Xiangmin Xu
Chancellor's Professor, Anatomy & Neurobiology
School of Medicine
School of Medicine
Joint appointment, Biomedical Engineering
The Henry Samueli School of Engineering
The Henry Samueli School of Engineering
Joint Appointment, Computer Science
Donald Bren School of Information and Computer Sciences
Donald Bren School of Information and Computer Sciences
Joint Appointment, Microbiology and Molecular Genetics
School of Medicine
School of Medicine
Ph.D., Vanderbilt University, 2004, Psychology / Neuroscience
Bachelor of Medicine, Shanghai Medical University, 1995
Bachelor of Medicine, Shanghai Medical University, 1995
University of California, Irvine
Office Room: 2048
Interdisciplinary Science and Engineering Building (ISEB)
Irvine, CA 92697
Office Room: 2048
Interdisciplinary Science and Engineering Building (ISEB)
Irvine, CA 92697
Research Interests
Neural circuits, Neural plasticity, Sensory perception, Learning and memory, Alzheimer’s disease, Viral genetic tool development
Academic Distinctions
12/2023 Awarded the title of Chancellor's Professor, University of California, Irvine
04/2023 Outstanding Mid-Career Faculty Research Award, School of Medicine, UCI
12/2021 Samueli Scholar 2021, Susan and Henry Samueli College of Health Sciences, UCI
07/2020 Awarded the title of Chancellor’s Fellow, University of California, Irvine
07/2020 – 06/2024 Standing Member, Pathophysiological Basis of Mental Disorders and Addictions Study Section (PMDA), Center for Scientific Review, National Institutes of Health
04/2014 Recipient of the 2014 C. J. Herrick Award in Neuroanatomy of the American Association of Anatomists
09/2013 Recipient of the 2013 Krieg Cortical Explorer Award, the Cajal Club Foundation
04/2013 2013 Randolph Blake Early Career Award, Vanderbilt University
08/2012 2012 NARSAD Young Investigator Award, Brain & Behavior Research Foundation
2010-2011 The Best 1st Year Course Award from the Association of Students, UCI School of Medicine [Histology, teaching faculty]
12/2006 NIH Pathway to Independence Award (K99/R00), National Institute on Drug Abuse / NIH
11/2004 Kreig Cortical Kudos Award (Cortical Scholar Award), the Cajal Club / Society for Neuroscience
09/1998 - 06/1999 University Scholarship & Fellowship, Vanderbilt University
04/2023 Outstanding Mid-Career Faculty Research Award, School of Medicine, UCI
12/2021 Samueli Scholar 2021, Susan and Henry Samueli College of Health Sciences, UCI
07/2020 Awarded the title of Chancellor’s Fellow, University of California, Irvine
07/2020 – 06/2024 Standing Member, Pathophysiological Basis of Mental Disorders and Addictions Study Section (PMDA), Center for Scientific Review, National Institutes of Health
04/2014 Recipient of the 2014 C. J. Herrick Award in Neuroanatomy of the American Association of Anatomists
09/2013 Recipient of the 2013 Krieg Cortical Explorer Award, the Cajal Club Foundation
04/2013 2013 Randolph Blake Early Career Award, Vanderbilt University
08/2012 2012 NARSAD Young Investigator Award, Brain & Behavior Research Foundation
2010-2011 The Best 1st Year Course Award from the Association of Students, UCI School of Medicine [Histology, teaching faculty]
12/2006 NIH Pathway to Independence Award (K99/R00), National Institute on Drug Abuse / NIH
11/2004 Kreig Cortical Kudos Award (Cortical Scholar Award), the Cajal Club / Society for Neuroscience
09/1998 - 06/1999 University Scholarship & Fellowship, Vanderbilt University
Research Abstract
Dr. Xu's interests are in neural circuitry, which applies to understanding the neurobiology of sensory perception, learning and memory, stress, and epilepsy. Understanding how neural circuits give rise to perception, cognition, and behavior is central to understanding how the brain works. This is also key to understanding the mechanistic basis of neurological disorders. Our research is focused on understanding cell-type specific cortical circuit organization and function, using combined approaches of electrophysiology, optical stimulation and imaging, molecular genetics and viral tracing. Our research work has significant potential for translational applications for better treatments of neurodevelopmental disorders and neurological diseases. Our recent directions include 1) using the latest single cell genomic technologies coupled with functional circuit mapping and behavioral analysis to determine how the transcriptome and epigenome shape neural circuit activity and learning and memory behaviors that change with aging and AD progression; 2) applying our findings towards treating Alzheimer’s disease based on our conceptual advances in circuit manipulation-based strategies in AD animal models.
Publications
Xu, X.*, Olivas, N.D., Levi, R., Ikrar, T., Nenadic, Z. (2010) High resolution and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. Journal of Neurophysiology 103, 2301 – 2312. * Senior and corresponding author
Shi, Y., Nenadic, Z., Xu, X. (2010) Novel use of matched filtering for synaptic event detection and extraction. PLoS ONE 5(11): e15517. doi:10.1371/journal.pone.0015517.
