Zeba Wunderlich

Assistant Professor, Developmental & Cell Biology
School of Biological Sciences

B.A., Rutgers University, 2003, Molecular Biology & Biochemistry; Statistics
Ph.D., Harvard University, 2008, Biophysics

Phone: (949) 824-5959
Email: zeba@uci.edu

University of California, Irvine
4107 Natural Sciences II
Mail Code: 2305
Irvine, CA 92697
Research Interests
transcriptional regulation; Drosophila; development; computational biology; systems biology
Postdoctoral Fellow in Systems Biology, Harvard Medical School, 9/2008-3/2015
Research Abstract
Understanding the organization of regulatory information in the genome

Regulatory DNA encodes the gene regulatory networks that are required for virtually every process in an animal, from development to immunity. The Wunderlich lab is interested in understanding how a gene regulatory network's tasks influence its architecture, robustness, and evolvability. To probe these questions, we use two model systems: the Drosophila early embryonic patterning system and the Drosophila innate immune response. In both systems, we pair imaging-based and genomic measurements of gene expression with statistical and physically-based computational models to explore questions of gene regulatory network function. We exploit naturally-occuring sequence variation between individuals and species as a tool to measure how changes in regulatory DNA affect transcriptional regulation.
Professional Society
Genetics Society of America, member
Graduate Programs
Cellular and Molecular Biosciences

Mathematical and Computational Biology

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