Lilit Mnatsakanyan, MD

Picture of Lilit Mnatsakanyan, MD
Associate Clinical Professor, Neurology
Director Intraoperative Neuromonitoring Program
Program Director, Neurology Residency Training
M.D.
Phone: (714) 456- 6203
Fax: 714 - 456 -3652
Email: mnatsakl@uci.edu
University of California, Irvine
Pav I, 1st Floor
Irvine, CA 92868
Academic Distinctions
Orange County Physician of Excellence (“Top Doctors”) 2020, 2021
Faculty Of The Year. UCI Neurology, 2017 and 2018
Orange County Physician of Excellence (“Top Doctors”) 2017- 2019
Fellow American Clinical Neurophysiology Society (FACNS) 2016
Southern California Super Doctors “Rising stars” 2015
Tomas Cesario Clinician of the year Award Nomination 2013
Southern California Super Doctors “Rising stars” 2013
Chief Resident University of Chicago 2008-2009
Americal Academy of Neurology Resident 2009 scholarship
Top Scholar Epilepsy Career Development, Boston, MA, 2009
Publications
K. Tran, D. Tran, L. Mnatsakanyan, J.Lin, F.Hsu, S. Vadera. Treatment of multifocal epilepsy with resective surgery plus RNS: One Institution’s experience. Frontiers 2020

L.Hirsch, E. Miro, V. Salanova, T. Witt, C.Drees, M. Brown, R. Lee, T.Sadler, E. Felton, P. Rutecki, H. Shin, E. Hadar, M. Hedge, V. Rao, L. Mnatsakanyan,
D. Madhavan, T. Zakaria, A.Liu, C. Heck, J. Greenwood, J. Bigelow, D. Nair, A. Alexopoulous, M. Mackow, J. Edwards, N. Sotudeh, R. Kuzniecky, R. Gwinn, M. Doherty, E. Geller, M. Morell. Mesial Temporal Resection Following Long-Term Ambulatory Intracranial EEG Monitoring with a Direct Brain-Responsive Neurostimulation System. Epilepsia Mar.2020 PMID: 32072621

R. Helfrich, J. Lendner, B. Mander, H. Guillen, M. Paff, L. Mnatsakanyan, S. Vadera, M. Walker, J. J Lin, R. Knight. Bidirectional Prefrontal-Hippocampal Dynamics Organize Information Transfer during Sleep in Humans. Nat Commun. 2019 Aug 8;10(1):3572. doi: 10.1038. PMID: 31395890

K. Tran, M. Paff, L. Mnatsakanyan, I. Sen-Gupta, J.J. Lin, F. Hsu, S. Vadera. A Novel Robotic-Assisted Technique To Implant The Responsive Neurostimulation System. Operative Neurosurg (Hagerstown). 2020 Jun 1;18(6):728-735. doi: 10.1093. PMID: 31538187

Zheng J, Stevenson R, Mander B., Mnatsakanyan, L, Hsu F., Vadera S, Knight RT, Yassa MA, Lin JJ. Multiplexing of Theta and Alpha Rhythms in the Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information. Neuron 2019 May 22; 102(4): 887-898. doi: 10.1016. PMID: 30979537

Stevenson R, Zheng J, Mnatsakanyan, L, Vadera S, Knight RT, Lin JJ, Yassa MA, Hippocampal CA1 gamma power predicts the precision of spatial memory judgments. Nature Neuroscience. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10148-10153. doi: 10.1073. PMID: 30224452

M.Young, S.Vadera, J. Lin, L.Mnatsakanyan. Using electrocorticogram baseline seizure frequency to assess the efficacy of responsive neurostimulation. Epilepsy Behav. 2018 Aug;85:7-9. doi: 10.1016. PMID: 29890343

S. Vadera, A.Y Chan, J. Lin, L. Mnatsankanyan, M. Sazgar, I. Sen-Gupta, F. Hsu. Strategic Hospital Partnerships: Improved access to care and Increased epilepsy surgical volume. Neurosurg Focus. 2018 May;44(5):E9. doi: 10.3171 PMID: 29712523