Olivas, N.D., Quintanar-Zilinskas, V., Nenadic, Z., Xu, X. (2012) Laminar circuit organization and response modulation in mouse visual cortex. Frontiers in Neural Circuits 6:70. doi: 10.3389/fncir.2012.00070 [PMCID: PMC3464489]
Ahrar, S., Nguyen, T.V., Shi, Y., Thomas, P.V., Ikrar, T., Xu, X.*, Hui, E.E.* (2013) Optical stimulation and imaging of functional brain circuitry in a laminar flow chamber. Lab Chip 13:536-41. [PMID: 23044655] * Co-corresponding Authors
Haettig, J.#, Sun, Y.#, Wood, M.A.*, Xu, X*. (2013) Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learning & Memory 20:139-146. [PMID: 23418393] #Co-first authors; * Co-corresponding Authors
Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T., Xu, X.*, Trachtenberg, J.T.* (2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature (Advanced Online Publication): August 2013. DOI: 10.1038/nature12485. #Co-first authors; * Co-corresponding Authors
San Antonio, A., Liban, K., Ikrar, T., Tsyganovskiy, E., Xu, X. (2013). Distinct physiological and developmental properties of hippocampal CA2 subfield revealed using anti-Purkinje cell protein 4 (PCP4) immunostaining. Journal of Comparative Neurology. 2013 Oct 25. doi: 10.1002/cne.23486. [Epub ahead of print].
Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H., Hen, R., Xu, X.*, Sahay, A. * Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits, 26 December 2013 | doi: 10.3389/fncir.2013.00204. * Co-corresponding Authors
Shi, Y., Ikrar, T., Olivas, N.D., Xu, X. (2013) Bi-directional global spontaneous network activity immediately precedes the canonical unidirectional circuit organization in the developing hippocampus. Journal of Comparative Neurology (2013 doi: 10.1002/cne.23528). [Epub ahead of print] [PMID: 24357090]
Parks, G. #, Olivas, N.D. #, Ikrar, T. #, Sanathara, N., Wang, L., Wang, Z., Civelli, O. *, Xu, X. * (2014) Histamine inhibits the melanin-concentrating hormone system: Implications for sleep and arousal. Journal of Physiology (http://jp.physoc.org/content/early/2014/03/17/jphysiol.2013.268771.long) [Epub ahead of print] [PMID: 24639485] # Co-first authors; * Co-corresponding authors
Sun, Y., Nguyen, A., Nguyen, J., Le, L., Saur, D., Choi, J., Callaway, E.M., Xu, X. (2014) Cell-type specific circuit connectivity of hippocampal CA1 revealed through Cre-dependent rabies tracing. Cell Reports 7: 269–280. http://dx.doi.org/10.1016/j.celrep.2014.02.030. [PMCID: PMC3998524]
Shi, Y., Nenadic, Z., Xu, X. (2010) Novel use of matched filtering for synaptic event detection and extraction. PLoS ONE 5(11): e15517. doi:10.1371/journal.pone.0015517.
Olivas, N.D., Quintanar-Zilinskas, V., Nenadic, Z., Xu, X. (2012) Laminar circuit organization and response modulation in mouse visual cortex. Frontiers in Neural Circuits 6:70. doi: 10.3389/fncir.2012.00070 [PMCID: PMC3464489]
Ahrar, S., Nguyen, T.V., Shi, Y., Thomas, P.V., Ikrar, T., Xu, X.*, Hui, E.E.* (2013) Optical stimulation and imaging of functional brain circuitry in a laminar flow chamber. Lab Chip 13:536-41. [PMID: 23044655] * Co-corresponding Authors
Haettig, J.#, Sun, Y.#, Wood, M.A.*, Xu, X*. (2013) Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learning & Memory 20:139-146. [PMID: 23418393] #Co-first authors; * Co-corresponding Authors
Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T., Xu, X.*, Trachtenberg, J.T.* (2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature (Advanced Online Publication): August 2013. DOI: 10.1038/nature12485. #Co-first authors; * Co-corresponding Authors
San Antonio, A., Liban, K., Ikrar, T., Tsyganovskiy, E., Xu, X. (2013). Distinct physiological and developmental properties of hippocampal CA2 subfield revealed using anti-Purkinje cell protein 4 (PCP4) immunostaining. Journal of Comparative Neurology. 2013 Oct 25. doi: 10.1002/cne.23486. [Epub ahead of print].
Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H., Hen, R., Xu, X.*, Sahay, A. * Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits, 26 December 2013 | doi: 10.3389/fncir.2013.00204. * Co-corresponding Authors
Shi, Y., Ikrar, T., Olivas, N.D., Xu, X. (2013) Bi-directional global spontaneous network activity immediately precedes the canonical unidirectional circuit organization in the developing hippocampus. Journal of Comparative Neurology (2013 doi: 10.1002/cne.23528). [Epub ahead of print] [PMID: 24357090]
Parks, G. #, Olivas, N.D. #, Ikrar, T. #, Sanathara, N., Wang, L., Wang, Z., Civelli, O. *, Xu, X. * (2014) Histamine inhibits the melanin-concentrating hormone system: Implications for sleep and arousal. Journal of Physiology (http://jp.physoc.org/content/early/2014/03/17/jphysiol.2013.268771.long) [Epub ahead of print] [PMID: 24639485] # Co-first authors; * Co-corresponding authors
Sun, Y., Nguyen, A., Nguyen, J., Le, L., Saur, D., Choi, J., Callaway, E.M., Xu, X. (2014) Cell-type specific circuit connectivity of hippocampal CA1 revealed through Cre-dependent rabies tracing. Cell Reports 7: 269–280. http://dx.doi.org/10.1016/j.celrep.2014.02.030. [PMCID: PMC3998524]
Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2015 Dec 30; PubMed PMID: 26718312.
Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 1;594 (7):1891-910. PubMed PMID: 26844927.
Xu X, Ikrar T, Sun Y, Santos R, Holmes, TC, Francesconi W, Berton, F. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory versus strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016, 115:3204-16. [PMID: 27052587]
Xu X, Sun Y, Holmes, TC, López A. Non-canonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016, 524:3666-3673 [PMID: 27150503]
Baohan, A., Ikrar, T., Tring, E., Xu, X.*, Trachtenberg, T.* Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex. Nature Communications 2016 7:12829 doi: 10.1038/ncomms12829 * Co-corresponding Authors
Sun, Y., Ikrar, T., Davis, M.F., Gong, N., Zheng, X., Luo, Z.D., Lai, C., Mei, L., Holmes, T.C., Gandhi, S.P., Xu, X.* Neuregulin-1 / ErbB4 signaling regulates visual cortical plasticity. Neuron 92:160-173. http://dx.doi.org/10.1016/j.neuron.2016.08.033 [PMID: 27641496] * Corresponding Author
Stephany, C., Ikrar, T., Nguyen, C., Xu, X.*, McGee, A.W.* Nogo receptor 1 confines a dishinhibitory microcircuit to the critical period in visual cortex. J Neurosci. 2016, 36:11006-11012. * Co-corresponding Authors
Garcia-Junco-Clemente, P., Ikrar, T., Tring, E., Xu, X., Ringach, D.L. & Trachtenberg, J.T. An inhibitory pull-push circuit in frontal cortex Nature Neuroscience 2017, 20:389-392. doi: 10.1038/nn.4483. [PMID: 28114295]
Yanjun Sun, Steven Grieco, Todd Holmes, and Xiangmin Xu. Local and long-range circuit connections to hilar mossy cells in the dentate gyrus. eNuro 2017 ENEURO.0097-17.2017. doi: 10.1523/ENEURO.0097-17.2017.
Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 1;594 (7):1891-910. PubMed PMID: 26844927.
Xu X, Ikrar T, Sun Y, Santos R, Holmes, TC, Francesconi W, Berton, F. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory versus strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016, 115:3204-16. [PMID: 27052587]
Xu X, Sun Y, Holmes, TC, López A. Non-canonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016, 524:3666-3673 [PMID: 27150503]
Baohan, A., Ikrar, T., Tring, E., Xu, X.*, Trachtenberg, T.* Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex. Nature Communications 2016 7:12829 doi: 10.1038/ncomms12829 * Co-corresponding Authors
Sun, Y., Ikrar, T., Davis, M.F., Gong, N., Zheng, X., Luo, Z.D., Lai, C., Mei, L., Holmes, T.C., Gandhi, S.P., Xu, X.* Neuregulin-1 / ErbB4 signaling regulates visual cortical plasticity. Neuron 92:160-173. http://dx.doi.org/10.1016/j.neuron.2016.08.033 [PMID: 27641496] * Corresponding Author
Stephany, C., Ikrar, T., Nguyen, C., Xu, X.*, McGee, A.W.* Nogo receptor 1 confines a dishinhibitory microcircuit to the critical period in visual cortex. J Neurosci. 2016, 36:11006-11012. * Co-corresponding Authors
Garcia-Junco-Clemente, P., Ikrar, T., Tring, E., Xu, X., Ringach, D.L. & Trachtenberg, J.T. An inhibitory pull-push circuit in frontal cortex Nature Neuroscience 2017, 20:389-392. doi: 10.1038/nn.4483. [PMID: 28114295]
Yanjun Sun, Steven Grieco, Todd Holmes, and Xiangmin Xu. Local and long-range circuit connections to hilar mossy cells in the dentate gyrus. eNuro 2017 ENEURO.0097-17.2017. doi: 10.1523/ENEURO.0097-17.2017.
