Arash Kheradvar

picture of Arash  Kheradvar

Professor of Biomedical Engineering and Medicine, Biomedical Engineering
The Henry Samueli School of Engineering

Ph.D., California Institute of Technology, 2006, Bioengineering
M.D., Tehran University of Medical Sciences, 2000, Medicine

ORCiD: 0000-0003-3864-1359

Phone: (949) 824-6538
Fax: (949) 824-9968

University of California, Irvine
2410 Engineering Hall
Mail Code: 2730
Irvine, CA 92697
Research Interests
Heart Valve Engineering, Artificial Inteligence, Cardiac Imaging, Cardiac Mechancis, Mitochondrial Transplantation
Awards and Honors
Fulbright Distinguished Chair in Health Sciences by J. William Fulbright Foreign Scholarship Board
J58. Arafati A, Morisawa D, Avendi MR, Amini, MR, Assadi RA, Jafarkhani H, Kheradvar A. Generalizable Fully Automated Multi-Label Segmentation of 4-Chamber View Echocardiograms based on Deep Convolutional Adversarial Networks. Journal of the Royal Society Interface, 2020, in press.
J57. Wang DD, Qian Z, Vukicevic M, Engelhardt S, Kheradvar A, Zhang C, Little SH, Verjans J, Comaniciu D, O’Neill WW, Vannan MA. 3D Printing, Computational Modeling and Artificial Intelligence for Structural Heart Disease. Journal of American College of Cardiology: Cardiovascular Imaging, 2020, in press.
J56. Ali Pour P, Kenney CM, Kheradvar A. Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes, J Am Heart Assoc. 2020 Apr 7;9(7):e014501. doi: 10.1161/JAHA.119.014501. Epub 2020 Mar 23.
J55. Kulkarni A, Morisawa D, Gonzalez D, Kheradvar A. Age-related Changes in Diastolic Function in Children: Echocardiographic Association with Vortex Formation Time, Echocardiography, 2019 October 36(10); 1869-1875.
J54. Arafati A, Hu P, Finn JP, Rickers C, Cheng AL, Jafarkhani H, Kheradvar A. Artificial Intelligence in Pediatric and Adult Congenital Cardiac MRI: An Unmet Clinical Need, Cardiovascular Diagnosis and Therapy, 2019 October Vol 9, Supplement 2.
J53. Kheradvar A, Rickers C, Morisawa D, Kim M, Hong GR, Pedrizzetti G. Diagnostic and Prognostic Significance of Cardiovascular Vortex Formation, Journal of Cardiology, 2019 November 74(5); 403-11.
J52. Zareian R, Tseng JC, Fraser R, Meganck J, Kilduff M, Sarraf M, Dvir D, Kheradvar A. Effect of Stent-Crimping on Calcification of Transcatheter Aortic Valves, Interactive CardioVascular and Thoracic Surgery, 2019 Jul 1;29(1):64-73 (Featured on the cover of the July 2019 issue).
J51. Gabbert D, Hart C, Jerosch-Herold M, Wegner P, Salehi Ravesh M, Voges I, Kristo I, AL Bulushi A, Scheewe J, Kheradvar A, Kramer HH, Rickers C. Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation; Scientific Reports, 2019 Feb 14;9(1):2034.
J50. Morisawa D, Falahatpisheh A, Avenatti E, Little SH, Kheradvar A. Intraventricular Vortex Interaction between Transmitral Flow and Paravalvular Leak, Scientific Reports, 2018 Oct 23;8(1):15657.
J49. Kheradvar A, Zareian R, Kawauchi S, Goodwin RL, Rugonyi S. Animal Models for Heart Valve Research and Development. Drug Discovery Today: Disease Models, 2017 Summer;24:55-62.
J48. Kheradvar A. On the accuracy of intracardiac flow velocimetry methods, Journal of Echocardiography, 2017 June;15(2): 67-69.
