Claudia A Benavente

picture of Claudia A Benavente

Associate Professor, Department of Pharmaceutical Sciences
School of Pharmacy & Pharmaceutical Sciences

Program Member, Chao Family Comprehensive Cancer Center

Joint Faculty, Developmental & Cell Biology
School of Biological Sciences


B.S., Universidad de Chile, 2001, Molecular Biotechnology Engineering
M.S., Universidad de Chile, 2002, Molecular Biotechnology Engineering
Ph.D., The University of Arizona, 2007, Cancer Biology

ORCiD: 0000-0002-6875-3186

Phone: (949) 824-7845
Email: claudia.benavente@uci.edu

University of California, Irvine
108 Sprague Hall
Mail Code: 3958
Irvine, CA 92697
Research Interests
Genetics, epigenetics, cancer, pediatric cancer, retinoblastoma, osteosarcoma, Rb
URL
Research Abstract
Our laboratory is focused on understanding the chromatin remodeling
processes that establish the normal epigenetic landscape in developing tissue,
how it can be perturbed to promote carcinogenesis, and provide insight for the
development of new therapies. We are particularly interested in how the RB
pathway, which is altered in virtually every cancer, control epigenetic events
that control cell fate specification and differentiation in normal cells - aiming to
elucidate the relationship between cell differentiation and tumorigenesis in the
absence of the RB family. We are currently studying the role of chromatin
remodelers regulated by the RB pathway in the formation of retinal, bone, and
lung cancers. Our work will likely influence the development of new therapeutic
interventions for retinoblastoma, osteosarcoma, small cell lung cancer, and
other cancers with RB pathway inactivation.
Awards and Honors
2018 – 2020 AACR-Aflac Career Development Award for Pediatric Cancer Research
2013 – 2017 NIH Pathway to Independence Award
2003 – 2005 Fulbright Scholar
Publications
20. Guzman, F., Fazeli, Y., Khuu, M., Salcido, K., Singh, S., Benavente, C.A. Retinoblastoma tumor suppressor protein roles in epigenetic regulation (2020). Cancers 12(10), 2807. https://doi.org/10.3390/cancers12102807
 
19. Wang S, Drummond ML, Guerrero-Juarez CF, Tarapore E, MacLean AL, Stabell AR, Wu SC, Gutierrez G, That BT, Benavente CA, Nie Q, Atwood SX. (2020) Single cell transcriptomics of human epidermis reveals basal stem cell transition states. Nature Communications. In press. bioRxiv, 784579; doi: https://doi.org/10.1101/784579
 
18. Zocchi L, Wu SC, Benavente CA. (2020). Heavenly HELLS? – A potential new therapeutic target for retinoblastoma. Oncoscience, 7:23-15. https://doi.org/10.18632/oncoscience.502. PMC7217136
 
17. Zocchi L, Mehta A, Wu SC, Wu J, Gu Y, Wang J, Suh S, Spitale RC, Benavente CA. (2020). Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. Oncogenesis, 9:25. https://doi.org/10.1038/s41389-020-0210-7. PMC7028996.
 
16. Wu SC, Benavente CA. Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is dispensable for osteosarcoma tumorigenesis. (2018) Oncotarget, 9(66):32580-32592. doi: 10.18632/oncotarget.25953. PMC6135699.
 
15. Zocchi L., Wu S.C., Wu J., Hayama K., Benavente, C.A. (2018) The Cyclin-Dependent Kinase Inhibitor Flavopiridol (Alvocidib) Inhibits Metastasis of Human Osteosarcoma Cells. Oncotarget, 9(34):23505-23518. doi: 10.18632/oncotarget.25239. PMC5955096.
 
14. Zocchi, L., Benavente, C. A. (2018) DNA repair and epigenetic regulation in cancer (Ch. 18). Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology. CRC Press/Taylor & Francis Group.
 
13. Aldiri I, Ajioka I, Beisi X, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio L, Dyer MA. Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. (2015) Development 142(23):4092-106.
 
12. Stewart, E., Goshorn, R., Bradley, C., Griffiths, L. M., Benavente, C. A., Twarog, N. R., Miller, G. M., W. C., Freeman, B. B., III, Bahrami, A., Pappo, A., Wu, J., Loh, A., Karlstrom, A., Calabrese, C., Gordon, B., Tsurkan, L., Hatfield, J., Potter, P. M., Snyder, S. E., Thiagarajan, S., Shirinifard, A., Sablauer, A., Shelat, A. A., Dyer, M. A. (2014). Targeting the DNA repair pathway in Ewing sarcoma. Cell Reports, 9(3), 829-41. doi: 10.1016/j.celrep.2014.09.028. PMCID: PMC4386669.
 
11. Benavente CA, Dyer MA. Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma. (2015) Methods in Molecular Biology, Humana Press 1267:307-17.
 
10. Benavente CA, Dyer MA. Genetics and epigenetics of human retinoblastoma. (2015) Annual Reviews of Pathology: Mechanisms of Disease 10:547-562.
 
9. Benavente CA, Finkelstein D, Johnson DA, Marine JC, Ashery-Padan R, Dyer MA. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. (2014) Oncotargets 5(20): 9594-608.
 
7. Benavente CA, McEvoy JD, Finkelstein D, Wei L, Kang G, Wang Y, Neale G, Ragsdale S, Valentine V, Bahrami A , Temirov J, Pounds S, Zhang J, Dyer MA. Cross-species genomic and epigenomic landscape of retinoblastoma. (2013) Oncotarget 4(6): 844-859.
 
6. Zhang J*, Benavente CA*, McEvoy J*, Flores-Otero J*, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing J and Dyer MA. A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses. (2012) Nature, 481, 329-334. doi: 10.1038/nature10733. Faculty of 1000 (F1000)
 
5. Benavente CA, Schnell SA, Jacobson EL. Effects of niacin restriction on Sirtuin and PARP responses to photodamage. (2012) PLoS ONE 7(7): e42276. doi:10.1371/journal.pone.0042276
 
4. Bermudez Y, Benavente CA, Meyer RG, Coyle WR, Jacobson MK, Jacobson EL. Nicotinic Acid Receptor Abnormalities in Human Skin Cancer: Implications for a Role in Epidermal Differentiation. (2011) PLoS ONE 6(5): e20487. doi:10.1371/journal.pone.0020487
 
3. Benavente CA, Jacobson MK, Jacobson EL. NAD in skin: therapeutic approaches for niacin. (2009) Current Pharmaceutical Design 15(1): 29-38.
 
2. Benavente CA, Jacobson EL.Niacin restriction upregulates NADPH oxidase and ROS in human keratinocytes. (2008) Free Radical Biology and Medicine Feb 15; 44(4): 527-37.
 
1. Benavente CA, Conget P, Sierralta W, Minguell JJ. Subcellular distribution and mitogenic effect of basic fibroblast growth factor in mesenchymal uncommitted stem cells. (2003) Growth Factors Jun; 21(2): 87-94.
Grants
NIH/NCI CA229696
American Cancer Society - Research Scholar Grant
Professional Societies
AACR
AAAS
Graduate Programs
Medicinal Chemistry and Pharmacology

Cellular and Molecular Biosciences

Last updated
07/11/2022