Grieco, S.F., Holmes, T.H., Xu, X. (2018) Neuregulin directed molecular mechanisms of visual cortical plasticity. Journal of Comparative Neurology. 2018 Feb 21. doi: 10.1002/cne.24414. [Epub ahead of print]
Lin, X., Itoga, C.A., Taha, S., Li, M.H., Chen, R., Sami, K., Berton, F., Francesconi, W., Xu, X. c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress. Neurobiology of Stress. 2018 Volume 8, February 2018, Pages 92-102 https://doi.org/10.1016/j.ynstr.2018.02.001
Yulin Shi*, Steven Grieco*, Todd Holmes, and Xiangmin Xu (2019) Development of local circuit connections to hilar mossy cells in the mouse dentate gyrus. eNeuro 7 March 2019, ENEURO.0370-18.2019; DOI: https://doi.org/10.1523/ENEURO.0370-18.2019
Christy Itoga, Yuncai Chen, Cameron Fateri, Paula Echeverry, Jennifer Lai, Jasmine Delgado, Shapatur Badhon, Annabel Short, Tallie Z. Baram, Xiangmin Xu. (2019) New Viral-Genetic Mapping Uncovers an Enrichment of Corticotropin-Releasing Hormone-Expressing Neuronal Inputs to the Nucleus Accumbens from Stress-Related Brain Regions. Journal of Comparative Neurology 2019 Mar 12. doi: 10.1002/cne.24676. [Epub ahead of print]
Grieco, Steven; Wang, Gina; Mahapatra, Ananya; Lai, Cary; Holmes, Todd; Xu, Xiangmin (2019) Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. Journal of Comparative Neurology Aug 27. doi: 10.1002/cne.24762. [Epub ahead of print]
Nian Gong, Garo Hagopian, Todd C. Holmes, Z. David Luo*, and Xiangmin Xu* (2019) Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro 2019 Sep 18. pii: ENEURO.0272-19.2019. doi: 10.1523/ENEURO.0272-19.2019. [Epub ahead of print]
Yanjun Sun *, Suoqin Jin *, Xiaoxiao Lin, Lujia Chen, Xin Qiao, Li Jiang, Pengcheng Zhou, Kevin G. Johnston , Peyman Golshani, Qing Nie, Todd C. Holmes, Douglas A. Nitz #, Xiangmin Xu # (2019) CA1-projecting subiculum neurons facilitate object–place learning. Nature Neuroscience, published: 23 September 2019 https://doi.org/10.1038/s41593-019-0496-y
Guo, Zhi-Ling #; Lin, Xiaoxiao; Samaniego, Tracy; Isreb, Alexander; Cao, Stacey; Malik, Shaista; Holmes, Todd; Xu, Xiangmin # (2019) Fos-CreER Based Genetic Mapping of Forebrain Regions Activated by Acupuncture. Journal of Comparative Neurology 2019 Oct 10. doi: 10.1002/cne.24789. [Epub ahead of print]
Michael G Frantz, Emily C Crouse, Guela Sokhadze, Taruna Ikrar, Céleste-Élise Stephany, Collins Nguyen, Xiangmin Xu, Aaron W McGee (2020) Layer 4 gates experience-dependent plasticity in visual cortex independent of a canonical microcircuit. Current Biology, August 3, 2020 https://doi.org/10.1016/j.cub.2020.05.067
Lin, X., Itoga, C.A., Taha, S., Li, M.H., Chen, R., Sami, K., Berton, F., Francesconi, W., Xu, X. c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress. Neurobiology of Stress. 2018 Volume 8, February 2018, Pages 92-102 https://doi.org/10.1016/j.ynstr.2018.02.001
Yulin Shi*, Steven Grieco*, Todd Holmes, and Xiangmin Xu (2019) Development of local circuit connections to hilar mossy cells in the mouse dentate gyrus. eNeuro 7 March 2019, ENEURO.0370-18.2019; DOI: https://doi.org/10.1523/ENEURO.0370-18.2019
Christy Itoga, Yuncai Chen, Cameron Fateri, Paula Echeverry, Jennifer Lai, Jasmine Delgado, Shapatur Badhon, Annabel Short, Tallie Z. Baram, Xiangmin Xu. (2019) New Viral-Genetic Mapping Uncovers an Enrichment of Corticotropin-Releasing Hormone-Expressing Neuronal Inputs to the Nucleus Accumbens from Stress-Related Brain Regions. Journal of Comparative Neurology 2019 Mar 12. doi: 10.1002/cne.24676. [Epub ahead of print]
Grieco, Steven; Wang, Gina; Mahapatra, Ananya; Lai, Cary; Holmes, Todd; Xu, Xiangmin (2019) Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. Journal of Comparative Neurology Aug 27. doi: 10.1002/cne.24762. [Epub ahead of print]
Nian Gong, Garo Hagopian, Todd C. Holmes, Z. David Luo*, and Xiangmin Xu* (2019) Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro 2019 Sep 18. pii: ENEURO.0272-19.2019. doi: 10.1523/ENEURO.0272-19.2019. [Epub ahead of print]
Yanjun Sun *, Suoqin Jin *, Xiaoxiao Lin, Lujia Chen, Xin Qiao, Li Jiang, Pengcheng Zhou, Kevin G. Johnston , Peyman Golshani, Qing Nie, Todd C. Holmes, Douglas A. Nitz #, Xiangmin Xu # (2019) CA1-projecting subiculum neurons facilitate object–place learning. Nature Neuroscience, published: 23 September 2019 https://doi.org/10.1038/s41593-019-0496-y
Guo, Zhi-Ling #; Lin, Xiaoxiao; Samaniego, Tracy; Isreb, Alexander; Cao, Stacey; Malik, Shaista; Holmes, Todd; Xu, Xiangmin # (2019) Fos-CreER Based Genetic Mapping of Forebrain Regions Activated by Acupuncture. Journal of Comparative Neurology 2019 Oct 10. doi: 10.1002/cne.24789. [Epub ahead of print]
Michael G Frantz, Emily C Crouse, Guela Sokhadze, Taruna Ikrar, Céleste-Élise Stephany, Collins Nguyen, Xiangmin Xu, Aaron W McGee (2020) Layer 4 gates experience-dependent plasticity in visual cortex independent of a canonical microcircuit. Current Biology, August 3, 2020 https://doi.org/10.1016/j.cub.2020.05.067
Steven F Grieco, Xin Qiao, Xiaoting Zheng, Yongjun Liu, Lujia Chen, Hai Zhang, Jeffrey Gavornik, Cary Lai, Sunil Gandhi, Todd C Holmes, Xiangmin Xu (2020) Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia. Current Biology https://doi.org/10.1016/j.cub.2020.07.008
Xiangmin Xu, Todd C. Holmes, Min-Hua Luo, Kevin T. Beier, Gregory D. Horwitz, Fei Zhao, Wenbo Zeng, May Hui, Bert L. Semler, Rozanne M. Sandri-Goldin (2020) Viral vectors for neural circuit mapping and recent advances in trans-synaptic anterograde tracers. Neuron (PRIMER review article) https://doi.org/10.1016/j.neuron.2020.07.010
Yong-Jun Liu, Elizabeth Spangenberg, Bryan Tang, Todd C Holmes, Kim N Green, Xiangmin Xu. (2020) Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex. J Neurosci. 2020 Dec 23; JN-RM-2140-20. doi: 10.1523/JNEUROSCI.2140-20.2020. Online ahead of print. PMID: 33380470
XiaoTing Zheng, Kirstie J. Salinas, Dario X. Figueroa Velez, Taylor Nakayama, Xiaoxiao Lin, Xiangmin Xu, Sunil P. Gandhi. (2021) Host Interneurons Mediate Cortical Plasticity Reactivated by Embryonic Inhibitory Cell Transplantation. Nature Communications 2021 Feb 8;12(1):862. doi: 10.1038/s41467-021-21097-4. PMID: 33558487.