J47. Avendi MR, Kheradvar A, Jafarkhani H. Automatic Segmentation of the Right Ventricle from Cardiac MRI Using a Learning-based Approach, Magnetic Resonance in Medicine, accepted.
J46. Alavi SH, Soriano Baliarda M, Bonessio N, Valdevit L, Kheradvar A. A Tri-leaflet Nitinol Mesh Scaffold for Engineering Heart Valves, Annals of Biomedical Engineering, in press.
J45. Sievers HH, Putman LM, Kheradvar A, Gabbert D, Wegner P, Scheewe J, Salehi-Ravesh M, Kramer HH, Rickers C. 4D flow streamline characteristics of the great arteries twenty years after Lecompte and direct spiral arterial switch operation (DSASO) in simple TGA, Global Cardiology Science and Practice 2016 (3):29.
J44. Dasi LP, Hatoum H, Kheradvar A, Zareian R, Alavi SH, Sun W, Martin C, Pham T, Wang Q, Midha P, Gowda VS, Yoganathan A. On the Mechanics of Transcatheter Aortic Valve Replacement, Annals of Biomedical Engineering, in press.
J43. Falahatpisheh A, Morisawa D, Toosky TT, Kheradvar A. A Calcified Polymeric Valve for Valve-in-Valve Applications, Journal of Biomechanics, 2017 Jan; 50(1): 77–82.
J42. Sievers HH, Kheradvar A, Kramer HH and Rickers C. 3D Heart Model and 4D Flow MRI 20 Years after Spiral Arterial Switch Operation. Thorac Cardiov Surg Reports, 2016 Dec; 05(01): 44-46.
J41. Hajiaghayi M, Groves EM, Jafarkhani H, and Kheradvar A. A 3D Active Contour Method for Automated Segmentation of the Left Ventricle from Magnetic Resonance Images, IEEE Transactions on Biomedical Engineering, 2017 Jan; 64 (1): 134-144.
J40. Avendi MR, Kheradvar A, Jafarkhani H. A Combined Deep-Learning and Deformable-Model Approach to Fully Automatic Segmentation of the Left Ventricle in Cardiac MRI, Medical Image Analysis, 2016 Feb 6;30:108-119.
J39. Rickers C, Falahatpisheh A, Kheradvar A, Wegner P, Gabbert D, Jerosch-Herold M, Hart C, Voges I, Putman L, Kristo I, Fischer G, Scheewe J, Sievers HH. Is the Lecompte Technique the last word on transposition of the great arteries repair for all patients? A magnetic resonance imaging study including a spiral technique two decades postoperatively, Interactive CardioVascular and Thoracic Surgery, accepted.
J38. Falahatpisheh A and Kheradvar A. A Framework for Synthetic Validation of 3D Echocardiographic Particle Image Velocimetry. Meccanica, in press.
J37. Falahatpisheh A, Rickers C, Gabbert DD, Heng EL, Stalder A, Kramer HH, Kilner PJ, Kheradvar A. Simplified Bernoulli's method significantly underestimates pulmonary transvalvular pressure Drop. Journal of Magnetic Resonance Imaging, in press.
J36. Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MRK, Alavi SH, Tranquillo R, Dasi LP, Simmons, CA, Goergen, CJ, Baaijens, F, Little SH, Canic S, Griffith B. Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies, Annals of Biomedical Engineering, 2015 Oct;43(10):2314-2333.
J35. Alavi SH, Sinha A, Steward E, Milliken JC, and Kheradvar A. Load Dependent Extracellular Matrix Organization in Atrioventricular Heart Valves: Differences and Similarities, American Journal of Physiology - Heart and Circulatory Physiology, 2015 Jul 15;309(2):H276-84.
J34. Falahatpisheh A, Pahlevan NM, Kheradvar A. Effect of the Mitral Valve’s Anterior Leaflet of on Axisymmetry of Transmitral Vortex Ring, Annals of Biomedical Engineering, 2015 Oct;43(10):2349-2360.