Chan AY, Mnatsakanyan L, Sazgar M, Sen-Gupta I, Lin JJ, Hsu FPK, Vadera S. Accuracy and Efficacy for Robotic Assistance in Implanting Responsive Neurostimulation Device Electrodes in Bilateral Mesial Temporal Lobe Epilepsy.
Oper Neurosurg (Hagerstown). 2018 Mar 1;14(3):267-272

L. Mnatsakanyan, MD, S. Vadera, MD, C. Ingalls, PhD, J. Zheng, M. Sazgar, MD, F. P. Hsu MD, PhD and J.J. Lin, MD. Language recovery after epilepsy surgery of the Broca’s area. Epilepsy & Behavior Case Reports. June 2017

Jie Zheng, Kristopher L. Anderson, Stephanie L. Leal, Avgusta Shestyuk, Gultekin Gulsen, Lilit Mnatsakanyan, Sumeet Vadera, Frank P.K. Hsu, Michael A. Yassa, Robert T. Knight & Jack J. Lin. Amygdala-hippocampal dynamics during salient information processing. Nat. Commun. 2017 Feb 8; 8 14413

A.Y Chan BS, S. Kharrat, L. Mnatsakanyan MD, M. Sazgar MD, I. Sen-Gupta MD, J. J Lin MD, F. PK Hsu MD PhD, S. Vadera, MD. Length of Stay for Patients Undergoing Invasive Electrode Monitoring with Stereoelectroencephalography and Subdural Grids Correlates Positively with Increased Institutional Profitability. Epilepsia 2017 Feb 28

J. Ledesma, L. Mnatsakanyan, MD, J. Lin, MD, I. Sen-Gupta, MD, M. Sazgar, MD,
F. P. K. Hsu, MD PhD, Sumeet Vadera, MD. Responsive Neurostimulation System (RNS) in setting of cranioplasty and history of multiple craniotomies. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 5 (2016) 29–31

A.Y Chan BS, J. J Lin MD, Lilit Mnatsakanyan MD, M. Sazgar MD, I. Sen-Gupta MD, F. Hsu MD PhD, S. Vadera MD. Robot-Assisted Stereotactic Laser Ablation of Residual Epileptogenic Focus in the Setting of Chronic Low Back Pain. International Journal of Case Reports and Images, Vol. 7 No. 8, August 2016

A.Y Chan BS, J. J Lin MD, Lilit Mnatsakanyan MD, M. Sazgar MD, I. Sen-Gupta MD, F. Hsu MD PhD, S. Vadera MD. Robot-Assisted Placement of Depth Electrodes along the Long Axis of the Amygdalohippocampal Complex. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 6 (2016) 38–41
L. Mnatsakanyan, J. Chung, E.,Tsimerinov, D. Eliashiv. Intravenous Lacosamide in Refractory Nonconvulsive Status Epilepticus. Seizure 21 (2012) 198–201

L. Mnatsakanyan, F. N. Ross-Cisneros, V. Carelli, M. Y Wang, A. A. Sadun. Axonal degeneration in peripheral nerves in a case of Leber's Hereditary Optic Neuropathy. J Neuroophthalmol. 2011 Mar;31(1):6-11

B. T. Lund, Y. Chakryan, N. Ashikian, L. Mnatsakanyan, C. J. Bevan, M. W. Jakowec. Association of MBP peptides with Hsp70 in normal appearing human white matter. Journal of the Neurological Sciences 249 (2006) 122–134



L. Mnatsakanyan. Progressive confusion and fatigue in a 38-year-old man. Medlink Neurology Grand Rounds session (Medlink.com), December 2010

L. Mnatsakanyan Continuous muscle twitching. Medlink Neurology Grand Rounds session (Medlink.com) May 2010

L. Mnatsakanyan Stroke in atrial fibrillation, hemorrhagic transformation, safety and timing of holding the oral anticoagulation. Medlink Neurology Grand Rounds session (Medlink.com), August 2009

L. Mnatsakanyan Bilateral lower extremity weakness. Medlink Neurology Grand Rounds session (medlink.com), May 2009



POSTERS
B. Hussain, J. Lin, L. Mnatsakanyan, M. Sazgar. The Effectiveness of Cannabidiol as Treatment for Drug Resistant Epilepsy. AES 2020