Steven F. Grieco, Xin Qiao, Kevin Johnston, Lujia Che1, Renetta R. Nelson, Cary Lai, Todd C. Holmes, Xiangmin Xu (2021). Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine. Translational Psychiatry 2021 Feb 24;11(1):144. doi: 10.1038/s41398-021-01255-4. PMID: 33627623
Jennifer Wong, Steven Grieco, Karoni Dutt, Luija Chen, Jacquelyn Thelin, George Andrew Inglis, Shangrila Parvin, Sandra Garraway, Xiangmin Xu, Alan Goldin, and Andrew Escayg (2021). Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacolog https://www.nature.com/articles/s41386-021-00985-9
Zhaoxia Yu#, Michele Guindani, Steven F. Grieco, Lujia Chen, Todd C. Holmes, Xiangmin Xu# (2021) Beyond t-Test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron https://doi.org/10.1016/j.neuron.2021.10.030
Xiaoxiao Lin, Lujia Chen; David Baglietto-Vargas; Qiao Ye; Frank M LaFerla; Douglas A. Nitz; Todd C. Holmes; Xiangmin Xu (2021) Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model. Neurobiology of Disease https://doi.org/10.1016/j.nbd.2021.105562.
Xiaoxiao Lin, Michelle Amalraj, Crisylle Blanton, Brenda Avila, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu (2021) Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway. PLOS Biology 2021 Dec 20;19(12):e3001127. doi: 10.1371/journal.pbio.3001127.
Xiangmin Xu, Todd C. Holmes, Min-Hua Luo, Kevin T. Beier, Gregory D. Horwitz, Fei Zhao, Wenbo Zeng, May Hui, Bert L. Semler, Rozanne M. Sandri-Goldin (2020) Viral vectors for neural circuit mapping and recent advances in trans-synaptic anterograde tracers. Neuron (PRIMER review article) https://doi.org/10.1016/j.neuron.2020.07.010
Yong-Jun Liu, Elizabeth Spangenberg, Bryan Tang, Todd C Holmes, Kim N Green, Xiangmin Xu. (2020) Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex. J Neurosci. 2020 Dec 23; JN-RM-2140-20. doi: 10.1523/JNEUROSCI.2140-20.2020. Online ahead of print. PMID: 33380470
XiaoTing Zheng, Kirstie J. Salinas, Dario X. Figueroa Velez, Taylor Nakayama, Xiaoxiao Lin, Xiangmin Xu, Sunil P. Gandhi. (2021) Host Interneurons Mediate Cortical Plasticity Reactivated by Embryonic Inhibitory Cell Transplantation. Nature Communications 2021 Feb 8;12(1):862. doi: 10.1038/s41467-021-21097-4. PMID: 33558487.
Steven F. Grieco, Xin Qiao, Kevin Johnston, Lujia Che1, Renetta R. Nelson, Cary Lai, Todd C. Holmes, Xiangmin Xu (2021). Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine. Translational Psychiatry 2021 Feb 24;11(1):144. doi: 10.1038/s41398-021-01255-4. PMID: 33627623
Jennifer Wong, Steven Grieco, Karoni Dutt, Luija Chen, Jacquelyn Thelin, George Andrew Inglis, Shangrila Parvin, Sandra Garraway, Xiangmin Xu, Alan Goldin, and Andrew Escayg (2021). Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacolog https://www.nature.com/articles/s41386-021-00985-9
Zhaoxia Yu#, Michele Guindani, Steven F. Grieco, Lujia Chen, Todd C. Holmes, Xiangmin Xu# (2021) Beyond t-Test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron https://doi.org/10.1016/j.neuron.2021.10.030
Xiaoxiao Lin, Lujia Chen; David Baglietto-Vargas; Qiao Ye; Frank M LaFerla; Douglas A. Nitz; Todd C. Holmes; Xiangmin Xu (2021) Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model. Neurobiology of Disease https://doi.org/10.1016/j.nbd.2021.105562.
Xiaoxiao Lin, Michelle Amalraj, Crisylle Blanton, Brenda Avila, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu (2021) Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway. PLOS Biology 2021 Dec 20;19(12):e3001127. doi: 10.1371/journal.pbio.3001127.
