M Reza Mirbolooki

Picture of M Reza Mirbolooki
Lecturer (Summer Session), Biomedical Engineering
The Henry Samueli School of Engineering
Project Scientist, Medicine
School of Medicine
Ph.D., University of Alberta, 2008, Experimental Surgery
M.D., Babol University of Medical Sciences, 2000, General Medicine
Phone: (949) 824-7814
Fax: (949) 824-7814
Email: rezam@uci.edu
University of California, Irvine
Department of Medicine, Division of Endocrinology
Gillespie Neuroscience Research Facility, Rm:2226
Irvine, CA 92697
Research Interests
Surface protein interactions in pancreatic beta cells in patients with diabetes
Academic Distinctions
1999 Afzalipour Research Award, Kerman University of Medical Sciences, Kerman, Iran
2000 Dean's Honor Roll in Research by Babol University of Medical Sciences, Iran
2002 Razi's National Medical Researches Award (National prize, 3rd rank) by: Ministry of Health and Medical Education, Iran
2003 Young Investigator Award (18th IDF Congress in Paris) by Eli Lilly Co., USA (Beirut Branch)
2005 GSA Graduate Student Award by Graduate Students Association, University of Alberta
2006 Mary Louise Imrie Graduate Student Award by Faculty of Graduate Studies, University of Alberta
2007 REACH (Recognition of Excellence and Achievement) Academy Award by University of Alberta Hospital, Capital Health Authority
2009 NIH-JDRF Award “Imaging the Pancreatic Beta Cell, Fourth Workshop”, Bethesda, MD
2012 Society of Nuclear Medicine Award "2012 SNM annual Meeting", Miami, FL
Publications
Books Contributions:

1. March C, Mirbolooki M, Lakey JRT. Risk Factors Affecting Islet Yield and Function. In: Islet Transplantation: Biology, Immunology and Clinical Applications. Kandeel F (Ed). Springer, 2013

2. Mirbolooki M, Bozorgmanesh H, Foster CE, Kuhtrieber W, Lakey JRT, Tissue and Cell Isolation. In: Comprehensive Biotechnology, 2nd edition. Moo-Young M, Butler M. (Eds.), Elsevier 2011 Volume 1, Chapter 44, pp 591-8.

3. Fisher JS, Mirbolooki M, Lakey JRT, Robertson P, March C. Pancreas and Islet Transplantation. In: Comprehensive Clinical Nephrology, 4th edition. Feehally J, Floege J, Johnson RJ (Eds). Mosby 2010, Chapter 106. pp:1232-1244

4. Fisher JS, Lakey JRT, Mirbolooki M, Robertson P, March C. Pancreas and Islet Transplantation. In: Comprehensive Clinical Nephrology, 3rd edition. Feehally J, Floege J, Johnson RJ (Eds). Mosby 2007, Chapter 98. pp: 1131-1144

5. Kin T, Mirbolooki M, Lakey JRT. Design and implementation of cell isolation facility In: Cellular Transplantation from Laboratory to Clinic, Halberstadt CF, Emerich DR (Eds). Elsevier, 2007, Chapter 33. pp: 629-634.

6. Mirbolooki M, Lakey JRT, Kin T, Murdoch T, Shapiro AMJ. Aspects and Challenges in islet isolation. In: Islet Transplantation and Beta Cell Replacement Therapy, Shapiro AMJ, Shawn AMJ (Eds). Informa healthcare, 2007, Chapter 6. pp: 115-134

7. Mirbolooki M, Lakey JRT. Pancreas preservation for islet isolation. In: Islet Transplantation and Beta Cell Replacement Therapy, Shapiro AMJ, Shawn AMJ (Eds). Informa healthcare, 2007, Chapter 5. pp: 99-114

Journals Contribution
Full articles

1. Mirbolooki MR, Constantinescu CC, Pan ML, Mukherjee J. Targeting presynaptic norepinephrine transporter in brown adipose tissue: A novel imaging approach and potential treatment for diabetes and obesity. Synapse. 2013, 67(2): 79-93.

2. Upadhyay SK, Eckel-Mahan K, Mirbolooki MR, Tjong IW, Griffey S, Schmunk G, Koehne A, Halbout B, Iadonato SP, Borrelli E, Wang PH, Mukharjee J, Sassoni-Corsi P, Chandy KG. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. PNAS (under review)

3. Constantinescu C, Garcia A, Mirbolooki MR, Pan ML, Mukherjee J. Evaluation of 18F-Nifene biodistribution and dosimetry based on whole-body PET imaging of mice. Nucl Med Biol 2012 Dec. doi:pii: S0969-8051(12)00293-4. 10.1016/j.nucmedbio.2012.11.004

4. Mirbolooki MR, Constantinescu C, Pan ML, Mukherjee J. Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and ?3-adrenergic receptor activation. EJNMMI Res. 2011 Dec 1;1(1):30.

