Alan Widgerow

picture of Alan  Widgerow

Adjunct Professor, Director Center for Tissue Engineering UCI Dept of Plastic Surgery, Plastic Surgery
School of Medicine

MBBCh, University of Witwatersrand South Africa, 1980
MMed, University of Witwatersrand South Africa, 1991, Plastic Surgery
FCS (Plast), College of Medicine South Africa, 1989, Plastic Surgery
FACS, American College of Surgeons, 1998, Plastic Surgery

Phone: (714) 456-3482
Email: awidgero@uci.edu

University of California, Irvine
101 S City Drive
Building 55 Suite 108a
Orange, CA 926868
Research Interests
adipose derived stem cells; wound healing; burns
Academic Distinctions
- Clinical (Adjunct) Professor Plastic Surgery, Director Research & Center for Tissue Engineering Dept of Plastic Surgery, University of California, Irvine; July 2012 - present
- Association of Plastic & Reconstructive Surgeons of Southern Africa:
President 1996-1998, Secretary 1994-1996, Executive Committee Member 1992 - 2000
- Honorary/Emeritus Professor University Witwatersrand, Plastic Surgery Feb 1999 – present
- Nominated for Investec Bank award for a Considerable Contribution in a Career / Profession 2010
- Nominated to Scientific Board for Africa, World Society of Aesthetic Surgery, May 1998.
- European Tissue Repair Society – 2007-2010
- Wound Healing Society (US) – 2011 on
- Exco member Wound Healing Assoc of South Africa (WHASA)
- Elected to the Faculty of Plastic and Reconstructive Surgery of the College of Medicine of South
Africa, 1998 – 2001: 2005 - 2008
- New York Academy of Sciences (1996)
- Listed in Who’s Who in The World, 1997on & Who’s Who in Medicine & Healthcare, 1996on
- Nominated as convener and examiner for the final examination F.C.S. (SA) Plastic &
Reconstructive Surgery Part II for the College of Medicine of South Africa, May 1996-2009 and for the University of Pretoria Masters MMed degree in Plastic and Reconstructive Surgery, May 1999 – 2009.
- Winner publication of the year APRSSA (Plastic Surgery Association) 2004
- Winner publication of the year APRSSA (Plastic Surgery Association) 2003
- Winner publication of the year APRSSA (Plastic Surgery Association) 2001
- Winner publication of the year APRSSA (Plastic Surgery Association) 2000
- Nominated for Phillip Tobias & Convocation Distinguished Teachers Award – judged by Dean’s selection committee for the University of the Witwatersrand, 1999.
- Winner publication of the year APRSSA (Plastic Surgery Association), 1997
- Michael and Janie Miller Award 1989 - First plastic surgeon to win this award for the top Witwatersrand University surgical graduate based on exam scores and overall resident curriculum (inclusive of general surgery, orthopedics, otolaryngology, plastic surgery, ophthalmology, urology).
- Plastic Surgery Resident Representative 1988 & 1989, University of the Witwatersrand
- Awarded U.S. Green Card Status, 1995, in the Category of “Exceptional Academic Merit.”
Appointments
Professor Widgerow completed his undergraduate and post-graduate studies at the University of the Witwatersrand, South Africa. He was the top surgical graduate at the University of Witwatersrand in 1989. He has held various positions in numerous academic and professional associations including that of President of the Association of Plastic and Reconstructive surgery of Southern Africa (APRSSA). He is a Fellow of the American College of Surgeons and was appointed Honorary Professor by the Senate of Wits University in 1999. He is author of over 110 plastic surgical related publications and 2 books. He is currently editor-in-chief of Wound Healing Southern Africa. He was also the founder and medical director of 11 wound clinics in South Africa. His current fields of interest are translational basic science research, medical device innovations, tissue engineering and wound healing.


After 20 years in private plastic surgical practice in South Africa, Prof Widgerow relocated to Irvine California in Dec 2009 to pursue his interests in research, medical device innovations and wound care, but he still plays an active role in academic medicine world-wide. In August 2012 he joined the University of California Irvine Plastic Surgery Division as Clinical Professor and Director Center for Tissue Engineering. He has redesigned and introduced major Research projects to the TERM Lab and has entered submissions on multiple Grant proposals. He has recruited a team of 20 researchers and runs a vibrant, dynamic research facility at UCIMC
Research Abstract
1. Micro/nanobubbles and wound healing

Micro/nanobubbles (MNBs) offer a new technology for creating oxygen-enriched fluids. Bubbles are gas-containing cavities in an aqueous solution. Microbubbles have a diameter between 1 and 100 µm, and nanobubbles - less than 1 µm. Fluids can be saturated with various gases, e.g. oxygen, using MNB technology with our designed device. This results in an excellent vehicle for external oxygen delivery to tissues. Nanobubbles have several unique properties. They can form freely and remain in an aqueous solution for extended periods of time with the capacity to act as a reservoir and store oxygen; thus, interest in micro/nanobubbles is growing.