J33. Alavi SH and Kheradvar A. A Hybrid Tissue-Engineered Heart Valve, Annals of Thoracic Surgery, 2015 Jun;99(6):2183-2187.
J32. Pedrizzetti G, Vlachos P, Little W, Sotiropoulos F, Gharib M, Kheradvar A. On Proper Use of Fluid Dynamics Conservation Laws in Defining the Contribution of Diastolic Vortex Ring to Left Ventricular Filling, Journal of American College of Cardiology, Jun 16;65(23):2573-4.
J31. Kheradvar A, Groves EM and Tseng E. FOLDAVALVE: A Novel 14Fr Totally Repositionable and Retrievable Transcatheter Aortic Valve: Proof of Concept in Sheep. Euro Interventions 2015 Mar 16;10(11) pii: 20141002-01.
J30. Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo RT, Grande-Allen KJ, Simmons CA, Griffith BE, Falahatpisheh A, Goergen CJ, Mofrad MRK, Baaijens FPT, Little SH, Canic S. Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future, Annals of Biomedical Engineering, 2015 Apr;43(4):833-43.
J29. Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo RT, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MRK, Falahatpisheh A, Griffith BE, Baaijens FPT, Little SH, Canic S. Emerging Trends in Heart Valve Engineering: Part II. Novel and Standard Technologies for Aortic Valve Replacement, Annals of Biomedical Engineering, 2015 Apr;43(4):844-57.
J28. Falahatpisheh A, Pedrizzetti G, Kheradvar A. Three-Dimensional Reconstruction of Cardiac Flows Based on Multi-Planar Velocity Fields, Experiments in Fluids, November 2014, 55:1848.
J27. Falahatpisheh A, Kheradvar A. A Measure of Axisymmetry for Vortex Rings, European Journal of Mechanics - B/Fluids, 49 (2015) 264–271.
J26. Kheradvar A, Groves EM, Simmons CA, Griffith BE, Alavi SH, Tranquillo RT, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MRK, Baaijens FPT, Canic S, Little SH. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for mitral valve repair and replacement, Annals of Biomedical Engineering, 2015 Apr;43(4):858-70.
J25. Groves EM, Falahatpisheh A, Su JL, Kheradvar A. The Effects of Positioning of Transcatheter Aortic Valve on Fluid Dynamics of the Aortic Root, ASAIO J. 2014 Sep-Oct;60(5):545-52 (Featured on the cover of the Sep-Oct 2014 issue).
J24. Alavi SH, Groves EM, Kheradvar A. The Effects of Transcatheter Valve Crimping on Pericardial Leaflets, The Annals of Thoracic Surgery, 2014 Apr;97(4):1260-6.
J23. Abe H, Caracciolo G, Kheradvar A, Pedrizzetti G, Khandheria BK, Narula J, Sengupta PP. Contrast echocardiography for assessing left ventricular vortex strength: a prospective case–control pilot study in heart failure, European Heart Journal – Cardiovascular Imaging, accepted.
J22. Mangual JO, Föll D, Jung B, Pedrizzetti G, Kheradvar A. Aging does not Affect Radial Viscoelastic Behavior of the Left Ventricle, Cardiology, accepted.
J21. Alavi SH, Ruiz V, Krasieva T, Botvinick EL, and Kheradvar A. Characterizing the Collagen Fiber Orientation in Pericardial Leaflets under Mechanical Loading Conditions, Annals of Biomedical Engineering, 2013,41 (3) 547-561.
J20. Alavi SH, Liu WF, Kheradvar A. Inflammatory Response Assessment of a Hybrid Tissue-Engineered Heart Valve Leaflet. Annals of Biomedical Engineering, 2013, 41 (2) 316-26.
J19. Falahatpisheh A, Kheradvar A. High-Speed Particle Image Velocimetry to Assess Cardiac Fluid Dynamics in vitro: From Performance to Validation, European Journal of Mechanics - B/Fluids, 35 (2012) 2–8.