5. Garcia A*, Mirbolooki MR*, Constantinescu C, Pan ML, Sevrioukov E, Milne N, Wang PH, Lakey JRT, Chandy KG, Mukherjee J. 18F-Fallypride PET Imaging of Pancreatic Islets Cells: In Vitro and In Vivo Rodent Studies. J Nucl Med. 2011, 52(7): 1125-32

6. Mirbolooki MR, Alexander M, Hoyt DB, Lakey JRT. Pancreatic duct: A suitable route to oxygenate tissue during pancreas hypothermic preservation? Transplant Immunology. 2010, 22(3-4): 191-4. (IF:2.5; 12th in the field of Transplantation, Out of 24)

7. Mirbolooki MR, Taylor GE, Knutzen VK, Scharp DW, Willcourt R, Lakey JRT. Pulsatile Intravenous Insulin Therapy: The Best Practice to Reverse Diabetes Complications? Medical Hypotheses. 2009, 73(3): 363-369

8. Mirmiran P, Mirbolooki M, Heydarian P, Salehi P, Azizi F. Intrafamilial associations of lipid profiles and the role of nutrition: the Tehran lipid and glucose study. Ann Nutr Metab. 2008;52(1):68-73

9. Lakey JRT, Mirbolooki M, Rogers C, Mohr J. Demand of allograft tissue in Canada. Cell and Tissue Banking. 2007; 8 (1): 31-42

10.Lakey JRT, Mirbolooki M, Rogers C, Mohr J. Supply for allograft tissue in Canada. Cell and Tissue Banking. 2007;8(2):135-50

11.Miszta-Lane H, Gill P, Mirbolooki M, Lakey JRT. Effect of Slow-Freezing versus Vitrification on the Recovery of Mouse Embryonic Stem Cells. Cell Preservation Technology. 2007; 5(1): 16-24

12.Mirbolooki M, Shapiro AMJ, Lakey JRT. A Perspective on Clinical Islet Transplantation: Past, Present, and Developments for Future. Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents. 2006, 6(2): 191-208. (IF:4.7; 4th in the field of Chemistry, Out of 46)

13.Salehi P, Mirbolooki M*, Kin T, Tsujimura T, Shapiro AMJ, Churchill TA, Lakey JRT. Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solution. Cell Transplantation. 2006, 15(2): 187-94. (IF:5.1; Second in the field of Transplantation)

14.Miszta-Lane H, Mirbolooki M*, Shapiro AMJ, Lakey JRT. Stem cell sources for clinical islet transplantation in type 1 diabetes: Embryonic and adult stem cells. Medical Hypotheses, 2006, 67(4): 909-913.

15.Swift S, Kin T, Mirbolooki M, Wilson R, Lakey JRT. Comparison of cooling systems during islet purification. Cell Transplantation. 2006, 15(2): 175-80. (IF:5.1; Second in the field of Transplantation)

16.Lakey JRT, Mirbolooki M, Shapiro AMJ. Current status of clinical islet cell transplantation. Methods Mol Biol. 2006; 333: 47-104.

17.Kin T, Mirbolooki M, Salehi P, Tsukada M, O’Gorman D, Imes S, Ryan EA, Shapiro AM, Lakey JRT. Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using pre-oxygenated perfluorocarbon. Transplantation 2006, 82 (10): 1286-90 (IF:3.5; Sixth in the field of Transplantation)

18.Mirbolooki M, Lakey JRT. Oxygen and pancreas preservation. Transplantation, 2006, 81 (3): 249. (IF:3.5; Sixth in the field of Transplantation)

* Co-First Author

Published Abstracts

1.Mirbolooki MR, Constantinescu C, Naqvi SA, Thorosian N, Pan ML, Mukherjee J. Enhancement of brown adipose tissue metabolism through adrenergic system activation quantifiable with 18F-FDG PET/CT in mice J NUCL MED 2012, 53: 1776

2.Constantinescu C, Mirbolooki MR, Vikram B, Pan ML, Borrelli E, Mukherjee J. Probing the D3R system using D2R knockout mice imaging with selective D3 agonist [18F]FHXPAT and D2/D3 antagonist [18F]fallypride J NUCL MED 2012, 53: 358

3.Mirbolooki MR, Constantinescu C, Pan ML, Mukherjee J. Imaging dopamine receptors in brown adipose tissue using 18F-fallypride and 18F-FHXPAT. J NUCL MED 2012, 53: 407

4.Constantinescu C, Corches A, Mirbolooki MR, Pan ML, Mukherjee J. Effect of acetylcholinesterase inhibitor, donepezil, on in vivo binding of nicotinic {alpha}4{beta}2 receptor agonist [18F]nifene in the rat brain. J NUCL MED 2012, 53: 1891

5.Majji D, Pan ML, Constantinescu C, Mirbolooki MR, Mukherjee J. Rodent PET evaluation of fluorine-18 labeled dopamine D3 receptor agonist, 18F-7-OH-FHXPAT. J NUCL MED 2012, 53: 1634