Xiaoxiao Lin,, Lujia Chen, Amandine Jullienne, Arjang Salehi, Mary Hamer, Todd Holmes, Andre Obenaus*, Xiangmin Xu * (2022) Longitudinal dynamics of micro-vascular recovery after acquired cortical injury. Acta Neuropathologica Communications 10, 59 (2022). https://doi.org/10.1186/s40478-022-01361-4
Xu Chen, Riccardo Calandrelli, John Girardini, Zhangming Yan, Zhiqun Tan, Xiangmin Xu, Sheng Zhong (2022) PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms. Cell Metabolism 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.
Kevin G. Johnston, S. F. G., Hai Zhang, Suoqin Jin, Xiangmin Xu*, Qing Nie*. Tracking Longitudinal Population Dynamics of Single Neuronal Calcium Signal Using SCOUT. Cell Reports Methods, doi:https://www.cell.com/cell-reports-methods/pdfExtended/S2667-2375(22)00065-0 (2022).
Ding Quan Ng; Daniella Chan; Parisa Agrawal; Weian Zhao; Xiangmin Xu; Munjal Acharya, Alexandre Chan (2022). Evidence of Brain-Derived Neurotrophic Factor in Ameliorating Cancer-Related Cognitive Impairment: A Systematic Review of Human Studies. Crit Rev Oncol Hematol. 2022 Jun 17;176:103748. doi: 10.1016/j.critrevonc.2022.103748. Online ahead of print.
Qiao Ye, Gocylen Gast, Xilin Su, Takashi Saito, Takaomi C. Saido, Todd C. Holmes, Xiangmin Xu (2022). Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing. Neurobiol Dis. 2022 Jul 14;105820. doi: 10.1016/j.nbd.2022.105820. Online ahead of print.
Grieco SF, Holmes TC, Xu X. Meeting report for the 2022 UC Irvine Center for neural circuit mapping conference: linking brain function to cell types and circuits. Mol Psychiatry. 2023 Jan;28(1):2-3. doi: 10.1038/s41380-022-01810-5. PMID: 36198768.
Yanxiao Zhang*, Maria Luisa Amaral*, Chenxu Zhu, Steven F. Grieco, Xiaomeng Hou, Lin Lin, Justin Buchanan, Liqi Tong, Sebastian Preissl, Xiangmin Xu, Bing Ren. Single-cell Epigenome Analysis Reveals Age-associated Decay of Heterochromatin Domains in Excitatory Neurons in the Mouse Brain. Nature Cell Research (https://doi.org/10.1038/s41422-022-00719-6).
Grieco SF, Castrén E, Knudsen GM, Kwan AC, Olson DE, Zuo Y, Holmes TC, Xu X. Psychedelics and Neural Plasticity: Therapeutic Implications. J Neurosci. 2022 Nov 9;42(45):8439-8449. doi: 10.1523/JNEUROSCI.1121-22.2022. PMID: 36351821
Zhang H, Chen L, Johnston KG, Crapser J, Green KN, Ha NM, Tenner AJ, Holmes TC, Nitz DA, Xu X. Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer's disease. Neurobiol Dis. 2023 Jan;176:105939. doi: 10.1016/j.nbd.2022.105939. Epub 2022 Dec 1. PMID: 36462718
Tan Z, Garduño BM, Aburto PF, Chen L, Ha N, Cogram P, Holmes TC, Xu X. Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer's disease. Acta Neuropathol Commun. 2022 Dec 19;10(1):182. doi: 10.1186/s40478-022-01481-x. PMID: 36529803
Sun Y, Zweifel LS, Holmes TC, Xu X. Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse.
Neurobiol Stress. 2023 Feb 15;23:100527. doi: 10.1016/j.ynstr.2023.100527. eCollection 2023 Mar. PMID: 36861029
Zhao W, Johnston KG, Ren H, Xu X, Nie Q. Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat. Nat Commun. 2023 Feb 28;14(1):1128. doi: 10.1038/s41467-023-36800-w. PMID: 36854676
Grieco SF, Holmes TC, Xu X. Probing neural circuit mechanisms in Alzheimer's disease using novel technologies. Mol Psychiatry. 2023 Mar 23. doi: 10.1038/s41380-023-02018-x. Online ahead of print. PMID: 36959497
Lujia Chen*, Xiaoxiao Lin*, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz#, Xiangmin Xu Hippocampal CA1 activity dynamics for environmental representation are anatomically organized. iScience Volume 26, Issue 5, 19 May 2023, 106703. https://doi.org/10.1016/j.isci.2023.106703.
Xiaoxiao Lin, Neeyaz Cyrus, Brenda Avila, Todd C. Holmes, Xiangmin Xu. Hippocampal CA3 inhibitory neurons receive extensive noncanonical synaptic inputs from CA1 and subicular complex. Journal of Comparative Neurology (First published: 13 June 2023) https://doi.org/10.1002/cne.25510.
Paff M, Grieco SF, Xu X. Obtaining brain tissue from living patients for psychiatry research: collaboration with patients with epilepsy and neurosurgeons. Lancet Psychiatry. 2023 Jun;10(6):381. doi: 10.1016/S2215-0366(23)00142-6. Epub 2023 Apr 21. PMID: 37088087.
Grieco SF, Johnston KG, Gao P, Garduño BM, Tang B, Yi E, Sun Y, Horwitz GD, Yu Z, Holmes TC, Xu X. Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions. Mol Psychiatry. 2023 Jul 13. doi: 10.1038/s41380-023-02153-5.