Chronic non-healing wounds constitute a major health problem particularly in the elderly population. Local tissue hypoxia, related to health problems such as diabetes, venous stasis and peripheral vascular disease, is a common feature accompanying all types of chronic wounds with ischemia reperfusion cycles contributing significantly to tissue damage. Oxygen delivery has been identified as a major factor affecting wound healing and it is accepted that limited oxygenation can lead to a chronic nonhealing ulcer. Maintaining an appropriate level of oxygen in these wounds continues to be a challenge.

We hypothesize that MNB technology can be successfully used for transporting oxygen to tissues in state of hypoxia. Potentially, the stability of MNBs can allow for the production of off-the-shelf solutions with a known concentration of oxygen. When used to irrigate wounds, such solutions would be expected to have the following effects: (1) to increase wound oxygen tension; (2) to provide debridement and (3) to subsequently promote healing.

2. Mechanical Stress and the regenerative cell

Diabetes constitutes a global emergency and the diabetic foot ulcer (DFU), a complication of the disease, is the leading cause of nontraumatic lower limb amputations. Current methods for DFU prevention are primarily through education and physical offloading, while treatment after ulcer formation is laden with expense and unpredictable outcomes. Autologous fat grafting enriched with adipose-derived mesenchymal stem cells (MSCs) has tremendous promise for enhanced lipofilling and therefore replacement of the atrophied fat pad for the prevention of DFUs. Additionally, recent mouse and human studies have demonstrated that direct injection of healthy human MSCs can significantly alter the clinical course of the DFU by increasing angiogenesis and improving wound healing. Unfortunately, diabetic patients have fewer endogenous MSCs that exhibit decreased stem cell markers, cellular functioning and ability to proliferate. Recently, our group demonstrated that mechanical stress can be used to induce a ~7.5 fold increase in the universal stem cell marker CD34 as well as statistically significant increases in MSCs, endothelial progenitor cells, and pluripotent Muse cells in healthy adipose tissue. We hypothesize that similar processing can be used to activate the senescent stem cells in diabetic adipose tissue which can then be used for autologous enriched fat graft prevention of DFU development or for the direct injection to heal established DFUs


3. Deconstructing Adipo-induction In Decellularized Adipose Matrix (AAM)

Collaborative partnership with Musculoskeletal Transplant Foundation (MTF) exploring the use of acellular adipose derived matrices in fat generation, wound healing and tissue engineered frameworks
Global hypothesis: Adipogenesis has been demonstrated to occur when unseeded AAM is injected subcutaneously in an area relatively devoid of fat. The sequential cellular and chemokine response to AAM results in a microenvironment that is conducive to adipogenesis. We hypothesize that the AAM provides the necessary stimulus for cellular attraction, attachment, signaling and vasculogenesis that promotes the transformation of acellular extracellular matrix to definitive adipose tissue.
Global aim: To delineate the sequence of events occurring following implantation of AAM to the final process of adipogenesis
Specific individual aims:
• compare adipoinduction of adipose/fascia complex to that of adipose fraction alone
• identify early and late cellular infiltrates
• identify cytokines, adipokines, enzymes (related to macrophage phenotype and lipoproteins)


4. Tissue engineered 3-D ear cartilage construct

Generation of cartilage engineered frameworks using unique adipose derived matrices, chondrocytes and adipose derived stem cells. Collaborative effort with MTF, RapidTech BME, UCI (3-D printing) and Lakey laboratory