J18. Sengupta PP, Pedrizzetti G, Kilner PJ, Kheradvar A, Ebbers T, Tonti G, Fraser, AG, Narula, J. Emerging Trends in Cardiovascular Flow Visualization, Journal of American College of Cardiology: Cardiovascular Imaging, 2012, 5; 305-16.
J17. Alavi SH, Kheradvar A. Metal Mesh Scaffold for Tissue Engineering of Membranes, Tissue Engineering Part C: Methods,2012, 18 (4); 293-301.
J16. Kheradvar A, Assadi R, Falahatpisheh, A, Sengupta, PP. Assessment of Transmitral Vortex Formation in Patients with Diastolic Dysfunction, Journal of American Society of Echocardiography, 2012, 25 (2) 220-7.
J15. Kheradvar A, Falahatpisheh, A. The Effects of Dynamic Saddle Annulus and Leaflet Length on Transmitral Flow Pattern and Leaflet Stress of a Bi-leaflet Bioprosthetic Mitral Valve, Journal of Heart Valve Disease, in press.
J14. Mangual JO, Jung B, Ritter JA, Kheradvar A, Modeling Radial Viscoelastic Behavior of Left Ventricle based on MRI Tissue Phase Mapping, Annals of Biomedical Engineering, 2010, 38 (10) 3102-3111.
J13. Kheradvar A, Houle H, Pedrizzetti G, Tonti G, Belcik T, Ashraf M, Lindner JR, Gharib M, Sahn DJ. Echocardiographic Particle Image Velocimetry: A Novel Technique for Quantification of Left Ventricular Blood Vorticity Pattern, Journal of American Society of Echocardiography (JASE) 2010, 23(1) 86-94.
J12. Grosberg A, Gharib M, Kheradvar A. The Effect of Fiber Geometry on Pulsatile Pumping and Energy Expenditure, Bulletin of Mathematical Biology, 2009, 71: 1580–1598.
J11. Kheradvar A, Gharib M. On Mitral Valve Dynamics and its connection to Early Diastolic Flow, Annals of Biomedical Engineering, 2009 Jan, 37(1):1-13.
J10. Kheradvar A, Gharib M. Influence of ventricular pressure-drop on mitral annulus dynamics through the process of vortex ring formation, Annals of Biomedical Engineering 2007, 35 (12):2050-2064.
J09. Kheradvar A, Milano M, Gharib M. Correlation between vortex ring formation and mitral annulus dynamics during ventricular rapid filling, ASAIO Journal (Journal of American Society of Artificial Internal Organs), Jan-Feb 2007 53(1): 8-16.
J08. Kheradvar A, Milano M, Gorman RC, Gorman III JH, Gharib M. Assessment of left ventricular viscoelastic components based on ventricular harmonic behavior; Cardiovascular Engineering, 2006 March 6(1): 30-39.
J07. Gharib M, Rambod E, Kheradvar A, Sahn DJ, Dabiri JO. A global index for heart failure based on optimal vortex formation in the left ventricle. Proceedings of National Academy of Sciences (PNAS) 2006, 103 (16): 6305-6308.
J06. Kheradvar A, Kasalko J, Johnson D, Gharib M. An in-vitro study of changing profile heights in mitral bioprostheses and their influence on flow. ASAIO Journal 2006 Jan-Feb 52(1):34-38.
J05. Amirzargar AA, Tabassi A, Khosravi F, Kheradvar A, Rezaei N, Naroueynejad M, Ansaripour B, Moradi B, Nikbin B. Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study. European Journal of Neurology 2005 Jan;12(1):25-30.
J04. Kheradvar A, Tabassi AR, Nikbin B, Khosravi F, Naroueynejad M, Moradi B, Amirzargar AA. Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study. Multiple Sclerosis. 2004 Oct;10(5):526-31.