Grieco SF, Holmes TC, Xu X. Meeting report for the 2023 UC Irvine Center for Neural Circuit Mapping Conference: structure, function and development of neural circuits. Mol Psychiatry. 2023 Nov 2. doi: 10.1038/s41380-023-02308-4. Epub ahead of print. PMID: 37919404.
Zhang H, Sumbria RK, Chang R, Sun J, Cribbs DH, Holmes TC, Fisher MJ, Xu X. Erythrocyte-brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo. J Neuroinflammation. 2023 Nov 15;20(1):265. doi: 10.1186/s12974-023-02932-5. PMID: 37968737; PMCID: PMC10647121.
Xin Qiao, Steven Grieco, Zhaoxia Yu, Todd Holmes, and Xiangmin Xu (2023) Intranasal Delivery of Ketamine Induces Cortical Disinhibition. eNeuro 2024 Jan 17;11(1):ENEURO.0107-23.2023. doi: 10.1523/ENEURO.0107-23.2023.
Alexis Bouin1#, Ginny Wu#, Orkide O. Koyuncu, Qiao Ye, Keun-Young Kim, Michele Wu, Liqi Tong, Lujia Chen, Sebastien Phan, Mason R. Mackey, Ranjan Ramachandra, Mark H. Ellisman, Todd C. Holmes, Bert L. Semler*, Xiangmin Xu* (2024) New rabies viral resources for multi-scale neural circuit mapping. Molecular Psychiatry Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02451-6
Yanjun Sun, Douglas A Nitz, Xiangmin Xu, Lisa M Giocomo (2024) The subiculum encodes environmental geometry. Nature (In press) bioRxiv doi: https://doi.org/10.1101/2023.05.07.539721
Usha Nekanti, Pooja Sakthivel, Atena Zahedi, Dana Creasman, Rebecca Nishi, Courtney Dumont, Katja Piltti, Glenn Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian David, Zhiling Guo, Stephanie Seidlits, Xiangmin Xu, Lonnie Shea, Brian Cummings, Aileen Anderson (2024) Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI. npj Regenerative Medicine (in press).
B. M. Garduñ, Patrick Hanni, Chelsea Hays, Patricia Cogram, Nathan Insel*, Xiangmin Xu* (2024) How the Forebrain Transitions to Adulthood: Developmental Plasticity Markers in a Long-lived Rodent Reveal Region Diversity and the Uniqueness of Adolescence. Front. Neurosci. Sec. Neurodevelopment Volume 18 - 2024 | doi: 10.3389/fnins.2024.1365737
Patricia Cograma*, B. Maximiliano Garduño, Bing Ren, Xiangmin Xu* (2024) First International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging. Journal of Alzheimer's Disease. 2024 Feb 20. doi: 10.3233/JAD-249004. Online ahead of print. PMID: 38393919 DOI: 10.3233/JAD-249004
Xu Chen, Riccardo Calandrelli, John Girardini, Zhangming Yan, Zhiqun Tan, Xiangmin Xu, Sheng Zhong (2022) PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms. Cell Metabolism 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.
Kevin G. Johnston, S. F. G., Hai Zhang, Suoqin Jin, Xiangmin Xu*, Qing Nie*. Tracking Longitudinal Population Dynamics of Single Neuronal Calcium Signal Using SCOUT. Cell Reports Methods, doi:https://www.cell.com/cell-reports-methods/pdfExtended/S2667-2375(22)00065-0 (2022).
Ding Quan Ng; Daniella Chan; Parisa Agrawal; Weian Zhao; Xiangmin Xu; Munjal Acharya, Alexandre Chan (2022). Evidence of Brain-Derived Neurotrophic Factor in Ameliorating Cancer-Related Cognitive Impairment: A Systematic Review of Human Studies. Crit Rev Oncol Hematol. 2022 Jun 17;176:103748. doi: 10.1016/j.critrevonc.2022.103748. Online ahead of print.
Qiao Ye, Gocylen Gast, Xilin Su, Takashi Saito, Takaomi C. Saido, Todd C. Holmes, Xiangmin Xu (2022). Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing. Neurobiol Dis. 2022 Jul 14;105820. doi: 10.1016/j.nbd.2022.105820. Online ahead of print.
Grieco SF, Holmes TC, Xu X. Meeting report for the 2022 UC Irvine Center for neural circuit mapping conference: linking brain function to cell types and circuits. Mol Psychiatry. 2023 Jan;28(1):2-3. doi: 10.1038/s41380-022-01810-5. PMID: 36198768.
Yanxiao Zhang*, Maria Luisa Amaral*, Chenxu Zhu, Steven F. Grieco, Xiaomeng Hou, Lin Lin, Justin Buchanan, Liqi Tong, Sebastian Preissl, Xiangmin Xu, Bing Ren. Single-cell Epigenome Analysis Reveals Age-associated Decay of Heterochromatin Domains in Excitatory Neurons in the Mouse Brain. Nature Cell Research (https://doi.org/10.1038/s41422-022-00719-6).