Tissue engineering technologies offer new approaches in the field of external ear reconstruction. In this treatment setting, attempts have been made to use the patients’ own chondrocytes isolated from the remnants of auricular cartilage and cultured in the laboratory with the aim of creating bioengineered cartilage matrices. However, cartilage engineering has many challenges, starting with the difficulty in culturing sufficient chondrocytes. Small pieces of cartilage like that obtained from microtia patients tend to give low yields of chondrogenic cells. Moreover, adequately expanding these cells is challenging as chondrocytes tend to lose their specific properties and acquire a fibroblast-like phenotype in monolayer cultures. To overcome these difficulties, research in the field of cartilage engineering has been conducted in two main directions:
(1) the use of co-cultures to expand the number of chondrogenic cells
(2) culturing on three-dimensional (3D) scaffolds that resemble the native environment of chondrocytes inside the body.
Publications
1. Widgerow AD, Edinburg M, Biddulph S. An Analysis of proximal phalangeal fractures. Journal of Hand Surgery (Am) 12 A, 134,January 1987.
2. Edinburg M, Widgerow AD, Biddulph S. Early post-operative mobilization of flexor tendon injuries using a modification of the Kleinert Technique. American Journal of Hand Surgery, 12A, 34 January 1987 (second author). Also appears in the Year Book of Plastic Surgery 1988.
3. Widgerow AD, Murray J. Fibrosarcoma of the Hand. S.A. Journal of Surgery, 26,118, Sept 1988
4. Widgerow AD. Iatrogenic instrumentation-induced plastic surgical referrals. Plastic & Reconstructive Surgery, 82, 1083, Dec 1988.
5. Widgerow AD. Shaving and dermabrasion of the facial lesions in tuberous sclerosis. S.A. Medical Journal, 76, 169, August 1989.
6. Widgerow AD, Ford TD Prevention of deformity in the neglected burn. Trauma and Emergency Medicine,
6, 13, Feb.1989
7. Widgerow AD. Full house/ spaghetti wrist injuries —analysis of results. S.A. Journal of Surg, 28,6, March 1990.
8. Widgerow AD. Klippel Feil Anomaly, Cleft palate and Bifid Tongue. Annals of Plast Surg, 25, 216, April 1990.
9. Ford T, Widgerow AD. Umbilical keloid—an early start. Annals of Plast Surg, 25, 214, April 1990.
10. Widgerow AD, Ford TD, Botha M. Burn Contracture preventing Uterine Expansion. Annals of Plast Surg,
27, 269, Sept 1991.
11. Widgerow AD. Keloids and hypertrophic scars. Diseases of the Skin, 6, 39, May 1992
12. Chait LA, Widgerow AD. Horse bites of the ear. Trauma and Emergency Medicine, 637,July/August 1992.
13. Widgerow AD.. Abdominoplasty following colostomy. Annals of Plast Surg, 29, 454,Nov 1992.
14. Widgerow AD, Chait LA. • Degloving injuries and flap viability assessment. S.A. Medical Journal, 83, 97, February 1993.
15. Widgerow AD. Plastic Surgery- more than just a nip and tuck –OPINION. S.A. Medical Journal, 84,7, Jan 1994.
16. Widgerow AD, Ritz M, Song C. • Load cycling closure of fasciotomies following puff adder bites. Eur Journal of Plastic Surgery, 17,40, 1994.
17. Widgerow AD, Brink AJ, Koornhof HJ. Atypical Mycobacterium and breast surgery. Annals of Plast Surg.35, 205, August 1995.
18. Widgerow AD. Cosmetic surgery—the quest for zero defect. Review Diseases of the Skin, 11,33, Oct 1996.
19. Reyneke JP, Widgerow AD Nasomaxillary osteotomy for the correction of Binder’s Syndrome (nasomaxillary dysplasia) Int Journal of Adult Orthognathic Surgery, 11,117, 1996.
20. Widgerow AD, Sacks L, Greenberg D, Becker PJ. Intergroup comparisons of carpal tunnel dimensions. Journal of Hand Surgery (Am), 21A, 357, May 1996.
21. Widgerow AD, Song C, Ritz M, Potgieter E. Wound modulation via sclerotherapy and tissue adhesion – observation and discussion. S. A. Journal of Surg 35, 88, May 1997.
22. Widgerow AD. Blepharoplasty lateral internal suspension suture: Bliss technique. Aesthetic Plast Surg
22,130, 1998.
23. Widgerow AD and Chait L. Aesthetic Perspectives Regarding Physically and Mentally Challenged Patients.
Plast & Reconstr Surg. Vol 105, No 6, 2251, May 2000
24. Chait L and Widgerow AD. In Search of the Ideal Nose. Plast & Reconstr Surg. Vol 105, No 7, June 2000.
25. Widgerow AD and Braun S .Post-laser Hypersensitivity and the Atopic patient. Plast & Reconstr Surg. Vol 106, No 1, 155, July 2000.
26. Widgerow AD, LA Chait, R Stahls and P Stahls. New Innovations in Scar Management. . Aesthetic Plast Surg 24; 227-234, 2000
27. Widgerow AD, C Ladas, Anatomical Attachments to the proximal phalanx – a case for fracture stability? Scand J Plast Reconstr & Hand Surg 35;85-90,2001
28. Widgerow AD Revision Otoplasty: The Contracted Antihelical Fold. Plast & Reconstr Surg. Vol 110, No 3, 827, September 2002.
29. Widgerow AD. Upper Blepharoplasty with lateral segmental orbicularis excision. Annals Plast Surg. Vol 50, No 5,471, May 2003
30. Widgerow AD, Jackson L: Irritable Bowel Syndrome and Abdominoplasty. Plast & Reconstr Surg. Vol 113, No 3, 1050, March 2004.
31. Widgerow AD, First Signals – Editorial; Plast & Reconstr Surg. Vol 113, No 7, 2206, June 2004.
32. Widgerow AD, Breast reduction with inferior pedicle fascial suspension – Aesth Plast Surg Nov/Dec 2005
33. Widgerow AD, Management of Infection in Plastic Surgery - The Specialist Forum, Vol 6 No2, 40, Feb 2006