J03. Rad AS, Jabbarvand M, Farahvash MM, Kheradvar A. Laser in situ keratomileusis and diode thermal keratoplasty for correction of hyperopia from +5.00 to +10.00 diopters. Journal of Refractive Surgery. 2002 May-Jun;18(3 Suppl):S318-20.
J02. Rad AS, Kheradvar A. Juvenile xanthogranuloma: concurrent involvement of skin and eye. Cornea, The Journal of Cornea and External disease. 2001 Oct;20(7):760-2.
J01. Behnia H, Kheradvar A, Shahrokhi M. An anatomic study of the lingual nerve in the third molar region. Journal of Oral & Maxillofacial Surgery. 2000 Jun;58(6):649-51.
G24. PI for the American Heart Association Grant-in-Aid: “Assessing the Risk of Transcatheter Heart Valve Calcification and Biomechanical Failure”, until June 30, 2018 G23. PI for NIH-1R21EB021513-01A1: “Ultrasound-Guided Delivery System for Accurate Positioning/Repositioning of Transcatheter Aortic Valves”; until July 2018. G22. PI for the American Heart Association Innovative Research Grant: “IVUS-Guided Delivery System for Accurate Positioning/Repositioning of Transcatheter Aortic Valves”, until December 2017. G21. Mentor for the American Heart Association postdoctoral grant (Fellow: S Hamed Alavi, Ph.D.): “Tissue Engineered Heart Valve with a Non-Degradable Scaffold”, until December 2017. G20. PI for NIH UC Center for Accelerated Innovation for the project: “A bio-inspired transcatheter mitral valve”, until September 2017 G19. PI for NIH UC Center for Accelerated Innovation for the project: “Development of a Self-Regenerative Hybrid Heart Valve”, until July 2017. G18. Gift from the Edwards Lifesciences Foundation for Preclinical Studies Related to the Self-Regenerating Hybrid Heart Valve program. G17. Mentor for the American Heart Association postdoctoral grant (Fellow: Ahmad Falahatpisheh, Ph.D.): “Computation of kinetic energy dissipation inside the right heart of patients with repaired tetralogy of Fallot”, until June 2016. G16. PI for Children’s Heart Foundation grant: “A Self-Regenerative Hybrid Heart Valve”, Until December 31, 2015. G15. Mentor for the American Heart Association Medical Student Research Program (Fellow: S. Reed Plimpton): “Development and Testing of a Bio-Prosthetic Mitral Valve with Dynamic Annulus”, 06/01/2013-08/31/2014 G14. PI for 2013-14 CORCL's Multi-Investigator Research Grant: 3D Segmentation of Cardiac Magnetic Resonance Images”, Until July 2015. G13. PI for 2013 Unmet Clinical Needs in Cardiovascular Medicine Seed Grant Competition: “Development of a Bio-Inspired Transcatheter Mitral Valve for Transapical Implantation”, Until December 31, 2015. G12. PI for American Heart Association Grant-in-Aid: “Assessment of the right ventricular flow in patients with RV dysfunction”, until December 31, 2015. G11. Gift from the Edwards Lifesciences for the Development and Testing of a First Hybrid, Self-Regenerating Heart Valve program. G10. PI for ICTS Translation of Device-Based Research Grant: “Animal Feasibility Study for the First Patient-Specific Hybrid Heart Valve”. Until July 2015 G09. Mentor for the American Heart Association predoctoral grant (Fellow: Ahmad Falahatpisheh): “Modeling the flow inside the right heart of patients with repaired tetralogy of Fallot” until December 31, 2014. G08. PI for the California-Catalonia Program for Engineering Innovation Award: “Development of a Biocompatible Tissue Engineered Heart Valve Leaflet Using Stem Cell” until November 2013 G07. PI for Coulter Translational Research Award: “Development of a Novel Self-expandable Bioprosthetic Heart Valve for Percutaneo
Professional Society
Fellow, American Heart Association
Research Center
The Edwards Lifesciences Center for Advanced Cardiovascular Technology
Last updated