Olga V Razorenova

picture of Olga V Razorenova

Associate Professor, Molecular Biology and Biochemistry
School of Biological Sciences

Ph.D., Engelhardt Institute of Molecular Biology (Moscow, Russia), 2006, Molecular Biology
M.S., Lomonosov Moscow State University (Moscow, Russia), 2000, Molecular Genetics

Phone: (949) 824-8156
Email: olgar~at~uci.edu

University of California, Irvine
845 Health Sciences Road
Gross Hall - Room 3010
Mail Code: 3900
Irvine, CA 92697
Research Interests
Tumor Microenvironment, Hypoxia, Tumor Progression, Metastasis, Therapeutic Target, Drug Screening, siRNA Screening
Ph.D. Student, Laboratory of Peter Chumakov, Engelhardt Institute of Molecular Biology
Research Scholar, Laboratories of Peter Chumakov and Tatiana Byzova, Lerner Research Institute, Cleveland Clinic
Postdoctoral Scholar, Laboratory of Amato Giaccia, Stanford University
Research Abstract
My research interests include molecular, cellular and genetic basis of cancer. Dissection of mechanisms of tumor initiation and progression based on mouse models of ovarian and breast cancers. Primary focus is on the role of hypoxia and tumor micro-environment in the progression and metastatic spread of epithelial tumors. Additional area of expertise includes small molecule chemical library screens to identify anti-cancer drugs in multiple cell reporter based assays and the use of synthetic lethality concept.
Thompson J.M., Alvarez A., Singha M.K., Pavesic M.W., Nguyen Q.H., Nelson L.J., Fruman D.A., Razorenova O.V.* Targeting the mevalonate pathway suppresses VHL-deficient CC-RCC through a HIF-dependent mechanism. Molecular Cancer Therapeutics. 2018; in press. * - corresponding author
Wright H.J.#, Hou J.#, Xu B., Cortez M., Potma E.O., Tromberg B.J., Razorenova O.V.* CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid droplet abundance and stimulation of fatty acid oxidation. Proc Natl Acad Sci USA. 2017; in press. # - equal contribution, * - corresponding author
Thompson J.M., Nguyen Q.H., Singh M., Pavesic M.W., Nesterenko I., Nelson L.J., Liao A., Razorenova O.V.* Rho-Associated Kinase 1 (ROCK1) inhibition is synthetically lethal with Von Hippel Lindau (VHL) deficiency in Clear Cell Renal Cell Carcinoma (CC-RCC). Oncogene. 2017; 36(8): 1080-1089. * - corresponding author
Wright H.J., Arulmoli J., Motazedi M., Nelson L.J., Heinemann F.S., Flanagan L.A., Razorenova O.V.* CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene. 2016; 35(36):4762-4772.
* - corresponding author
Thompson JM, Nguyen QH, Singh M, Razorenova OV.* Approaches to identifying synthetic lethal interactions in cancer. Yale J Biol Med;88(2):145-55. Review.
* - corresponding author
Thompson J.M., Landman J., Razorenova O.V.* Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers. Small GTPases, 2017; in press. MiniReview. * - corresponding author
Wright H.J., Police A.M., Razorenova O.V.* Targeting CDCP1 dimerization in Triple-Negative Breast Cancer. Cell Cycle. 2016; 15(18):2385-6. Editorials: Cell Cycle Features. * - corresponding author
Arulmoli J., Wright H.J., Phan D.T., Sheth U, Que R.A., Botten G.A., Keating M., Botvinick E.L., Pathak M.M., Zarembinski T.I., Yanni D.S., Razorenova O.V., Hughes C.C., Flanagan L.A. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomaterialia. 2016; 43:122-138.
Hou J.*, Wright H.J.*, Chan N., Tran R., Razorenova O.V., Potma E.O., Tromberg B.J. Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption. J Biomed Opt. 2016; 21(6):60503. * - equal contribution
Castellini L., Krieg A.J., Razorenova O.V., Giaccia A.J. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Research. 2017; 45(7):3674-3692.
Razorenova O.V.*, Castellini L.*, Colavitti R.*, Edgington L.E., Nicolau M., Huang X., Bedogni B., Mills E.M., Bogyo M., Giaccia A.J. The Apoptosis Repressor with a CARD Domain (ARC) is a Direct HIF1 Target Gene and Promotes Survival and Proliferation of VHL Deficient Renal Cancer Cells. Mol Cell Biol. 2014; 34(4):739-751.
* - equal contribution
Razorenova O.V.* Brain and Muscle ARNT-Like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to Hypoxia Inducible Factor mediated pathway. Cell Cycle. 2012; 11(2):213-214. Invited News and Views.
* - corresponding author
Razorenova O.V., Finger E., Colavitti R., Chernikova S.B., Boiko A.D., Chan C., Krieg A.J., Bedogni B., LaGory E., Weissman I.L., Broome-Powell M., Giaccia A.J. VHL loss in renal cell carcinoma leads to HIF-dependent upregulation of CUB domain-containing protein 1 to stimulate PKCdelta-driven migration. Proc Natl Acad Sci USA. 2011; 108(5):1931-1936.
Razorenova O.V. and Giaccia A.J. Hypoxia, Gene Expression, and Metastasis. Chapter 3 in "The Tumor Microenvironment" Book, ed. Bagley RG. 2010; pp 43-58.