34. Potgieter A, Candy G, Leong CV, Widgerow A.Topical Interferon-a2b and Keloid Treatment: A Place for Pretreatment? Plast Reconstr Surg 117(5); 1645-1646, 2006.
35. Widgerow AD, Murdoch M, Edwards G, Norval C - Patient-Controlled Expansion: Applying a New Technique to Breast Reconstruction; Aesth Plast Surg; 31, 299, 2007.
36. Widgerow AD, Wittstock C, Candy G; Lavage drain extension for local anaesthetic instillation into abdominal wounds; SA Journal of Surgery Vol46,No 1 Feb 2008.
37. Widgerow AD, Chait LA, Stals P Multi-modality Scar Management Program; Poster Congress -World Union of Wound Healing Societies Toronto 2008
38. Widgerow AD, Wound Care in South Africa – Defining the specialty and its reimbursement; Journal of Wound technology; 66, No4, April 2009.
39. Widgerow AD, Chait LAC; Stals R; Stals P; Candy G; Multimodality Scar management program Aesthetic Plastic Surgery; Vol 33; No 4; 533, 2009.
40. Widgerow AD, Nanocrystalline silver, gelatinases and the clinical implications, Burns 36, 7, Pages 965-974 November 2010
41. Widgerow AD, Cellular/extracellular matrix cross talk in scar evolution and control – Wound Rep Reg. 19; 117–133, 2011.
42. Roberts C, Ivins I, Widgerow AD, ACTICOAT™ AND ALLEVYN™ made easy, Wounds International, 2011, 2,2, S7-S12
43. Widgerow AD, Scar management – the principles and their practical applications WCET Journal 31; 1 ; 18-21; 2011.
44. Widgerow AD, Chronic wound exudate – thinking outside the box – Wound Repair Reg 19; 287-291; 2011
45. Widgerow AD and Grekin S; Effecting Skin renewal – a multi-faceted approach – Journal of Cosmetic Dermatology; 10, 2, 126-130. June 2011.
46. Widgerow AD, Current concepts in scar evolution and control – Aesthetic Plastic Surgery: Volume 35, Issue 4 (2011), Page 628-635.
47. Widgerow AD, Toxic Epidermal Necrolysis – management issues and treatment options; Int J Burn Trauma 2011;1(1):42-50.
48. Widgerow AD, Scar management practice and science - a comprehensive approach to controlling scar tissue and avoiding hypertrophic scarring– Advances in Skin and Wound Care (US) – 2011; 24;12; 555-521.
49. Leak K, Widgerow AD, Johnson S, Pilonidal sinus (Jeep’s disease): an improved model of care, Wounds UK, 2011, Vol 7, No 2. 72-77.
50. Widgerow AD, Cellular resolution of inflammation – Catabasis; Wound Repair & Regen;2012; 20;1;2-77.
51. Widgerow AD, Deconstructing the ‘stalled wound’ – Wounds 2012; 24 93): 58-66.
52. Widgerow AD, Kalaria S; Pain mediators and wound healing – establishing the connection – Burns 38 (2012), pp. 951-959.
53. Widgerow AD, Bioengineered matrices Part 1: Attaining structural success in biologic skin substitutes – Ann Plast Surg. 2012 Jun;68(6):568-73.
54. Widgerow AD Bioengineered matrices Part 2: Focal adhesion, integrins and the fibroblast effect – critical factors affecting the healing matrix and impacting on bioengineered matrix design Ann Plast Surg. 2012 Jun;68(6):568-73.
55. Widgerow AD. Chronic wounds – is cellular ‘reception’ at fault? Examining integrins and intracellular signalling. Int Wound J 2013; 10:185–192.
56. Widgerow AD, Bachman M, Klopfer M, Zaldivan F, Bernal N, Ferreira TS, Afzel H, Awad A, Evans GRD. Signaling Profile of Thermal Trauma (SPoTT): Exudate Analysis in Acute Burn Patients. ICTS Poster Presentation. The University of California, Irvine. Irvine California, June 3, 2013.
57. Salibian A, Widgerow AD, M Abrouk and Evans RD. Stem cells in plastic surgery: a review of current clinical and translational applications. Archives in Plastic Surgery, Vol. 40 / No. 6 / November 2013.
58. Widgerow AD, Salibian A, Lalezari S, Ferreira T and Evans G. Neuromodulatory nerve regeneration - adipose tissue-derived stem cells and neurotrophic mediation in peripheral nerve regeneration; Journal of Neuroscience Research Volume 91, Issue 12, pages 1517–1524, December 2013
59. Widgerow AD, New Advances in Widespread Burn/Scar Management; Expert Reviews in Dermatology 2013 Expert Review of Dermatology, December 2013, Vol. 8, No. 6 , Pages 589-592.
60. Widgerow AD. Ischemia Reperfusion Injury – Influencing the microcirculatory and cellular environment – Ann Plast Surg. 72;2; 253-261, Feb 2014.
61. Widgerow AD. Bioengineered skin substitute considerations in the Diabetic Foot Ulcer – Ann Plast Surg. Aug;73(2):239-44, 2014
62. Widgerow AD, Salibian A, Kohan E, Ferrira T, Afzel A, Tham T and Evans G. Strategic Sequences in
Adipose Derived Stem Cell Nerve Regeneration; Microsurgery 34:324–330, 2014.
63. Banyard DA, Ferreira TS, Widgerow AD and Evans GRD; Poster: Primed to Perform: Adipose-Derived Stem Cell Proliferation and Secretome Function in Neuronal-Conditioned Media, Poster AAPS meeting Miami 2014
64. Banyard DA, Tocco Tussardi I, Widgerow AD, Evans GRD: Burn Wound Exudate: Depth of Burn Predicts Cellular Recruitment ; Poster American Burns association April 2014.
65. Tocco- Tussardi I, Widgerow AD, Lalezari S, Banyard D, Shaterian A, Evans RD Lipotransfer: The
Potential from bench to bedside; Annals of plastic surgery 2014; 72(5):599-609.
66. Thomas S, Widgerow AD, Lakey J, Banyard D, Salibian A, Evans GRD; Adipose derived stem cells and diabetic wound healing – a promising therapeutic modality – CellR4 2014; 2 (6): e1309
67. Banyard D, Salibian A, , Widgerow AD, Evans RGD; Implications for Human Adipose-Derived Stem Cells in Plastic Surgery – J. Cell. Mol. Med. Vol 19, No 1, 2015 pp. 21-30
