 American College of Neuropsychopharmacology, Travel Grant, Miami, Florida
2011 National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award, University of California, Los Angeles
2012 Shane Endowment, University of California, Los Angeles
2013 Shane Endowment, University of California, Los Angeles
2013 Tobacco-Related Disease Research Program, University of California, Los Angeles
2014 Brain and Behavior Research Foundation Young Investigator Award
2014 Tobacco Related Disease Research Program
2016 Tobacco Related Disease Research Program (No Cost Extension)
2016 Brain and Behavior Foundation (No Cost Extension)
2016 UC Irvine ADVANCE Career Development Award
2017 Tobacco Related Disease Research Program (No Cost Extension)
Professional Societies
Society for Research on Nicotine and Tobacco
Society for Neuroscience
Australian-American Fulbright Alumni Association
Graduate Programs
Interdepartmental Neuroscience Program

Pharmacological Sciences

Research Center
Irvine Center for Addiction Neuroscience: http://ican.bio.uci.edu/ http://irvinecan.com/
Last updated
10/03/2018