Feng Liu-smith

Assistant Professor, Epidemiology
School of Medicine

Ph.D., Iowa State University, 2002, Genetics

M.S., University of California Irvine, 2016, Epidemiology

Phone: (949) 824-2778
Email: liufe@uci.edu

University of California, Irvine
109 E Yale Loop
Mail Code: 4048
Irvine, CA 92697

Melanoma etiology, molecular epidemiology, redox biology and melanoma resistance mechanisms to BRAF inhibitors.
Publications 1. Feng Liu-Smith and Argyrios Ziogas, An age-dependent interaction between sex and geographical UV index in melanoma risk. J Am Acad Dermatol, in press
2. Tze-An Yuan, Vandy Yourk, Ali M. Farhat, Argyrios Ziogas, Angela Garcia, Frank L. Meyskens Jr, Hoda Anton-Culver, Feng Liu-Smith, 2017. The Associations between Single Nucleotide Polymorphisms in the Redox Pathway and Risk of Melanoma. Plos One, in revision.
3. Yonghong Li, Victor Pham1, Michelle Bui, Liankun Song, Chunli Wu1, Arman Walia, Edward Uchio, Feng Smith-Liu, Xiaolin Zi. Rhodiola rosea L.: an herb with anti-stress, anti-aging and immunostimulating properties for cancer chemoprevention. Current Pharmacology Reports, 2017, in press.
4. Meyskens FL Jr, Liu-Smith F, Redox-Redux and NADPH Oxidase (NOX): Even More Complicated than We Thought it Might Be. J Invest Dermatol. 2017 Jun;137(6):1208-1210.
5. Liu-Smith F*, Farhat Ahmed Majid, Arce Anthony, Ziogas Argyrios, Taylor Thomas, Wang Zi, Yourk Vandy, Liu Jing, Wu Jun, McEligot Archana J., Anton-Culver Hoda, and Meyskens Frank L.. Gender differences in the association between the incidence of cutaneous melanoma and geographic UV exposure. J Am Acad Dermatol. 2017 Mar;76(3):499-505. (*corresponding author)
6. Roy Mridul, Liang Long, Xiao Xiaojuan, Peng Yuanliang, Luo Yuhao, Zhou Weihua, Zhang Ji, Zhang Shuaishuai, Qiu Lugui, Liu Feng, Ye Mao, Zhou Wen, Liu Jing. Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma. 2016, Theranostics. 2016 Sep 24;6(12):2209-2224
7. Jia J, Li C, Luo S, Liu-Smith F, Yang J, Wang X, Wang N, Lai B, Lei T, Wang Q, et al. Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS. J Invest Dermatol. 2016 Jun;136(6):1267-77. doi: 10.1016/j.jid.2016.02.005. Epub 2016 Feb 20. PubMed PMID: 26902922.
8. Liu-Smith F*, Meyskens FL. Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma. Mol Nutr Food Res. 2016 Jun;60(6):1264-74. doi: 10.1002/mnfr.201500822. Epub 2016 Mar 21. Review. PubMed PMID: 26865001; PubMed Central PMCID: PMC4900912. (*corresponding author)
9. Wang Z, Ma B, Li H, Xiao X, Zhou W, Liu F, Zhang B, Zhu M, Yang Q, Zeng Y, et al. Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC. Oncotarget. 2016 Jan 5;7(1):509-23. doi: 10.18632/oncotarget.6312. PubMed PMID: 26575790; PubMed Central PMCID: PMC4808014.
10. Liu-Smith F*, Poe C, Farmer PJ, and Meyskens FL, Jr. Amyloids, melanins and oxidative stress in melanomagenesis. Exp Dermatol March 2015; 24(3):171-4. (*corresponding author)
11. Yang Z, Yang S, Misner BJ, Liu-Smith F, and Meyskens FL. The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression. Int J Oncol May 2014; 45(5):1820-8.
12. Liu-Smith F*, Dellinger R, and Meyskens FL, Jr. Updates of reactive oxygen species in melanoma etiology and progression. Arch Biochem Biophys 2014; 563:51-5. PMC4209333 (*corresponding author)
13. Dellinger RW, Liu-Smith F, and Meyskens FL, Jr. Continuing to illuminate the mechanisms underlying UV-mediated melanomagenesis. J Photochem Photobiol B 2014; 138:317-23. PMC4230791
14. Sun W, Zheng Y, Lu Z, Wang H, Feng Z, Wang J, Xiao S, Liu F, and Liu J. LL-37 attenuates inflammatory impairment via mTOR signaling-dependent mitochondrial protection. Int J Biochem Cell Biol 2014; 54:26-35.
15. Sun W, Zheng Y, Lu Z, Cui Y, Tian Q, Xiao S, Liu F, and Liu J. Overexpression of S100A7 protects LPS-induced mitochondrial dysfunction and stimulates IL-6 and IL-8 in HaCaT cells. PLoS One 2014; 9(3):e92927. PMC3966836
16. Qu X, Shen L, Zheng Y*, Cui Y, Feng Z, Liu F*, and Liu J. A signal transduction pathway from TGF-beta1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma. J Invest Dermatol 2014; 134(1):159-67. (*co-coresponding author)