68. Widgerow AD, Tocco-Tussardi I, King K, Banyard D, Chiang R, Awad, A, Malkumyan S, Bhatnager S,
Afzel H, Evans RD. The Burn Wound Exudate – an under-utilized resource, Burns 41 (2015), pp. 11-17.
69. Guo J, Widgerow AD, Banyard D, Toranto J, Wirth GA, Paydar K, Tocco Tussardi I, Evans GRD. Strategic Sequences in Fat Graft survival, Annals of Plastic Surgery • Volume 74, Number 3, March 2015.
70. Klopfer M, Campos K, Widgerow AD, and Bachman M. Microbubble Technology for Wound Care and Health Applications. Poster Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) 2015.
71. Banyard DA, Martin J, Widgerow AD, Evans GRD. Regenerative Biomaterials: A Review; Plast Reconstr Surg 135; 6; 1740–1748, 2015.
72. Dalal S, Widgerow AD and Evans RD. The plantar fat pad and the diabetic foot ulcer. Int Wound J Dec2015; 12: 636–640
73. Nguyen A, Guo J, Fadavi D, Banyard D, Toranto J, Wirth G, Paydar K, Evans G and Widgerow AD ,Stromal Vascular Fraction - a regenerative reality? Part 1 - Currents Concepts and review of the literature. JPRAS 2016; 69; 170-179
74. Guo J, Nguyen A, Fadavi D, Banyard D, Toranto J, Wirth G, Paydar K, Evans G and Widgerow AD Stromal Vascular Fraction - a regenerative reality? Part 2 - Mechanisms of regenerative action- JPRAS 2016; 69; 180-188
75. Banyard DA, Adnani BO, Melkumyan S, Araniego CA and Widgerow AD. Endothelial Progenitor Cells and Burn Injury – Exploring the Relationship, Burns& Trauma 2016, 4:4:2-7
76. Klopfer M, Banyard D, Li G-P, Widgerow AD, and Bachman M. A fluid collection system for dermal wounds in clinical investigations. Biomicrofluidics 10 , 024113 (2016); doi: 10.1063/1.4943133
77. Banyard DA, Borad V, Amezcua E, Wirth GA, Evans GRD and Widgerow AD Preparation, Characterization, and Clinical Implications of Human Decellularized Adipose Tissue Extracellular Matrix (hDAM): A Comprehensive Review. Aesthetic Surgery Journal 2016, Vol 36(3) 349–357
78. Widgerow, A., Fabi, S., Palestine, R., Rivkin, A., Ortiz, A., Bucay, V., . . . Chasan, P. (2016). Extracellular Matrix Modulation: Optimizing Skin Care and Rejuvenation Procedures. Journal of Drugs in Dermatology, 15 (Suppl4), s63-s71.
79. Chiang RS, Borovikova AA, King K, Banyard D, Lalezari S, Toranto JD, Paydar KZ, Wirth GA and Evans GRD, Widgerow AD. Current concepts Related to Hypertrophic Scarring in Burn Injuries, Wound Rep Reg (2016) 24 466–477
80. Banyard, DA, Sarantopoulos CN, Borovikova A, Qiu, X, Wirth, GA, Paydar, KZ, Haun JB and Evans GRD, Widgerow AD. Phenotypic Analysis of Stromal Vascular Fraction After Mechanical Shear Reveals Stress-induced Progenitor Populations, Accepted Plast & Reconstr Surg 138; 237e Aug 2016
81. Salibian, A. A., Rosario, A. T., Severo, L. A., Nguyen, L., Banyard, D. A., Toranto, J. D and Widgerow, A. D. Current concepts on burn wound conversion-A review of recent advances in understanding the secondary progressions of burns. Burns. (2016) 42; 1025-1035
82. Lalezari S, Lee C, Borovikova AA, Banyard DA, Paydar K, Wirth GA and Widgerow AD. Deconstructing Negative Pressure Wound Therapy, published ahead of print Int Wound J Oct 2016
83. Maksim V. Plikus, Christian F. Guerrero-Juarez, Mayumi Ito, Yun Rose Li, Priya H. Dedhia, Ying Zheng, Mengle Shao, Denise L. Gay, Raul Ramos, Tsai-Ching His, Ji Won Oh, Xiaojie Wang, Amanda Ramirez, Sara E. Konopelski, Arijh Elzein, Anne Wang, Rarinthip June Supapannachart, Hye-Lim Lee, Chae Ho Lim, Arben Nace, Amy Guo, Elsa Treffeisen, Thomas Andl, Ricardo N. Ramirez, Rabi Murad, Stefan Offermanns, Daniel Metzger, Pierre Chambon, Alan D. Widgerow, Tai-Lan Tuan, Ali Mortazavi, Rana K. Gupta, Bruce A. Hamilton, Sarah E. Millar, Patrick Seale, Warren S. Pear, Mitchell A. Lazar, George Cotsarelis. Regeneration of fat cells from myofibroblasts during wound healing. Science, 2017 DOI: 10.1126/science.aai8792
84. Sarantopoulos CN, Banyard DA, Ziegler ME, Sun B, Shaterian A and Widgerow, AD. Elucidating the Preadipocyte and its Role in Adipocyte Formation: A Comprehensive Review, Stem Cell Reviews and reports Stem Cell Rev and Rep (2018) 14:27–42
85. Sayadi LR, Banyard DA, Ziegler ME, Obagi Z, Prussak J, Klopfer M, Evans GRD and Widgerow AD. Topical Oxygen Therapy & Micro/nanobubbles: A New Modality for Tissue Oxygen Delivery; Int Wound J. 2018;15:363–374.
86. Borovikova AA, Ziegler M, Banyard DA, Wirth GA, Paydar KZ, Evans GRD and Widgerow AD, Adipose-derived tissue in the treatment of dermal fibrosis: antifibrotic effects of adipose-derived stem cells. Annals of Plastic Surgery, Volume 80, Number 3, March 2018
87. Widgerow, AD, Jiang, LI, Calame, A. A single-center clinical trial to evaluate the efficacy of a tripeptide/hexapeptide antiaging regimen. J Cosmet Dermatol. 2018 Mar 4. doi: 10.1111/jocd.12507. [Epub ahead of print]. March 2018
88. Lohrasb R. Sayadi, MD; Zaidal Obagi, MS; Derek A. Banyard, MD, MBA; Mary E. Ziegler, PhD; Jordyne Prussak; Luke Tomlinson; Gregory R.D. Evans, MD, FACS; and Alan D. Widgerow, Platelet-Rich Plasma, Adipose Tissue, and Scar Modulation. Aesth Surg J Prepublication online April 2018
89. Fijany A, Sayadi LR, Khoshab N, Banyard, DA, Shaterian, A, Alexander M, Lakey, JRT, Paydar, KZ,Evans, GRD and Widgerow, Alan D. Mesenchymal stem cell dysfunction in diabetes. Mol Biol Rep 2018 online first.