Razorenova O.V., Ivanov A.V., Budanov A.V., Chumakov P.M. Development of virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1. Gene. 2005; 350(1):89-98.
Razorenova O.V., Agapova L.S., Chumakov P.M. p53 gene expression and activation of p53-dependent transcription in melanoma cell lines. Mol Biol (Mosk). 2005; 39(3):445-456. Russian.
Razorenova O.V., Agapova L.S., Budanov A.V., Ivanov A.V., Strunina S.M., Chumakov P.M. Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors. Mol Biol (Mosk). 2005; 39(2):286-293. Russian.
Razorenova O.V., Karpova N.N., Smirnova Iu.B., Kusulidu L.K., Reneva N.K., Subocheva E.A., Kim A.I., Liubomirskaia N.V., Il'in Iu.V. Interlineage distribution and characteristics of the structure of two subfamilies of Drosophila melanogaster MDG4 (gypsy) retrotransposon. Genetika. 2001; 37(2):175-182. Russian.
Boiko A.D., Razorenova O.V., van de Rijn M., Swetter S.M., Johnson D.L., Ly D.P., Butler P.D., Yang G.P., Joshua B., Kaplan M.J., Longaker M.T., Weissman I.L. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature. 2010; 466:133-137.
Chernikova S.B., Razorenova O.V., Higgins J., Sishc B.J., Nicolau M., Dorth J.A., Chernikova D.A., Kwok S., Brooks J.D., Bailey S.M., Game J.C., Brown J.M. Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Research. 2012; 72(8):2111-9.
Chernikova S.B., Dorth J.A., Razorenova O.V., Game J.C., Brown J.M. Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian Cells. Radiat Res. 2010; 174(5):558-65.
Krieg A.J., Rankin E.B., Chan D., Razorenova O., Fernandez S., Giaccia A.J. Regulation of the Histone Demethylase JMJD1A by HIF-1? Enhances Hypoxic Gene Expression and Tumor Growth. Mol Cell Biol. 2009; 30(1):344-353.
Malinin N.L., Zhang L., Choi J., Ciocea A., Razorenova O., Ma Y.Q., Podrez E.A., Tosi M., Lennon D.P., Caplan A.I., Shurin S.B., Plow E.F., Byzova T.V. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nature Medicine. 2009; 15(3):313-318.
Mahabeleshwar G.H., Chen J., Feng W., Somanath P.R., Razorenova O.V., Byzova T.V. Integrin affinity modulation in angiogenesis. Cell Cycle. 2008; 7(3):335-347.
Somanath P.R.*, Razorenova O.V.*, Chen J., Byzova T.V. Role for Akt1 kinase in angiogenesis and endothelial cell biology. Cell Cycle. 2006; 5(5):512-518. Review.
* - equal contribution
Boiko A.D., Porteous S., Razorenova O.V., Krivokrysenko V.I., Williams B., Gudkov A.V. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes and Development. 2006; 20(2):236-252.
Chen J.*, Somanath P.R.*, Razorenova O., Chen W.S., Hay N., Bornstein P., Byzova T.V. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nature Medicine. 2005; 11(11):1188-1196.
* - equal contribution.
De S., Razorenova O., McCabe N.P., O’Toole T.E., Qin J., Byzova T.V. VEGF–integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci USA. 2005; 102(21):7589-7594.
Narizhneva N.V., Razorenova O.V., Podrez E.A., Chen J., Chandraesekharan U., DiCorleto P.E., Plow E.F., Topol E.J., Byzova T.V. Thrombospondin-1 upregulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 2005; 19(9):1158-1160.
Gurova K.V., Hill J.E., Razorenova O.V., Chumakov P.M., Gudkov A.V. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res. 2004; 64(6):1951-1958.
Lyubomirskaya N.V., Smirnova J.B., Razorenova O.V., Karpova N.N., Surkov S.A., Avedisov S.N., Kim A.I., Ilyin Y.V. Two variants of the Drosophila melanogaster retrotransposon gypsy (MDG4): structural and functional differences, and distribution in fly stocks. Mol Genet Genomics. 2001; 265(2):367-374.
Kusulidu L.K., Karpova N.N., Razorenova O.V., Glukhov I.A., Kim A.I., Liubomirskaia N.V., Il'in Iu.V. Mobile genetic element MDG4 (gypsy) in Drosophila melanogaster. Features of structure and regulation of transposition. Genetika. 2001; 37(12):1589-1597. Russian.
Kusulidu L.K., Karpova N.N., Razorenova O.V., Glukhov I.A., Kim A.I., Lyubomirskaya N.V., Ilyin Y.V. Structural polymorphism of the transposable element MDG4 (gypsy) in Drosophila melanogaster strains. Doklady Akademii Nauk. 2001; 376(1):133-138. Russian.
Kim A.I., Pasiukova E.G., Karpova N.N., Razorenova O.V. Genomic factors regulating the transposition of Drosophila mobile elements. Genetika. 1999; 35(11):1511-1521. Review. Russian.
Concern Foundation CONquer CanCER Now Award
Kure It Cancer Foundation
American Cancer Society Research Scholar grant
Professional Society
American Association for Cancer Research - AACR
Other Experience
Graduate Programs
Cancer Biology

Cell Biology

Cellular and Molecular Biosciences

Developmental Biology and Genetics

Mechanisms of Gene Expression

Research Centers
Chao Family Comprehensive Cancer Center
Sue&Bill Gross Stem Cell Research Center
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