Grieco SF, Castrén E, Knudsen GM, Kwan AC, Olson DE, Zuo Y, Holmes TC, Xu X. Psychedelics and Neural Plasticity: Therapeutic Implications. J Neurosci. 2022 Nov 9;42(45):8439-8449. doi: 10.1523/JNEUROSCI.1121-22.2022. PMID: 36351821
Zhang H, Chen L, Johnston KG, Crapser J, Green KN, Ha NM, Tenner AJ, Holmes TC, Nitz DA, Xu X. Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer's disease. Neurobiol Dis. 2023 Jan;176:105939. doi: 10.1016/j.nbd.2022.105939. Epub 2022 Dec 1. PMID: 36462718
Tan Z, Garduño BM, Aburto PF, Chen L, Ha N, Cogram P, Holmes TC, Xu X. Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer's disease. Acta Neuropathol Commun. 2022 Dec 19;10(1):182. doi: 10.1186/s40478-022-01481-x. PMID: 36529803
Sun Y, Zweifel LS, Holmes TC, Xu X. Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse.
Neurobiol Stress. 2023 Feb 15;23:100527. doi: 10.1016/j.ynstr.2023.100527. eCollection 2023 Mar. PMID: 36861029
Zhao W, Johnston KG, Ren H, Xu X, Nie Q. Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat. Nat Commun. 2023 Feb 28;14(1):1128. doi: 10.1038/s41467-023-36800-w. PMID: 36854676
Grieco SF, Holmes TC, Xu X. Probing neural circuit mechanisms in Alzheimer's disease using novel technologies. Mol Psychiatry. 2023 Mar 23. doi: 10.1038/s41380-023-02018-x. Online ahead of print. PMID: 36959497
Lujia Chen*, Xiaoxiao Lin*, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz#, Xiangmin Xu Hippocampal CA1 activity dynamics for environmental representation are anatomically organized. iScience Volume 26, Issue 5, 19 May 2023, 106703. https://doi.org/10.1016/j.isci.2023.106703.
Xiaoxiao Lin, Neeyaz Cyrus, Brenda Avila, Todd C. Holmes, Xiangmin Xu. Hippocampal CA3 inhibitory neurons receive extensive noncanonical synaptic inputs from CA1 and subicular complex. Journal of Comparative Neurology (First published: 13 June 2023) https://doi.org/10.1002/cne.25510.
Paff M, Grieco SF, Xu X. Obtaining brain tissue from living patients for psychiatry research: collaboration with patients with epilepsy and neurosurgeons. Lancet Psychiatry. 2023 Jun;10(6):381. doi: 10.1016/S2215-0366(23)00142-6. Epub 2023 Apr 21. PMID: 37088087.
Grieco SF, Johnston KG, Gao P, Garduño BM, Tang B, Yi E, Sun Y, Horwitz GD, Yu Z, Holmes TC, Xu X. Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions. Mol Psychiatry. 2023 Jul 13. doi: 10.1038/s41380-023-02153-5.
Grieco SF, Holmes TC, Xu X. Meeting report for the 2023 UC Irvine Center for Neural Circuit Mapping Conference: structure, function and development of neural circuits. Mol Psychiatry. 2023 Nov 2. doi: 10.1038/s41380-023-02308-4. Epub ahead of print. PMID: 37919404.
Zhang H, Sumbria RK, Chang R, Sun J, Cribbs DH, Holmes TC, Fisher MJ, Xu X. Erythrocyte-brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo. J Neuroinflammation. 2023 Nov 15;20(1):265. doi: 10.1186/s12974-023-02932-5. PMID: 37968737; PMCID: PMC10647121.
Xin Qiao, Steven Grieco, Zhaoxia Yu, Todd Holmes, and Xiangmin Xu (2023) Intranasal Delivery of Ketamine Induces Cortical Disinhibition. eNeuro 2024 Jan 17;11(1):ENEURO.0107-23.2023. doi: 10.1523/ENEURO.0107-23.2023.
Alexis Bouin1#, Ginny Wu#, Orkide O. Koyuncu, Qiao Ye, Keun-Young Kim, Michele Wu, Liqi Tong, Lujia Chen, Sebastien Phan, Mason R. Mackey, Ranjan Ramachandra, Mark H. Ellisman, Todd C. Holmes, Bert L. Semler*, Xiangmin Xu* (2024) New rabies viral resources for multi-scale neural circuit mapping. Molecular Psychiatry Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02451-6
Yanjun Sun, Douglas A Nitz, Xiangmin Xu, Lisa M Giocomo (2024) The subiculum encodes environmental geometry. Nature (In press) bioRxiv doi: https://doi.org/10.1101/2023.05.07.539721
Usha Nekanti, Pooja Sakthivel, Atena Zahedi, Dana Creasman, Rebecca Nishi, Courtney Dumont, Katja Piltti, Glenn Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian David, Zhiling Guo, Stephanie Seidlits, Xiangmin Xu, Lonnie Shea, Brian Cummings, Aileen Anderson (2024) Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI. npj Regenerative Medicine (in press).
B. M. Garduñ, Patrick Hanni, Chelsea Hays, Patricia Cogram, Nathan Insel*, Xiangmin Xu* (2024) How the Forebrain Transitions to Adulthood: Developmental Plasticity Markers in a Long-lived Rodent Reveal Region Diversity and the Uniqueness of Adolescence. Front. Neurosci. Sec. Neurodevelopment Volume 18 - 2024 | doi: 10.3389/fnins.2024.1365737
Patricia Cograma*, B. Maximiliano Garduño, Bing Ren, Xiangmin Xu* (2024) First International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging. Journal of Alzheimer's Disease. 2024 Feb 20. doi: 10.3233/JAD-249004. Online ahead of print. PMID: 38393919 DOI: 10.3233/JAD-249004
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6039
https://faculty.uci.edu/profile/?facultyId=6039
Last updated
02/25/2024
02/25/2024