Wound Healing Southern Africa (Editor-in-chief 2008-2015):
90. Widgerow AD, THE WHASA WHEEL – Integrating multiple specialties in patient management with Wound Healing as the common basis. Wound Healing Southern Africa, Vol 1 No.1, May 2008.
91. Widgerow AD, Persistence of the Chronic Wound – Implicating biofilm. Wound Healing Southern Africa, Vol 1 No.2, Oct 2008.
92. Widgerow AD, Deconstructing the Chronic Wound. Wound Healing Southern Africa, Vol 2 No.1, April 2009.
93. Widgerow AD, A new look at Venous ulceration; Wound Healing Southern Af – Vol 2, 2. 1-4, 2009
94. Widgerow AD, Review: Scar management – marrying the practical with the science. Vol 3 No 1. Wound Healing Southern Africa, 2010
95. Widgerow AD, Leak K, Hypergranulation – evolution, control and potential elimination; Wound Healing Southern Africa, 3, 2, 1-3, 2010.
96. Widgerow AD Wound fluid intervention: influencing wound healing from the outside; Wound Healing Southern Africa, Vol 4, No 1 (2011)
97. Widgerow AD. Stevens-Johnson syndrome and toxic epidermal necrolysis: topical treatment influencing systemic response; Wound Healing Southern Africa, Vol 4, No 1 (2011).
98. Widgerow AD, ‘When healing stops’ – Wound Healing Southern Africa – Vol 4; 2; 2011
99. Widgerow AD Bioengineering and the diabetic foot ulcer; Wound Healing SA Vol5; 2; 2012 64-67.
100. Widgerow AD, Hypertrophic burn scar evolution and management. Wound Healing SA; 6, 2.2013.
101. Widgerow AD, Tussardi IT; Banyard DA, King K, Chiang R,Wirth G,Evans GRD, Burn wound fluid: an important diagnostic source; Wound Healing SA, Vol 7, 1; 9-12, 2014
102. Chiang RS, King K, Banyard S, Lalezari S, Tocco Tussardi I, Toranto JD and Widgerow AD, Evans RD. An exploration of the relationship of fatty tissue, burn injury and scarring; Wound Healing Southern Africa 2014; 7(2):66-69.