B. Jung, S.Vadera, M. Sazgar, N. Sen-Gupta, J.J. Lin and L. Mnatsakanyan. Cognitive and psychiatric outcomes following epilepsy surgery in a single academic center.
AES 2020

M. Nagamine, S. Osman, N. Chen, L. Mnatsakanyan et al. Covid-19 Presenting as Post-infectious Myelitis: A Case Report. ANA 10/2020

B. Jung, S.Vadera, M. Sazgar, N. Sen-Gupta, J.J. Lin and L. Mnatsakanyan. Cognitive and psychiatric outcomes following epilepsy surgery. AAN 2020 Toronto, Canada

B. Jung, J. Lu, L. Mnatsakanyan. An Unusual Presentation of a Progressive Myoclonic syndrome. AAN 2020, Toronto, Canada

E. Valenti, S.Vadera, M. Sazgar, N. Sen-Gupta, J.J. Lin and L. Mnatsakanyan. Prevalence and Outcomes of Mood Disorder Following Temporal Lobectomy. AES 2019 Baltimore Platform and Poster

I. Skelin, H. Zhang, A. J. O. Dede, S. Vadera, M. Paff, I. Sen-Gupta, L.Mnatsakanyan, F. P. K. Hsu et al. Feedback tuning of single neurons: evidence for distributed learning signals in the human brain. Society for Neurosciences, Chicago 10/2019

K. Tran, L. Mnatsakanyan, J. Lin, F. Hsu, S. Vadera. Improved Seizure Reduction Associated with Novel Robotic assisted Technique to implant Responsive Neurostimulation. AES 2018 New Orleans

L.Hirsch, E. Miro, V. Salanova, C. Drees, M. Brown, L. Mnatsakanyan et al. Outcomes after Mesial Temporal Lobe Resection Following Long-Term Ambulatory Recording by the RNS System. Multicenter study. AES 2018 New Orleans

E. Valenti, M. Young, S. Vadera, J. Lin, L. Mnatsakanyan. Comparison of Seizure onset patterns with stereotactic EEG and chronic Ecog. AES 2018 New Orleans

J. Zheng, S. Vadera, L. Mnatsakanyan, J. Lin and R. Knight. Frontotemporal network temporally encodes emotional sequences in humans. Society of Neuroscience Meeting 2018, San Diego 11/6/2018 Oral Presentation in the Nanosymposium

J. Zheng, S. Vadera, L. Mnatsakanyan, J. Lin. Orbitofrontal Cortext Integrates Amygdala-Hippocampal Information and Guides Scheme-Based Emotional Categorization. Cognitive Neuroscience Society Meeting. Boston 3/2018

H. Guillen, I. Sen-Gupta, L. Mnatsakanyan. Testing Reliability of Modified Electrode Positioning to Record wave V. International Clinical Neurophysiology Conference, Washington DC 2018

J. Zheng, S. Vadera, L. Mnatsakanyan, J. Lin. Context Modulates Facial Emotion in the Frontotemporal Network. UC Irvine Epi-Conference 2018

M. Young, F. Bannout, S. Vadera, J. J. Lin, Lilit Mnatsakanyan. Using Electrocorticogram Baseline Seizure Frequency to Assess Responsive Neurostimulation Efficacy. AES 2017 Platform session and the Poster session

S. Bederman, N. Jain, D.Yanni, H. Guillen, L. Mnatsakanyan. Saphenous Nerve Somatosensory Evoked Potentials monitoring during Lateral Interbody Fusion. Global Spine Journal, May 2017

M. Young, M. Sazgar, I. Sen-Gupta, S. Vadera, F. Hsu, T. Losey, F. Bannout, J. Lin, L. Mnatsakanyan. The rate of false lateralization from scalp EEG in epilepsy patients with bilaterally implanted intracranial EEG. ACNS Meeting 2016, Orlando FL

H. Guillen, B. Nye, M. Ross, I. Sen-Gupta, L. Mnatsakanyan. The use of multipulse stimulation for somatosensory evoked potentials (SSEP) as an alternative method in poorly reproducing signals. ACNS Meeting 2016, Orlando FL