6.Mukherjee M, Pan ML, Mirbolooki MR, Constantinescu C, Mukherjee J. 11C-TAZA, a new PET imaging agent for A{beta}-amyloid plaques in the human brain. J NUCL MED 2012, 53: 1631

7.Bui V, Pan ML, Liang C, Mirbolooki MR, Constantinescu C, Mukherjee J. Schiff base PET imaging analogs for human Alzheimer's disease (AD) senile plaque. J NUCL MED 2012, 53: 1626

8.Liang C, Pan ML, Mirbolooki MR, Constantinescu C, Mukherjee J. Synthesis and analysis of [18F]-4-fluoromethylcyclohexanoic acid, a metabolite of 18F-Mefway. J NUCL MED 2012, 53: 1625

9.Thio J, Liang C, Pan ML, Mirbolooki MR, Constantinescu C, Mukherjee J. 3-18F-Mefway, an isomeric analog of mefway for imaging serotonin 5HT1a receptors. J NUCL MED 2012, 53: 1611

10.Patel B, Pan ML, Liang C, Mirbolooki MR, Constantinescu C, Mukherjee J. 11C-Dalene, a new agent for beta amyloid senile plaques in the human brain. J NUCL MED 2012, 53: 1604

11.Pan ML, Mukherjee M, Patel B, Patel H, Liang C, Vasilevko V,
Constantinescu C, Mirbolooki MR, Mukherjee J. 11C-TAZA and 11C-Dalene: new PET imaging agents for human brain senile plaques also bind to norepinephrine transporter. Journal of Cerebral Blood Flow & Metabolism 2012, 32, S117; doi:10.1038/jcbfm.2012.79

12.Mirbolooki MR, Pan ML, Patel B, Liang C, Patel H, Mukherjee M, Constantinescu C, Mukherjee J. Imaging norepinephrine transporter and glucose metabolism in rat brown adipose tissue. Journal of Cerebral Blood Flow & Metabolism 2012, 32, S119; doi:10.1038/jcbfm.2012.79

13.Upadhyay SK, Eckel-Mahan K, Mirbolooki MR, Tjong IW, Mukharjee J, Iadonato SP, Sassoni-Corsi P, Wang PH, Chandy KG. Anti-Obesity Effect of Shk-186, a K+ Channel Blocker. Biophysical journal 2012, 102 (3): 658a

14.Mukherjee J, Pan ML, Liang C, Mukherjee M, Vasilevko V, Patel H, Constantinescu C, Mirbolooki MR. Norepinephrine binds to 11C-PIB labeled ?-amyloid plaques in post-mortem Alzheimer's disease brain. Journal of Cerebral Blood Flow & Metabolism 2012, 32, S78; doi:10.1038/jcbfm.2012.78

15.Constantinescu C, Borelli E, Pan ML, Mirbolooki MR, Liang C and Mukherjee J. Evaluation of D3 versus D2 receptor binding in rats and D2R knockout mice using in vivo PET imaging with [18F]desmetoxyfallypride and [18F]fallypride. Journal of Cerebral Blood Flow & Metabolism 2012, 32, S82; doi:10.1038/jcbfm.2012.78

16.Constantinescu C, Pan ML, Patel B, Mukherjee M, Patel H, Liang C, Mirbolooki MR, Mukherjee J. Preliminary evaluation of in vivo NET binding in the rat brain with [11C]Dalene and [11C]TAZA using PET imaging. Journal of Cerebral Blood Flow & Metabolism 2012, 32, S165; doi:10.1038/jcbfm.2012.80

17.Mirbolooki MR, Sevrioukov E, Garcia A, Constantinescu C, Mukherjee J. Imaging brown adipose tissue activation using {beta}3-adrenoceptor agonist. J NUCL MED 2011, 52: 516

18.Garcia A, Grewal S, Milne N, Mirbolooki MR, Constantinescu C, PanML, Wang P, Chandy GK, Mukherjee J. 18F-Fallypride PET/CT scanning in type 1 diabetic patients. J NUCL MED 2011, 52: 222

19.Garcia A, Milne N, Mirbolooki MR, PanML, Pandey S, Constantinescu C, Lakey J, Wang P, Chandy GK, Mukherjee J. 18F-Fallypride PET to monitor pancreatic beta cell loss in diabetes mellitus. J NUCL MED 2009, 50: 1947

20.Mirbolooki MR, Garcia A, Constantinescu C, Kant R, Pan ML, Pandey S, Coleman R, Milne N, Grewal SR, Wang PH, Hoyt DB, Chandy GK, Mukherjee J, Lakey JRT. 18F-Fallypride PET imaging to monitor transplanted islets. Xenotransplantation 2009, 16(5):343

21.Mirbolooki MR, Alexander A, Bozorgmanesh A, Steward E, Malinoski D, Hoyt DB, Lakey JRT. Glucose and Oxygen Supplements in UW Solution Improve Islet Isolation Outcome. Xenotransplantation 2009, 16 (5):420
Last updated
10/01/2013