17. Sun Z and Liu F*. Association of Nox1 and vinculin with colon cancer progression. Cancer Invest 2013; 31(4):273-8. (*corresponding author)
18. Liu F*, Bessonova L, Taylor TH, Ziogas A, Meyskens FL, Jr., and Anton-Culver H. A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important. Pigment Cell Melanoma Res 2013; 26(1):128-35. PMC4028153 (*corresponding author)
19. Krasieva TB, Stringari C, Liu F, Sun CH, Kong Y, Balu M, Meyskens FL, Gratton E, and Tromberg BJ. Two-photon excited fluorescence lifetime imaging and spectroscopy of melanins in vitro and in vivo. J Biomed Opt 2013; 18(3):31107. PMC3595716
20. Liu F*, Gomez Garcia AM, and Meyskens FL, Jr. NADPH oxidase 1 overexpression enhances invasion via matrix metalloproteinase-2 and epithelial-mesenchymal transition in melanoma cells. J Invest Dermatol 2012; 132(8):2033-41. (*corresponding author)
21. Liu F*, Singh A, Yang Z, Garcia A, Kong Y, and Meyskens FL, Jr. MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells. Mol Cancer 2010; 9:214. PMC2928201 (*corresponding author)
22. Liu F*, Fu Y, and Meyskens FL, Jr. MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1. J Invest Dermatol 2009; 129(2):422-31. PMC4321967 (*corresponding author)
23. Liu HL, Xu JJ, Dai XM, Shi JB, Xu S, Gao J, Yao QZ, and Liu F. Both DNA damage and mitochondrial dysfunction are involved in novel oxadiazolo[3,4-d]pyrimidine nucleoside derivatives-induced cancer cell death. J Appl Toxicol 2009; 29(6):489-95.
24. Yang Z, Yang S, Misner BJ, Chiu R, Liu F, and Meyskens FL, Jr. Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol. Mol Cancer Ther 2008; 7(12):3751-60.
25. Tang Y, Simoneau AR, Liao WX, Yi G, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Hoang BH, and Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther 2009; 8(2):458-68. PMC2768341
26. Liu F and Lee WH. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol 2006; 26(8):3124-34. PMC1446954
27. Chen PL*, Liu F*, Cai S, Lin X, Li A, Chen Y, Gu B, Lee EY, and Lee WH. Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol 2005; 25(9):3535-42. PMC1084307 (*co-first author)
28. Qiu F, Guo L, Wen TJ, Liu F, Ashlock DA, and Schnable PS. DNA sequence-based "bar codes" for tracking the origins of expressed sequence tags from a maize cDNA library constructed using multiple mRNA sources. Plant Physiol 2003; 133(2):475-81. PMC523874
29. Cui X, Hsia AP, Liu F, Ashlock DA, Wise RP, and Schnable PS. Alternative transcription initiation sites and polyadenylation sites are recruited during Mu suppression at the rf2a locus of maize. Genetics 2003; 163(2):685-98. PMC1462470
30. Skibbe DS*, Liu F*, Wen TJ*, Yandeau MD, Cui X, Cao J, Simmons CR, and Schnable PS. Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis. Plant Mol Biol 2002; 48(5-6):751-64. (*co-first author)
31. Liu F and Schnable PS. Functional specialization of maize mitochondrial aldehyde dehydrogenases. Plant Physiol 2002; 130(4):1657-74. PMC166681
32. Liu F, Cui X, Horner HT, Weiner H, and Schnable PS. Mitochondrial aldehyde dehydrogenase activity is required for male fertility in maize. Plant Cell 2001; 13(5):1063-78. PMC135560
Grants NCI/NIH K07 (PI): Melanoma Risk: Interactions between UV radiation and NADPH Oxidase Gene family, 2013-2018
NIH, R01 (co-I): Selective Inhibition of Nitric Oxide Synthase for Multiple Indications.Aug 2015– July 2019
Melanoma Research Alliance, Young Investigator Award, PI, Molecular epidemiology on gender difference in early onset melanoma, 2017-2020
UCI-CFCCC and CSUF, the P20 Partnership for Cancer Health Disparities, PI, Epigenetic Mechanisms of Gender Disparities in Early Onset Melanoma, 2013-2015
American Association of Cancer Research
Pan-American Society for Pigment Cell Research (PASPCR)
Society for Melanoma Research (SMR)
Society of Free Radical Biology and Medicine (SFRBM)
American Society of Preventive Oncology (ASPO)
American Society of Clinical Oncology (ASCO)
Graduate Programs Epidemiology

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Last updated 09/05/2017