IN SUBMISSION:


• CHAPTER - PREPARATION, CHARACTERIZATION, AND CLINICAL IMPLICATIONS OF HUMAN DECELLULARIZED ADIPOSE TISSUE EXTRACELLULAR MATRIX. Derek A. Banyard, Christos Sarantopoulos, , Jade Tassey, Mary Ziegler, Evangelia Chnari, Gregory R.D Evans and Alan D Widgerow –Editor Melvin Shiffman REGENERATIVE MEDICINE IN PLASTIC SURGERY.



Medical Newspaper publications:

103. Widgerow AD. Balanced perspective on silicone breast implants. Medical Chronicle, September 1993
104. Widgerow AD. Australia & South Africa–combined Plastic Surgical experiences, Med Chron,Jan 1998
105. Widgerow AD. In strong defense of silicone implants, Medical Chronicle, Feb 1998.
106. Widgerow AD. Vitality Medicine – a sign of things to come? Medical Chronicle, March 1998.
107. Widgerow AD. Vitamin E and scars – the giant marketing myth. Medical Chronicle, April1998.
108. Widgerow AD. Breast reduction – the weight of the matter. Medical Chronicle, May1998.
109. Widgerow AD. Dr Fickle and Mr Pride. Medical Chronicle, June1998.
110. Widgerow AD. Just put that nail back! Medical Chronicle, July1998.
111. Widgerow AD. Open injuries of the hand. Medical Chronicle, May, 1999
112. Widgerow AD. Don’t just lick your wounds – moisten them. Medical Chronicle, August1998.
113. Widgerow AD. Wound dressings revisited. Medical Chronicle, March, 1999.
114. Widgerow AD. What’s this beast called cellulite? Medical Chronicle, Sept,1998.
115. Widgerow AD. Breast reconstruction – the whole story. ? Medical Chronicle, Jan,1999.
116. Widgerow AD. Hair, there and everywhere. Medical Chronicle, July, 1999
117. Widgerow AD. Scar management breakthrough. Medical Chronicle Sept, 1999
118. Widgerow AD. The wound clinic concept. Medical Chronicle Nov 1999
119. Widgerow AD. The anti-aging revolution. . Medical Chronicle March 2000
120. Widgerow AD . The final word on silicone. Medical Chronicle May 2000
121. Widgerow AD. The problem scar; part 1 - Keloid Medical Chronicle July 2000
122. Widgerow AD. The problem scar; part 2 – Hypertrophic scar Medical Chronicle Sept 2000
123. Widgerow AD. APRSSA Congress 2000 Medical Chronicle Nov 2000
124. Widgerow AD. Wound Care Course for 2003 Medical Chronicle Nov 2002
125. Widgerow AD. The vanity indictment. Medical Chronicle Jan 2000
126. Widgerow AD, Don’t just lick your wounds – moisten them. The Specialist forum Vol 1;5;4-8, Oct 2001.
127. Widgerow AD, Injury may not be the final nail in the coffin The Specialist forum Vol 2;2;337-40, Feb 2002.
128. Widgerow AD. The Physiology of Wound healing – Part 1 Jan 2003
129. Widgerow AD. The Physiology of Wound healing – Part 2 Feb 2003
130. Widgerow AD. Wound assessment – March 2003
131. Widgerow AD. Selection of Dressings –Part 1 April 2003
132. Widgerow AD Selection of Dressings –Part 2 May 2003
133. Widgerow AD The Infected Wound, June 2003.
134. Widgerow AD Venous Ulcers, July 2003
135. Widgerow AD Arterial Ulcers, August 2003.
136. Widgerow AD Pressure Ulcers, Sept 2003.
137. Widgerow AD Chronic Wounds, Oct. 2003.
138. Widgerow AD Cosmetic Surgery Considerations – The Specialist Forum Vol 4. No.9 2004
139. Widgerow AD Cosmetic Surgery Considerations – The Specialist Forum Vol 4. No.9 2004
140. Widgerow AD, What’s new in Plastic Surgery Research The Specialist Forum Nov 2005.
141. Widgerow AD Update on Venous Ulceration Medical Chronicle Aug 2005
142. Widgerow AD The Diabetic Foot Ulcer Medical Chronicle Sept 2005
143. Widgerow AD, The Diabetic foot ulcer –a unique wound care problem - The Specialist Forum, Vol 6 No11, Nov 2006
144. Widgerow AD, The Diabetic foot ulcer 2 - The Specialist Forum, Vol 7 No.6, 5, June 2007.
145. Widgerow AD. Pressure Ulcers: Important prevention Strategies Medical Chronicle Jan 2007
146. Widgerow AD.Venous and arterial Ulcers; The Specialist Forum, Vol 7 No.9, 5, Sept. 2007
147. Widgerow AD. Wound assessment; The Specialist Forum, Vol 7 No.11, November. 2007
148. Widgerow AD The Infected Wound – The Specialist Forum Vol 8. April 2008
149. Widgerow AD. Pressure Ulcers: pathophysiology Medical Chronicle April 2009