N. Naderi, J. Lin, M. Sazgar, I. Sen-Gupta, L. Mnatsakanyan. Predictors of In-Hospital Mortality in Status Epilepticus; Data from The Nationwide Inpatient Sample Database, 2008-2012. AAN 2015, Washington DC

N. Jain, L. Mnatsakanyan, D.Yanni, S. Bederman Saphenous Nerve Somatosensory Evoked Potentials monitoring during Lateral Interbody Fusion. Global Spine Congress, Buenos Aires, Argentina 2015

N. Naderi, D. Moriyama, J. Lin, M. Sazgar, I. Sen- Gupta, L. Mnatsakanyan. Predictors Of In-hospital Mortality in Status Epilepticus. Data from Nationwide Inpatient Sample Database. AES Late-braking poster session Seattle, Washington 12.2014
L. Mnatsakanyan, MD, S. Bederman, MD, PhD and D. Yanni, MD. Saphenous Nerve SSEP during Lateral Interbody Fusion. Poster session ACNS 2014, Atlanta, Georgia
V. Doan, JJ. Lin, M. Sazgar, and L. Mnatsakanyan. Treatment of acute migraines with Vagal Nerve Stimulator (VNS). International Congress of Clinical Neurophysiology (ICCN) 2014, Berlin, Germany

Mnatsakanyan L., Bederman S.S., Guillen H., Yanni D. Saphenous Nerve Somatosensory Evoked Potentials (SSEP) monitoring during Lateral Interbody Fusion (LIF) in preventing femoral nerve injury. ICCN 2014, Berlin, Germany

M. Connolly, J. D. Riley, M. Sazgar, L. Mnatsakanyan, A. Linane, F.Hsu, J. J. Lin. Differential Hippocampal and Extrahippocampal Predictors of Verbal and Visual Memory in Right and Left TLE patients. Poster session AES Washington DC 2013

A. Shah, L. Mnatsakanyan, J. Chung, D. Eliashiv, E I. Tsimerinov. Comparison of Continuous 32 Channel EEG Monitoring and SSEPs Monitoring with Burst Suppression during Carotid Endarterectomy (CEA) in Predicting Surgical Outcome (Update). Poster session ACNS 2013, Miami and AAMWC platform session 2013, Los Angeles (L. Mnatsakanyan presenter)

L. Mnatsakanyan, J. Chung, E. Tsimerinov, D. Eliashiv. Intravenous Lacosamide in Refractory Nonconvulsive Status Epilepticus. International Epilepsy Congress. Rome 9/2011

L. Mnatsakanyan, D. Eliashiv, J. Chung, E. Tsimerinov. Comparison of Continuous 32 Channel EEG Monitoring and SSEPs Monitoring with Burst Suppression during Carotid Endarterectomy (CEA) in Predicting Surgical Outcome. American Academy of Neurology (AAN ) 2011 Poster and Clinical Neurophysiology Highlights sessions, Honolulu, HI

D. Eliashiv, E. Tsimerinov, J. Nativ, L. Mnatsakanyan et al. Prevalence of Seizures in the Critical Care Setting: Continuos EEG Monitoring and Effect on Outcome. AAN 2011 Honolulu, HI

L. Mnatsakanyan, F. Goldenberg, J. Frank. Treatable Solitary Blindness: An Unusual Initial Manifestation of Herpes Simplex Virus Type 2 (HSV2) Meningoencephalitis in a Cancer Patient. American Academy of Neurology (AAN) 2009 poster session, Seattle, WA

L. Mnatsakanyan, F. N. Ross-Cisneros, V. Carelli, A. A. Sadun.
Degeneration of peripheral nerves in Leber’s Hereditary Optic Neuropathy. Association for Research in Vision and Ophthalmology (ARVO): 2005 poster session
Professional Societies
Americam Academy of Neurology
American Epilepsy society
American Academy of Clinical Neurophysiology
Other Experience
Epilepsy and Clinical Neurophsyiology Fellowship
UCLA/Cedars Sinai Medical Center 2009—2011
Adult Neurology Residency
University of Chicago Medical Center 2006—2009
Internship Internal Medicine
Griffin Hospital affiliated with Yale university 2005—2006
Research Fellow
Doheny Neuroophthalmology Research Center, University of Southern California 2004—2005
Last updated
08/03/2021