Claudia A Benavente

picture of Claudia A Benavente

Assistant Professor, Pharmaceutical Sciences
Pharmaceutical Sciences
Program Member, Chao Family Comprehensive Cancer Center
Joint Faculty, Developmental & Cell Biology
School of Biological Sciences

B.S., Universidad de Chile, 2001, Molecular Biotechnology Engineering
M.S., Universidad de Chile, 2002, Molecular Biotechnology Engineering
Ph.D., The University of Arizona, 2007, Cancer Biology

Phone: (949) 824-7845
Email: claudia.benavente@uci.edu

University of California, Irvine
108 Sprague Hall
Mail Code: 3958
Irvine, CA 92697
Research Interests
Genetics, epigenetics, cancer, pediatric cancer, retinoblastoma, osteosarcoma, Rb
URL
Academic Distinctions
2018 – 2020 AACR-Aflac Career Development Award for Pediatric Cancer Research
2013 – 2017 NIH Pathway to Independence Award
2003 – 2005 Fulbright Scholar
Appointments
St Jude Children's Research Hospital - 2009-2014 (Michael A. Dyer Lab)
Research Abstract
My laboratory is interested in understanding the molecular and cellular mechanisms that drive tumor progression. Our research is focused on the genetic and epigenetic changes that occur following tumor initiation, particularly those associated with loss of the RB tumor suppressor gene. The goals of our research are directed toward identifying the downstream genes or pathways that are regulated by the retinoblastoma protein (RB) and have the potential to become alternative therapeutic targets for the treatment of cancer.

Furthermore, while functional loss of RB1 is sufficient for the retinal cell of origin to form retinoblastoma, osteoblasts require additional inactivation of the TP53 tumor suppressor for osteosarcoma (bone cancer) formation. Through the study of the epigenetic landscape of retinoblastoma and osteosarcoma, we hope to determine why some cell types are more susceptible to tumor formation than other cell types, in particular following RB1 inactivation. This has been an unanswered question in the field of cancer biology since the cloning of the first tumor suppressor gene (RB1) and progress in this area is needed to better target cancer therapy in the future.
Publications
15. Zocchi, L., Benavente, C. A. (2018) DNA repair and epigenetic regulation in cancer (Ch. 18). Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology. CRC Press/Taylor & Francis Group.
 
14. Wu SC, Benavente CA. Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is dispensable for osteosarcoma tumorigenesis. (2018) Oncotarget, 9(66):32580-32592. doi: 10.18632/oncotarget.25953. PMC6135699.
 
13. Zocchi L., Wu S.C., Wu J., Hayama K., Benavente, C.A. (2018) The Cyclin-Dependent Kinase Inhibitor Flavopiridol (Alvocidib) Inhibits Metastasis of Human Osteosarcoma Cells. Oncotarget, 9(34):23505-23518. doi: 10.18632/oncotarget.25239. PMC5955096.
 
12. Aldiri I, Ajioka I, Beisi X, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio L, Dyer MA. Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. (2015) Development 142(23):4092-106.
 
11. Benavente CA, Dyer MA. Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma. (2015) Methods in Molecular Biology, Humana Press 1267:307-17.
 
10. Benavente CA, Dyer MA. Genetics and epigenetics of human retinoblastoma. (2015) Annual Reviews of Pathology: Mechanisms of Disease 10:547-562.
 
9. Benavente CA, Finkelstein D, Johnson DA, Marine JC, Ashery-Padan R, Dyer MA. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. (2014) Oncotargets 5(20): 9594-608.
 
8. Stewart E, Goshorn DR, Bradley C. Parker M, Ma X, Griffiths LM, Benavente CA, Twarog NR, Miller GM, Caufield W, Freeman BB, Bahrami A, Pappo A, Wu J, Loh A, Karlström A, Krafcik F, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder S, Thiagarajan S, Shirinifard A, Sablauer A, Nagahawatte P, Rusch M, Hedlund E, Easton J, Shurtleff S, Mardis ER, Wilson RK, Zhang J, Downing J, Shelat A, Dyer MA. Targeting the DNA repair pathway in Ewing sarcoma. (2014) Cell Reports 9, 829–840.
 
7. Benavente CA, McEvoy JD, Finkelstein D, Wei L, Kang G, Wang Y, Neale G, Ragsdale S, Valentine V, Bahrami A , Temirov J, Pounds S, Zhang J, Dyer MA. Cross-species genomic and epigenomic landscape of retinoblastoma. (2013) Oncotarget 4(6): 844-859.
 
6. Zhang J*, Benavente CA*, McEvoy J*, Flores-Otero J*, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing J and Dyer MA. A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses. (2012) Nature, 481, 329-334. doi: 10.1038/nature10733. Faculty of 1000 (F1000)
 
5. Benavente CA, Schnell SA, Jacobson EL. Effects of niacin restriction on Sirtuin and PARP responses to photodamage. (2012) PLoS ONE 7(7): e42276. doi:10.1371/journal.pone.0042276
 
4. Bermudez Y, Benavente CA, Meyer RG, Coyle WR, Jacobson MK, Jacobson EL. Nicotinic Acid Receptor Abnormalities in Human Skin Cancer: Implications for a Role in Epidermal Differentiation. (2011) PLoS ONE 6(5): e20487. doi:10.1371/journal.pone.0020487
 
3. Benavente CA, Jacobson MK, Jacobson EL. NAD in skin: therapeutic approaches for niacin. (2009) Current Pharmaceutical Design 15(1): 29-38.
 
2. Benavente CA, Jacobson EL.Niacin restriction upregulates NADPH oxidase and ROS in human keratinocytes. (2008) Free Radical Biology and Medicine Feb 15; 44(4): 527-37.
 
1. Benavente CA, Conget P, Sierralta W, Minguell JJ. Subcellular distribution and mitogenic effect of basic fibroblast growth factor in mesenchymal uncommitted stem cells. (2003) Growth Factors Jun; 21(2): 87-94.
Grants
American Cancer Society - IRG
American Association for Cancer Research – Aflac Inc.
Professional Society
AACR
Graduate Programs
Medicinal Chemistry and Pharmacology

Cellular and Molecular Biosciences

Last updated
11/14/2018