PUBLISHED BOOKS:
1. A Cut Above The Rest – PSP Publications; Author – Professor Alan D Widgerow, 2004
2. Advanced Wound Care – Med Chronicle Publications; Author Prof Alan D Widgerow,2004;monologue
Grant
Grant and Contract Support 2013- 2018: 2018 Design Team winner annual biomedical engineering device design UCI Innovations competition, Bubtech, micronanobubble project, June 2018 Mentor Dr Widgerow - $15000 Marjan Farid, MD - Eye Bank Association of America (EBAA) grant proposal entitled “Micro/nanobubbles: A New Modality for Corneal Transplant Preservation” and has selected it for funding. You will be awarded $4400 to complete this project. Mentor/collaborator Alan Widgerow Nitara Tariqi, Keenan Ferguson, Nikita Ganeshan, Lauren S. Lastra, Stephanie J. Yeh: Undergraduate Research Opportunities Program (UROP) Faculty Advisory Board has recommended your appointment as a UROP Fellow at UCI for the 2017-2018 academic year. We are awarding $600 in support of your proposed research project, "A Micro/Nanobubble Generator Designed to Promote Wound Healing and Tissue Preservation," under the supervision of Dr. Alan Widgerow, Professor G.P. Li and Dr. Michael Klopfer. Alexandria M. Sorensen:Undergraduate Research Opportunities Program (UROP) Faculty Advisory Board has recommended your appointment as a UROP Fellow at UCI for the 2017-2018 academic year. We are awarding $400 in support of your proposed research project, "Micro/Nanobubbles: Quantification of Bubble Oxygen Content," under the supervision of Dr. Alan Widgerow. ASERF Interim Research Grant ; Ross Sayadi – Fellow CTE - $6670 ¬- "New Innovation For Projected Flap Design" – Mentor AD Widgerow Nov 2017-Nov2018 NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES Mechanical Activation of Adipose-Derived Stem Cells for the Treatment of Diabetic Foot Ulcers Using a Novel CD-Microfluidic Device 09/15/2017 – 08/31/2018; Grant # 1R43DK116389-01; Principal Investigator(s): Alan D Widgerow, MBBCh (CTE) Ahmed Nabil Zobi (Syntr Health) - $300,000 Musculoskeletal Transplant Foundation Award 2017/2018 – PI – A D Widgerow - $215,625 - 2017/2018; Deconstructing Adipo-induction in Allograft Adipose Matrix (AAM) 2017 PSEF Research Grant Award 2017 – Banyard DA, Evans GE, Widgerow AD (CTE laboratory) - $50,000 – Activated adipopse stem cells for the prevention/treatment of diabetic foot ulcers – 2017/2018 Undergraduate Research Opportunities Program (UROP) Research proposal entitled " Time Dependent CD34 Expression In Shear Stressed Mesenchymal Stem Cells." Nikolaos Sarantopoulos under the supervision of Professor Alan Widgerow awarded an UROP Fellowship for the 2017-2018 academic year ($500). PSEF/MTF Dermal Tissue Research Grant Award 2016/2017 – A D Widgerow PI - $50,000 – Tissue Engineered 3-D cartilage construct Musculoskeletal Transplant Foundation Award 2016/2017 – collaborative projects - 3 yrs – PI – A D Widgerow - $215,000 - 2016/2017; Deconstructing Adipo-induction in Acellularized Adipose Matrix (AAM) ----------- Sponsored by STEMCELL Technologies,(TranScience, the reviewers) - Christos Sarantopoulos, D Banyard, supervised by A D Widgerow. Your prop
Other Experience
President
Association of Plastic & Reconstructive Surgeons of Southern Africa 1996—1998

Chief Medical Officer
Alastin SkinCare Inc 2015

President
Adar Science Inc 2010

Graduate Programs
Plastic Surgery

Research Center
Center for Tissue Engineering Dept of Plastic Surgery
Last updated
01/14/2019